当前位置： SCI文献检索 > Cell Host & Microbe期刊下所有文献 > Fragment and Conquer.

Fragment and Conquer.

Abstract：

:The replication vacuole of Legionella pneumophila makes contact with host mitochondria. In this issue of Cell Host & Microbe, Escoll et al. (2017) dissect the mechanisms of this interaction, the effect of the T4SS effector MitF on mitochondrial function, and the resultant metabolic reprogramming of infected cells to benefit the bacteria.

journal_name

Cell Host Microbe

journal_title

Cell host & microbe

authors

Kozjak-Pavlovic V,Chowdhury SR,Rudel T

doi

10.1016/j.chom.2017.08.014

subject

Has Abstract

pub_date

2017-09-13 00:00:00

pages

255-257

issue

3

eissn

1931-3128

issn

1934-6069

pii

S1931-3128(17)30347-5

journal_volume

22

pub_type

评论,杂志文章

相关文献

Cell Host & Microbe文献大全
  • Microbiota-Dependent Priming of Antiviral Intestinal Immunity in Drosophila.

    abstract：:Enteric pathogens must overcome intestinal defenses to establish infection. In Drosophila, the ERK signaling pathway inhibits enteric virus infection. The intestinal microflora also impacts immunity but its role in enteric viral infection is unknown. Here we show that two signals are required to activate antiviral ERK...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2015.10.010

    authors： Sansone CL,Cohen J,Yasunaga A,Xu J,Osborn G,Subramanian H,Gold B,Buchon N,Cherry S

    更新日期：2015-11-11 00:00:00

  • Taking sides: interferons in leprosy.

    abstract：:In a recent Science paper, Teles et al. (2013) show that type I and II interferons (IFNs) are reciprocally expressed in the polar immune forms of leprosy, with type I IFNs inducing IL-10 that interferes with the antimycobacterial effects of type II IFNs (IFNγ) at the site of infection. ...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2013.04.001

    authors： Desvignes LP,Ernst JD

    更新日期：2013-04-17 00:00:00

  • Olfactory plays a key role in spatiotemporal pathogenesis of cerebral malaria.

    abstract：:Cerebral malaria is a complication of Plasmodium falciparum infection characterized by sudden coma, death, or neurodisability. Studies using a mouse model of experimental cerebral malaria (ECM) have indicated that blood-brain barrier disruption and CD8 T cell recruitment contribute to disease, but the spatiotemporal m...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2014.04.008

    authors： Zhao H,Aoshi T,Kawai S,Mori Y,Konishi A,Ozkan M,Fujita Y,Haseda Y,Shimizu M,Kohyama M,Kobiyama K,Eto K,Nabekura J,Horii T,Ishino T,Yuda M,Hemmi H,Kaisho T,Akira S,Kinoshita M,Tohyama K,Yoshioka Y,Ishii KJ,Co

    更新日期：2014-05-14 00:00:00

  • A Viral Deamidase Targets the Helicase Domain of RIG-I to Block RNA-Induced Activation.

    abstract：:RIG-I detects double-stranded RNA (dsRNA) to trigger antiviral cytokine production. Protein deamidation is emerging as a post-translational modification that chiefly regulates protein function. We report here that UL37 of herpes simplex virus 1 (HSV-1) is a protein deamidase that targets RIG-I to block RNA-induced act...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2016.10.011

    authors： Zhao J,Zeng Y,Xu S,Chen J,Shen G,Yu C,Knipe D,Yuan W,Peng J,Xu W,Zhang C,Xia Z,Feng P

    更新日期：2016-12-14 00:00:00

  • A mouse model for the human pathogen Salmonella typhi.

    abstract：:Salmonella enterica serovar Typhi (S. Typhi) causes typhoid fever, a life-threatening human disease. The lack of animal models due to S. Typhi's strict human host specificity has hindered its study and vaccine development. We find that immunodeficient Rag2(-/-) γc(-/-) mice engrafted with human fetal liver hematopoiet...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2010.09.003

    authors： Song J,Willinger T,Rongvaux A,Eynon EE,Stevens S,Manz MG,Flavell RA,Galán JE

    更新日期：2010-10-21 00:00:00

  • Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASC.

    abstract：:Cryopyrin (CIAS1, NLRP3) and ASC are components of the inflammasome, a multiprotein complex required for caspase-1 activation and cytokine IL-1beta production. CIAS1 mutations underlie autoinflammation characterized by excessive IL-1beta secretion. Disease-associated cryopyrin also causes a program of necrosis-like ce...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2007.07.009

    authors： Willingham SB,Bergstralh DT,O'Connor W,Morrison AC,Taxman DJ,Duncan JA,Barnoy S,Venkatesan MM,Flavell RA,Deshmukh M,Hoffman HM,Ting JP

    更新日期：2007-09-13 00:00:00

  • A Ribose-Scavenging System Confers Colonization Fitness on the Human Gut Symbiont Bacteroides thetaiotaomicron in a Diet-Specific Manner.

    abstract：:Efficient nutrient acquisition in the human gut is essential for microbial persistence. Although polysaccharides have been well-studied nutrients for the gut microbiome, other resources such as nucleic acids and nucleosides are less studied. We describe several ribose-utilization systems (RUSs) that are broadly repres...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2019.11.009

    authors： Glowacki RWP,Pudlo NA,Tuncil Y,Luis AS,Sajjakulnukit P,Terekhov AI,Lyssiotis CA,Hamaker BR,Martens EC

    更新日期：2020-01-08 00:00:00

  • The MAP4 Kinase SIK1 Ensures Robust Extracellular ROS Burst and Antibacterial Immunity in Plants.

    abstract：:Microbial patterns are recognized by cell-surface receptors to initiate pattern-triggered immunity (PTI) in plants. Receptor-like cytoplasmic kinases (RLCKs), such as BIK1, and calcium-dependent protein kinases (CPKs) are engaged during PTI to activate the NADPH oxidase RBOHD for reactive oxygen species (ROS) producti...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2018.08.007

    authors： Zhang M,Chiang YH,Toruño TY,Lee D,Ma M,Liang X,Lal NK,Lemos M,Lu YJ,Ma S,Liu J,Day B,Dinesh-Kumar SP,Dehesh K,Dou D,Zhou JM,Coaker G

    更新日期：2018-09-12 00:00:00

  • Phosphoinositides influence pathogen surfing: EPEC rights the SHIP.

    abstract：:Tir, a translocated effector protein from enteropathogenic E. coli (EPEC), contains two phosphotyrosines that initiate cellular signaling cascades, leading to localized actin polymerization into pedestals. A recent study now shows that two additional tyrosines within Tir recruit the inositol phosphatase SHIP2 to gener...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2009.12.006

    authors： Campellone KG

    更新日期：2010-01-21 00:00:00

  • A stable prefusion intermediate of the alphavirus fusion protein reveals critical features of class II membrane fusion.

    abstract：:Alphaviruses infect cells via a low-pH-triggered membrane fusion reaction mediated by the class II virus fusion protein E1, an elongated molecule with three extramembrane domains (DI-III). E1 drives fusion by inserting its fusion peptide loop into the target membrane and refolding to a hairpin-like trimer in which DII...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2008.10.012

    authors： Sánchez-San Martín C,Sosa H,Kielian M

    更新日期：2008-12-11 00:00:00

  • Establishing Causality: Opportunities of Synthetic Communities for Plant Microbiome Research.

    abstract：:Plant microbiome research highlights the importance of indigenous microbial communities for host phenotypes such as growth and health. It aims to discover the molecular basis by which host-microbe and microbe-microbe interactions shape and maintain microbial communities and to understand the role of individual microor...

    journal_title：Cell host & microbe

    pub_type： 杂志文章,评审

    doi：10.1016/j.chom.2017.07.004

    authors： Vorholt JA,Vogel C,Carlström CI,Müller DB

    更新日期：2017-08-09 00:00:00

  • Impaired stimulation of p38α-MAPK/Vps41-HOPS by LPS from pathogenic Coxiella burnetii prevents trafficking to microbicidal phagolysosomes.

    abstract：:Variations in lipopolysaccharide (LPS), a bacterial outer membrane component, determine virulence of the obligate intracellular bacterium Coxiella burnetii, but the underlying mechanisms are unknown. We find that while avirulent C. burnetii LPS (avLPS) stimulates host p38α-MAPK signaling required for proper traffickin...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2012.10.015

    authors： Barry AO,Boucherit N,Mottola G,Vadovic P,Trouplin V,Soubeyran P,Capo C,Bonatti S,Nebreda A,Toman R,Lemichez E,Mege JL,Ghigo E

    更新日期：2012-12-13 00:00:00

  • In Vivo CRISPR Screen Identifies TgWIP as a Toxoplasma Modulator of Dendritic Cell Migration.

    abstract：:Toxoplasma can reach distant organs, especially the brain, leading to a lifelong chronic phase. However, genes involved in related in vivo processes are currently unknown. Here, we use focused CRISPR libraries to identify Toxoplasma genes that affect in vivo fitness. We focus on TgWIP, whose deletion affects Toxoplasm...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2019.09.008

    authors： Sangaré LO,Ólafsson EB,Wang Y,Yang N,Julien L,Camejo A,Pesavento P,Sidik SM,Lourido S,Barragan A,Saeij JPJ

    更新日期：2019-10-09 00:00:00

  • Making It Stick: A Compelling Case for Precision Microbiome Reconstitution.

    abstract：:Modification of the intestinal microbiome is an emerging target to improve health and prevent or treat a number of diseases. In this issue of Cell Host & Microbe, Maldonado-Gómez et al. (2016) uncover the basic principles that govern the successful establishment and persistence of an exogenously introduced gut bacteri...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2016.09.012

    authors： Berry D

    更新日期：2016-10-12 00:00:00

  • Digest this! A role for autophagy in controlling pathogens.

    abstract：:Autophagy provides a mechanism for cells to conserve nutrients, but was recently associated with immunity to intracellular pathogens. Here, Zhao et al. (2008) present direct in vivo evidence that autophagy is linked to macrophage control of Toxoplasma gondii and Listeria monocytogenes and highlights that this process ...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2008.10.008

    authors： Whitmarsh RJ,Hunter CA

    更新日期：2008-11-13 00:00:00

  • Leishmania evades host immunity by inhibiting antigen cross-presentation through direct cleavage of the SNARE VAMP8.

    abstract：:During phagocytosis, microorganisms are taken up by immune cells into phagosomes. Through membrane-trafficking events mediated by SNARE proteins, phagosomes fuse with lysosomes, generating degradative phagolysosomes. Phagolysosomes contribute to host immunity by linking microbial killing within these organelles with a...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2013.06.003

    authors： Matheoud D,Moradin N,Bellemare-Pelletier A,Shio MT,Hong WJ,Olivier M,Gagnon E,Desjardins M,Descoteaux A

    更新日期：2013-07-17 00:00:00

  • Caging and COM-Bating Antibiotic Resistance.

    abstract：:Horizontal gene transfer (HGT) facilitates spead of antibiotic resistance elements. In this issue of Cell Host & Microbe, Domenech et al. discover that compounds disrupting proton motive force block natural competence (COM) and interrupt intraspecies HGT and exchange of antibiotic resistance. Such strategies might min...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2020.03.013

    authors： Rosch JW,Tuomanen EI

    更新日期：2020-04-08 00:00:00

  • Human formyl peptide receptor 2 senses highly pathogenic Staphylococcus aureus.

    abstract：:Virulence of emerging community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) and other highly pathogenic S. aureus strains depends on their production of phenol-soluble modulin (PSM) peptide toxins, which combine the capacities to attract and lyse neutrophils. The molecular basis of PSM-stimulated ...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2010.05.012

    authors： Kretschmer D,Gleske AK,Rautenberg M,Wang R,Köberle M,Bohn E,Schöneberg T,Rabiet MJ,Boulay F,Klebanoff SJ,van Kessel KA,van Strijp JA,Otto M,Peschel A

    更新日期：2010-06-25 00:00:00

  • Harnessing endogenous miRNAs to control virus tissue tropism as a strategy for developing attenuated virus vaccines.

    abstract：:Live attenuated vaccines remain the safest, most cost-effective intervention against viral infections. Because live vaccine strains are generated empirically and the basis for attenuation is usually ill defined, many important viruses lack an efficient live vaccine. Here, we present a general strategy for the rational...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2008.08.003

    authors： Barnes D,Kunitomi M,Vignuzzi M,Saksela K,Andino R

    更新日期：2008-09-11 00:00:00

  • The enteropathogenic E. coli effector EspB facilitates microvillus effacing and antiphagocytosis by inhibiting myosin function.

    abstract：:Enteropathogenic Escherichia coli (EPEC) destroys intestinal microvilli and suppresses phagocytosis by injecting effectors into infected cells through a type III secretion system (TTSS). EspB, a component of the TTSS, is also injected into the cytoplasm of host cells. However, the physiological functions of EspB withi...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2007.09.012

    authors： Iizumi Y,Sagara H,Kabe Y,Azuma M,Kume K,Ogawa M,Nagai T,Gillespie PG,Sasakawa C,Handa H

    更新日期：2007-12-13 00:00:00

  • STING Requires the Adaptor TRIF to Trigger Innate Immune Responses to Microbial Infection.

    abstract：:The intracellular microbial nucleic acid sensors, TLR3 and STING, recognize pathogen molecules and signal to activate the interferon pathway. The TIR-domain containing protein TRIF is the sole adaptor of TLR3. Here, we report an essential role for TRIF in STING signaling: various activators of STING could not induce g...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2016.08.002

    authors： Wang X,Majumdar T,Kessler P,Ozhegov E,Zhang Y,Chattopadhyay S,Barik S,Sen GC

    更新日期：2016-09-14 00:00:00

  • RIG-I goes beyond naked recognition.

    abstract：:It is currently unclear at which point during viral replication that RNA genomes are first recognized as nonself by the immune system. In this issue of Cell Host & Microbe, Weber et al. show that incoming nucleocapsid-bound genomes are sufficient to bind and activate innate immune sensors. ...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2013.02.012

    authors： Bowzard JB,Ranjan P,Sambhara S

    更新日期：2013-03-13 00:00:00

  • HIV-1 envelope gp41 antibodies can originate from terminal ileum B cells that share cross-reactivity with commensal bacteria.

    abstract：:Monoclonal antibodies derived from blood plasma cells of acute HIV-1-infected individuals are predominantly targeted to the HIV Env gp41 and cross-reactive with commensal bacteria. To understand this phenomenon, we examined anti-HIV responses in ileum B cells using recombinant antibody technology and probed their rela...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2014.07.003

    authors： Trama AM,Moody MA,Alam SM,Jaeger FH,Lockwood B,Parks R,Lloyd KE,Stolarchuk C,Scearce R,Foulger A,Marshall DJ,Whitesides JF,Jeffries TL Jr,Wiehe K,Morris L,Lambson B,Soderberg K,Hwang KK,Tomaras GD,Vandergrift N,Ja

    更新日期：2014-08-13 00:00:00

  • Surveillance of European Domestic Pig Populations Identifies an Emerging Reservoir of Potentially Zoonotic Swine Influenza A Viruses.

    abstract：:Swine influenza A viruses (swIAVs) can play a crucial role in the generation of new human pandemic viruses. In this study, in-depth passive surveillance comprising nearly 2,500 European swine holdings and more than 18,000 individual samples identified a year-round presence of up to four major swIAV lineages on more th...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2020.07.006

    authors： Henritzi D,Petric PP,Lewis NS,Graaf A,Pessia A,Starick E,Breithaupt A,Strebelow G,Luttermann C,Parker LMK,Schröder C,Hammerschmidt B,Herrler G,Beilage EG,Stadlbauer D,Simon V,Krammer F,Wacheck S,Pesch S,Schwemmle M

    更新日期：2020-10-07 00:00:00

  • Multiple targets of nitric oxide in the tricarboxylic acid cycle of Salmonella enterica serovar typhimurium.

    abstract：:Host nitric oxide (NO⋅) production is important for controlling intracellular bacterial pathogens, including Salmonella enterica serovar Typhimurium, but the underlying mechanisms are incompletely understood. S. Typhmurium 14028s is prototrophic for all amino acids but cannot synthesize methionine (M) or lysine (K) du...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2011.06.004

    authors： Richardson AR,Payne EC,Younger N,Karlinsey JE,Thomas VC,Becker LA,Navarre WW,Castor ME,Libby SJ,Fang FC

    更新日期：2011-07-21 00:00:00

  • Hemagglutinin Traits Determine Transmission of Avian A/H10N7 Influenza Virus between Mammals.

    abstract：:In 2014, an outbreak of avian A/H10N7 influenza virus occurred among seals along North-European coastal waters, significantly impacting seal populations. Here, we examine the cross-species transmission and mammalian adaptation of this influenza A virus, revealing changes in the hemagglutinin surface protein that incre...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2020.08.011

    authors： Herfst S,Zhang J,Richard M,McBride R,Lexmond P,Bestebroer TM,Spronken MIJ,de Meulder D,van den Brand JM,Rosu ME,Martin SR,Gamblin SJ,Xiong X,Peng W,Bodewes R,van der Vries E,Osterhaus ADME,Paulson JC,Skehel JJ,Fouch

    更新日期：2020-10-07 00:00:00

  • Th17 Cells Are Preferentially Infected Very Early after Vaginal Transmission of SIV in Macaques.

    abstract：:The difficulty in detecting rare infected cells immediately after mucosal HIV transmission has hindered our understanding of the initial cells targeted by the virus. Working with the macaque simian immunodeficiency virus (SIV) vaginal challenge model, we developed methodology to identify discrete foci of SIV (mac239) ...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2016.03.005

    authors： Stieh DJ,Matias E,Xu H,Fought AJ,Blanchard JL,Marx PA,Veazey RS,Hope TJ

    更新日期：2016-04-13 00:00:00

  • Longitudinal Human Antibody Repertoire against Complete Viral Proteome from Ebola Virus Survivor Reveals Protective Sites for Vaccine Design.

    abstract：:Evolution of antibody repertoire against the Ebola virus (EBOV) proteome was characterized in an acutely infected patient receiving supportive care alone to elucidate virus-host interactions over time. Differential kinetics are observed for IgM-IgG-IgA epitope diversity, antibody binding, and affinity maturation to EB...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2020.01.001

    authors： Khurana S,Ravichandran S,Hahn M,Coyle EM,Stonier SW,Zak SE,Kindrachuk J,Davey RT Jr,Dye JM,Chertow DS

    更新日期：2020-02-12 00:00:00

  • H. pylori's BabA Embraces Change.

    abstract：:Long before the cause was discovered, peptic ulcers were known to occur preferentially in individuals of certain blood groups. In this issue of Cell Host & Microbe, Moonens et al. (2016) perform structural analyses of the Helicobacter pylori adhesin BabA to determine how the bacteria discriminately bind different bloo...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2015.12.013

    authors： Sweeney EG,Guillemin K

    更新日期：2016-01-13 00:00:00

  • Making sense of antisense in antibiotic drug discovery.

    abstract：:In an era of increasing antibiotic resistance, growing clinical need for new drugs, and few lead molecules, new research is helping to identify new targets and the mechanism of action of lead molecules. ...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2009.08.009

    authors： Wright GD

    更新日期：2009-09-17 00:00:00