当前位置： SCI文献检索 > Cell Host & Microbe期刊下所有文献 > Digest this! A role for autophagy in controlling pathogens.

Digest this! A role for autophagy in controlling pathogens.

Abstract：

:Autophagy provides a mechanism for cells to conserve nutrients, but was recently associated with immunity to intracellular pathogens. Here, Zhao et al. (2008) present direct in vivo evidence that autophagy is linked to macrophage control of Toxoplasma gondii and Listeria monocytogenes and highlights that this process intersects with cytokine-mediated antimicrobial responses.

journal_name

Cell Host Microbe

journal_title

Cell host & microbe

authors

Whitmarsh RJ,Hunter CA

doi

10.1016/j.chom.2008.10.008

subject

Has Abstract

pub_date

2008-11-13 00:00:00

pages

413-4

issue

5

eissn

1931-3128

issn

1934-6069

pii

S1931-3128(08)00335-1

journal_volume

4

pub_type

评论,杂志文章

相关文献

Cell Host & Microbe文献大全
  • Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection.

    abstract：:Anti-helminth immunity involves CD4+ T cells, yet the precise effector mechanisms responsible for parasite killing or expulsion remain elusive. We now report an essential role for antibodies in mediating immunity against the enteric helminth Heligmosomoides polygyrus (Hp), a natural murine parasite that establishes ch...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2008.08.014

    authors： McCoy KD,Stoel M,Stettler R,Merky P,Fink K,Senn BM,Schaer C,Massacand J,Odermatt B,Oettgen HC,Zinkernagel RM,Bos NA,Hengartner H,Macpherson AJ,Harris NL

    更新日期：2008-10-16 00:00:00

  • A mouse model for the human pathogen Salmonella typhi.

    abstract：:Salmonella enterica serovar Typhi (S. Typhi) causes typhoid fever, a life-threatening human disease. The lack of animal models due to S. Typhi's strict human host specificity has hindered its study and vaccine development. We find that immunodeficient Rag2(-/-) γc(-/-) mice engrafted with human fetal liver hematopoiet...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2010.09.003

    authors： Song J,Willinger T,Rongvaux A,Eynon EE,Stevens S,Manz MG,Flavell RA,Galán JE

    更新日期：2010-10-21 00:00:00

  • Colitis-Induced Th17 Cells Increase the Risk for Severe Subsequent Clostridium difficile Infection.

    abstract：:Clostridium difficile infection (CDI) is the number one hospital-acquired infection in the United States. CDI is more common and severe in inflammatory bowel disease patients. Here, we studied the mechanism by which prior colitis exacerbates CDI. Mice were given dextran sulfate sodium (DSS) colitis, recovered for 2 we...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2019.03.003

    authors： Saleh MM,Frisbee AL,Leslie JL,Buonomo EL,Cowardin CA,Ma JZ,Simpson ME,Scully KW,Abhyankar MM,Petri WA Jr

    更新日期：2019-05-08 00:00:00

  • Mycobacterium tuberculosis activates the DNA-dependent cytosolic surveillance pathway within macrophages.

    abstract：:Cytosolic bacterial pathogens activate the cytosolic surveillance pathway (CSP) and induce innate immune responses, but how the host detects vacuolar pathogens like Mycobacterium tuberculosis is poorly understood. We show that M. tuberculosis also initiates the CSP upon macrophage infection via limited perforation of ...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2012.03.007

    authors： Manzanillo PS,Shiloh MU,Portnoy DA,Cox JS

    更新日期：2012-05-17 00:00:00

  • Mapping the Evolutionary Potential of RNA Viruses.

    abstract：:The deterministic force of natural selection and stochastic influence of drift shape RNA virus evolution. New deep-sequencing and microfluidics technologies allow us to quantify the effect of mutations and trace the evolution of viral populations with single-genome and single-nucleotide resolution. Such experiments ca...

    journal_title：Cell host & microbe

    pub_type： 杂志文章,评审

    doi：10.1016/j.chom.2018.03.012

    authors： Dolan PT,Whitfield ZJ,Andino R

    更新日期：2018-04-11 00:00:00

  • Hypomorphic mutation in the site-1 protease Mbtps1 endows resistance to persistent viral infection in a cell-specific manner.

    abstract：:The prototypic arenavirus lymphocytic choriomeningitis virus (LCMV), which naturally persists in rodents, represents a model for HIV, HBV, and HCV. Cleavage of the viral glycoprotein precursor by membrane-bound transcription factor peptidase, site 1 (Mbtps1 or site-1 protease), is crucial for the life cycle of arenavi...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2011.02.006

    authors： Popkin DL,Teijaro JR,Sullivan BM,Urata S,Rutschmann S,de la Torre JC,Kunz S,Beutler B,Oldstone M

    更新日期：2011-03-17 00:00:00

  • Commensals, bacterial pathogens and intestinal inflammation: an intriguing ménage à trois.

    abstract：:According to a classical view of bacterial-host interactions at intestinal surfaces, the commensal microbiota establishes tolerance, and invasive pathogens cause stereotypic inflammation. The reality is more complex, marked by a "ménage à trois" situation encompassing three emerging concepts: (1) pathogens take advant...

    journal_title：Cell host & microbe

    pub_type： 杂志文章,评审

    doi：10.1016/j.chom.2008.05.010

    authors： Pédron T,Sansonetti P

    更新日期：2008-06-12 00:00:00

  • Carving a Niche for Antibacterial α-Defensins when Craving.

    abstract：:In this issue of Cell Host & Microbe, Liang et al. (2019) show that α-defensins in the gastrointestinal tract sustain defenses to enteric pathogens during starvation. mTOR-dependent sensing of nutrient loss promotes production of an α-defensin regulator, which sustains α-defensin levels, loss of which increases lethal...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2019.04.009

    authors： Foerster EG,Girardin SE

    更新日期：2019-05-08 00:00:00

  • Duffy antigen receptor for chemokines mediates trans-infection of HIV-1 from red blood cells to target cells and affects HIV-AIDS susceptibility.

    abstract：:Duffy antigen receptor for chemokines (DARC) expressed on red blood cells (RBCs) influences plasma levels of HIV-1-suppressive and proinflammatory chemokines such as CCL5/RANTES. DARC is also the RBC receptor for Plasmodium vivax. Africans with DARC -46C/C genotype, which confers a DARC-negative phenotype, are resista...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2008.06.002

    authors： He W,Neil S,Kulkarni H,Wright E,Agan BK,Marconi VC,Dolan MJ,Weiss RA,Ahuja SK

    更新日期：2008-07-17 00:00:00

  • Microbiota-Dependent Priming of Antiviral Intestinal Immunity in Drosophila.

    abstract：:Enteric pathogens must overcome intestinal defenses to establish infection. In Drosophila, the ERK signaling pathway inhibits enteric virus infection. The intestinal microflora also impacts immunity but its role in enteric viral infection is unknown. Here we show that two signals are required to activate antiviral ERK...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2015.10.010

    authors： Sansone CL,Cohen J,Yasunaga A,Xu J,Osborn G,Subramanian H,Gold B,Buchon N,Cherry S

    更新日期：2015-11-11 00:00:00

  • H10N8 and H6N1 maintain avian receptor binding.

    abstract：:Influenza viruses of animals can cross species and infect humans. In this issue of Cell Host & Microbe, Zhang et al. (2015) and Tzarum et al. (2015) describe crystal structures and receptor-binding properties of hemagglutinins of avian-origin H10N8 and H6N1 influenza viruses. Human infections with these viruses are no...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2015.02.020

    authors： Richard M,Fouchier RAM

    更新日期：2015-03-11 00:00:00

  • Cholesterol Metabolism by Uncultured Human Gut Bacteria Influences Host Cholesterol Level.

    abstract：:The human microbiome encodes extensive metabolic capabilities, but our understanding of the mechanisms linking gut microbes to human metabolism remains limited. Here, we focus on the conversion of cholesterol to the poorly absorbed sterol coprostanol by the gut microbiota to develop a framework for the identification ...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2020.05.013

    authors： Kenny DJ,Plichta DR,Shungin D,Koppel N,Hall AB,Fu B,Vasan RS,Shaw SY,Vlamakis H,Balskus EP,Xavier RJ

    更新日期：2020-08-12 00:00:00

  • Heme oxygenase-1 is an anti-inflammatory host factor that promotes murine plasmodium liver infection.

    abstract：:The clinically silent Plasmodium liver stage is an obligatory step in the establishment of malaria infection and disease. We report here that expression of heme oxygenase-1 (HO-1, encoded by Hmox1) is upregulated in the liver following infection by Plasmodium berghei and Plasmodium yoelii sporozoites. HO-1 overexpress...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2008.04.003

    authors： Epiphanio S,Mikolajczak SA,Gonçalves LA,Pamplona A,Portugal S,Albuquerque S,Goldberg M,Rebelo S,Anderson DG,Akinc A,Vornlocher HP,Kappe SH,Soares MP,Mota MM

    更新日期：2008-05-15 00:00:00

  • Histone modifications and chromatin remodeling during bacterial infections.

    abstract：:The link between bacteria and host chromatin remodeling is an emerging topic. The exciting recent discoveries on bacterial impact on host epigenetics, as discussed in this Review, highlight yet another strategy used by bacterial pathogens to interfere with key cellular processes. The study of how pathogens provoke hos...

    journal_title：Cell host & microbe

    pub_type： 杂志文章,评审

    doi：10.1016/j.chom.2008.07.009

    authors： Hamon MA,Cossart P

    更新日期：2008-08-14 00:00:00

  • Transcriptional pausing controls a rapid antiviral innate immune response in Drosophila.

    abstract：:Innate immune responses are characterized by precise gene expression whereby gene subsets are temporally induced to limit infection, although the mechanisms involved are incompletely understood. We show that antiviral immunity in Drosophila requires the transcriptional pausing pathway, including negative elongation fa...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2012.08.011

    authors： Xu J,Grant G,Sabin LR,Gordesky-Gold B,Yasunaga A,Tudor M,Cherry S

    更新日期：2012-10-18 00:00:00

  • Adenovirus evasion of interferon-mediated innate immunity by direct antagonism of a cellular histone posttranslational modification.

    abstract：:Overcoming the cellular type I interferon (IFN) host defense response is critical for a virus to ensure successful infection. Investigating the effects of human adenovirus (HAdV) infection on global cellular histone posttranslational modification (hPTM), we discovered that virus infection-induced activation of IFN sig...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2012.05.005

    authors： Fonseca GJ,Thillainadesan G,Yousef AF,Ablack JN,Mossman KL,Torchia J,Mymryk JS

    更新日期：2012-06-14 00:00:00

  • Dicer-2-Dependent Generation of Viral DNA from Defective Genomes of RNA Viruses Modulates Antiviral Immunity in Insects.

    abstract：:The RNAi pathway confers antiviral immunity in insects. Virus-specific siRNA responses are amplified via the reverse transcription of viral RNA to viral DNA (vDNA). The nature, biogenesis, and regulation of vDNA are unclear. We find that vDNA produced during RNA virus infection of Drosophila and mosquitoes is present ...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2018.02.001

    authors： Poirier EZ,Goic B,Tomé-Poderti L,Frangeul L,Boussier J,Gausson V,Blanc H,Vallet T,Loyd H,Levi LI,Lanciano S,Baron C,Merkling SH,Lambrechts L,Mirouze M,Carpenter S,Vignuzzi M,Saleh MC

    更新日期：2018-03-14 00:00:00

  • The Innate Sense of Bacteriophages.

    abstract：:Perturbation of the gut microbiota is associated with inflammatory bowel disease, obesity, and even cancer. In this issue of Cell Host & Microbe, Gogokhia et al. 2019 sought to kill cancer-causing bacteria with bacteriophages. However, the bacteriophages themselves directly stimulated an immune response, which worsene...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2019.01.020

    authors： Bollyky PL,Secor PR

    更新日期：2019-02-13 00:00:00

  • Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin.

    abstract：:Regulatory T cells (Tregs) are required to establish immune tolerance to commensal microbes. Tregs accumulate abruptly in the skin during a defined window of postnatal tissue development. However, the mechanisms mediating Treg migration to neonatal skin are unknown. Here we show that hair follicle (HF) development fac...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2017.03.001

    authors： Scharschmidt TC,Vasquez KS,Pauli ML,Leitner EG,Chu K,Truong HA,Lowe MM,Sanchez Rodriguez R,Ali N,Laszik ZG,Sonnenburg JL,Millar SE,Rosenblum MD

    更新日期：2017-04-12 00:00:00

  • Shigella phagocytic vacuolar membrane remnants participate in the cellular response to pathogen invasion and are regulated by autophagy.

    abstract：:Intracellular pathogens like Shigella flexneri enter host cells by phagocytosis. Once inside, the pathogen breaks the vacuolar membrane for cytosolic access. The fate and function of the vacuolar membrane remnants are not clear. Examining Shigella-infected nonmyeloid cells, we observed that proteins associated with va...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2009.07.005

    authors： Dupont N,Lacas-Gervais S,Bertout J,Paz I,Freche B,Van Nhieu GT,van der Goot FG,Sansonetti PJ,Lafont F

    更新日期：2009-08-20 00:00:00

  • Increased expression of LDL receptor-related protein 1 during human cytomegalovirus infection reduces virion cholesterol and infectivity.

    abstract：:In response to virus infection, cells can alter protein expression to modify cellular functions and limit viral replication. To examine host protein expression during infection with human cytomegalovirus (HCMV), an enveloped DNA virus, we performed a semiquantitative, temporal analysis of the cell surface proteome in ...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2012.05.012

    authors： Gudleski-O'Regan N,Greco TM,Cristea IM,Shenk T

    更新日期：2012-07-19 00:00:00

  • H. pylori's BabA Embraces Change.

    abstract：:Long before the cause was discovered, peptic ulcers were known to occur preferentially in individuals of certain blood groups. In this issue of Cell Host & Microbe, Moonens et al. (2016) perform structural analyses of the Helicobacter pylori adhesin BabA to determine how the bacteria discriminately bind different bloo...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2015.12.013

    authors： Sweeney EG,Guillemin K

    更新日期：2016-01-13 00:00:00

  • HIV-1 envelope gp41 antibodies can originate from terminal ileum B cells that share cross-reactivity with commensal bacteria.

    abstract：:Monoclonal antibodies derived from blood plasma cells of acute HIV-1-infected individuals are predominantly targeted to the HIV Env gp41 and cross-reactive with commensal bacteria. To understand this phenomenon, we examined anti-HIV responses in ileum B cells using recombinant antibody technology and probed their rela...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2014.07.003

    authors： Trama AM,Moody MA,Alam SM,Jaeger FH,Lockwood B,Parks R,Lloyd KE,Stolarchuk C,Scearce R,Foulger A,Marshall DJ,Whitesides JF,Jeffries TL Jr,Wiehe K,Morris L,Lambson B,Soderberg K,Hwang KK,Tomaras GD,Vandergrift N,Ja

    更新日期：2014-08-13 00:00:00

  • Proteome-wide quantification and characterization of oxidation-sensitive cysteines in pathogenic bacteria.

    abstract：:Thiol-group oxidation of active and allosteric cysteines is a widespread regulatory posttranslational protein modification. Pathogenic bacteria, including Pseudomonas aeruginosa and Staphylococcus aureus, use regulatory cysteine oxidation to respond to and overcome reactive oxygen species (ROS) encountered in the host...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2013.02.004

    authors： Deng X,Weerapana E,Ulanovskaya O,Sun F,Liang H,Ji Q,Ye Y,Fu Y,Zhou L,Li J,Zhang H,Wang C,Alvarez S,Hicks LM,Lan L,Wu M,Cravatt BF,He C

    更新日期：2013-03-13 00:00:00

  • All for one and one for all: herpesviral microRNAs close in on their prey.

    abstract：:Herpesviruses subvert immune cell activation by inhibiting NK cell receptor (NKG2D)-activating ligands such as MICB. A human cytomegalovirus microRNA was recently shown to repress MICB expression. Nachmani et al. (2009) extend this finding to two other human herpesviruses, providing evidence for a conserved functional...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2009.03.009

    authors： Dölken L,Jonjic S

    更新日期：2009-04-23 00:00:00

  • Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASC.

    abstract：:Cryopyrin (CIAS1, NLRP3) and ASC are components of the inflammasome, a multiprotein complex required for caspase-1 activation and cytokine IL-1beta production. CIAS1 mutations underlie autoinflammation characterized by excessive IL-1beta secretion. Disease-associated cryopyrin also causes a program of necrosis-like ce...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2007.07.009

    authors： Willingham SB,Bergstralh DT,O'Connor W,Morrison AC,Taxman DJ,Duncan JA,Barnoy S,Venkatesan MM,Flavell RA,Deshmukh M,Hoffman HM,Ting JP

    更新日期：2007-09-13 00:00:00

  • The HIV-1 Tat team gets bigger.

    abstract：:Productive transcription of the HIV-1 genome involves RNA polymerase II working in concert with the viral protein Tat and its team of cofactors in a highly orchestrated process. Now, Pagans and colleagues report that the lysine methyltransferase Set7/9-KMT7 associates with Tat to stimulate RNA polymerase II elongation...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2010.03.001

    authors： Rice AP

    更新日期：2010-03-18 00:00:00

  • The Landscape Ecology and Microbiota of the Human Nose, Mouth, and Throat.

    abstract：:Landscape ecology examines the relationships between the spatial arrangement of different landforms and the processes that give rise to spatial and temporal patterns in local community structure. The spatial ecology of the microbial communities that inhabit the human body-in particular, those of the nose, mouth, and t...

    journal_title：Cell host & microbe

    pub_type： 杂志文章,评审

    doi：10.1016/j.chom.2017.03.011

    authors： Proctor DM,Relman DA

    更新日期：2017-04-12 00:00:00

  • Adaptive Strategies of the Candidate Probiotic E. coli Nissle in the Mammalian Gut.

    abstract：:Probiotics are living microorganisms that are increasingly used as gastrointestinal therapeutics by virtue of their innate or engineered genetic function. Unlike abiotic therapeutics, probiotics can replicate in their intended site, subjecting their genomes and therapeutic properties to natural selection. We exposed t...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2019.02.005

    authors： Crook N,Ferreiro A,Gasparrini AJ,Pesesky MW,Gibson MK,Wang B,Sun X,Condiotte Z,Dobrowolski S,Peterson D,Dantas G

    更新日期：2019-04-10 00:00:00

  • Host restriction factor SAMHD1 limits human T cell leukemia virus type 1 infection of monocytes via STING-mediated apoptosis.

    abstract：:Human T cell leukemia virus type 1 (HTLV-1) is the causative agent of adult T cell leukemia and HTLV-1-associated myelopathies. In addition to T cells, HTLV-1 infects cells of the myeloid lineage, which play critical roles in the host innate response to viral infection. Investigating the monocyte depletion observed du...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2013.09.009

    authors： Sze A,Belgnaoui SM,Olagnier D,Lin R,Hiscott J,van Grevenynghe J

    更新日期：2013-10-16 00:00:00