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Original Antigenic Sin: Friend or Foe in Developing a Broadly Cross-Reactive Vaccine to Influenza?

Abstract：

:In this issue of Cell Host & Microbe, two articles (Lee et al., 2019; Henry et al., 2019) find the influenza-specific antibody repertoire in humans becomes static over time and with age, despite repeated exposures. Identified persistent dominant clones target conserved viral epitopes, supporting the feasibility of a universal influenza vaccine.

journal_name

Cell Host Microbe

journal_title

Cell host & microbe

authors

Devarajan P,Swain SL

doi

10.1016/j.chom.2019.02.009

subject

Has Abstract

pub_date

2019-03-13 00:00:00

pages

354-355

issue

3

eissn

1931-3128

issn

1934-6069

pii

S1931-3128(19)30105-2

journal_volume

25

pub_type

评论,杂志文章

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