Abstract:
:The mechanisms through which commensal bacterial populations cause inflammatory disease when shifted to dysbiotic community structures are poorly understood. Jiao et al. (2013) demonstrate that, in the case of inflammatory disease in the mouth, stimulation of the intracellular pattern recognition receptor Nod1 is a critical determinant.
journal_name
Cell Host Microbejournal_title
Cell host & microbeauthors
Curtis Mdoi
10.1016/j.chom.2013.05.001subject
Has Abstractpub_date
2013-05-15 00:00:00pages
503-505issue
5eissn
1931-3128issn
1934-6069pii
S1931-3128(13)00159-5journal_volume
13pub_type
评论,杂志文章abstract::Vibrio cholerae is the causative agent of the diarrheal disease cholera. Although many V. cholerae virulence factors have been studied, the role of interbacterial interactions within the host gut and their influence on colonization are poorly understood. Here, we utilized the conjugative properties of a Vibrio-specifi...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2017.12.006
更新日期:2018-02-14 00:00:00
abstract::Herpes simplex virus 1 (HSV-1) establishes infections in humans and mice, but some non-human primates exhibit resistance via unknown mechanisms. Innate immune recognition pathways are highly conserved but are pivotal in determining susceptibility to DNA virus infections. We report that variation of a single amino acid...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2018.07.004
更新日期:2018-08-08 00:00:00
abstract::During viral infection, RIG-I-like receptors (RLRs) are activated upon dephosphorylation by the phosphatase PP1, resulting in type I interferon production. In this issue, Davis et al. (2014) and Mesman et al. (2014) show that measles virus inhibits this antiviral response by targeting PP1 and thus preventing RLR depho...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2014.06.013
更新日期:2014-07-09 00:00:00
abstract::Evolution of antibody repertoire against the Ebola virus (EBOV) proteome was characterized in an acutely infected patient receiving supportive care alone to elucidate virus-host interactions over time. Differential kinetics are observed for IgM-IgG-IgA epitope diversity, antibody binding, and affinity maturation to EB...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2020.01.001
更新日期:2020-02-12 00:00:00
abstract::It is currently unclear at which point during viral replication that RNA genomes are first recognized as nonself by the immune system. In this issue of Cell Host & Microbe, Weber et al. show that incoming nucleocapsid-bound genomes are sufficient to bind and activate innate immune sensors. ...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2013.02.012
更新日期:2013-03-13 00:00:00
abstract::The intracellular microbial nucleic acid sensors, TLR3 and STING, recognize pathogen molecules and signal to activate the interferon pathway. The TIR-domain containing protein TRIF is the sole adaptor of TLR3. Here, we report an essential role for TRIF in STING signaling: various activators of STING could not induce g...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2016.08.002
更新日期:2016-09-14 00:00:00
abstract::Here I revisit our early experiments published in Cell Host & Microbe (Turnbaugh et al., 2008) showing that a diet rich in fat and simple sugars alters the gut microbiome in a manner that contributes to host adiposity, and reflect upon the remarkable advances and remaining challenges in this field. ...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2017.02.021
更新日期:2017-03-08 00:00:00
abstract::Salmonella enterica serovar Typhi (S. Typhi) causes typhoid fever, a life-threatening human disease. The lack of animal models due to S. Typhi's strict human host specificity has hindered its study and vaccine development. We find that immunodeficient Rag2(-/-) γc(-/-) mice engrafted with human fetal liver hematopoiet...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2010.09.003
更新日期:2010-10-21 00:00:00
abstract::In addition to classically defined immune mechanisms, cell-intrinsic processes can restrict virus infection and have shaped virus evolution. The details of this virus-host interaction are still emerging. Following a genome-wide siRNA screen for host factors affecting replication of Semliki Forest virus (SFV), a positi...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2014.08.007
更新日期:2014-09-10 00:00:00
abstract::To maintain tissue homeostasis and avoid disease, epithelial cells damaged by pathogens need to be readily replenished, and this is mainly achieved by the activation of stem cells. In this Short Review, we discuss recent developments in the exciting field of host epithelia-pathogen interaction in Drosophila as well as...
journal_title:Cell host & microbe
pub_type: 杂志文章,评审
doi:10.1016/j.chom.2009.10.001
更新日期:2009-10-22 00:00:00
abstract::Vaccines are needed to combat the global rise in fungal diseases. In this issue of Cell Host & Microbe, Wüthrich et al. (2015) identify calnexin as a target of antigen-specific CD4 T cell responses against multiple fungal pathogens. This study illustrates that a conserved epitope triggers convergent cell-mediated immu...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2015.03.012
更新日期:2015-04-08 00:00:00
abstract::The Arabidopsis immune receptors RPS4 and RRS1 interact to co-confer responsiveness to bacterial effectors. The RRS1-R allele, with RPS4, responds to AvrRps4 and PopP2, whereas RRS1-S responds only to AvrRps4. Here, we show that the C terminus of RRS1-R but not RRS1-S is phosphorylated. Phosphorylation at Thr1214 in t...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2020.03.008
更新日期:2020-05-13 00:00:00
abstract::In this issue of Cell Host & Microbe, Liang et al. (2019) show that α-defensins in the gastrointestinal tract sustain defenses to enteric pathogens during starvation. mTOR-dependent sensing of nutrient loss promotes production of an α-defensin regulator, which sustains α-defensin levels, loss of which increases lethal...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2019.04.009
更新日期:2019-05-08 00:00:00
abstract::Dengue hemorrhagic fever is shown to correlate with secondary infection with a virus serotype different from the previous infection. However, only a small fraction of secondary infections leads to hemorrhagic fever. A recent Science paper suggests that the fucosylation state and isotype of IgGs elicited in patients ma...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2017.02.011
更新日期:2017-03-08 00:00:00
abstract::The replication vacuole of Legionella pneumophila makes contact with host mitochondria. In this issue of Cell Host & Microbe, Escoll et al. (2017) dissect the mechanisms of this interaction, the effect of the T4SS effector MitF on mitochondrial function, and the resultant metabolic reprogramming of infected cells to b...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2017.08.014
更新日期:2017-09-13 00:00:00
abstract::Thiol-group oxidation of active and allosteric cysteines is a widespread regulatory posttranslational protein modification. Pathogenic bacteria, including Pseudomonas aeruginosa and Staphylococcus aureus, use regulatory cysteine oxidation to respond to and overcome reactive oxygen species (ROS) encountered in the host...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2013.02.004
更新日期:2013-03-13 00:00:00
abstract::Quorum-sensing molecules (QSMs) are secreted by bacteria to signal population density. Upon reaching a critical concentration, QSMs induce transcriptional alterations in bacteria, which enable virulence factor expression and biofilm formation. It is unclear whether mammalian hosts can recognize QSMs to trigger respons...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2019.06.003
更新日期:2019-07-10 00:00:00
abstract::Hepatitis C virus (HCV) is a single-stranded RNA virus encoding a single polyprotein whose translation is driven by an internal ribosome entry site (IRES). HCV infection strongly induces antiviral interferon-stimulated gene (ISG) expression in the liver, yet it persists, suggesting that HCV can block ISG effector func...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2009.11.004
更新日期:2009-12-17 00:00:00
abstract::The emergence of circulating vaccine-derived polioviruses through evolution of the oral polio vaccine (OPV) poses a significant obstacle to polio eradication. Understanding the early genetic changes that occur as OPV evolves and transmits is important for preventing future outbreaks. Here, we use deep sequencing to de...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2020.10.011
更新日期:2021-01-13 00:00:00
abstract::Regulatory T cells (Tregs) are required to establish immune tolerance to commensal microbes. Tregs accumulate abruptly in the skin during a defined window of postnatal tissue development. However, the mechanisms mediating Treg migration to neonatal skin are unknown. Here we show that hair follicle (HF) development fac...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2017.03.001
更新日期:2017-04-12 00:00:00
abstract::Swine influenza A viruses (swIAVs) can play a crucial role in the generation of new human pandemic viruses. In this study, in-depth passive surveillance comprising nearly 2,500 European swine holdings and more than 18,000 individual samples identified a year-round presence of up to four major swIAV lineages on more th...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2020.07.006
更新日期:2020-10-07 00:00:00
abstract::Enveloped viruses escape infected cells by budding through limiting membranes. In the decade since the discovery that HIV recruits cellular ESCRT (endosomal sorting complexes required for transport) machinery to facilitate viral budding, this pathway has emerged as the major escape route for enveloped viruses. In cell...
journal_title:Cell host & microbe
pub_type: 杂志文章,评审
doi:10.1016/j.chom.2013.08.012
更新日期:2013-09-11 00:00:00
abstract::Proviral latency is a major barrier to a cure for HIV. In this issue of Cell Host & Microbe, Hataye et al. (2019) show that reactivation of HIV latency is a non-deterministic, highly stochastic (i.e., noisy) process and propose that stochastic transitions to exponential viral expansion require a critical threshold of ...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2019.11.010
更新日期:2019-12-11 00:00:00
abstract::Biotrophic plant pathogens encounter a postinfection basal resistance layer controlled by the lipase-like protein enhanced disease susceptibility 1 (EDS1) and its sequence-related interaction partners, senescence-associated gene 101 (SAG101) and phytoalexin deficient 4 (PAD4). Maintainance of separate EDS1 family memb...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2013.11.006
更新日期:2013-12-11 00:00:00
abstract::Much of the mutualistic relationship between humans and their resident intestinal Bacteroides species is founded on glycans. The host provides plant polysaccharides and host-derived glycans and, in return, receives beneficial end products of bacterial fermentation. Glycans from the bacteria themselves are required for...
journal_title:Cell host & microbe
pub_type: 杂志文章,评审
doi:10.1016/j.chom.2009.05.010
更新日期:2009-06-18 00:00:00
abstract::Microbial CRISPR-Cas acts as a defense, but also as a gatekeeper controlling the flow of new genes into microbial genomes. In a recent Cell paper, Jiang et al. (2016) uncover the functional importance of transcription-dependent RNA targeting in type III-A CRISPR-Cas antiviral defense and provide insight into the co-ev...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2016.01.015
更新日期:2016-02-10 00:00:00
abstract::Variations in lipopolysaccharide (LPS), a bacterial outer membrane component, determine virulence of the obligate intracellular bacterium Coxiella burnetii, but the underlying mechanisms are unknown. We find that while avirulent C. burnetii LPS (avLPS) stimulates host p38α-MAPK signaling required for proper traffickin...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2012.10.015
更新日期:2012-12-13 00:00:00
abstract::Pioneering plant research has shown that many Nod-like receptors (NLRs) detect pathogens indirectly via recognizing modifications of other host proteins. In this issue, two groups show that the RPM1 NLR is activated by phosphorylation of the host protein RIN4, probably resulting from activation of a host kinase by pat...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2011.02.002
更新日期:2011-02-17 00:00:00
abstract::Control of virus infection relies on the stimulation of interferon-stimulated genes (ISGs) that inhibit viral replication. In a recent Nature paper, Gizzi et al. (2018) discovered that the ISG viperin inhibits virus replication by generating the ribonucleotide ddhCTP, which interferes with RNA synthesis, thus offering...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2018.07.014
更新日期:2018-08-08 00:00:00
abstract::Cytosolic bacterial pathogens activate the cytosolic surveillance pathway (CSP) and induce innate immune responses, but how the host detects vacuolar pathogens like Mycobacterium tuberculosis is poorly understood. We show that M. tuberculosis also initiates the CSP upon macrophage infection via limited perforation of ...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2012.03.007
更新日期:2012-05-17 00:00:00