Not Your Typical Anti-CRISPR.

Abstract:

:In this issue of Cell Host & Microbe, two papers by Osuna et al. describe the characterization of AcrIIA1, an anti-CRISPR protein distributed widely among Listeria phages. AcrIIA1 functions as an anti-CRISPR and as a dynamic repressor of acr loci, suggesting it may play an important role in lysogeny.

journal_name

Cell Host Microbe

journal_title

Cell host & microbe

authors

Johnson WE

doi

10.1016/j.chom.2020.06.016

subject

Has Abstract

pub_date

2020-07-08 00:00:00

pages

1-2

issue

1

eissn

1931-3128

issn

1934-6069

pii

S1931-3128(20)30357-7

journal_volume

28

pub_type

评论,杂志文章
  • Nutritional Support from the Intestinal Microbiota Improves Hematopoietic Reconstitution after Bone Marrow Transplantation in Mice.

    abstract::Bone marrow transplantation (BMT) offers curative potential for patients with high-risk hematologic malignancies, but the post-transplantation period is characterized by profound immunodeficiency. Recent studies indicate that the intestinal microbiota not only regulates mucosal immunity, but can also contribute to sys...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2018.03.002

    authors: Staffas A,Burgos da Silva M,Slingerland AE,Lazrak A,Bare CJ,Holman CD,Docampo MD,Shono Y,Durham B,Pickard AJ,Cross JR,Stein-Thoeringer C,Velardi E,Tsai JJ,Jahn L,Jay H,Lieberman S,Smith OM,Pamer EG,Peled JU,Cohen

    更新日期:2018-04-11 00:00:00

  • Cholesterol Metabolism by Uncultured Human Gut Bacteria Influences Host Cholesterol Level.

    abstract::The human microbiome encodes extensive metabolic capabilities, but our understanding of the mechanisms linking gut microbes to human metabolism remains limited. Here, we focus on the conversion of cholesterol to the poorly absorbed sterol coprostanol by the gut microbiota to develop a framework for the identification ...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2020.05.013

    authors: Kenny DJ,Plichta DR,Shungin D,Koppel N,Hall AB,Fu B,Vasan RS,Shaw SY,Vlamakis H,Balskus EP,Xavier RJ

    更新日期:2020-08-12 00:00:00

  • Beating Cancer with a Gut Feeling.

    abstract::Blockade of immune checkpoint molecules, a group of molecules normally involved in maintaining self-tolerance and limiting T cell responses, has emerged as a breakthrough in cancer therapy. Two recent studies published in Science show that, in mice, gut commensal microbes promote antitumor immunity and may determine t...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2015.11.014

    authors: Gorjifard S,Goldszmid RS

    更新日期:2015-12-09 00:00:00

  • Cell-to-cell transfer of HIV-1 via virological synapses leads to endosomal virion maturation that activates viral membrane fusion.

    abstract::HIV-1 can infect T cells by cell-free virus or by direct virion transfer between cells through cell contact-induced structures called virological synapses (VS). During VS-mediated infection, virions accumulate within target cell endosomes. We show that after crossing the VS, the transferred virus undergoes both matura...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2011.10.015

    authors: Dale BM,McNerney GP,Thompson DL,Hubner W,de Los Reyes K,Chuang FY,Huser T,Chen BK

    更新日期:2011-12-15 00:00:00

  • Malaria pulls a FASt one.

    abstract::Cure of rodent malaria with the biocide triclosan highlighted the enzyme FabI as an antimalarial drug target. In this issue of Cell Host & Microbe, Yu et al. (2008) show that FabI is not the principle target of triclosan yet plays an important role specifically in malaria liver stage development. ...

    journal_title:Cell host & microbe

    pub_type: 评论,杂志文章

    doi:10.1016/j.chom.2008.11.006

    authors: Spalding MD,Prigge ST

    更新日期:2008-12-11 00:00:00

  • Commensal Bacteroides species induce colitis in host-genotype-specific fashion in a mouse model of inflammatory bowel disease.

    abstract::The intestinal microbiota is important for induction of inflammatory bowel disease (IBD). IBD is associated with complex shifts in microbiota composition, but it is unclear whether specific bacterial subsets induce IBD and, if so, whether their proportions in the microbiota are altered during disease. Here, we fulfill...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2011.04.009

    authors: Bloom SM,Bijanki VN,Nava GM,Sun L,Malvin NP,Donermeyer DL,Dunne WM Jr,Allen PM,Stappenbeck TS

    更新日期:2011-05-19 00:00:00

  • Bacteroides in the infant gut consume milk oligosaccharides via mucus-utilization pathways.

    abstract::Newborns are colonized with an intestinal microbiota shortly after birth, but the factors governing the retention and abundance of specific microbial lineages are unknown. Nursing infants consume human milk oligosaccharides (HMOs) that pass undigested to the distal gut, where they may be digested by microbes. We deter...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2011.10.007

    authors: Marcobal A,Barboza M,Sonnenburg ED,Pudlo N,Martens EC,Desai P,Lebrilla CB,Weimer BC,Mills DA,German JB,Sonnenburg JL

    更新日期:2011-11-17 00:00:00

  • Diversity of Functionally Permissive Sequences in the Receptor-Binding Site of Influenza Hemagglutinin.

    abstract::Influenza A virus hemagglutinin (HA) initiates viral entry by engaging host receptor sialylated glycans via its receptor-binding site (RBS). The amino acid sequence of the RBS naturally varies across avian and human influenza virus subtypes and is also evolvable. However, functional sequence diversity in the RBS has n...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2017.05.011

    authors: Wu NC,Xie J,Zheng T,Nycholat CM,Grande G,Paulson JC,Lerner RA,Wilson IA

    更新日期:2017-06-14 00:00:00

  • Activation of plant nod-like receptors: how indirect can it be?

    abstract::Pioneering plant research has shown that many Nod-like receptors (NLRs) detect pathogens indirectly via recognizing modifications of other host proteins. In this issue, two groups show that the RPM1 NLR is activated by phosphorylation of the host protein RIN4, probably resulting from activation of a host kinase by pat...

    journal_title:Cell host & microbe

    pub_type: 评论,杂志文章

    doi:10.1016/j.chom.2011.02.002

    authors: Innes RW

    更新日期:2011-02-17 00:00:00

  • The enteropathogenic E. coli effector EspB facilitates microvillus effacing and antiphagocytosis by inhibiting myosin function.

    abstract::Enteropathogenic Escherichia coli (EPEC) destroys intestinal microvilli and suppresses phagocytosis by injecting effectors into infected cells through a type III secretion system (TTSS). EspB, a component of the TTSS, is also injected into the cytoplasm of host cells. However, the physiological functions of EspB withi...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2007.09.012

    authors: Iizumi Y,Sagara H,Kabe Y,Azuma M,Kume K,Ogawa M,Nagai T,Gillespie PG,Sasakawa C,Handa H

    更新日期:2007-12-13 00:00:00

  • NMD: nonsense-mediated defense.

    abstract::Initially described as an RNA surveillance pathway, nonsense-mediated decay (NMD) is also recognized to function in the regulation of host gene expression. In this issue of Cell Host & Microbe, three studies describe NMD-mediated defense strategies of plants and mammalian cells in response to pathogen infection. ...

    journal_title:Cell host & microbe

    pub_type: 评论,杂志文章

    doi:10.1016/j.chom.2014.08.015

    authors: Wachter A,Hartmann L

    更新日期:2014-09-10 00:00:00

  • An in vivo RNAi screening approach to identify host determinants of virus replication.

    abstract::RNA interference (RNAi) has been extensively used to identify host factors affecting virus infection but requires exogenous delivery of short interfering RNAs (siRNAs), thus limiting the technique to nonphysiological infection models and a single defined cell type. We report an alternative screening approach using siR...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2013.08.007

    authors: Varble A,Benitez AA,Schmid S,Sachs D,Shim JV,Rodriguez-Barrueco R,Panis M,Crumiller M,Silva JM,Sachidanandam R,tenOever BR

    更新日期:2013-09-11 00:00:00

  • GM-CSF-facilitated dendritic cell recruitment and survival govern the intestinal mucosal response to a mouse enteric bacterial pathogen.

    abstract::Granulocyte-macrophage colony-stimulating factor (GM-CSF) promotes dendritic cell (DC) differentiation and survival in vitro. However, its role in host defense at the intestinal mucosa is unknown. We report that infection with the mouse enteric pathogen, Citrobacter rodentium, increased colonic GM-CSF production and C...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2010.01.006

    authors: Hirata Y,Egea L,Dann SM,Eckmann L,Kagnoff MF

    更新日期:2010-02-18 00:00:00

  • Taking sides: interferons in leprosy.

    abstract::In a recent Science paper, Teles et al. (2013) show that type I and II interferons (IFNs) are reciprocally expressed in the polar immune forms of leprosy, with type I IFNs inducing IL-10 that interferes with the antimycobacterial effects of type II IFNs (IFNγ) at the site of infection. ...

    journal_title:Cell host & microbe

    pub_type: 评论,杂志文章

    doi:10.1016/j.chom.2013.04.001

    authors: Desvignes LP,Ernst JD

    更新日期:2013-04-17 00:00:00

  • In Vivo CRISPR Screen Identifies TgWIP as a Toxoplasma Modulator of Dendritic Cell Migration.

    abstract::Toxoplasma can reach distant organs, especially the brain, leading to a lifelong chronic phase. However, genes involved in related in vivo processes are currently unknown. Here, we use focused CRISPR libraries to identify Toxoplasma genes that affect in vivo fitness. We focus on TgWIP, whose deletion affects Toxoplasm...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2019.09.008

    authors: Sangaré LO,Ólafsson EB,Wang Y,Yang N,Julien L,Camejo A,Pesavento P,Sidik SM,Lourido S,Barragan A,Saeij JPJ

    更新日期:2019-10-09 00:00:00

  • Reciprocal inhibition between intracellular antiviral signaling and the RNAi machinery in mammalian cells.

    abstract::RNA interference (RNAi) is an established antiviral defense mechanism in plants and invertebrates. Whether RNAi serves a similar function in mammalian cells remains unresolved. We find that in some cell types, mammalian RNAi activity is reduced shortly after viral infection via poly-ADP-ribosylation of the RNA-induced...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2013.09.002

    authors: Seo GJ,Kincaid RP,Phanaksri T,Burke JM,Pare JM,Cox JE,Hsiang TY,Krug RM,Sullivan CS

    更新日期:2013-10-16 00:00:00

  • Bone morphogenetic protein 4 signaling regulates epithelial renewal in the urinary tract in response to uropathogenic infection.

    abstract::The transitional epithelium of the bladder normally turns over slowly but upon injury undergoes rapid regeneration fueled by basal uroepithelial stem and/or early progenitor cells (USCs). Little is known about the mechanisms underlying the injury response. We investigate the mechanism of bladder epithelial regeneratio...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2009.04.005

    authors: Mysorekar IU,Isaacson-Schmid M,Walker JN,Mills JC,Hultgren SJ

    更新日期:2009-05-08 00:00:00

  • A neuron-specific role for autophagy in antiviral defense against herpes simplex virus.

    abstract::Type I interferons (IFNs) are considered to be the universal mechanism by which viral infections are controlled. However, many IFN-stimulated genes (ISGs) rely on antiviral pathways that are toxic to host cells, which may be detrimental in nonrenewable cell types, such as neurons. We show that dorsal root ganglionic (...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2012.07.013

    authors: Yordy B,Iijima N,Huttner A,Leib D,Iwasaki A

    更新日期:2012-09-13 00:00:00

  • A stable prefusion intermediate of the alphavirus fusion protein reveals critical features of class II membrane fusion.

    abstract::Alphaviruses infect cells via a low-pH-triggered membrane fusion reaction mediated by the class II virus fusion protein E1, an elongated molecule with three extramembrane domains (DI-III). E1 drives fusion by inserting its fusion peptide loop into the target membrane and refolding to a hairpin-like trimer in which DII...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2008.10.012

    authors: Sánchez-San Martín C,Sosa H,Kielian M

    更新日期:2008-12-11 00:00:00

  • Cooperating Commensals Restore Colonization Resistance to Vancomycin-Resistant Enterococcus faecium.

    abstract::Antibiotic-mediated microbiota destruction and the consequent loss of colonization resistance can result in intestinal domination with vancomycin-resistant Enterococcus (VRE), leading to bloodstream infection in hospitalized patients. Clearance of VRE remains a challenging goal that, if achieved, would reduce systemic...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2017.04.002

    authors: Caballero S,Kim S,Carter RA,Leiner IM,Sušac B,Miller L,Kim GJ,Ling L,Pamer EG

    更新日期:2017-05-10 00:00:00

  • Virus budding and the ESCRT pathway.

    abstract::Enveloped viruses escape infected cells by budding through limiting membranes. In the decade since the discovery that HIV recruits cellular ESCRT (endosomal sorting complexes required for transport) machinery to facilitate viral budding, this pathway has emerged as the major escape route for enveloped viruses. In cell...

    journal_title:Cell host & microbe

    pub_type: 杂志文章,评审

    doi:10.1016/j.chom.2013.08.012

    authors: Votteler J,Sundquist WI

    更新日期:2013-09-11 00:00:00

  • Duffy antigen receptor for chemokines mediates trans-infection of HIV-1 from red blood cells to target cells and affects HIV-AIDS susceptibility.

    abstract::Duffy antigen receptor for chemokines (DARC) expressed on red blood cells (RBCs) influences plasma levels of HIV-1-suppressive and proinflammatory chemokines such as CCL5/RANTES. DARC is also the RBC receptor for Plasmodium vivax. Africans with DARC -46C/C genotype, which confers a DARC-negative phenotype, are resista...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2008.06.002

    authors: He W,Neil S,Kulkarni H,Wright E,Agan BK,Marconi VC,Dolan MJ,Weiss RA,Ahuja SK

    更新日期:2008-07-17 00:00:00

  • A Highly Pathogenic Avian H7N9 Influenza Virus Isolated from A Human Is Lethal in Some Ferrets Infected via Respiratory Droplets.

    abstract::Low pathogenic H7N9 influenza viruses have recently evolved to become highly pathogenic, raising concerns of a pandemic, particularly if these viruses acquire efficient human-to-human transmissibility. We compared a low pathogenic H7N9 virus with a highly pathogenic isolate, and two of its variants that represent neur...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2017.09.008

    authors: Imai M,Watanabe T,Kiso M,Nakajima N,Yamayoshi S,Iwatsuki-Horimoto K,Hatta M,Yamada S,Ito M,Sakai-Tagawa Y,Shirakura M,Takashita E,Fujisaki S,McBride R,Thompson AJ,Takahashi K,Maemura T,Mitake H,Chiba S,Zhong G,Fan

    更新日期:2017-11-08 00:00:00

  • A PfRH5-based vaccine is efficacious against heterologous strain blood-stage Plasmodium falciparum infection in aotus monkeys.

    abstract::Antigenic diversity has posed a critical barrier to vaccine development against the pathogenic blood-stage infection of the human malaria parasite Plasmodium falciparum. To date, only strain-specific protection has been reported by trials of such vaccines in nonhuman primates. We recently showed that P. falciparum ret...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2014.11.017

    authors: Douglas AD,Baldeviano GC,Lucas CM,Lugo-Roman LA,Crosnier C,Bartholdson SJ,Diouf A,Miura K,Lambert LE,Ventocilla JA,Leiva KP,Milne KH,Illingworth JJ,Spencer AJ,Hjerrild KA,Alanine DG,Turner AV,Moorhead JT,Edgel KA,Wu

    更新日期:2015-01-14 00:00:00

  • Arrhythmic Gut Microbiome Signatures Predict Risk of Type 2 Diabetes.

    abstract::Lifestyle, obesity, and the gut microbiome are important risk factors for metabolic disorders. We demonstrate in 1,976 subjects of a German population cohort (KORA) that specific microbiota members show 24-h oscillations in their relative abundance and identified 13 taxa with disrupted rhythmicity in type 2 diabetes (...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2020.06.004

    authors: Reitmeier S,Kiessling S,Clavel T,List M,Almeida EL,Ghosh TS,Neuhaus K,Grallert H,Linseisen J,Skurk T,Brandl B,Breuninger TA,Troll M,Rathmann W,Linkohr B,Hauner H,Laudes M,Franke A,Le Roy CI,Bell JT,Spector T,Bau

    更新日期:2020-08-12 00:00:00

  • A Ribose-Scavenging System Confers Colonization Fitness on the Human Gut Symbiont Bacteroides thetaiotaomicron in a Diet-Specific Manner.

    abstract::Efficient nutrient acquisition in the human gut is essential for microbial persistence. Although polysaccharides have been well-studied nutrients for the gut microbiome, other resources such as nucleic acids and nucleosides are less studied. We describe several ribose-utilization systems (RUSs) that are broadly repres...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2019.11.009

    authors: Glowacki RWP,Pudlo NA,Tuncil Y,Luis AS,Sajjakulnukit P,Terekhov AI,Lyssiotis CA,Hamaker BR,Martens EC

    更新日期:2020-01-08 00:00:00

  • Salmonella gut invasion involves TTSS-2-dependent epithelial traversal, basolateral exit, and uptake by epithelium-sampling lamina propria phagocytes.

    abstract::Salmonella Typhimurium causes diarrhea by infecting the epithelium and lamina propria of the intestinal mucosa and by secreting various effector proteins through type III secretion systems (TTSSs). However, the mechanisms by which Salmonella transverses the epithelium and is subsequently released into the lamina propr...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2011.11.013

    authors: Müller AJ,Kaiser P,Dittmar KE,Weber TC,Haueter S,Endt K,Songhet P,Zellweger C,Kremer M,Fehling HJ,Hardt WD

    更新日期:2012-01-19 00:00:00

  • The Landscape Ecology and Microbiota of the Human Nose, Mouth, and Throat.

    abstract::Landscape ecology examines the relationships between the spatial arrangement of different landforms and the processes that give rise to spatial and temporal patterns in local community structure. The spatial ecology of the microbial communities that inhabit the human body-in particular, those of the nose, mouth, and t...

    journal_title:Cell host & microbe

    pub_type: 杂志文章,评审

    doi:10.1016/j.chom.2017.03.011

    authors: Proctor DM,Relman DA

    更新日期:2017-04-12 00:00:00

  • Regional Diversity of the Gastrointestinal Microbiome.

    abstract::The role of gut microbes in health and disease has often been surmised from stool, which is easily sampled and rich in microbial diversity, density, and abundance. Microbial analyses of stool have been accepted as measures to determine the relationship of gut microbiomes with host health and disease, based on the beli...

    journal_title:Cell host & microbe

    pub_type: 杂志文章,评审

    doi:10.1016/j.chom.2019.08.011

    authors: Martinez-Guryn K,Leone V,Chang EB

    更新日期:2019-09-11 00:00:00

  • Bacterial persistence: finding the "sweet spot".

    abstract::Studies described by Eisele et al. (2013) and Xavier et al. (2013) in this issue of Cell Host & Microbe show that the bacterial pathogens Salmonella and Brucella exploit the increased levels of glucose present in alternatively activated macrophages to sustain chronic infections in experimentally infected mice. ...

    journal_title:Cell host & microbe

    pub_type: 评论,杂志文章

    doi:10.1016/j.chom.2013.07.016

    authors: Roop RM 2nd,Caswell CC

    更新日期:2013-08-14 00:00:00