Abstract:
:Vaccines are the most effective means available for preventing infectious diseases. However, vaccine-induced immune responses are highly variable between individuals and between populations in different regions of the world. Understanding the basis of this variation is, thus, of fundamental importance to human health. Although the factors that are associated with intra- and inter-population variation in vaccine responses are manifold, emerging evidence points to a key role for the gut microbiome in controlling immune responses to vaccination. Much of this evidence comes from studies in mice, and causal evidence for the impact of the microbiome on human immunity is sparse. However, recent studies on vaccination in subjects treated with broad-spectrum antibiotics have provided causal evidence and mechanistic insights into how the microbiota controls immune responses in humans.
journal_name
Cell Host Microbejournal_title
Cell host & microbeauthors
de Jong SE,Olin A,Pulendran Bdoi
10.1016/j.chom.2020.06.014subject
Has Abstractpub_date
2020-08-12 00:00:00pages
169-179issue
2eissn
1931-3128issn
1934-6069pii
S1931-3128(20)30355-3journal_volume
28pub_type
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