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Dicer-2-Dependent Generation of Viral DNA from Defective Genomes of RNA Viruses Modulates Antiviral Immunity in Insects.

Abstract：

:The RNAi pathway confers antiviral immunity in insects. Virus-specific siRNA responses are amplified via the reverse transcription of viral RNA to viral DNA (vDNA). The nature, biogenesis, and regulation of vDNA are unclear. We find that vDNA produced during RNA virus infection of Drosophila and mosquitoes is present in both linear and circular forms. Circular vDNA (cvDNA) is sufficient to produce siRNAs that confer partially protective immunity when challenged with a cognate virus. cvDNAs bear homology to defective viral genomes (DVGs), and DVGs serve as templates for vDNA and cvDNA synthesis. Accordingly, DVGs promote the amplification of vDNA-mediated antiviral RNAi responses in infected Drosophila. Furthermore, vDNA synthesis is regulated by the DExD/H helicase domain of Dicer-2 in a mechanism distinct from its role in siRNA generation. We suggest that, analogous to mammalian RIG-I-like receptors, Dicer-2 functions like a pattern recognition receptor for DVGs to modulate antiviral immunity in insects.

journal_name

Cell Host Microbe

journal_title

Cell host & microbe

authors

Poirier EZ,Goic B,Tomé-Poderti L,Frangeul L,Boussier J,Gausson V,Blanc H,Vallet T,Loyd H,Levi LI,Lanciano S,Baron C,Merkling SH,Lambrechts L,Mirouze M,Carpenter S,Vignuzzi M,Saleh MC

doi

10.1016/j.chom.2018.02.001

subject

Has Abstract

pub_date

2018-03-14 00:00:00

pages

353-365.e8

issue

3

eissn

1931-3128

issn

1934-6069

pii

S1931-3128(18)30087-8

journal_volume

23

pub_type

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