当前位置： SCI文献检索 > Cell Host & Microbe期刊下所有文献 > Induction of bone loss by pathobiont-mediated Nod1 signaling in the oral cavity.

Induction of bone loss by pathobiont-mediated Nod1 signaling in the oral cavity.

Abstract：

:Periodontitis is a common disease that is characterized by resorption of the alveolar bone and mediated by commensal bacteria that trigger host immune responses and bone destruction through unidentified mechanisms. We report that Nod1, an innate intracellular host receptor for bacterial peptidoglycan-related molecules, is critical for commensal-induced periodontitis in a mouse model. Mice lacking Nod1 exhibit reduced bone resorption as well as impaired recruitment of neutrophils to gingival tissues and osteoclasts to the alveolar bone, which mediate tissue and bone destruction. Further analysis showed that accumulation of a Nod1-stimulating commensal bacterium, NI1060, at gingival sites was sufficient to induce neutrophil recruitment and bone resorption. Genomic sequencing revealed that NI1060 is a mouse-specific bacterium that is related to bacteria associated with the development of aggressive periodontitis in humans. These findings provide insight into commensal-host interactions contributing to periodontitis and identify a potential target for preventing this common oral disease.

journal_name

Cell Host Microbe

journal_title

Cell host & microbe

authors

Jiao Y,Darzi Y,Tawaratsumida K,Marchesan JT,Hasegawa M,Moon H,Chen GY,Núñez G,Giannobile WV,Raes J,Inohara N

doi

10.1016/j.chom.2013.04.005

subject

Has Abstract

pub_date

2013-05-15 00:00:00

pages

595-601

issue

5

eissn

1931-3128

issn

1934-6069

pii

S1931-3128(13)00147-9

journal_volume

13

pub_type

杂志文章

相关文献

Cell Host & Microbe文献大全
  • Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling.

    abstract：:The ongoing epidemic of Zika virus (ZIKV) illustrates the importance of flaviviruses as emerging human pathogens. All vector-borne flaviviruses studied thus far have to overcome type I interferon (IFN) to replicate and cause disease in vertebrates. The mechanism(s) by which ZIKV antagonizes IFN signaling is unknown. H...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2016.05.009

    authors： Grant A,Ponia SS,Tripathi S,Balasubramaniam V,Miorin L,Sourisseau M,Schwarz MC,Sánchez-Seco MP,Evans MJ,Best SM,García-Sastre A

    更新日期：2016-06-08 00:00:00

  • Type I Interferon Response Dysregulates Host Iron Homeostasis and Enhances Candida glabrata Infection.

    abstract：:Type I interferons (IFNs-I) fulfil multiple protective functions during pathogenic infections, but they can also cause detrimental effects and enhance immunopathology. Here, we report that IFNs-I promote the dysregulation of iron homeostasis in macrophages during systemic infections with the intracellular pathogen Can...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2020.01.023

    authors： Riedelberger M,Penninger P,Tscherner M,Seifert M,Jenull S,Brunnhofer C,Scheidl B,Tsymala I,Bourgeois C,Petryshyn A,Glaser W,Limbeck A,Strobl B,Weiss G,Kuchler K

    更新日期：2020-03-11 00:00:00

  • Adaptive Strategies of the Candidate Probiotic E. coli Nissle in the Mammalian Gut.

    abstract：:Probiotics are living microorganisms that are increasingly used as gastrointestinal therapeutics by virtue of their innate or engineered genetic function. Unlike abiotic therapeutics, probiotics can replicate in their intended site, subjecting their genomes and therapeutic properties to natural selection. We exposed t...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2019.02.005

    authors： Crook N,Ferreiro A,Gasparrini AJ,Pesesky MW,Gibson MK,Wang B,Sun X,Condiotte Z,Dobrowolski S,Peterson D,Dantas G

    更新日期：2019-04-10 00:00:00

  • Nutritional Support from the Intestinal Microbiota Improves Hematopoietic Reconstitution after Bone Marrow Transplantation in Mice.

    abstract：:Bone marrow transplantation (BMT) offers curative potential for patients with high-risk hematologic malignancies, but the post-transplantation period is characterized by profound immunodeficiency. Recent studies indicate that the intestinal microbiota not only regulates mucosal immunity, but can also contribute to sys...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2018.03.002

    authors： Staffas A,Burgos da Silva M,Slingerland AE,Lazrak A,Bare CJ,Holman CD,Docampo MD,Shono Y,Durham B,Pickard AJ,Cross JR,Stein-Thoeringer C,Velardi E,Tsai JJ,Jahn L,Jay H,Lieberman S,Smith OM,Pamer EG,Peled JU,Cohen

    更新日期：2018-04-11 00:00:00

  • Surviving as a Community: Antibiotic Tolerance and Persistence in Bacterial Biofilms.

    abstract：:Biofilms are surface-associated bacterial communities that play both beneficial and harmful roles in nature, medicine, and industry. Tolerant and persister cells are thought to underlie biofilm-related bacterial recurrence in medical and industrial contexts. Here, we review recent progress aimed at understanding the m...

    journal_title：Cell host & microbe

    pub_type： 杂志文章,评审

    doi：10.1016/j.chom.2019.06.002

    authors： Yan J,Bassler BL

    更新日期：2019-07-10 00:00:00

  • miR-122 stimulates hepatitis C virus RNA synthesis by altering the balance of viral RNAs engaged in replication versus translation.

    abstract：:The liver-specific microRNA, miR-122, stabilizes hepatitis C virus (HCV) RNA genomes by recruiting host argonaute 2 (AGO2) to the 5' end and preventing decay mediated by exonuclease Xrn1. However, HCV replication requires miR-122 in Xrn1-depleted cells, indicating additional functions. We show that miR-122 enhances HC...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2014.12.014

    authors： Masaki T,Arend KC,Li Y,Yamane D,McGivern DR,Kato T,Wakita T,Moorman NJ,Lemon SM

    更新日期：2015-02-11 00:00:00

  • Prevotella as a Hub for Vaginal Microbiota under the Influence of Host Genetics and Their Association with Obesity.

    abstract：:While the vaginal ecosystem is maintained through mutualistic relationships between the host and the vaginal bacteria, the effect of host genetics on the vaginal microbiota has not been well characterized. We examined the heritability of vaginal microbiota and its association with obesity in 542 Korean females, includ...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2016.11.010

    authors： Si J,You HJ,Yu J,Sung J,Ko G

    更新日期：2017-01-11 00:00:00

  • A deficiency in the autophagy gene Atg16L1 enhances resistance to enteric bacterial infection.

    abstract：:Polymorphisms in the essential autophagy gene Atg16L1 have been linked with susceptibility to Crohn's disease, a major type of inflammatory bowel disease (IBD). Although the inability to control intestinal bacteria is thought to underlie IBD, the role of Atg16L1 during extracellular intestinal bacterial infections has...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2013.07.013

    authors： Marchiando AM,Ramanan D,Ding Y,Gomez LE,Hubbard-Lucey VM,Maurer K,Wang C,Ziel JW,van Rooijen N,Nuñez G,Finlay BB,Mysorekar IU,Cadwell K

    更新日期：2013-08-14 00:00:00

  • Be a good neighbor: organ-to-organ communication during the innate immune response.

    abstract：:Local infection in the Drosophila larval intestine elicits a systemic immune reaction in fat bodies. In this issue, Wu and colleagues (2012) show that this is a reactive oxygen species-dependent communication. ...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2012.04.003

    authors： Amcheslavsky A,Ip YT

    更新日期：2012-04-19 00:00:00

  • Leishmania evades host immunity by inhibiting antigen cross-presentation through direct cleavage of the SNARE VAMP8.

    abstract：:During phagocytosis, microorganisms are taken up by immune cells into phagosomes. Through membrane-trafficking events mediated by SNARE proteins, phagosomes fuse with lysosomes, generating degradative phagolysosomes. Phagolysosomes contribute to host immunity by linking microbial killing within these organelles with a...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2013.06.003

    authors： Matheoud D,Moradin N,Bellemare-Pelletier A,Shio MT,Hong WJ,Olivier M,Gagnon E,Desjardins M,Descoteaux A

    更新日期：2013-07-17 00:00:00

  • Transcriptional pausing controls a rapid antiviral innate immune response in Drosophila.

    abstract：:Innate immune responses are characterized by precise gene expression whereby gene subsets are temporally induced to limit infection, although the mechanisms involved are incompletely understood. We show that antiviral immunity in Drosophila requires the transcriptional pausing pathway, including negative elongation fa...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2012.08.011

    authors： Xu J,Grant G,Sabin LR,Gordesky-Gold B,Yasunaga A,Tudor M,Cherry S

    更新日期：2012-10-18 00:00:00

  • Not Your Typical Anti-CRISPR.

    abstract：:In this issue of Cell Host & Microbe, two papers by Osuna et al. describe the characterization of AcrIIA1, an anti-CRISPR protein distributed widely among Listeria phages. AcrIIA1 functions as an anti-CRISPR and as a dynamic repressor of acr loci, suggesting it may play an important role in lysogeny. ...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2020.06.016

    authors： Johnson WE

    更新日期：2020-07-08 00:00:00

  • ESCRT-I part II: forming the real ESCRT-I complex.

    abstract：:Many enveloped viruses hijack the cellular ESCRT machinery to catalyze their escape from host cells. One paper in a recent issue of Cell by Kostelansky et al. and another in this issue of Cell Host & Microbe by Morita et al. shed new light on the structure and function of ESCRT-I. Both papers focus on a fourth ESCRT-I...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2007.06.006

    authors： Weissenhorn W,Göttlinger H

    更新日期：2007-07-12 00:00:00

  • To die or not to die: Shigella has an answer.

    abstract：:Invasion of epithelial cells by Shigella is a critical step in the pathogenesis of bacillary dysentery. In this issue of Cell Host & Microbe, Bergounioux et al. (2012) uncover a complex interplay of proinvasion, prosurvival, and prodeath signals centered on the activation of calpain protease by the Shigella VirA prote...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2012.02.004

    authors： Rudel T

    更新日期：2012-03-15 00:00:00

  • Intestinal Bile Acids Induce a Morphotype Switch in Vancomycin-Resistant Enterococcus that Facilitates Intestinal Colonization.

    abstract：:Vancomycin-resistant Enterococcus (VRE) are highly antibiotic-resistant and readily transmissible pathogens that cause severe infections in hospitalized patients. We discovered that lithocholic acid (LCA), a secondary bile acid prevalent in the cecum and colon of mice and humans, impairs separation of growing VRE dipl...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2019.03.008

    authors： McKenney PT,Yan J,Vaubourgeix J,Becattini S,Lampen N,Motzer A,Larson PJ,Dannaoui D,Fujisawa S,Xavier JB,Pamer EG

    更新日期：2019-05-08 00:00:00

  • A two-pronged mechanism for HIV-1 Nef-mediated endocytosis of immune costimulatory molecules CD80 and CD86.

    abstract：:The Nef protein of HIV-1 mediates immune evasion by relocating major histocompatibility complex (MHC) molecules and the immune costimulatory molecules CD80 and CD86 away from the monocytic cell surface. We describe a two-pronged mechanism by which Nef removes CD80 and CD86 from the cell surface. While MHCI, CD80, and ...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2007.01.001

    authors： Chaudhry A,Das SR,Jameel S,George A,Bal V,Mayor S,Rath S

    更新日期：2007-03-15 00:00:00

  • Establishing Causality: Opportunities of Synthetic Communities for Plant Microbiome Research.

    abstract：:Plant microbiome research highlights the importance of indigenous microbial communities for host phenotypes such as growth and health. It aims to discover the molecular basis by which host-microbe and microbe-microbe interactions shape and maintain microbial communities and to understand the role of individual microor...

    journal_title：Cell host & microbe

    pub_type： 杂志文章,评审

    doi：10.1016/j.chom.2017.07.004

    authors： Vorholt JA,Vogel C,Carlström CI,Müller DB

    更新日期：2017-08-09 00:00:00

  • Partially Open HIV-1 Envelope Structures Exhibit Conformational Changes Relevant for Coreceptor Binding and Fusion.

    abstract：:HIV-1 Env, a trimer of gp120-gp41 heterodimers, mediates membrane fusion after binding host receptor CD4. Receptor binding displaces V1V2 loops from Env's apex, allowing coreceptor binding and opening Env to enable gp41-mediated fusion. We present 3.54 Å and 4.06 Å cryoelectron microscopy structures of partially open ...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2018.09.003

    authors： Wang H,Barnes CO,Yang Z,Nussenzweig MC,Bjorkman PJ

    更新日期：2018-10-10 00:00:00

  • Original Antigenic Sin: Friend or Foe in Developing a Broadly Cross-Reactive Vaccine to Influenza?

    abstract：:In this issue of Cell Host & Microbe, two articles (Lee et al., 2019; Henry et al., 2019) find the influenza-specific antibody repertoire in humans becomes static over time and with age, despite repeated exposures. Identified persistent dominant clones target conserved viral epitopes, supporting the feasibility of a u...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2019.02.009

    authors： Devarajan P,Swain SL

    更新日期：2019-03-13 00:00:00

  • Restriction of Zika Virus by Host Innate Immunity.

    abstract：:Recent epidemics of Zika virus (ZIKV) have brought increasing concerns of heightened disease severity and neurotropism. In this issue of Cell Host & Microbe, Lazear et al. (2016) and Bayer et al. (2016) show that innate immunity can restrict ZIKV infection and disease development. ...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2016.04.019

    authors： Xie X,Shan C,Shi PY

    更新日期：2016-05-11 00:00:00

  • Host metabolism regulates intracellular growth of Trypanosoma cruzi.

    abstract：:Metabolic coupling of intracellular pathogens with host cells is essential for successful colonization of the host. Establishment of intracellular infection by the protozoan Trypanosoma cruzi leads to the development of human Chagas' disease, yet the functional contributions of the host cell toward the infection proce...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2012.11.011

    authors： Caradonna KL,Engel JC,Jacobi D,Lee CH,Burleigh BA

    更新日期：2013-01-16 00:00:00

  • Digest this! A role for autophagy in controlling pathogens.

    abstract：:Autophagy provides a mechanism for cells to conserve nutrients, but was recently associated with immunity to intracellular pathogens. Here, Zhao et al. (2008) present direct in vivo evidence that autophagy is linked to macrophage control of Toxoplasma gondii and Listeria monocytogenes and highlights that this process ...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2008.10.008

    authors： Whitmarsh RJ,Hunter CA

    更新日期：2008-11-13 00:00:00

  • A Bacterial Pathogen Targets a Host Rab-Family GTPase Defense Pathway with a GAP.

    abstract：:Cell-autonomous defense mechanisms are potent strategies that protect individual cells against intracellular pathogens. The Rab-family GTPase Rab32 was previously shown to restrict the intracellular human pathogen Salmonella Typhi, but its potential broader role in antimicrobial defense remains unknown. We show that R...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2016.01.004

    authors： Spanò S,Gao X,Hannemann S,Lara-Tejero M,Galán JE

    更新日期：2016-02-10 00:00:00

  • Automated Prediction and Annotation of Small Open Reading Frames in Microbial Genomes.

    abstract：:Small open reading frames (smORFs) and their encoded microproteins play central roles in microbes. However, there is a vast unexplored space of smORFs within human-associated microbes. A recent bioinformatic analysis used evolutionary conservation signals to enhance prediction of small protein families. To facilitate ...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2020.11.002

    authors： Durrant MG,Bhatt AS

    更新日期：2021-01-13 00:00:00

  • Phosphorylation-Regulated Activation of the Arabidopsis RRS1-R/RPS4 Immune Receptor Complex Reveals Two Distinct Effector Recognition Mechanisms.

    abstract：:The Arabidopsis immune receptors RPS4 and RRS1 interact to co-confer responsiveness to bacterial effectors. The RRS1-R allele, with RPS4, responds to AvrRps4 and PopP2, whereas RRS1-S responds only to AvrRps4. Here, we show that the C terminus of RRS1-R but not RRS1-S is phosphorylated. Phosphorylation at Thr1214 in t...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2020.03.008

    authors： Guo H,Ahn HK,Sklenar J,Huang J,Ma Y,Ding P,Menke FLH,Jones JDG

    更新日期：2020-05-13 00:00:00

  • Transient inability to manage proteobacteria promotes chronic gut inflammation in TLR5-deficient mice.

    abstract：:Colitis results from breakdown of homeostasis between intestinal microbiota and the mucosal immune system, with both environmental and genetic influencing factors. Flagellin receptor TLR5-deficient mice (T5KO) display elevated intestinal proinflammatory gene expression and colitis with incomplete penetrance, providing...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2012.07.004

    authors： Carvalho FA,Koren O,Goodrich JK,Johansson ME,Nalbantoglu I,Aitken JD,Su Y,Chassaing B,Walters WA,González A,Clemente JC,Cullender TC,Barnich N,Darfeuille-Michaud A,Vijay-Kumar M,Knight R,Ley RE,Gewirtz AT

    更新日期：2012-08-16 00:00:00

  • Innate resistance against Toxoplasma gondii: an evolutionary tale of mice, cats, and men.

    abstract：:Recent studies have revealed remarkable species specificity of the Toll-like receptors (TLRs) TLR11 and TLR12 and the immunity-related GTPase (IRG) proteins that are essential elements for detection and immune control of Toxoplasma gondii in mice, but not in humans. The biological and evolutionary implications of thes...

    journal_title：Cell host & microbe

    pub_type： 杂志文章,评审

    doi：10.1016/j.chom.2014.01.004

    authors： Gazzinelli RT,Mendonça-Neto R,Lilue J,Howard J,Sher A

    更新日期：2014-02-12 00:00:00

  • Increased expression of LDL receptor-related protein 1 during human cytomegalovirus infection reduces virion cholesterol and infectivity.

    abstract：:In response to virus infection, cells can alter protein expression to modify cellular functions and limit viral replication. To examine host protein expression during infection with human cytomegalovirus (HCMV), an enveloped DNA virus, we performed a semiquantitative, temporal analysis of the cell surface proteome in ...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2012.05.012

    authors： Gudleski-O'Regan N,Greco TM,Cristea IM,Shenk T

    更新日期：2012-07-19 00:00:00

  • Modeling virus- and antibody-specific factors to predict human immunodeficiency virus neutralization efficiency.

    abstract：:Efforts to prevent human immunodeficiency virus type 1 (HIV-1) infection would benefit from understanding the factors that govern virus neutralization by antibodies. We present a mechanistic model for HIV-1 neutralization that includes both virus and antibody parameters. Variations in epitope integrity on the viral en...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2013.10.006

    authors： Haim H,Salas I,McGee K,Eichelberger N,Winter E,Pacheco B,Sodroski J

    更新日期：2013-11-13 00:00:00

  • Longitudinal Human Antibody Repertoire against Complete Viral Proteome from Ebola Virus Survivor Reveals Protective Sites for Vaccine Design.

    abstract：:Evolution of antibody repertoire against the Ebola virus (EBOV) proteome was characterized in an acutely infected patient receiving supportive care alone to elucidate virus-host interactions over time. Differential kinetics are observed for IgM-IgG-IgA epitope diversity, antibody binding, and affinity maturation to EB...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2020.01.001

    authors： Khurana S,Ravichandran S,Hahn M,Coyle EM,Stonier SW,Zak SE,Kindrachuk J,Davey RT Jr,Dye JM,Chertow DS

    更新日期：2020-02-12 00:00:00