Fragment and Conquer.


:The replication vacuole of Legionella pneumophila makes contact with host mitochondria. In this issue of Cell Host & Microbe, Escoll et al. (2017) dissect the mechanisms of this interaction, the effect of the T4SS effector MitF on mitochondrial function, and the resultant metabolic reprogramming of infected cells to benefit the bacteria.


Cell Host Microbe


Cell host & microbe


Kozjak-Pavlovic V,Chowdhury SR,Rudel T




Has Abstract


2017-09-13 00:00:00














  • All for one and one for all: herpesviral microRNAs close in on their prey.

    abstract::Herpesviruses subvert immune cell activation by inhibiting NK cell receptor (NKG2D)-activating ligands such as MICB. A human cytomegalovirus microRNA was recently shown to repress MICB expression. Nachmani et al. (2009) extend this finding to two other human herpesviruses, providing evidence for a conserved functional...

    journal_title:Cell host & microbe

    pub_type: 评论,杂志文章


    authors: Dölken L,Jonjic S

    更新日期:2009-04-23 00:00:00

  • Homeostasis in infected epithelia: stem cells take the lead.

    abstract::To maintain tissue homeostasis and avoid disease, epithelial cells damaged by pathogens need to be readily replenished, and this is mainly achieved by the activation of stem cells. In this Short Review, we discuss recent developments in the exciting field of host epithelia-pathogen interaction in Drosophila as well as...

    journal_title:Cell host & microbe

    pub_type: 杂志文章,评审


    authors: Pitsouli C,Apidianakis Y,Perrimon N

    更新日期:2009-10-22 00:00:00

  • Listeria Phages Induce Cas9 Degradation to Protect Lysogenic Genomes.

    abstract::Bacterial CRISPR-Cas systems employ RNA-guided nucleases to destroy phage (viral) DNA. Phages, in turn, have evolved diverse "anti-CRISPR" proteins (Acrs) to counteract acquired immunity. In Listeria monocytogenes, prophages encode two to three distinct anti-Cas9 proteins, with acrIIA1 always present. However, the sig...

    journal_title:Cell host & microbe

    pub_type: 评论,杂志文章


    authors: Osuna BA,Karambelkar S,Mahendra C,Christie KA,Garcia B,Davidson AR,Kleinstiver BP,Kilcher S,Bondy-Denomy J

    更新日期:2020-07-08 00:00:00

  • Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis.

    abstract::Disruption of homeostasis between the host immune system and the intestinal microbiota leads to inflammatory bowel disease (IBD). Whether IBD is instigated by individual species or disruptions of entire microbial communities remains controversial. We characterized the fecal microbial communities in the recently descri...

    journal_title:Cell host & microbe

    pub_type: 杂志文章


    authors: Garrett WS,Gallini CA,Yatsunenko T,Michaud M,DuBois A,Delaney ML,Punit S,Karlsson M,Bry L,Glickman JN,Gordon JI,Onderdonk AB,Glimcher LH

    更新日期:2010-09-16 00:00:00

  • Bacteria Tell Us How to Protect Our Intestine.

    abstract::The inner colon mucus layer capacity to separate bacteria from the epithelium is dependent on bacterial colonizers signaling to the host epithelium. In this issue of Cell Host & Microbe, Wlodarska et al. (2017) demonstrate that the mucin-utilizing Peptostreptococcus russellii protects the host from inflammatory diseas...

    journal_title:Cell host & microbe

    pub_type: 杂志文章


    authors: Birchenough G,Hansson GC

    更新日期:2017-07-12 00:00:00

  • Impaired stimulation of p38α-MAPK/Vps41-HOPS by LPS from pathogenic Coxiella burnetii prevents trafficking to microbicidal phagolysosomes.

    abstract::Variations in lipopolysaccharide (LPS), a bacterial outer membrane component, determine virulence of the obligate intracellular bacterium Coxiella burnetii, but the underlying mechanisms are unknown. We find that while avirulent C. burnetii LPS (avLPS) stimulates host p38α-MAPK signaling required for proper traffickin...

    journal_title:Cell host & microbe

    pub_type: 杂志文章


    authors: Barry AO,Boucherit N,Mottola G,Vadovic P,Trouplin V,Soubeyran P,Capo C,Bonatti S,Nebreda A,Toman R,Lemichez E,Mege JL,Ghigo E

    更新日期:2012-12-13 00:00:00

  • STEVOR is a Plasmodium falciparum erythrocyte binding protein that mediates merozoite invasion and rosetting.

    abstract::Variant surface antigens play an important role in Plasmodium falciparum malaria pathogenesis and in immune evasion by the parasite. Although most work to date has focused on P. falciparum Erythrocyte Membrane Protein 1 (PfEMP1), two other multigene families encoding STEVOR and RIFIN are expressed in invasive merozoit...

    journal_title:Cell host & microbe

    pub_type: 杂志文章


    authors: Niang M,Bei AK,Madnani KG,Pelly S,Dankwa S,Kanjee U,Gunalan K,Amaladoss A,Yeo KP,Bob NS,Malleret B,Duraisingh MT,Preiser PR

    更新日期:2014-07-09 00:00:00

  • Dissecting How CD4 T Cells Are Lost During HIV Infection.

    abstract::Although the replicative life cycle of HIV within CD4 T cells is understood in molecular detail, less is known about how this human retrovirus promotes the loss of CD4 T lymphocytes. It is this cell death process that drives clinical progression to acquired immune deficiency syndrome (AIDS). Recent studies have highli...

    journal_title:Cell host & microbe

    pub_type: 杂志文章,评审


    authors: Doitsh G,Greene WC

    更新日期:2016-03-09 00:00:00

  • Measles virus takes a two-pronged attack on PP1.

    abstract::During viral infection, RIG-I-like receptors (RLRs) are activated upon dephosphorylation by the phosphatase PP1, resulting in type I interferon production. In this issue, Davis et al. (2014) and Mesman et al. (2014) show that measles virus inhibits this antiviral response by targeting PP1 and thus preventing RLR depho...

    journal_title:Cell host & microbe

    pub_type: 评论,杂志文章


    authors: Seya T

    更新日期:2014-07-09 00:00:00

  • Defining a core set of actin cytoskeletal proteins critical for actin-based motility of Rickettsia.

    abstract::Many Rickettsia species are intracellular bacterial pathogens that use actin-based motility for spread during infection. However, while other bacteria assemble actin tails consisting of branched networks, Rickettsia assemble long parallel actin bundles, suggesting the use of a distinct mechanism for exploiting actin. ...

    journal_title:Cell host & microbe

    pub_type: 杂志文章


    authors: Serio AW,Jeng RL,Haglund CM,Reed SC,Welch MD

    更新日期:2010-05-20 00:00:00

  • A Single Legionella Effector Catalyzes a Multistep Ubiquitination Pathway to Rearrange Tubular Endoplasmic Reticulum for Replication.

    abstract::Intracellular pathogens manipulate host organelles to support replication within cells. For Legionella pneumophila, the bacterium translocates proteins that establish an endoplasmic reticulum (ER)-associated replication compartment. We show here that the bacterial Sde proteins target host reticulon 4 (Rtn4) to control...

    journal_title:Cell host & microbe

    pub_type: 杂志文章


    authors: Kotewicz KM,Ramabhadran V,Sjoblom N,Vogel JP,Haenssler E,Zhang M,Behringer J,Scheck RA,Isberg RR

    更新日期:2017-02-08 00:00:00

  • Viperin Poisons Viral Replication.

    abstract::Control of virus infection relies on the stimulation of interferon-stimulated genes (ISGs) that inhibit viral replication. In a recent Nature paper, Gizzi et al. (2018) discovered that the ISG viperin inhibits virus replication by generating the ribonucleotide ddhCTP, which interferes with RNA synthesis, thus offering...

    journal_title:Cell host & microbe

    pub_type: 评论,杂志文章


    authors: Ng LFP,Hiscox JA

    更新日期:2018-08-08 00:00:00

  • Exploiting Combinatorial Interactions to Expand NLR Specificity.

    abstract::Intracellular nucleotide-binding leucine-rich repeat (NLR) receptors play central roles in human and plant innate immunity. In this issue of Cell Host & Microbe, Wang et al. (2015) show that a single plant NLR can detect diverse pathogen effectors by partnering with different scaffolding proteins, which can each recog...

    journal_title:Cell host & microbe

    pub_type: 评论,杂志文章


    authors: Innes RW

    更新日期:2015-09-09 00:00:00

  • Type I Interferon Response Dysregulates Host Iron Homeostasis and Enhances Candida glabrata Infection.

    abstract::Type I interferons (IFNs-I) fulfil multiple protective functions during pathogenic infections, but they can also cause detrimental effects and enhance immunopathology. Here, we report that IFNs-I promote the dysregulation of iron homeostasis in macrophages during systemic infections with the intracellular pathogen Can...

    journal_title:Cell host & microbe

    pub_type: 杂志文章


    authors: Riedelberger M,Penninger P,Tscherner M,Seifert M,Jenull S,Brunnhofer C,Scheidl B,Tsymala I,Bourgeois C,Petryshyn A,Glaser W,Limbeck A,Strobl B,Weiss G,Kuchler K

    更新日期:2020-03-11 00:00:00

  • Multi-Donor Longitudinal Antibody Repertoire Sequencing Reveals the Existence of Public Antibody Clonotypes in HIV-1 Infection.

    abstract::Characterization of single antibody lineages within infected individuals has provided insights into the development of Env-specific antibodies. However, a systems-level understanding of the humoral response against HIV-1 is limited. Here, we interrogated the antibody repertoires of multiple HIV-infected donors from an...

    journal_title:Cell host & microbe

    pub_type: 杂志文章


    authors: Setliff I,McDonnell WJ,Raju N,Bombardi RG,Murji AA,Scheepers C,Ziki R,Mynhardt C,Shepherd BE,Mamchak AA,Garrett N,Karim SA,Mallal SA,Crowe JE Jr,Morris L,Georgiev IS

    更新日期:2018-06-13 00:00:00

  • Pseudogenization of the Secreted Effector Gene sseI Confers Rapid Systemic Dissemination of S. Typhimurium ST313 within Migratory Dendritic Cells.

    abstract::Genome degradation correlates with host adaptation and systemic disease in Salmonella. Most lineages of the S. enterica subspecies Typhimurium cause gastroenteritis in humans; however, the recently emerged ST313 lineage II pathovar commonly causes systemic bacteremia in sub-Saharan Africa. ST313 lineage II displays ge...

    journal_title:Cell host & microbe

    pub_type: 杂志文章


    authors: Carden SE,Walker GT,Honeycutt J,Lugo K,Pham T,Jacobson A,Bouley D,Idoyaga J,Tsolis RM,Monack D

    更新日期:2017-02-08 00:00:00

  • Hemagglutinin Traits Determine Transmission of Avian A/H10N7 Influenza Virus between Mammals.

    abstract::In 2014, an outbreak of avian A/H10N7 influenza virus occurred among seals along North-European coastal waters, significantly impacting seal populations. Here, we examine the cross-species transmission and mammalian adaptation of this influenza A virus, revealing changes in the hemagglutinin surface protein that incre...

    journal_title:Cell host & microbe

    pub_type: 杂志文章


    authors: Herfst S,Zhang J,Richard M,McBride R,Lexmond P,Bestebroer TM,Spronken MIJ,de Meulder D,van den Brand JM,Rosu ME,Martin SR,Gamblin SJ,Xiong X,Peng W,Bodewes R,van der Vries E,Osterhaus ADME,Paulson JC,Skehel JJ,Fouch

    更新日期:2020-10-07 00:00:00

  • Cell-to-cell transfer of HIV-1 via virological synapses leads to endosomal virion maturation that activates viral membrane fusion.

    abstract::HIV-1 can infect T cells by cell-free virus or by direct virion transfer between cells through cell contact-induced structures called virological synapses (VS). During VS-mediated infection, virions accumulate within target cell endosomes. We show that after crossing the VS, the transferred virus undergoes both matura...

    journal_title:Cell host & microbe

    pub_type: 杂志文章


    authors: Dale BM,McNerney GP,Thompson DL,Hubner W,de Los Reyes K,Chuang FY,Huser T,Chen BK

    更新日期:2011-12-15 00:00:00

  • HIV Latency: Stochastic across Multiple Scales.

    abstract::Proviral latency is a major barrier to a cure for HIV. In this issue of Cell Host & Microbe, Hataye et al. (2019) show that reactivation of HIV latency is a non-deterministic, highly stochastic (i.e., noisy) process and propose that stochastic transitions to exponential viral expansion require a critical threshold of ...

    journal_title:Cell host & microbe

    pub_type: 评论,杂志文章


    authors: Hansen MMK,Martin B,Weinberger LS

    更新日期:2019-12-11 00:00:00

  • Importance of glycans to the host-bacteroides mutualism in the mammalian intestine.

    abstract::Much of the mutualistic relationship between humans and their resident intestinal Bacteroides species is founded on glycans. The host provides plant polysaccharides and host-derived glycans and, in return, receives beneficial end products of bacterial fermentation. Glycans from the bacteria themselves are required for...

    journal_title:Cell host & microbe

    pub_type: 杂志文章,评审


    authors: Comstock LE

    更新日期:2009-06-18 00:00:00

  • Induced ER chaperones regulate a receptor-like kinase to mediate antiviral innate immune response in plants.

    abstract::Mounting an effective innate immune response against pathogens requires the rapid and global reprogramming of host cellular processes. Here we employed complementary proteomic methods to identify differentially regulated proteins early during a plant's defense response. Besides defense-related proteins, constituents o...

    journal_title:Cell host & microbe

    pub_type: 杂志文章


    authors: Caplan JL,Zhu X,Mamillapalli P,Marathe R,Anandalakshmi R,Dinesh-Kumar SP

    更新日期:2009-11-19 00:00:00

  • Plasmodium Merozoite TRAP Family Protein Is Essential for Vacuole Membrane Disruption and Gamete Egress from Erythrocytes.

    abstract::Surface-associated TRAP (thrombospondin-related anonymous protein) family proteins are conserved across the phylum of apicomplexan parasites. TRAP proteins are thought to play an integral role in parasite motility and cell invasion by linking the extracellular environment with the parasite submembrane actomyosin motor...

    journal_title:Cell host & microbe

    pub_type: 杂志文章


    authors: Bargieri DY,Thiberge S,Tay CL,Carey AF,Rantz A,Hischen F,Lorthiois A,Straschil U,Singh P,Singh S,Triglia T,Tsuboi T,Cowman A,Chitnis C,Alano P,Baum J,Pradel G,Lavazec C,Ménard R

    更新日期:2016-11-09 00:00:00

  • The toxoplasma apicoplast phosphate translocator links cytosolic and apicoplast metabolism and is essential for parasite survival.

    abstract::Apicomplexa are unicellular eukaryotic pathogens that carry a vestigial algal endosymbiont, the apicoplast. The physiological function of the apicoplast and its integration into parasite metabolism remain poorly understood and at times controversial. We establish that the Toxoplasma apicoplast membrane-localized phosp...

    journal_title:Cell host & microbe

    pub_type: 杂志文章


    authors: Brooks CF,Johnsen H,van Dooren GG,Muthalagi M,Lin SS,Bohne W,Fischer K,Striepen B

    更新日期:2010-01-21 00:00:00

  • F11L-mediated inhibition of RhoA-mDia signaling stimulates microtubule dynamics during vaccinia virus infection.

    abstract::Microtubules play an important role in the transport of viral pathogens during the establishment of their infection cycles. The microtubule cytoskeleton also facilitates efficient release of newly assembled progeny at later stages of infection. However, the precise effects of viral infection on microtubule dynamics ar...

    journal_title:Cell host & microbe

    pub_type: 杂志文章


    authors: Arakawa Y,Cordeiro JV,Way M

    更新日期:2007-05-17 00:00:00

  • Understanding how hepatitis C virus builds its unctuous home.

    abstract::Hepatitis C virus genome replication occurs in endoplasmic reticulum-derived membrane compartments, but it is unknown how these structures arise. In this issue of Cell Host & Microbe, Reiss and colleagues (2011) show that the virus recruits a specific lipid kinase to replication sites, stimulates its kinase activity, ...

    journal_title:Cell host & microbe

    pub_type: 评论,杂志文章


    authors: Lindenbach BD

    更新日期:2011-01-20 00:00:00

  • Advances in norovirus biology.

    abstract::Human noroviruses are a major cause of epidemic and sporadic gastroenteritis worldwide and can chronically infect immunocompromised patients. Efforts to develop effective vaccines and antivirals have been hindered by the uncultivable nature and extreme genetic diversity of human noroviruses. Although they remain a par...

    journal_title:Cell host & microbe

    pub_type: 杂志文章,评审


    authors: Karst SM,Wobus CE,Goodfellow IG,Green KY,Virgin HW

    更新日期:2014-06-11 00:00:00

  • The blessings and curses of intestinal inflammation.

    abstract::The intestinal immune system has to strike a delicate balance between initiating inflammatory responses against invading bacterial pathogens and avoiding their induction against microbiota colonizing the lumen. Adequate inflammatory responses against bacterial invasion result in the lumenal secretion of antimicrobial ...

    journal_title:Cell host & microbe

    pub_type: 杂志文章,评审


    authors: Winter SE,Keestra AM,Tsolis RM,Bäumler AJ

    更新日期:2010-07-22 00:00:00

  • ESCRT-I part II: forming the real ESCRT-I complex.

    abstract::Many enveloped viruses hijack the cellular ESCRT machinery to catalyze their escape from host cells. One paper in a recent issue of Cell by Kostelansky et al. and another in this issue of Cell Host & Microbe by Morita et al. shed new light on the structure and function of ESCRT-I. Both papers focus on a fourth ESCRT-I...

    journal_title:Cell host & microbe

    pub_type: 评论,杂志文章


    authors: Weissenhorn W,Göttlinger H

    更新日期:2007-07-12 00:00:00

  • Fungal Mimicry of a Mammalian Aminopeptidase Disables Innate Immunity and Promotes Pathogenicity.

    abstract::Systemic fungal infections trigger marked immune-regulatory disturbances, but the mechanisms are poorly understood. We report that the pathogenic yeast of Blastomyces dermatitidis elaborates dipeptidyl-peptidase IVA (DppIVA), a close mimic of the mammalian ectopeptidase CD26, which modulates critical aspects of hemato...

    journal_title:Cell host & microbe

    pub_type: 杂志文章


    authors: Sterkel AK,Lorenzini JL,Fites JS,Subramanian Vignesh K,Sullivan TD,Wuthrich M,Brandhorst T,Hernandez-Santos N,Deepe GS Jr,Klein BS

    更新日期:2016-03-09 00:00:00

  • Intestinal Bile Acids Induce a Morphotype Switch in Vancomycin-Resistant Enterococcus that Facilitates Intestinal Colonization.

    abstract::Vancomycin-resistant Enterococcus (VRE) are highly antibiotic-resistant and readily transmissible pathogens that cause severe infections in hospitalized patients. We discovered that lithocholic acid (LCA), a secondary bile acid prevalent in the cecum and colon of mice and humans, impairs separation of growing VRE dipl...

    journal_title:Cell host & microbe

    pub_type: 杂志文章


    authors: McKenney PT,Yan J,Vaubourgeix J,Becattini S,Lampen N,Motzer A,Larson PJ,Dannaoui D,Fujisawa S,Xavier JB,Pamer EG

    更新日期:2019-05-08 00:00:00