Abstract：
:Genome degradation correlates with host adaptation and systemic disease in Salmonella. Most lineages of the S. enterica subspecies Typhimurium cause gastroenteritis in humans; however, the recently emerged ST313 lineage II pathovar commonly causes systemic bacteremia in sub-Saharan Africa. ST313 lineage II displays genome degradation compared to gastroenteritis-associated lineages; yet, the mechanisms and causal genetic differences mediating these infection phenotypes are largely unknown. We find that the ST313 isolate D23580 hyperdisseminates from the gut to systemic sites, such as the mesenteric lymph nodes (MLNs), via CD11b+ migratory dendritic cells (DCs). This hyperdissemination was facilitated by the loss of sseI, which encodes an effector that inhibits DC migration in gastroenteritis-associated isolates. Expressing functional SseI in D23580 reduced the number of infected migratory DCs and bacteria in the MLN. Our study reveals a mechanism linking pseudogenization of effectors with the evolution of niche adaptation in a bacterial pathogen.
journal_name
Cell Host Microbejournal_title
Cell host & microbeauthors
Carden SE,Walker GT,Honeycutt J,Lugo K,Pham T,Jacobson A,Bouley D,Idoyaga J,Tsolis RM,Monack Ddoi
10.1016/j.chom.2017.01.009subject
Has Abstractpub_date
2017-02-08 00:00:00pages
182-194issue
2eissn
1931-3128issn
1934-6069pii
S1931-3128(17)30031-8journal_volume
21pub_type
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