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HIV-1 envelope gp41 antibodies can originate from terminal ileum B cells that share cross-reactivity with commensal bacteria.

Abstract：

:Monoclonal antibodies derived from blood plasma cells of acute HIV-1-infected individuals are predominantly targeted to the HIV Env gp41 and cross-reactive with commensal bacteria. To understand this phenomenon, we examined anti-HIV responses in ileum B cells using recombinant antibody technology and probed their relationship to commensal bacteria. The dominant ileum B cell response was to Env gp41. Remarkably, a majority (82%) of the ileum anti-gp41 antibodies cross-reacted with commensal bacteria, and of those, 43% showed non-HIV-1 antigen polyreactivity. Pyrosequencing revealed shared HIV-1 antibody clonal lineages between ileum and blood. Mutated immunoglobulin G antibodies cross-reactive with both Env gp41 and microbiota could also be isolated from the ileum of HIV-1 uninfected individuals. Thus, the gp41 commensal bacterial antigen cross-reactive antibodies originate in the intestine, and the gp41 Env response in HIV-1 infection can be derived from a preinfection memory B cell pool triggered by commensal bacteria that cross-react with Env.

journal_name

Cell Host Microbe

journal_title

Cell host & microbe

authors

Trama AM,Moody MA,Alam SM,Jaeger FH,Lockwood B,Parks R,Lloyd KE,Stolarchuk C,Scearce R,Foulger A,Marshall DJ,Whitesides JF,Jeffries TL Jr,Wiehe K,Morris L,Lambson B,Soderberg K,Hwang KK,Tomaras GD,Vandergrift N,Ja

doi

10.1016/j.chom.2014.07.003

subject

Has Abstract

pub_date

2014-08-13 00:00:00

pages

215-226

issue

2

eissn

1931-3128

issn

1934-6069

pii

S1931-3128(14)00257-1

journal_volume

16

pub_type

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