The Impact of the Microbiome on Immunity to Vaccination in Humans.

Abstract:

:Vaccines are the most effective means available for preventing infectious diseases. However, vaccine-induced immune responses are highly variable between individuals and between populations in different regions of the world. Understanding the basis of this variation is, thus, of fundamental importance to human health. Although the factors that are associated with intra- and inter-population variation in vaccine responses are manifold, emerging evidence points to a key role for the gut microbiome in controlling immune responses to vaccination. Much of this evidence comes from studies in mice, and causal evidence for the impact of the microbiome on human immunity is sparse. However, recent studies on vaccination in subjects treated with broad-spectrum antibiotics have provided causal evidence and mechanistic insights into how the microbiota controls immune responses in humans.

journal_name

Cell Host Microbe

journal_title

Cell host & microbe

authors

de Jong SE,Olin A,Pulendran B

doi

10.1016/j.chom.2020.06.014

subject

Has Abstract

pub_date

2020-08-12 00:00:00

pages

169-179

issue

2

eissn

1931-3128

issn

1934-6069

pii

S1931-3128(20)30355-3

journal_volume

28

pub_type

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