Abstract：
:While the vaginal ecosystem is maintained through mutualistic relationships between the host and the vaginal bacteria, the effect of host genetics on the vaginal microbiota has not been well characterized. We examined the heritability of vaginal microbiota and its association with obesity in 542 Korean females, including 222 monozygotic and 56 dizygotic twins. The vaginal microbiota significantly varied depending on host menopausal status and bacterial vaginosis. Lactobacillus and Prevotella, whose relative abundances are strongly associated with bacterial vaginosis, were the most heritable bacteria among the beneficial and potentially pathogenic vaginal microbiota, respectively. Candidate gene analysis revealed an association between genetic variants of interleukin-5 and the abundance of Prevotella sp. Furthermore, host obesity significantly increased the diversity of the vaginal microbiota in association with Prevotella. Our results provide insight into the effect of host genetics on the vaginal microbiota and their association with both vaginal and non-vaginal health.
journal_name
Cell Host Microbejournal_title
Cell host & microbeauthors
Si J,You HJ,Yu J,Sung J,Ko Gdoi
10.1016/j.chom.2016.11.010subject
Has Abstractpub_date
2017-01-11 00:00:00pages
97-105issue
1eissn
1931-3128issn
1934-6069pii
S1931-3128(16)30488-7journal_volume
21pub_type
杂志文章abstract：:Hepatitis C virus genome replication occurs in endoplasmic reticulum-derived membrane compartments, but it is unknown how these structures arise. In this issue of Cell Host & Microbe, Reiss and colleagues (2011) show that the virus recruits a specific lipid kinase to replication sites, stimulates its kinase activity, ...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
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abstract：:HIV-1 Nef, which is required for the efficient onset of AIDS, enhances viral replication and infectivity by exerting multiple effects on infected cells. Nef downregulates cell-surface MHC-I molecules by an uncharacterized PI3K pathway requiring the actions of two Nef motifs-EEEE(65) and PXXP(75). We report that the Ne...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2007.03.004
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abstract：:Many Rickettsia species are intracellular bacterial pathogens that use actin-based motility for spread during infection. However, while other bacteria assemble actin tails consisting of branched networks, Rickettsia assemble long parallel actin bundles, suggesting the use of a distinct mechanism for exploiting actin. ...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2010.04.008
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abstract：:Studies described by Eisele et al. (2013) and Xavier et al. (2013) in this issue of Cell Host & Microbe show that the bacterial pathogens Salmonella and Brucella exploit the increased levels of glucose present in alternatively activated macrophages to sustain chronic infections in experimentally infected mice. ...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2013.07.016
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journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2017.08.014
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abstract：:Microbial CRISPR-Cas acts as a defense, but also as a gatekeeper controlling the flow of new genes into microbial genomes. In a recent Cell paper, Jiang et al. (2016) uncover the functional importance of transcription-dependent RNA targeting in type III-A CRISPR-Cas antiviral defense and provide insight into the co-ev...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2016.01.015
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journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2014.09.003
更新日期：2014-10-08 00:00:00
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journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2009.08.009
更新日期：2009-09-17 00:00:00
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journal_title：Cell host & microbe
pub_type： 杂志文章,评审
doi：10.1016/j.chom.2011.09.008
更新日期：2011-10-20 00:00:00
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journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2007.07.006
更新日期：2007-08-16 00:00:00
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journal_title：Cell host & microbe
pub_type： 杂志文章,评审
doi：10.1016/j.chom.2012.01.009
更新日期：2012-02-16 00:00:00
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journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2007.12.001
更新日期：2008-01-17 00:00:00
abstract：:Malaria starts with the infection of the liver by Plasmodium parasites. Although extensive analysis of Plasmodium has revealed the expression patterns of this parasite in every stage of its life cycle, the liver stage remained unexplored. Recently, Tarun et al. have published the first complete transcriptome and prote...
journal_title：Cell host & microbe
pub_type： 杂志文章,评审
doi：10.1016/j.chom.2008.01.004
更新日期：2008-02-14 00:00:00
abstract：:Genome degradation correlates with host adaptation and systemic disease in Salmonella. Most lineages of the S. enterica subspecies Typhimurium cause gastroenteritis in humans; however, the recently emerged ST313 lineage II pathovar commonly causes systemic bacteremia in sub-Saharan Africa. ST313 lineage II displays ge...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2017.01.009
更新日期：2017-02-08 00:00:00
abstract：:The ecological dynamics underlying the coexistence between antagonistic populations of bacteria and their viruses, bacteriophages (phages), in the mammalian gut microbiota remain poorly understood. We challenged a murine synthetic bacterial community with phages to study the factors allowing phages-bacteria coexistenc...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2020.06.002
更新日期：2020-09-09 00:00:00
abstract：:The intracellular fate of Mycobacterium tuberculosis is a subject of long debate. In this issue of Cell Host & Microbe, three independent studies reveal the detection of cytosolic mycobacterial DNA by the nucleotidyltransferase cGAS, emphasizing the concept of cytosolic access by M. tuberculosis and its role in balanc...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2015.05.017
更新日期：2015-06-10 00:00:00
abstract：:Parasites undergo complex life cycles that comprise a wide variety of cellular differentiation events in different host compartments and transmission across multiple hosts. As parasites depend on host resources, it is not surprising they have developed efficient mechanisms to sense alterations and adapt to the availab...
journal_title：Cell host & microbe
pub_type： 杂志文章,评审
doi：10.1016/j.chom.2018.05.018
更新日期：2018-06-13 00:00:00
abstract：:An important report by Bryk et al. in this issue of Cell Host & Microbe describes the properties of a rhodanine prodrug active against nonmultiplying Mycobacterium tuberculosis (Mtb). Considering the tolerance of nonreplicating Mtb to most currently available agents, such a drug could be a major addition to our antitu...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2008.02.013
更新日期：2008-03-13 00:00:00
abstract：:In this issue of Cell Host & Microbe, Walton et al. (2018) uncover the mycobacterial factors that activate VEGF signaling and promote aberrant angiogenesis in the tuberculous granuloma. Preventing abnormal angiogenesis in the granuloma represents a potential therapeutic approach for tuberculosis. ...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2018.09.016
更新日期：2018-10-10 00:00:00
abstract：:While there is growing appreciation that the microbiome regulates gut-brain signaling, the underlying mechanisms remain elusive. In this issue of Cell Host & Microbe, Bhattarai et al. (2018) identify bacteria-derived tryptamine as a ligand for the gut-epithelium-expressed GPCR 5-HT4 receptor, thereby functioning as a ...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2018.05.020
更新日期：2018-06-13 00:00:00
abstract：:Enteropathogenic Escherichia coli (EPEC) destroys intestinal microvilli and suppresses phagocytosis by injecting effectors into infected cells through a type III secretion system (TTSS). EspB, a component of the TTSS, is also injected into the cytoplasm of host cells. However, the physiological functions of EspB withi...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2007.09.012
更新日期：2007-12-13 00:00:00
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journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2016.05.009
更新日期：2016-06-08 00:00:00
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journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2014.04.008
更新日期：2014-05-14 00:00:00
abstract：:Alphaviruses infect cells via a low-pH-triggered membrane fusion reaction mediated by the class II virus fusion protein E1, an elongated molecule with three extramembrane domains (DI-III). E1 drives fusion by inserting its fusion peptide loop into the target membrane and refolding to a hairpin-like trimer in which DII...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2008.10.012
更新日期：2008-12-11 00:00:00
abstract：:The clinically silent Plasmodium liver stage is an obligatory step in the establishment of malaria infection and disease. We report here that expression of heme oxygenase-1 (HO-1, encoded by Hmox1) is upregulated in the liver following infection by Plasmodium berghei and Plasmodium yoelii sporozoites. HO-1 overexpress...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2008.04.003
更新日期：2008-05-15 00:00:00
abstract：:Eukaryotic small RNAs (sRNAs) are short non-coding regulatory molecules that induce RNA interference (RNAi). During microbial infection, host RNAi machinery is highly regulated and contributes to reprogramming gene expression and balancing plant immunity and growth. While most sRNAs function endogenously, some can tra...
journal_title：Cell host & microbe
pub_type： 杂志文章,评审
doi：10.1016/j.chom.2019.07.021
更新日期：2019-08-14 00:00:00
abstract：:In this issue of Cell Host & Microbe, Liang et al. (2019) show that α-defensins in the gastrointestinal tract sustain defenses to enteric pathogens during starvation. mTOR-dependent sensing of nutrient loss promotes production of an α-defensin regulator, which sustains α-defensin levels, loss of which increases lethal...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2019.04.009
更新日期：2019-05-08 00:00:00
abstract：:Viral proteins have evolved to target cellular organelles and usurp their functions for virus replication. Despite the knowledge of these critical functions for several organelles, little is known about peroxisomes during infection. Peroxisomes are primarily metabolic organelles with important functions in lipid metab...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2018.09.002
更新日期：2018-10-10 00:00:00
abstract：:Sleeping sickness is characterized by waves of the extracellular parasite Trypanosoma brucei in host blood, with infections continuing for months or years until inevitable host death. These waves reflect the dynamic conflict between the outgrowth of a succession of parasite antigenic variants and their control by the ...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2011.03.013
更新日期：2011-04-21 00:00:00
abstract：:Bacterial CRISPR-Cas systems employ RNA-guided nucleases to destroy phage (viral) DNA. Phages, in turn, have evolved diverse "anti-CRISPR" proteins (Acrs) to counteract acquired immunity. In Listeria monocytogenes, prophages encode two to three distinct anti-Cas9 proteins, with acrIIA1 always present. However, the sig...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2020.04.001
更新日期：2020-07-08 00:00:00
