Abstract：
:Malaria starts with the infection of the liver by Plasmodium parasites. Although extensive analysis of Plasmodium has revealed the expression patterns of this parasite in every stage of its life cycle, the liver stage remained unexplored. Recently, Tarun et al. have published the first complete transcriptome and proteome analysis of this intriguing parasite stage, providing a list of potential candidate target genes for antimalarial vaccines and drugs.
journal_name
Cell Host Microbejournal_title
Cell host & microbeauthors
Mota MM,Rodriguez Adoi
10.1016/j.chom.2008.01.004subject
Has Abstractpub_date
2008-02-14 00:00:00pages
63-5issue
2eissn
1931-3128issn
1934-6069pii
S1931-3128(08)00030-9journal_volume
3pub_type
杂志文章,评审abstract：:Influenza viruses are important pathogens which pose an ongoing threat to public health due to their ability to mutate and evade immunity elicited by prior infection or vaccination. Their evolutionary diversity is facilitated by the plasticity of the antigenically variable head domain of the major surface glycoprotein...
journal_title：Cell host & microbe
pub_type： 杂志文章,评审
doi：10.1016/j.chom.2018.06.016
更新日期：2018-07-11 00:00:00
abstract：:Efficient nutrient acquisition in the human gut is essential for microbial persistence. Although polysaccharides have been well-studied nutrients for the gut microbiome, other resources such as nucleic acids and nucleosides are less studied. We describe several ribose-utilization systems (RUSs) that are broadly repres...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2019.11.009
更新日期：2020-01-08 00:00:00
abstract：:Colitis results from breakdown of homeostasis between intestinal microbiota and the mucosal immune system, with both environmental and genetic influencing factors. Flagellin receptor TLR5-deficient mice (T5KO) display elevated intestinal proinflammatory gene expression and colitis with incomplete penetrance, providing...
journal_title：Cell host & microbe
pub_type： 杂志文章
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更新日期：2012-08-16 00:00:00
abstract：:Mutations in the autophagy gene EPG5 are linked to the multisystem human disease Vici syndrome, which is characterized in part by pulmonary abnormalities, including recurrent infections. We found that Epg5-deficient mice exhibited elevated baseline innate immune cellular and cytokine-based lung inflammation and were r...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2015.12.011
更新日期：2016-01-13 00:00:00
abstract：:Vaccines are needed to combat the global rise in fungal diseases. In this issue of Cell Host & Microbe, Wüthrich et al. (2015) identify calnexin as a target of antigen-specific CD4 T cell responses against multiple fungal pathogens. This study illustrates that a conserved epitope triggers convergent cell-mediated immu...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2015.03.012
更新日期：2015-04-08 00:00:00
abstract：:Toxoplasma can reach distant organs, especially the brain, leading to a lifelong chronic phase. However, genes involved in related in vivo processes are currently unknown. Here, we use focused CRISPR libraries to identify Toxoplasma genes that affect in vivo fitness. We focus on TgWIP, whose deletion affects Toxoplasm...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2019.09.008
更新日期：2019-10-09 00:00:00
abstract：:Alphaviruses infect cells via a low-pH-triggered membrane fusion reaction mediated by the class II virus fusion protein E1, an elongated molecule with three extramembrane domains (DI-III). E1 drives fusion by inserting its fusion peptide loop into the target membrane and refolding to a hairpin-like trimer in which DII...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2008.10.012
更新日期：2008-12-11 00:00:00
abstract：:Control of virus infection relies on the stimulation of interferon-stimulated genes (ISGs) that inhibit viral replication. In a recent Nature paper, Gizzi et al. (2018) discovered that the ISG viperin inhibits virus replication by generating the ribonucleotide ddhCTP, which interferes with RNA synthesis, thus offering...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2018.07.014
更新日期：2018-08-08 00:00:00
abstract：:The ongoing epidemic of Zika virus (ZIKV) illustrates the importance of flaviviruses as emerging human pathogens. All vector-borne flaviviruses studied thus far have to overcome type I interferon (IFN) to replicate and cause disease in vertebrates. The mechanism(s) by which ZIKV antagonizes IFN signaling is unknown. H...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2016.05.009
更新日期：2016-06-08 00:00:00
abstract：:Modification of the intestinal microbiome is an emerging target to improve health and prevent or treat a number of diseases. In this issue of Cell Host & Microbe, Maldonado-Gómez et al. (2016) uncover the basic principles that govern the successful establishment and persistence of an exogenously introduced gut bacteri...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2016.09.012
更新日期：2016-10-12 00:00:00
abstract：:Interactions between the host and its microbiota are of mutual benefit and promote health. Complex molecular pathways underlie this dialog, but the identity of microbe-derived molecules that mediate the mutualistic state remains elusive. Helicobacter hepaticus is a member of the mouse intestinal microbiota that is tol...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2017.11.002
更新日期：2017-12-13 00:00:00
abstract：:Salmonella Typhimurium causes diarrhea by infecting the epithelium and lamina propria of the intestinal mucosa and by secreting various effector proteins through type III secretion systems (TTSSs). However, the mechanisms by which Salmonella transverses the epithelium and is subsequently released into the lamina propr...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2011.11.013
更新日期：2012-01-19 00:00:00
abstract：:Parasites undergo complex life cycles that comprise a wide variety of cellular differentiation events in different host compartments and transmission across multiple hosts. As parasites depend on host resources, it is not surprising they have developed efficient mechanisms to sense alterations and adapt to the availab...
journal_title：Cell host & microbe
pub_type： 杂志文章,评审
doi：10.1016/j.chom.2018.05.018
更新日期：2018-06-13 00:00:00
abstract：:Our intestinal microbiota harbors a diverse microbial community, often containing opportunistic bacteria with virulence potential. However, mutualistic host-microbial interactions prevent disease by opportunistic pathogens through poorly understood mechanisms. We show that the epithelial interleukin-22 receptor IL-22R...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2014.08.017
更新日期：2014-10-08 00:00:00
abstract：:Transition metals such as iron, zinc, copper, and manganese are essential for the growth and development of organisms ranging from bacteria to mammals. Numerous studies have focused on the impact of iron availability during bacterial and fungal infections, and increasing evidence suggests that copper is also involved ...
journal_title：Cell host & microbe
pub_type： 杂志文章,评审
doi：10.1016/j.chom.2012.01.009
更新日期：2012-02-16 00:00:00
abstract：:The intestinal microbiota is important for induction of inflammatory bowel disease (IBD). IBD is associated with complex shifts in microbiota composition, but it is unclear whether specific bacterial subsets induce IBD and, if so, whether their proportions in the microbiota are altered during disease. Here, we fulfill...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2011.04.009
更新日期：2011-05-19 00:00:00
abstract：:Hepatitis C virus (HCV) vaccine efforts are hampered by the extensive genetic diversity of HCV envelope glycoproteins E1 and E2. Structures of broadly neutralizing antibodies (bNAbs) (e.g., HEPC3, HEPC74) isolated from individuals who spontaneously cleared HCV infection facilitate immunogen design to elicit antibodies...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2018.10.009
更新日期：2018-11-14 00:00:00
abstract：:The mechanisms through which commensal bacterial populations cause inflammatory disease when shifted to dysbiotic community structures are poorly understood. Jiao et al. (2013) demonstrate that, in the case of inflammatory disease in the mouth, stimulation of the intracellular pattern recognition receptor Nod1 is a cr...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2013.05.001
更新日期：2013-05-15 00:00:00
abstract：:The human microbiome encodes extensive metabolic capabilities, but our understanding of the mechanisms linking gut microbes to human metabolism remains limited. Here, we focus on the conversion of cholesterol to the poorly absorbed sterol coprostanol by the gut microbiota to develop a framework for the identification ...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2020.05.013
更新日期：2020-08-12 00:00:00
abstract：:Invasion of epithelial cells by Shigella is a critical step in the pathogenesis of bacillary dysentery. In this issue of Cell Host & Microbe, Bergounioux et al. (2012) uncover a complex interplay of proinvasion, prosurvival, and prodeath signals centered on the activation of calpain protease by the Shigella VirA prote...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2012.02.004
更新日期：2012-03-15 00:00:00
abstract：:The oral microbial community represents the best-characterized consortium associated with the human host. There are strong correlations between the qualitative composition of the oral microbiota and clinically healthy or diseased states. However, additional studies are needed to elucidate the mechanisms that define th...
journal_title：Cell host & microbe
pub_type： 杂志文章,评审
doi：10.1016/j.chom.2011.09.008
更新日期：2011-10-20 00:00:00
abstract：:Complement, a complex system of serum proteins, contributes to host defense through multiple mechanisms. In this issue of Cell Host & Microbe, Sorbara et al. (2018) discovered that cytosolic pathogens opsonized by complement are restricted by autophagy. This unexpected role for complement is important for cell-autonom...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2018.04.010
更新日期：2018-05-09 00:00:00
abstract：:Cytosolic bacterial pathogens activate the cytosolic surveillance pathway (CSP) and induce innate immune responses, but how the host detects vacuolar pathogens like Mycobacterium tuberculosis is poorly understood. We show that M. tuberculosis also initiates the CSP upon macrophage infection via limited perforation of ...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2012.03.007
更新日期：2012-05-17 00:00:00
abstract：:Horizontal gene transfer (HGT) facilitates spead of antibiotic resistance elements. In this issue of Cell Host & Microbe, Domenech et al. discover that compounds disrupting proton motive force block natural competence (COM) and interrupt intraspecies HGT and exchange of antibiotic resistance. Such strategies might min...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2020.03.013
更新日期：2020-04-08 00:00:00
abstract：:Polysaccharide A (PSA), the archetypical immunomodulatory molecule of the gut commensal Bacteroides fragilis, induces regulatory T cells to secrete the anti-inflammatory cytokine interleukin-10 (IL-10). The cellular mediators of PSA's immunomodulatory properties are incompletely understood. In a mouse model of colitis...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2014.03.006
更新日期：2014-04-09 00:00:00
abstract：:Peptidoglycan recognition proteins (PGRPs or Pglyrps) regulate antibacterial responses in Drosophila, yet their functions in humans remain unclear. In this issue of Cell Host & Microbe, Saha and colleagues report that mammalian PGRPs can prevent aberrant interferon-gamma--induced inflammatory damage in vivo by modulat...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2010.07.010
更新日期：2010-08-19 00:00:00
abstract：:Metabolic coupling of intracellular pathogens with host cells is essential for successful colonization of the host. Establishment of intracellular infection by the protozoan Trypanosoma cruzi leads to the development of human Chagas' disease, yet the functional contributions of the host cell toward the infection proce...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2012.11.011
更新日期：2013-01-16 00:00:00
abstract：:Cure of rodent malaria with the biocide triclosan highlighted the enzyme FabI as an antimalarial drug target. In this issue of Cell Host & Microbe, Yu et al. (2008) show that FabI is not the principle target of triclosan yet plays an important role specifically in malaria liver stage development. ...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2008.11.006
更新日期：2008-12-11 00:00:00
abstract：:The liver-specific microRNA, miR-122, stabilizes hepatitis C virus (HCV) RNA genomes by recruiting host argonaute 2 (AGO2) to the 5' end and preventing decay mediated by exonuclease Xrn1. However, HCV replication requires miR-122 in Xrn1-depleted cells, indicating additional functions. We show that miR-122 enhances HC...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2014.12.014
更新日期：2015-02-11 00:00:00
abstract：:Intracellular pathogens like Shigella flexneri enter host cells by phagocytosis. Once inside, the pathogen breaks the vacuolar membrane for cytosolic access. The fate and function of the vacuolar membrane remnants are not clear. Examining Shigella-infected nonmyeloid cells, we observed that proteins associated with va...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2009.07.005
更新日期：2009-08-20 00:00:00
