Abstract:
:Studying the microbial composition of internal organs and their associations with disease remains challenging due to the difficulty of acquiring clinical biopsies. We designed a statistical model to analyze the prevalence of species across sample types from The Cancer Genome Atlas (TCGA), revealing that species equiprevalent across sample types are predominantly contaminants, bearing unique signatures from each TCGA-designated sequencing center. Removing such species mitigated batch effects and isolated the tissue-resident microbiome, which was validated by original matched TCGA samples. Gene copies and nucleotide variants can further distinguish mixed-evidence species. We, thus, present The Cancer Microbiome Atlas (TCMA), a collection of curated, decontaminated microbial compositions of oropharyngeal, esophageal, gastrointestinal, and colorectal tissues. This led to the discovery of prognostic species and blood signatures of mucosal barrier injuries and enabled systematic matched microbe-host multi-omic analyses, which will help guide future studies of the microbiome's role in human health and disease.
journal_name
Cell Host Microbejournal_title
Cell host & microbeauthors
Dohlman AB,Arguijo Mendoza D,Ding S,Gao M,Dressman H,Iliev ID,Lipkin SM,Shen Xdoi
10.1016/j.chom.2020.12.001subject
Has Abstractpub_date
2020-12-21 00:00:00eissn
1931-3128issn
1934-6069pii
S1931-3128(20)30663-6pub_type
杂志文章abstract::The complex microbial community residing within the intestine plays important roles in host defense. However, the impact of enteric infection and inflammation on this resident community has not been fully explored. In this issue of Cell Host & Microbe, Lupp and coworkers reveal that the composition of the intestinal m...
journal_title:Cell host & microbe
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abstract::Typhoidal and non-typhoidal Salmonelleae (NTS) cause typhoid fever and gastroenteritis, respectively, in humans. Salmonella typhoid toxin contributes to typhoid disease progression and chronic infection, but little is known about the role of its NTS ortholog. We found that typhoid toxin and its NTS ortholog induce dif...
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journal_title:Cell host & microbe
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journal_title:Cell host & microbe
pub_type: 杂志文章,评审
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journal_title:Cell host & microbe
pub_type: 评论,杂志文章
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journal_title:Cell host & microbe
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journal_title:Cell host & microbe
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journal_title:Cell host & microbe
pub_type: 杂志文章
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journal_title:Cell host & microbe
pub_type: 评论,杂志文章
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journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2012.05.005
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journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2018.04.015
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journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2019.03.014
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journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2009.02.002
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abstract::Innate immune responses are characterized by precise gene expression whereby gene subsets are temporally induced to limit infection, although the mechanisms involved are incompletely understood. We show that antiviral immunity in Drosophila requires the transcriptional pausing pathway, including negative elongation fa...
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pub_type: 杂志文章
doi:10.1016/j.chom.2012.08.011
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journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2013.12.002
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journal_title:Cell host & microbe
pub_type: 杂志文章,评审
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journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2007.06.006
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journal_title:Cell host & microbe
pub_type: 杂志文章,评审
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journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2012.09.010
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journal_title:Cell host & microbe
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doi:10.1016/j.chom.2016.12.003
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abstract::RNA interference (RNAi) is an established antiviral defense mechanism in plants and invertebrates. Whether RNAi serves a similar function in mammalian cells remains unresolved. We find that in some cell types, mammalian RNAi activity is reduced shortly after viral infection via poly-ADP-ribosylation of the RNA-induced...
journal_title:Cell host & microbe
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journal_title:Cell host & microbe
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doi:10.1016/j.chom.2008.11.006
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journal_title:Cell host & microbe
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doi:10.1016/j.chom.2013.04.005
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journal_title:Cell host & microbe
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doi:10.1016/j.chom.2012.12.005
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journal_title:Cell host & microbe
pub_type: 评论,杂志文章
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journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2014.08.007
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