Abstract：
:In a recent Science paper, Teles et al. (2013) show that type I and II interferons (IFNs) are reciprocally expressed in the polar immune forms of leprosy, with type I IFNs inducing IL-10 that interferes with the antimycobacterial effects of type II IFNs (IFNγ) at the site of infection.
journal_name
Cell Host Microbejournal_title
Cell host & microbeauthors
Desvignes LP,Ernst JDdoi
10.1016/j.chom.2013.04.001subject
Has Abstractpub_date
2013-04-17 00:00:00pages
377-8issue
4eissn
1931-3128issn
1934-6069pii
S1931-3128(13)00121-2journal_volume
13pub_type
评论,杂志文章abstract：:Microbial patterns are recognized by cell-surface receptors to initiate pattern-triggered immunity (PTI) in plants. Receptor-like cytoplasmic kinases (RLCKs), such as BIK1, and calcium-dependent protein kinases (CPKs) are engaged during PTI to activate the NADPH oxidase RBOHD for reactive oxygen species (ROS) producti...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2018.08.007
更新日期：2018-09-12 00:00:00
abstract：:In response to virus infection, cells can alter protein expression to modify cellular functions and limit viral replication. To examine host protein expression during infection with human cytomegalovirus (HCMV), an enveloped DNA virus, we performed a semiquantitative, temporal analysis of the cell surface proteome in ...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2012.05.012
更新日期：2012-07-19 00:00:00
abstract：:Pathogenic H7N9 avian influenza viruses continue to represent a public health concern, and several candidate vaccines are currently being developed. It is vital to assess if protective antibodies are induced following vaccination and to characterize the diversity of epitopes targeted. Here we characterized the binding...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2016.05.014
更新日期：2016-06-08 00:00:00
abstract：:The ecological dynamics underlying the coexistence between antagonistic populations of bacteria and their viruses, bacteriophages (phages), in the mammalian gut microbiota remain poorly understood. We challenged a murine synthetic bacterial community with phages to study the factors allowing phages-bacteria coexistenc...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2020.06.002
更新日期：2020-09-09 00:00:00
abstract：:Duffy antigen receptor for chemokines (DARC) expressed on red blood cells (RBCs) influences plasma levels of HIV-1-suppressive and proinflammatory chemokines such as CCL5/RANTES. DARC is also the RBC receptor for Plasmodium vivax. Africans with DARC -46C/C genotype, which confers a DARC-negative phenotype, are resista...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2008.06.002
更新日期：2008-07-17 00:00:00
abstract：:Disruption of homeostasis between the host immune system and the intestinal microbiota leads to inflammatory bowel disease (IBD). Whether IBD is instigated by individual species or disruptions of entire microbial communities remains controversial. We characterized the fecal microbial communities in the recently descri...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2010.08.004
更新日期：2010-09-16 00:00:00
abstract：:For proliferation, the malaria parasite Plasmodium falciparum needs to modify the infected host cell extensively. To achieve this, the parasite exports proteins containing a Plasmodium export element (PEXEL) into the host cell. Phosphatidylinositol-3-phosphate binding and cleavage of the PEXEL are thought to mediate p...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2012.09.010
更新日期：2012-11-15 00:00:00
abstract：:Malaria starts with the infection of the liver by Plasmodium parasites. Although extensive analysis of Plasmodium has revealed the expression patterns of this parasite in every stage of its life cycle, the liver stage remained unexplored. Recently, Tarun et al. have published the first complete transcriptome and prote...
journal_title：Cell host & microbe
pub_type： 杂志文章,评审
doi：10.1016/j.chom.2008.01.004
更新日期：2008-02-14 00:00:00
abstract：:Although Drosophila systemic immunity is extensively studied, little is known about the fly's intestine-specific responses to bacterial infection. Global gene expression analysis of Drosophila intestinal tissue to oral infection with the Gram-negative bacterium Erwinia carotovora revealed that immune responses in the ...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2009.01.003
更新日期：2009-02-19 00:00:00
abstract：:In nonmyeloid cells, Shigella hijacks the mitochondrial checkpoint of cell death, thereby inducing a regulated form of necrosis depending on Bnip3 and cyclophilin D. Carneiro et al. (2009) describe the interplay between this program and a prosurvival response transmitted via the Nod1/Rip2/NF-kappaB/Bcl-2 axis, which d...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章,评审
doi：10.1016/j.chom.2009.01.002
更新日期：2009-02-19 00:00:00
abstract：:Successful viruses must overcome the body's immune defenses. In this issue of Cell Host & Microbe, Goffinet et al. (2009) provide evidence that the host protein CD317, the target of the HIV Vpu protein, is part of an ancient innate immune response directed against budding viruses. ...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2009.02.002
更新日期：2009-03-19 00:00:00
abstract：:Herpesviruses subvert immune cell activation by inhibiting NK cell receptor (NKG2D)-activating ligands such as MICB. A human cytomegalovirus microRNA was recently shown to repress MICB expression. Nachmani et al. (2009) extend this finding to two other human herpesviruses, providing evidence for a conserved functional...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2009.03.009
更新日期：2009-04-23 00:00:00
abstract：:During viral infection, RIG-I-like receptors (RLRs) are activated upon dephosphorylation by the phosphatase PP1, resulting in type I interferon production. In this issue, Davis et al. (2014) and Mesman et al. (2014) show that measles virus inhibits this antiviral response by targeting PP1 and thus preventing RLR depho...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2014.06.013
更新日期：2014-07-09 00:00:00
abstract：:Poxviruses are large DNA viruses that include the causal agent of human smallpox and vaccinia virus. Poxviruses replicate in cytoplasmic foci known as DNA factories. Here we show that a virus-encoded transcription factor, viral mRNA, cellular RNA-binding protein heterodimer G3BP/Caprin-1 (p137), translation initiation...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2007.08.005
更新日期：2007-10-11 00:00:00
abstract：:RNA interference (RNAi) has been extensively used to identify host factors affecting virus infection but requires exogenous delivery of short interfering RNAs (siRNAs), thus limiting the technique to nonphysiological infection models and a single defined cell type. We report an alternative screening approach using siR...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2013.08.007
更新日期：2013-09-11 00:00:00
abstract：:Human noroviruses are a major cause of epidemic and sporadic gastroenteritis worldwide and can chronically infect immunocompromised patients. Efforts to develop effective vaccines and antivirals have been hindered by the uncultivable nature and extreme genetic diversity of human noroviruses. Although they remain a par...
journal_title：Cell host & microbe
pub_type： 杂志文章,评审
doi：10.1016/j.chom.2014.05.015
更新日期：2014-06-11 00:00:00
abstract：:A vaginal microbicide should prevent pathogen transmission without disrupting tissue barriers to infection. Ideally, it would not need to be applied immediately before sexual intercourse, when compliance is a problem. Intravaginal administration of small interfering RNA (siRNA) lipoplexes targeting Herpes Simplex Viru...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2008.12.003
更新日期：2009-01-22 00:00:00
abstract：:Cure of rodent malaria with the biocide triclosan highlighted the enzyme FabI as an antimalarial drug target. In this issue of Cell Host & Microbe, Yu et al. (2008) show that FabI is not the principle target of triclosan yet plays an important role specifically in malaria liver stage development. ...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2008.11.006
更新日期：2008-12-11 00:00:00
abstract：:Here I revisit our early experiments published in Cell Host & Microbe (Turnbaugh et al., 2008) showing that a diet rich in fat and simple sugars alters the gut microbiome in a manner that contributes to host adiposity, and reflect upon the remarkable advances and remaining challenges in this field. ...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2017.02.021
更新日期：2017-03-08 00:00:00
abstract：:The clinically silent Plasmodium liver stage is an obligatory step in the establishment of malaria infection and disease. We report here that expression of heme oxygenase-1 (HO-1, encoded by Hmox1) is upregulated in the liver following infection by Plasmodium berghei and Plasmodium yoelii sporozoites. HO-1 overexpress...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2008.04.003
更新日期：2008-05-15 00:00:00
abstract：:Salmonella Typhimurium causes diarrhea by infecting the epithelium and lamina propria of the intestinal mucosa and by secreting various effector proteins through type III secretion systems (TTSSs). However, the mechanisms by which Salmonella transverses the epithelium and is subsequently released into the lamina propr...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2011.11.013
更新日期：2012-01-19 00:00:00
abstract：:Initially described as an RNA surveillance pathway, nonsense-mediated decay (NMD) is also recognized to function in the regulation of host gene expression. In this issue of Cell Host & Microbe, three studies describe NMD-mediated defense strategies of plants and mammalian cells in response to pathogen infection. ...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2014.08.015
更新日期：2014-09-10 00:00:00
abstract：:Parasites undergo complex life cycles that comprise a wide variety of cellular differentiation events in different host compartments and transmission across multiple hosts. As parasites depend on host resources, it is not surprising they have developed efficient mechanisms to sense alterations and adapt to the availab...
journal_title：Cell host & microbe
pub_type： 杂志文章,评审
doi：10.1016/j.chom.2018.05.018
更新日期：2018-06-13 00:00:00
abstract：:Plant microbiome research highlights the importance of indigenous microbial communities for host phenotypes such as growth and health. It aims to discover the molecular basis by which host-microbe and microbe-microbe interactions shape and maintain microbial communities and to understand the role of individual microor...
journal_title：Cell host & microbe
pub_type： 杂志文章,评审
doi：10.1016/j.chom.2017.07.004
更新日期：2017-08-09 00:00:00
abstract：:Dengue hemorrhagic fever is shown to correlate with secondary infection with a virus serotype different from the previous infection. However, only a small fraction of secondary infections leads to hemorrhagic fever. A recent Science paper suggests that the fucosylation state and isotype of IgGs elicited in patients ma...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2017.02.011
更新日期：2017-03-08 00:00:00
abstract：:In this issue of Cell Host & Microbe, Walton et al. (2018) uncover the mycobacterial factors that activate VEGF signaling and promote aberrant angiogenesis in the tuberculous granuloma. Preventing abnormal angiogenesis in the granuloma represents a potential therapeutic approach for tuberculosis. ...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2018.09.016
更新日期：2018-10-10 00:00:00
abstract：:In 2014, an outbreak of avian A/H10N7 influenza virus occurred among seals along North-European coastal waters, significantly impacting seal populations. Here, we examine the cross-species transmission and mammalian adaptation of this influenza A virus, revealing changes in the hemagglutinin surface protein that incre...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2020.08.011
更新日期：2020-10-07 00:00:00
abstract：:Complement, a complex system of serum proteins, contributes to host defense through multiple mechanisms. In this issue of Cell Host & Microbe, Sorbara et al. (2018) discovered that cytosolic pathogens opsonized by complement are restricted by autophagy. This unexpected role for complement is important for cell-autonom...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2018.04.010
更新日期：2018-05-09 00:00:00
abstract：:Genome degradation correlates with host adaptation and systemic disease in Salmonella. Most lineages of the S. enterica subspecies Typhimurium cause gastroenteritis in humans; however, the recently emerged ST313 lineage II pathovar commonly causes systemic bacteremia in sub-Saharan Africa. ST313 lineage II displays ge...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2017.01.009
更新日期：2017-02-08 00:00:00
abstract：:Evolution of antibody repertoire against the Ebola virus (EBOV) proteome was characterized in an acutely infected patient receiving supportive care alone to elucidate virus-host interactions over time. Differential kinetics are observed for IgM-IgG-IgA epitope diversity, antibody binding, and affinity maturation to EB...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2020.01.001
更新日期：2020-02-12 00:00:00
