Abstract：
:Fecal transfer from healthy donors is being explored as a microbiome modality. MicroRNAs (miRNAs) have been found to affect the microbiome. Multiple sclerosis (MS) patients have been shown to have an altered gut microbiome. Here, we unexpectedly found that transfer of feces harvested at peak disease from the experimental autoimmune encephalomyelitis (EAE) model of MS ameliorates disease in recipients in a miRNA-dependent manner. Specifically, we show that miR-30d is enriched in the feces of peak EAE and untreated MS patients. Synthetic miR-30d given orally ameliorates EAE through expansion of regulatory T cells (Tregs). Mechanistically, miR-30d regulates the expression of a lactase in Akkermansia muciniphila, which increases Akkermansia abundance in the gut. The expanded Akkermansia in turn increases Tregs to suppress EAE symptoms. Our findings report the mechanistic underpinnings of a miRNA-microbiome axis and suggest that the feces of diseased subjects might be enriched with miRNAs with therapeutic properties.
journal_name
Cell Host Microbejournal_title
Cell host & microbeauthors
Liu S,Rezende RM,Moreira TG,Tankou SK,Cox LM,Wu M,Song A,Dhang FH,Wei Z,Costamagna G,Weiner HLdoi
10.1016/j.chom.2019.10.008subject
Has Abstractpub_date
2019-12-11 00:00:00pages
779-794.e8issue
6eissn
1931-3128issn
1934-6069pii
S1931-3128(19)30532-3journal_volume
26pub_type
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journal_title：Cell host & microbe
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