Abstract:
:Swine influenza A viruses (swIAVs) can play a crucial role in the generation of new human pandemic viruses. In this study, in-depth passive surveillance comprising nearly 2,500 European swine holdings and more than 18,000 individual samples identified a year-round presence of up to four major swIAV lineages on more than 50% of farms surveilled. Phylogenetic analyses show that intensive reassortment with human pandemic A(H1N1)/2009 (H1pdm) virus produced an expanding and novel repertoire of at least 31 distinct swIAV genotypes and 12 distinct hemagglutinin/neuraminidase combinations with largely unknown consequences for virulence and host tropism. Several viral isolates were resistant to the human antiviral MxA protein, a prerequisite for zoonotic transmission and stable introduction into human populations. A pronounced antigenic variation was noted in swIAV, and several H1pdm lineages antigenically distinct from current seasonal human H1pdm co-circulate in swine. Thus, European swine populations represent reservoirs for emerging IAV strains with zoonotic and, possibly, pre-pandemic potential.
journal_name
Cell Host Microbejournal_title
Cell host & microbeauthors
Henritzi D,Petric PP,Lewis NS,Graaf A,Pessia A,Starick E,Breithaupt A,Strebelow G,Luttermann C,Parker LMK,Schröder C,Hammerschmidt B,Herrler G,Beilage EG,Stadlbauer D,Simon V,Krammer F,Wacheck S,Pesch S,Schwemmle Mdoi
10.1016/j.chom.2020.07.006subject
Has Abstractpub_date
2020-10-07 00:00:00pages
614-627.e6issue
4eissn
1931-3128issn
1934-6069pii
S1931-3128(20)30402-9journal_volume
28pub_type
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