Pathogens' exploitation of the intestinal food web.

Abstract:

:Competition for nutrients is a key factor controlling pathogen colonization within the gastrointestinal tract. In this issue, Ferreyra et al. (2014) and Curtis et al. (2014) show that diverse enteric pathogens can exploit a metabolic byproduct from the commensal microbiota, succinate, to enhance their own virulence expression and proliferation.

journal_name

Cell Host Microbe

journal_title

Cell host & microbe

authors

Pham N TA,Lawley TD

doi

10.1016/j.chom.2014.11.012

subject

Has Abstract

pub_date

2014-12-10 00:00:00

pages

703-5

issue

6

eissn

1931-3128

issn

1934-6069

pii

S1931-3128(14)00428-4

journal_volume

16

pub_type

评论,杂志文章
  • Co-option of Membrane Wounding Enables Virus Penetration into Cells.

    abstract::During cell entry, non-enveloped viruses undergo partial uncoating to expose membrane lytic proteins for gaining access to the cytoplasm. We report that adenovirus uses membrane piercing to induce and hijack cellular wound removal processes that facilitate further membrane disruption and infection. Incoming adenovirus...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2015.06.006

    authors: Luisoni S,Suomalainen M,Boucke K,Tanner LB,Wenk MR,Guan XL,Grzybek M,Coskun Ü,Greber UF

    更新日期:2015-07-08 00:00:00

  • Both Neutralizing and Non-Neutralizing Human H7N9 Influenza Vaccine-Induced Monoclonal Antibodies Confer Protection.

    abstract::Pathogenic H7N9 avian influenza viruses continue to represent a public health concern, and several candidate vaccines are currently being developed. It is vital to assess if protective antibodies are induced following vaccination and to characterize the diversity of epitopes targeted. Here we characterized the binding...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2016.05.014

    authors: Henry Dunand CJ,Leon PE,Huang M,Choi A,Chromikova V,Ho IY,Tan GS,Cruz J,Hirsh A,Zheng NY,Mullarkey CE,Ennis FA,Terajima M,Treanor JJ,Topham DJ,Subbarao K,Palese P,Krammer F,Wilson PC

    更新日期:2016-06-08 00:00:00

  • Arrhythmic Gut Microbiome Signatures Predict Risk of Type 2 Diabetes.

    abstract::Lifestyle, obesity, and the gut microbiome are important risk factors for metabolic disorders. We demonstrate in 1,976 subjects of a German population cohort (KORA) that specific microbiota members show 24-h oscillations in their relative abundance and identified 13 taxa with disrupted rhythmicity in type 2 diabetes (...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2020.06.004

    authors: Reitmeier S,Kiessling S,Clavel T,List M,Almeida EL,Ghosh TS,Neuhaus K,Grallert H,Linseisen J,Skurk T,Brandl B,Breuninger TA,Troll M,Rathmann W,Linkohr B,Hauner H,Laudes M,Franke A,Le Roy CI,Bell JT,Spector T,Bau

    更新日期:2020-08-12 00:00:00

  • Protectors of the Neonatal Gut: Clostridia Send Pathogens Packing.

    abstract::Commensal bacteria are known to provide colonization resistance in the gut. But exactly which ones provide this function? In a recent paper in Science, Kim et al. (2017) revealed that Clostridia added to mouse infant gut microbiota are sufficient to limit colonization of pathogenic Enterobacteriaceae. ...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2017.06.002

    authors: Behnsen J

    更新日期:2017-06-14 00:00:00

  • Colocalization of transcription and translation within cytoplasmic poxvirus factories coordinates viral expression and subjugates host functions.

    abstract::Poxviruses are large DNA viruses that include the causal agent of human smallpox and vaccinia virus. Poxviruses replicate in cytoplasmic foci known as DNA factories. Here we show that a virus-encoded transcription factor, viral mRNA, cellular RNA-binding protein heterodimer G3BP/Caprin-1 (p137), translation initiation...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2007.08.005

    authors: Katsafanas GC,Moss B

    更新日期:2007-10-11 00:00:00

  • Establishing Causality: Opportunities of Synthetic Communities for Plant Microbiome Research.

    abstract::Plant microbiome research highlights the importance of indigenous microbial communities for host phenotypes such as growth and health. It aims to discover the molecular basis by which host-microbe and microbe-microbe interactions shape and maintain microbial communities and to understand the role of individual microor...

    journal_title:Cell host & microbe

    pub_type: 杂志文章,评审

    doi:10.1016/j.chom.2017.07.004

    authors: Vorholt JA,Vogel C,Carlström CI,Müller DB

    更新日期:2017-08-09 00:00:00

  • Leishmania evades host immunity by inhibiting antigen cross-presentation through direct cleavage of the SNARE VAMP8.

    abstract::During phagocytosis, microorganisms are taken up by immune cells into phagosomes. Through membrane-trafficking events mediated by SNARE proteins, phagosomes fuse with lysosomes, generating degradative phagolysosomes. Phagolysosomes contribute to host immunity by linking microbial killing within these organelles with a...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2013.06.003

    authors: Matheoud D,Moradin N,Bellemare-Pelletier A,Shio MT,Hong WJ,Olivier M,Gagnon E,Desjardins M,Descoteaux A

    更新日期:2013-07-17 00:00:00

  • Duffy antigen receptor for chemokines mediates trans-infection of HIV-1 from red blood cells to target cells and affects HIV-AIDS susceptibility.

    abstract::Duffy antigen receptor for chemokines (DARC) expressed on red blood cells (RBCs) influences plasma levels of HIV-1-suppressive and proinflammatory chemokines such as CCL5/RANTES. DARC is also the RBC receptor for Plasmodium vivax. Africans with DARC -46C/C genotype, which confers a DARC-negative phenotype, are resista...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2008.06.002

    authors: He W,Neil S,Kulkarni H,Wright E,Agan BK,Marconi VC,Dolan MJ,Weiss RA,Ahuja SK

    更新日期:2008-07-17 00:00:00

  • Induction of bone loss by pathobiont-mediated Nod1 signaling in the oral cavity.

    abstract::Periodontitis is a common disease that is characterized by resorption of the alveolar bone and mediated by commensal bacteria that trigger host immune responses and bone destruction through unidentified mechanisms. We report that Nod1, an innate intracellular host receptor for bacterial peptidoglycan-related molecules...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2013.04.005

    authors: Jiao Y,Darzi Y,Tawaratsumida K,Marchesan JT,Hasegawa M,Moon H,Chen GY,Núñez G,Giannobile WV,Raes J,Inohara N

    更新日期:2013-05-15 00:00:00

  • Phosphoinositides influence pathogen surfing: EPEC rights the SHIP.

    abstract::Tir, a translocated effector protein from enteropathogenic E. coli (EPEC), contains two phosphotyrosines that initiate cellular signaling cascades, leading to localized actin polymerization into pedestals. A recent study now shows that two additional tyrosines within Tir recruit the inositol phosphatase SHIP2 to gener...

    journal_title:Cell host & microbe

    pub_type: 评论,杂志文章

    doi:10.1016/j.chom.2009.12.006

    authors: Campellone KG

    更新日期:2010-01-21 00:00:00

  • Breaking the Barrier: Host Cell Invasion by Lujo Virus.

    abstract::Lujo virus (LUJV) is an arenavirus that emerged in 2008 associated with a cluster of human cases of severe hemorrhagic fever. In this issue of Cell Host & Microbe, Raaben et al. (2017) identify neuropilin (NRP)-2 as cell surface receptor and the tetraspannin protein CD63 as intracellular entry factor for LUJV. ...

    journal_title:Cell host & microbe

    pub_type: 评论,杂志文章

    doi:10.1016/j.chom.2017.10.014

    authors: Kunz S,de la Torre JC

    更新日期:2017-11-08 00:00:00

  • NMD: nonsense-mediated defense.

    abstract::Initially described as an RNA surveillance pathway, nonsense-mediated decay (NMD) is also recognized to function in the regulation of host gene expression. In this issue of Cell Host & Microbe, three studies describe NMD-mediated defense strategies of plants and mammalian cells in response to pathogen infection. ...

    journal_title:Cell host & microbe

    pub_type: 评论,杂志文章

    doi:10.1016/j.chom.2014.08.015

    authors: Wachter A,Hartmann L

    更新日期:2014-09-10 00:00:00

  • Increased expression of LDL receptor-related protein 1 during human cytomegalovirus infection reduces virion cholesterol and infectivity.

    abstract::In response to virus infection, cells can alter protein expression to modify cellular functions and limit viral replication. To examine host protein expression during infection with human cytomegalovirus (HCMV), an enveloped DNA virus, we performed a semiquantitative, temporal analysis of the cell surface proteome in ...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2012.05.012

    authors: Gudleski-O'Regan N,Greco TM,Cristea IM,Shenk T

    更新日期:2012-07-19 00:00:00

  • Species-Specific Deamidation of cGAS by Herpes Simplex Virus UL37 Protein Facilitates Viral Replication.

    abstract::Herpes simplex virus 1 (HSV-1) establishes infections in humans and mice, but some non-human primates exhibit resistance via unknown mechanisms. Innate immune recognition pathways are highly conserved but are pivotal in determining susceptibility to DNA virus infections. We report that variation of a single amino acid...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2018.07.004

    authors: Zhang J,Zhao J,Xu S,Li J,He S,Zeng Y,Xie L,Xie N,Liu T,Lee K,Seo GJ,Chen L,Stabell AC,Xia Z,Sawyer SL,Jung J,Huang C,Feng P

    更新日期:2018-08-08 00:00:00

  • Mapping the Evolutionary Potential of RNA Viruses.

    abstract::The deterministic force of natural selection and stochastic influence of drift shape RNA virus evolution. New deep-sequencing and microfluidics technologies allow us to quantify the effect of mutations and trace the evolution of viral populations with single-genome and single-nucleotide resolution. Such experiments ca...

    journal_title:Cell host & microbe

    pub_type: 杂志文章,评审

    doi:10.1016/j.chom.2018.03.012

    authors: Dolan PT,Whitfield ZJ,Andino R

    更新日期:2018-04-11 00:00:00

  • Metropolitan microbes: type III secretion in multihost symbionts.

    abstract::Type III secretion systems (T3SS) are used by bacteria to deliver proteins into the cytoplasm of eukaryotic cells. Most studies of T3SS have focused on the role of these secretion systems in specific host interactions. However, there is increasing evidence to suggest that T3SS are also used in interactions with multip...

    journal_title:Cell host & microbe

    pub_type: 杂志文章,评审

    doi:10.1016/j.chom.2007.10.004

    authors: Preston GM

    更新日期:2007-11-15 00:00:00

  • Dissecting How CD4 T Cells Are Lost During HIV Infection.

    abstract::Although the replicative life cycle of HIV within CD4 T cells is understood in molecular detail, less is known about how this human retrovirus promotes the loss of CD4 T lymphocytes. It is this cell death process that drives clinical progression to acquired immune deficiency syndrome (AIDS). Recent studies have highli...

    journal_title:Cell host & microbe

    pub_type: 杂志文章,评审

    doi:10.1016/j.chom.2016.02.012

    authors: Doitsh G,Greene WC

    更新日期:2016-03-09 00:00:00

  • Olfactory plays a key role in spatiotemporal pathogenesis of cerebral malaria.

    abstract::Cerebral malaria is a complication of Plasmodium falciparum infection characterized by sudden coma, death, or neurodisability. Studies using a mouse model of experimental cerebral malaria (ECM) have indicated that blood-brain barrier disruption and CD8 T cell recruitment contribute to disease, but the spatiotemporal m...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2014.04.008

    authors: Zhao H,Aoshi T,Kawai S,Mori Y,Konishi A,Ozkan M,Fujita Y,Haseda Y,Shimizu M,Kohyama M,Kobiyama K,Eto K,Nabekura J,Horii T,Ishino T,Yuda M,Hemmi H,Kaisho T,Akira S,Kinoshita M,Tohyama K,Yoshioka Y,Ishii KJ,Co

    更新日期:2014-05-14 00:00:00

  • Mammalian PGRPs also mind the fort.

    abstract::Peptidoglycan recognition proteins (PGRPs or Pglyrps) regulate antibacterial responses in Drosophila, yet their functions in humans remain unclear. In this issue of Cell Host & Microbe, Saha and colleagues report that mammalian PGRPs can prevent aberrant interferon-gamma--induced inflammatory damage in vivo by modulat...

    journal_title:Cell host & microbe

    pub_type: 评论,杂志文章

    doi:10.1016/j.chom.2010.07.010

    authors: Rubino S,Lee J,Girardin SE

    更新日期:2010-08-19 00:00:00

  • Distinct Polysaccharide Utilization Profiles of Human Intestinal Prevotella copri Isolates.

    abstract::Gut-dwelling Prevotella copri (P. copri), the most prevalent Prevotella species in the human gut, have been associated with diet and disease. However, our understanding of their diversity and function remains rudimentary because studies have been limited to 16S and metagenomic surveys and experiments using a single ty...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2019.10.013

    authors: Fehlner-Peach H,Magnabosco C,Raghavan V,Scher JU,Tett A,Cox LM,Gottsegen C,Watters A,Wiltshire-Gordon JD,Segata N,Bonneau R,Littman DR

    更新日期:2019-11-13 00:00:00

  • A critical role for SOCS3 in innate resistance to Toxoplasma gondii.

    abstract::The innate and adaptive immune responses that confer resistance to the intracellular pathogen Toxoplasma gondii critically depend on IL-12 production, which drives interferon-γ (IFN-γ) expression. Certain cytokines can activate STAT3 and limit IL-12 production to prevent infection-associated immune pathology, but T. g...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2011.07.009

    authors: Whitmarsh RJ,Gray CM,Gregg B,Christian DA,May MJ,Murray PJ,Hunter CA

    更新日期:2011-09-15 00:00:00

  • Fungal Mimicry of a Mammalian Aminopeptidase Disables Innate Immunity and Promotes Pathogenicity.

    abstract::Systemic fungal infections trigger marked immune-regulatory disturbances, but the mechanisms are poorly understood. We report that the pathogenic yeast of Blastomyces dermatitidis elaborates dipeptidyl-peptidase IVA (DppIVA), a close mimic of the mammalian ectopeptidase CD26, which modulates critical aspects of hemato...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2016.02.001

    authors: Sterkel AK,Lorenzini JL,Fites JS,Subramanian Vignesh K,Sullivan TD,Wuthrich M,Brandhorst T,Hernandez-Santos N,Deepe GS Jr,Klein BS

    更新日期:2016-03-09 00:00:00

  • Transmission stages dominate trypanosome within-host dynamics during chronic infections.

    abstract::Sleeping sickness is characterized by waves of the extracellular parasite Trypanosoma brucei in host blood, with infections continuing for months or years until inevitable host death. These waves reflect the dynamic conflict between the outgrowth of a succession of parasite antigenic variants and their control by the ...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2011.03.013

    authors: MacGregor P,Savill NJ,Hall D,Matthews KR

    更新日期:2011-04-21 00:00:00

  • Th17 Cells Are Preferentially Infected Very Early after Vaginal Transmission of SIV in Macaques.

    abstract::The difficulty in detecting rare infected cells immediately after mucosal HIV transmission has hindered our understanding of the initial cells targeted by the virus. Working with the macaque simian immunodeficiency virus (SIV) vaginal challenge model, we developed methodology to identify discrete foci of SIV (mac239) ...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2016.03.005

    authors: Stieh DJ,Matias E,Xu H,Fought AJ,Blanchard JL,Marx PA,Veazey RS,Hope TJ

    更新日期:2016-04-13 00:00:00

  • Overcoming Barriers in the Path to a Universal Influenza Virus Vaccine.

    abstract::Influenza viruses are important pathogens which pose an ongoing threat to public health due to their ability to mutate and evade immunity elicited by prior infection or vaccination. Their evolutionary diversity is facilitated by the plasticity of the antigenically variable head domain of the major surface glycoprotein...

    journal_title:Cell host & microbe

    pub_type: 杂志文章,评审

    doi:10.1016/j.chom.2018.06.016

    authors: Coughlan L,Palese P

    更新日期:2018-07-11 00:00:00

  • Infection-Induced Peroxisome Biogenesis Is a Metabolic Strategy for Herpesvirus Replication.

    abstract::Viral proteins have evolved to target cellular organelles and usurp their functions for virus replication. Despite the knowledge of these critical functions for several organelles, little is known about peroxisomes during infection. Peroxisomes are primarily metabolic organelles with important functions in lipid metab...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2018.09.002

    authors: Jean Beltran PM,Cook KC,Hashimoto Y,Galitzine C,Murray LA,Vitek O,Cristea IM

    更新日期:2018-10-10 00:00:00

  • Impaired stimulation of p38α-MAPK/Vps41-HOPS by LPS from pathogenic Coxiella burnetii prevents trafficking to microbicidal phagolysosomes.

    abstract::Variations in lipopolysaccharide (LPS), a bacterial outer membrane component, determine virulence of the obligate intracellular bacterium Coxiella burnetii, but the underlying mechanisms are unknown. We find that while avirulent C. burnetii LPS (avLPS) stimulates host p38α-MAPK signaling required for proper traffickin...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2012.10.015

    authors: Barry AO,Boucherit N,Mottola G,Vadovic P,Trouplin V,Soubeyran P,Capo C,Bonatti S,Nebreda A,Toman R,Lemichez E,Mege JL,Ghigo E

    更新日期:2012-12-13 00:00:00

  • Making It Stick: A Compelling Case for Precision Microbiome Reconstitution.

    abstract::Modification of the intestinal microbiome is an emerging target to improve health and prevent or treat a number of diseases. In this issue of Cell Host & Microbe, Maldonado-Gómez et al. (2016) uncover the basic principles that govern the successful establishment and persistence of an exogenously introduced gut bacteri...

    journal_title:Cell host & microbe

    pub_type: 评论,杂志文章

    doi:10.1016/j.chom.2016.09.012

    authors: Berry D

    更新日期:2016-10-12 00:00:00

  • Human formyl peptide receptor 2 senses highly pathogenic Staphylococcus aureus.

    abstract::Virulence of emerging community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) and other highly pathogenic S. aureus strains depends on their production of phenol-soluble modulin (PSM) peptide toxins, which combine the capacities to attract and lyse neutrophils. The molecular basis of PSM-stimulated ...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2010.05.012

    authors: Kretschmer D,Gleske AK,Rautenberg M,Wang R,Köberle M,Bohn E,Schöneberg T,Rabiet MJ,Boulay F,Klebanoff SJ,van Kessel KA,van Strijp JA,Otto M,Peschel A

    更新日期:2010-06-25 00:00:00

  • Intestinal Bile Acids Induce a Morphotype Switch in Vancomycin-Resistant Enterococcus that Facilitates Intestinal Colonization.

    abstract::Vancomycin-resistant Enterococcus (VRE) are highly antibiotic-resistant and readily transmissible pathogens that cause severe infections in hospitalized patients. We discovered that lithocholic acid (LCA), a secondary bile acid prevalent in the cecum and colon of mice and humans, impairs separation of growing VRE dipl...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2019.03.008

    authors: McKenney PT,Yan J,Vaubourgeix J,Becattini S,Lampen N,Motzer A,Larson PJ,Dannaoui D,Fujisawa S,Xavier JB,Pamer EG

    更新日期:2019-05-08 00:00:00