当前位置： SCI文献检索 > Cell Host & Microbe期刊下所有文献 > Salmonella gut invasion involves TTSS-2-dependent epithelial traversal, basolateral exit, and uptake by epithelium-sampling lamina propria phagocytes.

Salmonella gut invasion involves TTSS-2-dependent epithelial traversal, basolateral exit, and uptake by epithelium-sampling lamina propria phagocytes.

Abstract：

:Salmonella Typhimurium causes diarrhea by infecting the epithelium and lamina propria of the intestinal mucosa and by secreting various effector proteins through type III secretion systems (TTSSs). However, the mechanisms by which Salmonella transverses the epithelium and is subsequently released into the lamina propria are poorly understood. Using a murine Salmonella-diarrhea model and in vivo microscopy, we show that epithelial traversal requires TTSS-1-mediated invasion and TTSS-2-dependent trafficking to the basolateral side. After being released into the lamina propria, the bacterium is transiently extracellular before being taken up by phagocytes, including CD11c(+)CX(3)CR1(high) monocytic phagocytes (MPs), which were found to constitutively sample cellular material shed from the basolateral side of the epithelium. Thus, Salmonella infects the cecal mucsa through a step-wise process wherein the bacterium transverses the epithelium through TTSS-2-dependent trafficking and then likely exploits lamina propria MPs, which are sampling the epithelium, to enter and replicate within the host.

journal_name

Cell Host Microbe

journal_title

Cell host & microbe

authors

Müller AJ,Kaiser P,Dittmar KE,Weber TC,Haueter S,Endt K,Songhet P,Zellweger C,Kremer M,Fehling HJ,Hardt WD

doi

10.1016/j.chom.2011.11.013

subject

Has Abstract

pub_date

2012-01-19 00:00:00

pages

19-32

issue

1

eissn

1931-3128

issn

1934-6069

pii

S1931-3128(11)00406-9

journal_volume

11

pub_type

杂志文章

相关文献

Cell Host & Microbe文献大全
  • Adenovirus evasion of interferon-mediated innate immunity by direct antagonism of a cellular histone posttranslational modification.

    abstract：:Overcoming the cellular type I interferon (IFN) host defense response is critical for a virus to ensure successful infection. Investigating the effects of human adenovirus (HAdV) infection on global cellular histone posttranslational modification (hPTM), we discovered that virus infection-induced activation of IFN sig...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2012.05.005

    authors： Fonseca GJ,Thillainadesan G,Yousef AF,Ablack JN,Mossman KL,Torchia J,Mymryk JS

    更新日期：2012-06-14 00:00:00

  • A deficiency in the autophagy gene Atg16L1 enhances resistance to enteric bacterial infection.

    abstract：:Polymorphisms in the essential autophagy gene Atg16L1 have been linked with susceptibility to Crohn's disease, a major type of inflammatory bowel disease (IBD). Although the inability to control intestinal bacteria is thought to underlie IBD, the role of Atg16L1 during extracellular intestinal bacterial infections has...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2013.07.013

    authors： Marchiando AM,Ramanan D,Ding Y,Gomez LE,Hubbard-Lucey VM,Maurer K,Wang C,Ziel JW,van Rooijen N,Nuñez G,Finlay BB,Mysorekar IU,Cadwell K

    更新日期：2013-08-14 00:00:00

  • Partially Open HIV-1 Envelope Structures Exhibit Conformational Changes Relevant for Coreceptor Binding and Fusion.

    abstract：:HIV-1 Env, a trimer of gp120-gp41 heterodimers, mediates membrane fusion after binding host receptor CD4. Receptor binding displaces V1V2 loops from Env's apex, allowing coreceptor binding and opening Env to enable gp41-mediated fusion. We present 3.54 Å and 4.06 Å cryoelectron microscopy structures of partially open ...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2018.09.003

    authors： Wang H,Barnes CO,Yang Z,Nussenzweig MC,Bjorkman PJ

    更新日期：2018-10-10 00:00:00

  • Microbiota-Dependent Priming of Antiviral Intestinal Immunity in Drosophila.

    abstract：:Enteric pathogens must overcome intestinal defenses to establish infection. In Drosophila, the ERK signaling pathway inhibits enteric virus infection. The intestinal microflora also impacts immunity but its role in enteric viral infection is unknown. Here we show that two signals are required to activate antiviral ERK...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2015.10.010

    authors： Sansone CL,Cohen J,Yasunaga A,Xu J,Osborn G,Subramanian H,Gold B,Buchon N,Cherry S

    更新日期：2015-11-11 00:00:00

  • Bacterial persistence: finding the "sweet spot".

    abstract：:Studies described by Eisele et al. (2013) and Xavier et al. (2013) in this issue of Cell Host & Microbe show that the bacterial pathogens Salmonella and Brucella exploit the increased levels of glucose present in alternatively activated macrophages to sustain chronic infections in experimentally infected mice. ...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2013.07.016

    authors： Roop RM 2nd,Caswell CC

    更新日期：2013-08-14 00:00:00

  • Programing of an Intravascular Immune Firewall by the Gut Microbiota Protects against Pathogen Dissemination during Infection.

    abstract：:Eradication of pathogens from the bloodstream is critical to prevent disseminated infections and sepsis. Kupffer cells in the liver form an intravascular firewall that captures and clears pathogens from the blood. Here, we show that the catching and killing of circulating pathogens by Kupffer cells in vivo are promote...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2020.07.014

    authors： McDonald B,Zucoloto AZ,Yu IL,Burkhard R,Brown K,Geuking MB,McCoy KD

    更新日期：2020-11-11 00:00:00

  • Epithelial IL-22RA1-mediated fucosylation promotes intestinal colonization resistance to an opportunistic pathogen.

    abstract：:Our intestinal microbiota harbors a diverse microbial community, often containing opportunistic bacteria with virulence potential. However, mutualistic host-microbial interactions prevent disease by opportunistic pathogens through poorly understood mechanisms. We show that the epithelial interleukin-22 receptor IL-22R...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2014.08.017

    authors： Pham TA,Clare S,Goulding D,Arasteh JM,Stares MD,Browne HP,Keane JA,Page AJ,Kumasaka N,Kane L,Mottram L,Harcourt K,Hale C,Arends MJ,Gaffney DJ,Sanger Mouse Genetics Project.,Dougan G,Lawley TD

    更新日期：2014-10-08 00:00:00

  • A Viral Deamidase Targets the Helicase Domain of RIG-I to Block RNA-Induced Activation.

    abstract：:RIG-I detects double-stranded RNA (dsRNA) to trigger antiviral cytokine production. Protein deamidation is emerging as a post-translational modification that chiefly regulates protein function. We report here that UL37 of herpes simplex virus 1 (HSV-1) is a protein deamidase that targets RIG-I to block RNA-induced act...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2016.10.011

    authors： Zhao J,Zeng Y,Xu S,Chen J,Shen G,Yu C,Knipe D,Yuan W,Peng J,Xu W,Zhang C,Xia Z,Feng P

    更新日期：2016-12-14 00:00:00

  • Induced ER chaperones regulate a receptor-like kinase to mediate antiviral innate immune response in plants.

    abstract：:Mounting an effective innate immune response against pathogens requires the rapid and global reprogramming of host cellular processes. Here we employed complementary proteomic methods to identify differentially regulated proteins early during a plant's defense response. Besides defense-related proteins, constituents o...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2009.10.005

    authors： Caplan JL,Zhu X,Mamillapalli P,Marathe R,Anandalakshmi R,Dinesh-Kumar SP

    更新日期：2009-11-19 00:00:00

  • A PfRH5-based vaccine is efficacious against heterologous strain blood-stage Plasmodium falciparum infection in aotus monkeys.

    abstract：:Antigenic diversity has posed a critical barrier to vaccine development against the pathogenic blood-stage infection of the human malaria parasite Plasmodium falciparum. To date, only strain-specific protection has been reported by trials of such vaccines in nonhuman primates. We recently showed that P. falciparum ret...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2014.11.017

    authors： Douglas AD,Baldeviano GC,Lucas CM,Lugo-Roman LA,Crosnier C,Bartholdson SJ,Diouf A,Miura K,Lambert LE,Ventocilla JA,Leiva KP,Milne KH,Illingworth JJ,Spencer AJ,Hjerrild KA,Alanine DG,Turner AV,Moorhead JT,Edgel KA,Wu

    更新日期：2015-01-14 00:00:00

  • HCV Broadly Neutralizing Antibodies Use a CDRH3 Disulfide Motif to Recognize an E2 Glycoprotein Site that Can Be Targeted for Vaccine Design.

    abstract：:Hepatitis C virus (HCV) vaccine efforts are hampered by the extensive genetic diversity of HCV envelope glycoproteins E1 and E2. Structures of broadly neutralizing antibodies (bNAbs) (e.g., HEPC3, HEPC74) isolated from individuals who spontaneously cleared HCV infection facilitate immunogen design to elicit antibodies...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2018.10.009

    authors： Flyak AI,Ruiz S,Colbert MD,Luong T,Crowe JE Jr,Bailey JR,Bjorkman PJ

    更新日期：2018-11-14 00:00:00

  • A critical role for SOCS3 in innate resistance to Toxoplasma gondii.

    abstract：:The innate and adaptive immune responses that confer resistance to the intracellular pathogen Toxoplasma gondii critically depend on IL-12 production, which drives interferon-γ (IFN-γ) expression. Certain cytokines can activate STAT3 and limit IL-12 production to prevent infection-associated immune pathology, but T. g...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2011.07.009

    authors： Whitmarsh RJ,Gray CM,Gregg B,Christian DA,May MJ,Murray PJ,Hunter CA

    更新日期：2011-09-15 00:00:00

  • Establishing Causality: Opportunities of Synthetic Communities for Plant Microbiome Research.

    abstract：:Plant microbiome research highlights the importance of indigenous microbial communities for host phenotypes such as growth and health. It aims to discover the molecular basis by which host-microbe and microbe-microbe interactions shape and maintain microbial communities and to understand the role of individual microor...

    journal_title：Cell host & microbe

    pub_type： 杂志文章,评审

    doi：10.1016/j.chom.2017.07.004

    authors： Vorholt JA,Vogel C,Carlström CI,Müller DB

    更新日期：2017-08-09 00:00:00

  • Mechanisms underlying robustness and tunability in a plant immune signaling network.

    abstract：:The plant immune signaling network needs to be robust against attack from fast-evolving pathogens and tunable to optimize immune responses. We investigated the basis of robustness and tunability in the signaling network controlling pattern-triggered immunity (PTI) in Arabidopsis. A dynamic network model containing fou...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2013.12.002

    authors： Kim Y,Tsuda K,Igarashi D,Hillmer RA,Sakakibara H,Myers CL,Katagiri F

    更新日期：2014-01-15 00:00:00

  • Duffy antigen receptor for chemokines mediates trans-infection of HIV-1 from red blood cells to target cells and affects HIV-AIDS susceptibility.

    abstract：:Duffy antigen receptor for chemokines (DARC) expressed on red blood cells (RBCs) influences plasma levels of HIV-1-suppressive and proinflammatory chemokines such as CCL5/RANTES. DARC is also the RBC receptor for Plasmodium vivax. Africans with DARC -46C/C genotype, which confers a DARC-negative phenotype, are resista...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2008.06.002

    authors： He W,Neil S,Kulkarni H,Wright E,Agan BK,Marconi VC,Dolan MJ,Weiss RA,Ahuja SK

    更新日期：2008-07-17 00:00:00

  • How Good Roommates Can Protect against Microbial Sepsis.

    abstract：:In this issue of Cell Host & Microbe, Wilmore et al. (2018) co-housed isogenic mouse populations, uncovering commensal bacteria-induced serum IgA and IgA-producing bone marrow plasma cells as critical components of resistance against sepsis. They further identified gut microbial taxa that may account for the induction...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2018.02.007

    authors： Beyaert R,Libert C

    更新日期：2018-03-14 00:00:00

  • HIV Latency: Stochastic across Multiple Scales.

    abstract：:Proviral latency is a major barrier to a cure for HIV. In this issue of Cell Host & Microbe, Hataye et al. (2019) show that reactivation of HIV latency is a non-deterministic, highly stochastic (i.e., noisy) process and propose that stochastic transitions to exponential viral expansion require a critical threshold of ...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2019.11.010

    authors： Hansen MMK,Martin B,Weinberger LS

    更新日期：2019-12-11 00:00:00

  • Pathogens' exploitation of the intestinal food web.

    abstract：:Competition for nutrients is a key factor controlling pathogen colonization within the gastrointestinal tract. In this issue, Ferreyra et al. (2014) and Curtis et al. (2014) show that diverse enteric pathogens can exploit a metabolic byproduct from the commensal microbiota, succinate, to enhance their own virulence ex...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2014.11.012

    authors： Pham N TA,Lawley TD

    更新日期：2014-12-10 00:00:00

  • Impaired stimulation of p38α-MAPK/Vps41-HOPS by LPS from pathogenic Coxiella burnetii prevents trafficking to microbicidal phagolysosomes.

    abstract：:Variations in lipopolysaccharide (LPS), a bacterial outer membrane component, determine virulence of the obligate intracellular bacterium Coxiella burnetii, but the underlying mechanisms are unknown. We find that while avirulent C. burnetii LPS (avLPS) stimulates host p38α-MAPK signaling required for proper traffickin...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2012.10.015

    authors： Barry AO,Boucherit N,Mottola G,Vadovic P,Trouplin V,Soubeyran P,Capo C,Bonatti S,Nebreda A,Toman R,Lemichez E,Mege JL,Ghigo E

    更新日期：2012-12-13 00:00:00

  • Shigella phagocytic vacuolar membrane remnants participate in the cellular response to pathogen invasion and are regulated by autophagy.

    abstract：:Intracellular pathogens like Shigella flexneri enter host cells by phagocytosis. Once inside, the pathogen breaks the vacuolar membrane for cytosolic access. The fate and function of the vacuolar membrane remnants are not clear. Examining Shigella-infected nonmyeloid cells, we observed that proteins associated with va...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2009.07.005

    authors： Dupont N,Lacas-Gervais S,Bertout J,Paz I,Freche B,Van Nhieu GT,van der Goot FG,Sansonetti PJ,Lafont F

    更新日期：2009-08-20 00:00:00

  • HIV-1 envelope gp41 antibodies can originate from terminal ileum B cells that share cross-reactivity with commensal bacteria.

    abstract：:Monoclonal antibodies derived from blood plasma cells of acute HIV-1-infected individuals are predominantly targeted to the HIV Env gp41 and cross-reactive with commensal bacteria. To understand this phenomenon, we examined anti-HIV responses in ileum B cells using recombinant antibody technology and probed their rela...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2014.07.003

    authors： Trama AM,Moody MA,Alam SM,Jaeger FH,Lockwood B,Parks R,Lloyd KE,Stolarchuk C,Scearce R,Foulger A,Marshall DJ,Whitesides JF,Jeffries TL Jr,Wiehe K,Morris L,Lambson B,Soderberg K,Hwang KK,Tomaras GD,Vandergrift N,Ja

    更新日期：2014-08-13 00:00:00

  • Carving a Niche for Antibacterial α-Defensins when Craving.

    abstract：:In this issue of Cell Host & Microbe, Liang et al. (2019) show that α-defensins in the gastrointestinal tract sustain defenses to enteric pathogens during starvation. mTOR-dependent sensing of nutrient loss promotes production of an α-defensin regulator, which sustains α-defensin levels, loss of which increases lethal...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2019.04.009

    authors： Foerster EG,Girardin SE

    更新日期：2019-05-08 00:00:00

  • Vpr overcomes macrophage-specific restriction of HIV-1 Env expression and virion production.

    abstract：:The HIV-1 accessory protein Vpr enhances infection of primary macrophages through unknown mechanisms. Recent studies demonstrated that Vpr interactions with the cellular DCAF1-DDB1-CUL4 E3 ubiquitin ligase complex limit activation of innate immunity and interferon (IFN) induction. We describe a restriction mechanism t...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2014.10.014

    authors： Mashiba M,Collins DR,Terry VH,Collins KL

    更新日期：2014-12-10 00:00:00

  • Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies.

    abstract：:The fusion peptide (FP) of HIV-1 envelope glycoprotein (Env) is essential for mediating viral entry. Detection of broadly neutralizing antibodies (bnAbs) that interact with the FP has revealed it as a site of vulnerability. We delineate X-ray and cryo-electron microscopy (cryo-EM) structures of bnAb ACS202, from an HI...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2019.04.011

    authors： Yuan M,Cottrell CA,Ozorowski G,van Gils MJ,Kumar S,Wu NC,Sarkar A,Torres JL,de Val N,Copps J,Moore JP,Sanders RW,Ward AB,Wilson IA

    更新日期：2019-06-12 00:00:00

  • The relationship of the oral microbiotia to periodontal health and disease.

    abstract：:The oral microbial community represents the best-characterized consortium associated with the human host. There are strong correlations between the qualitative composition of the oral microbiota and clinically healthy or diseased states. However, additional studies are needed to elucidate the mechanisms that define th...

    journal_title：Cell host & microbe

    pub_type： 杂志文章,评审

    doi：10.1016/j.chom.2011.09.008

    authors： Curtis MA,Zenobia C,Darveau RP

    更新日期：2011-10-20 00:00:00

  • Viperin Poisons Viral Replication.

    abstract：:Control of virus infection relies on the stimulation of interferon-stimulated genes (ISGs) that inhibit viral replication. In a recent Nature paper, Gizzi et al. (2018) discovered that the ISG viperin inhibits virus replication by generating the ribonucleotide ddhCTP, which interferes with RNA synthesis, thus offering...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2018.07.014

    authors： Ng LFP,Hiscox JA

    更新日期：2018-08-08 00:00:00

  • Hijacking Host Angiogenesis to Drive Mycobacterial Growth.

    abstract：:In this issue of Cell Host & Microbe, Walton et al. (2018) uncover the mycobacterial factors that activate VEGF signaling and promote aberrant angiogenesis in the tuberculous granuloma. Preventing abnormal angiogenesis in the granuloma represents a potential therapeutic approach for tuberculosis. ...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2018.09.016

    authors： Uusi-Mäkelä M,Rämet M

    更新日期：2018-10-10 00:00:00

  • A Bacterial Pathogen Targets a Host Rab-Family GTPase Defense Pathway with a GAP.

    abstract：:Cell-autonomous defense mechanisms are potent strategies that protect individual cells against intracellular pathogens. The Rab-family GTPase Rab32 was previously shown to restrict the intracellular human pathogen Salmonella Typhi, but its potential broader role in antimicrobial defense remains unknown. We show that R...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2016.01.004

    authors： Spanò S,Gao X,Hannemann S,Lara-Tejero M,Galán JE

    更新日期：2016-02-10 00:00:00

  • Bacteria Tell Us How to Protect Our Intestine.

    abstract：:The inner colon mucus layer capacity to separate bacteria from the epithelium is dependent on bacterial colonizers signaling to the host epithelium. In this issue of Cell Host & Microbe, Wlodarska et al. (2017) demonstrate that the mucin-utilizing Peptostreptococcus russellii protects the host from inflammatory diseas...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2017.06.011

    authors： Birchenough G,Hansson GC

    更新日期：2017-07-12 00:00:00

  • Keeping viruses in Chk: DNA damage signaling puts the brakes on transformation.

    abstract：:Oncogenic viruses infect many cells but rarely lead to tumorigenesis. In this issue of Cell Host & Microbe, Nikitin et al. describe how a protective DNA damage response acts to suppress transformation in the majority of cells latently infected with Epstein-Barr virus (EBV). ...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2010.11.010

    authors： Lilley CE,Weitzman MD

    更新日期：2010-12-16 00:00:00