Virus budding and the ESCRT pathway.

Abstract:

:Enveloped viruses escape infected cells by budding through limiting membranes. In the decade since the discovery that HIV recruits cellular ESCRT (endosomal sorting complexes required for transport) machinery to facilitate viral budding, this pathway has emerged as the major escape route for enveloped viruses. In cells, the ESCRT pathway catalyzes analogous membrane fission events required for the abscission stage of cytokinesis and for a series of "reverse topology" vesiculation events. Studies of enveloped virus budding are therefore providing insights into the complex cellular mechanisms of cell division and membrane protein trafficking (and vice versa). Here, we review how viruses mimic cellular recruiting signals to usurp the ESCRT pathway, discuss mechanistic models for ESCRT pathway functions, and highlight important research frontiers.

journal_name

Cell Host Microbe

journal_title

Cell host & microbe

authors

Votteler J,Sundquist WI

doi

10.1016/j.chom.2013.08.012

subject

Has Abstract

pub_date

2013-09-11 00:00:00

pages

232-41

issue

3

eissn

1931-3128

issn

1934-6069

pii

S1931-3128(13)00294-1

journal_volume

14

pub_type

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