Early-Life Formation of the Microbial and Immunological Environment of the Human Airways.


:Crosstalk between immune cells and the microbiota in mucosal tissues can set an individual on a trajectory toward health or disease. Little is known about these early-life events in the human respiratory tract. We examined bacterial colonization and immune system maturation in the lower airways over the first year of life. The lower respiratory tract microbiota forms within the first 2 postnatal months. Within the first weeks, three microbial profiles are evident, broadly distinguished as dysbiotic or diverse, and representing different microbial virulence potentials, including proteolysis of immunoglobulin A (IgA) that is critical for mucosal defense. Delivery mode determines microbiota constituents in preterm, but not term, births. Gestational age is a key determinant of immune maturation, with airway cells progressively increasing expression of proallergic cytokine interleukin-33 and genes linked with IgA. These data reveal microbial and immunological development in human airways, and may inform early-life interventions to prevent respiratory diseases.


Cell Host Microbe


Cell host & microbe


Pattaroni C,Watzenboeck ML,Schneidegger S,Kieser S,Wong NC,Bernasconi E,Pernot J,Mercier L,Knapp S,Nicod LP,Marsland CP,Roth-Kleiner M,Marsland BJ




Has Abstract


2018-12-12 00:00:00














  • Cooperating Commensals Restore Colonization Resistance to Vancomycin-Resistant Enterococcus faecium.

    abstract::Antibiotic-mediated microbiota destruction and the consequent loss of colonization resistance can result in intestinal domination with vancomycin-resistant Enterococcus (VRE), leading to bloodstream infection in hospitalized patients. Clearance of VRE remains a challenging goal that, if achieved, would reduce systemic...

    journal_title:Cell host & microbe

    pub_type: 杂志文章


    authors: Caballero S,Kim S,Carter RA,Leiner IM,Sušac B,Miller L,Kim GJ,Ling L,Pamer EG

    更新日期:2017-05-10 00:00:00

  • Serine phosphorylation of cortactin controls focal adhesion kinase activity and cell scattering induced by Helicobacter pylori.

    abstract::Cell migration and invasion require the coordinated regulation of cytoskeletal architectural changes by signaling factors, including the actin-binding protein cortactin. Bacterial and viral pathogens subvert these signaling factors to promote their uptake, spread and dissemination. We show that the gastric pathogen He...

    journal_title:Cell host & microbe

    pub_type: 杂志文章


    authors: Tegtmeyer N,Wittelsberger R,Hartig R,Wessler S,Martinez-Quiles N,Backert S

    更新日期:2011-06-16 00:00:00

  • Commensal Bacteroides species induce colitis in host-genotype-specific fashion in a mouse model of inflammatory bowel disease.

    abstract::The intestinal microbiota is important for induction of inflammatory bowel disease (IBD). IBD is associated with complex shifts in microbiota composition, but it is unclear whether specific bacterial subsets induce IBD and, if so, whether their proportions in the microbiota are altered during disease. Here, we fulfill...

    journal_title:Cell host & microbe

    pub_type: 杂志文章


    authors: Bloom SM,Bijanki VN,Nava GM,Sun L,Malvin NP,Donermeyer DL,Dunne WM Jr,Allen PM,Stappenbeck TS

    更新日期:2011-05-19 00:00:00

  • RIG-I goes beyond naked recognition.

    abstract::It is currently unclear at which point during viral replication that RNA genomes are first recognized as nonself by the immune system. In this issue of Cell Host & Microbe, Weber et al. show that incoming nucleocapsid-bound genomes are sufficient to bind and activate innate immune sensors. ...

    journal_title:Cell host & microbe

    pub_type: 评论,杂志文章


    authors: Bowzard JB,Ranjan P,Sambhara S

    更新日期:2013-03-13 00:00:00

  • Surviving as a Community: Antibiotic Tolerance and Persistence in Bacterial Biofilms.

    abstract::Biofilms are surface-associated bacterial communities that play both beneficial and harmful roles in nature, medicine, and industry. Tolerant and persister cells are thought to underlie biofilm-related bacterial recurrence in medical and industrial contexts. Here, we review recent progress aimed at understanding the m...

    journal_title:Cell host & microbe

    pub_type: 杂志文章,评审


    authors: Yan J,Bassler BL

    更新日期:2019-07-10 00:00:00

  • Pseudogenization of the Secreted Effector Gene sseI Confers Rapid Systemic Dissemination of S. Typhimurium ST313 within Migratory Dendritic Cells.

    abstract::Genome degradation correlates with host adaptation and systemic disease in Salmonella. Most lineages of the S. enterica subspecies Typhimurium cause gastroenteritis in humans; however, the recently emerged ST313 lineage II pathovar commonly causes systemic bacteremia in sub-Saharan Africa. ST313 lineage II displays ge...

    journal_title:Cell host & microbe

    pub_type: 杂志文章


    authors: Carden SE,Walker GT,Honeycutt J,Lugo K,Pham T,Jacobson A,Bouley D,Idoyaga J,Tsolis RM,Monack D

    更新日期:2017-02-08 00:00:00

  • Vpr overcomes macrophage-specific restriction of HIV-1 Env expression and virion production.

    abstract::The HIV-1 accessory protein Vpr enhances infection of primary macrophages through unknown mechanisms. Recent studies demonstrated that Vpr interactions with the cellular DCAF1-DDB1-CUL4 E3 ubiquitin ligase complex limit activation of innate immunity and interferon (IFN) induction. We describe a restriction mechanism t...

    journal_title:Cell host & microbe

    pub_type: 杂志文章


    authors: Mashiba M,Collins DR,Terry VH,Collins KL

    更新日期:2014-12-10 00:00:00

  • HIV Latency: Stochastic across Multiple Scales.

    abstract::Proviral latency is a major barrier to a cure for HIV. In this issue of Cell Host & Microbe, Hataye et al. (2019) show that reactivation of HIV latency is a non-deterministic, highly stochastic (i.e., noisy) process and propose that stochastic transitions to exponential viral expansion require a critical threshold of ...

    journal_title:Cell host & microbe

    pub_type: 评论,杂志文章


    authors: Hansen MMK,Martin B,Weinberger LS

    更新日期:2019-12-11 00:00:00

  • Transmission stages dominate trypanosome within-host dynamics during chronic infections.

    abstract::Sleeping sickness is characterized by waves of the extracellular parasite Trypanosoma brucei in host blood, with infections continuing for months or years until inevitable host death. These waves reflect the dynamic conflict between the outgrowth of a succession of parasite antigenic variants and their control by the ...

    journal_title:Cell host & microbe

    pub_type: 杂志文章


    authors: MacGregor P,Savill NJ,Hall D,Matthews KR

    更新日期:2011-04-21 00:00:00

  • Is the intestinal goblet cell a major immune cell?

    abstract::Recent reports indicate that both the inflammasome (Wlodarska et al., 2014) and autophagy (Patel et al., 2013) pathways in goblet cells control mucin secretion, defects in which are linked to difficulties in clearing pathogenic bacteria and maintaining intestinal homeostasis and control colitis. ...

    journal_title:Cell host & microbe

    pub_type: 评论,杂志文章


    authors: Johansson ME,Hansson GC

    更新日期:2014-03-12 00:00:00

  • ESCRT-I part II: forming the real ESCRT-I complex.

    abstract::Many enveloped viruses hijack the cellular ESCRT machinery to catalyze their escape from host cells. One paper in a recent issue of Cell by Kostelansky et al. and another in this issue of Cell Host & Microbe by Morita et al. shed new light on the structure and function of ESCRT-I. Both papers focus on a fourth ESCRT-I...

    journal_title:Cell host & microbe

    pub_type: 评论,杂志文章


    authors: Weissenhorn W,Göttlinger H

    更新日期:2007-07-12 00:00:00

  • Sociovirology: Conflict, Cooperation, and Communication among Viruses.

    abstract::Viruses are involved in various interactions both within and between infected cells. Social evolution theory offers a conceptual framework for how virus-virus interactions, ranging from conflict to cooperation, have evolved. A critical examination of these interactions could expand our understanding of viruses and be ...

    journal_title:Cell host & microbe

    pub_type: 杂志文章


    authors: Díaz-Muñoz SL,Sanjuán R,West S

    更新日期:2017-10-11 00:00:00

  • Original Antigenic Sin: Friend or Foe in Developing a Broadly Cross-Reactive Vaccine to Influenza?

    abstract::In this issue of Cell Host & Microbe, two articles (Lee et al., 2019; Henry et al., 2019) find the influenza-specific antibody repertoire in humans becomes static over time and with age, despite repeated exposures. Identified persistent dominant clones target conserved viral epitopes, supporting the feasibility of a u...

    journal_title:Cell host & microbe

    pub_type: 评论,杂志文章


    authors: Devarajan P,Swain SL

    更新日期:2019-03-13 00:00:00

  • Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection.

    abstract::Anti-helminth immunity involves CD4+ T cells, yet the precise effector mechanisms responsible for parasite killing or expulsion remain elusive. We now report an essential role for antibodies in mediating immunity against the enteric helminth Heligmosomoides polygyrus (Hp), a natural murine parasite that establishes ch...

    journal_title:Cell host & microbe

    pub_type: 杂志文章


    authors: McCoy KD,Stoel M,Stettler R,Merky P,Fink K,Senn BM,Schaer C,Massacand J,Odermatt B,Oettgen HC,Zinkernagel RM,Bos NA,Hengartner H,Macpherson AJ,Harris NL

    更新日期:2008-10-16 00:00:00

  • Host metabolism regulates intracellular growth of Trypanosoma cruzi.

    abstract::Metabolic coupling of intracellular pathogens with host cells is essential for successful colonization of the host. Establishment of intracellular infection by the protozoan Trypanosoma cruzi leads to the development of human Chagas' disease, yet the functional contributions of the host cell toward the infection proce...

    journal_title:Cell host & microbe

    pub_type: 杂志文章


    authors: Caradonna KL,Engel JC,Jacobi D,Lee CH,Burleigh BA

    更新日期:2013-01-16 00:00:00

  • Histone modifications and chromatin remodeling during bacterial infections.

    abstract::The link between bacteria and host chromatin remodeling is an emerging topic. The exciting recent discoveries on bacterial impact on host epigenetics, as discussed in this Review, highlight yet another strategy used by bacterial pathogens to interfere with key cellular processes. The study of how pathogens provoke hos...

    journal_title:Cell host & microbe

    pub_type: 杂志文章,评审


    authors: Hamon MA,Cossart P

    更新日期:2008-08-14 00:00:00

  • A lesson in survival: S. aureus versus the skin.

    abstract::Staphylococcus aureus epidemic strain USA300 is a highly successful pathogen. However, the underlying basis of this success is not clear. Now, Thurlow and colleagues (2013) provide evidence linking the bacterial arginine catabolic mobile element (ACME) to the dominance of USA300 as a pathogen of the skin. ...

    journal_title:Cell host & microbe

    pub_type: 评论,杂志文章


    authors: Alonzo F 3rd,Torres VJ

    更新日期:2013-01-16 00:00:00

  • Group A Streptococcal M1 Protein Sequesters Cathelicidin to Evade Innate Immune Killing.

    abstract::The antimicrobial peptide LL-37 is generated upon proteolytic cleavage of cathelicidin and limits invading pathogens by directly targeting microbial membranes as well as stimulating innate immune cell function. However, some microbes evade LL-37-mediated defense. Notably, group A Streptococcus (GAS) strains belonging ...

    journal_title:Cell host & microbe

    pub_type: 杂志文章


    authors: LaRock CN,Döhrmann S,Todd J,Corriden R,Olson J,Johannssen T,Lepenies B,Gallo RL,Ghosh P,Nizet V

    更新日期:2015-10-14 00:00:00

  • A critical role for SOCS3 in innate resistance to Toxoplasma gondii.

    abstract::The innate and adaptive immune responses that confer resistance to the intracellular pathogen Toxoplasma gondii critically depend on IL-12 production, which drives interferon-γ (IFN-γ) expression. Certain cytokines can activate STAT3 and limit IL-12 production to prevent infection-associated immune pathology, but T. g...

    journal_title:Cell host & microbe

    pub_type: 杂志文章


    authors: Whitmarsh RJ,Gray CM,Gregg B,Christian DA,May MJ,Murray PJ,Hunter CA

    更新日期:2011-09-15 00:00:00

  • Plasmodium protein export at higher PEXEL resolution.

    abstract::Intraerythrocytic malaria parasites send hundreds of effector proteins into the host cell. Diverse modes of export have been proposed for different proteins. In this issue, Grüring et al. (2012) present findings that bring the models together. ...

    journal_title:Cell host & microbe

    pub_type: 评论,杂志文章


    authors: Goldberg DE

    更新日期:2012-11-15 00:00:00

  • Virus budding and the ESCRT pathway.

    abstract::Enveloped viruses escape infected cells by budding through limiting membranes. In the decade since the discovery that HIV recruits cellular ESCRT (endosomal sorting complexes required for transport) machinery to facilitate viral budding, this pathway has emerged as the major escape route for enveloped viruses. In cell...

    journal_title:Cell host & microbe

    pub_type: 杂志文章,评审


    authors: Votteler J,Sundquist WI

    更新日期:2013-09-11 00:00:00

  • The enteropathogenic E. coli effector EspB facilitates microvillus effacing and antiphagocytosis by inhibiting myosin function.

    abstract::Enteropathogenic Escherichia coli (EPEC) destroys intestinal microvilli and suppresses phagocytosis by injecting effectors into infected cells through a type III secretion system (TTSS). EspB, a component of the TTSS, is also injected into the cytoplasm of host cells. However, the physiological functions of EspB withi...

    journal_title:Cell host & microbe

    pub_type: 杂志文章


    authors: Iizumi Y,Sagara H,Kabe Y,Azuma M,Kume K,Ogawa M,Nagai T,Gillespie PG,Sasakawa C,Handa H

    更新日期:2007-12-13 00:00:00

  • Bacteroides in the infant gut consume milk oligosaccharides via mucus-utilization pathways.

    abstract::Newborns are colonized with an intestinal microbiota shortly after birth, but the factors governing the retention and abundance of specific microbial lineages are unknown. Nursing infants consume human milk oligosaccharides (HMOs) that pass undigested to the distal gut, where they may be digested by microbes. We deter...

    journal_title:Cell host & microbe

    pub_type: 杂志文章


    authors: Marcobal A,Barboza M,Sonnenburg ED,Pudlo N,Martens EC,Desai P,Lebrilla CB,Weimer BC,Mills DA,German JB,Sonnenburg JL

    更新日期:2011-11-17 00:00:00

  • KREMEN1 Is a Host Entry Receptor for a Major Group of Enteroviruses.

    abstract::Human type A Enteroviruses (EV-As) cause diseases ranging from hand-foot-and-mouth disease to poliomyelitis-like disease. Although cellular receptors are identified for some EV-As, they remain elusive for the majority of EV-As. We identify the cell surface molecule KREMEN1 as an entry receptor for coxsackievirus A10 (...

    journal_title:Cell host & microbe

    pub_type: 杂志文章


    authors: Staring J,van den Hengel LG,Raaben M,Blomen VA,Carette JE,Brummelkamp TR

    更新日期:2018-05-09 00:00:00

  • Keeping viruses in Chk: DNA damage signaling puts the brakes on transformation.

    abstract::Oncogenic viruses infect many cells but rarely lead to tumorigenesis. In this issue of Cell Host & Microbe, Nikitin et al. describe how a protective DNA damage response acts to suppress transformation in the majority of cells latently infected with Epstein-Barr virus (EBV). ...

    journal_title:Cell host & microbe

    pub_type: 评论,杂志文章


    authors: Lilley CE,Weitzman MD

    更新日期:2010-12-16 00:00:00

  • Hypomorphic mutation in the site-1 protease Mbtps1 endows resistance to persistent viral infection in a cell-specific manner.

    abstract::The prototypic arenavirus lymphocytic choriomeningitis virus (LCMV), which naturally persists in rodents, represents a model for HIV, HBV, and HCV. Cleavage of the viral glycoprotein precursor by membrane-bound transcription factor peptidase, site 1 (Mbtps1 or site-1 protease), is crucial for the life cycle of arenavi...

    journal_title:Cell host & microbe

    pub_type: 杂志文章


    authors: Popkin DL,Teijaro JR,Sullivan BM,Urata S,Rutschmann S,de la Torre JC,Kunz S,Beutler B,Oldstone M

    更新日期:2011-03-17 00:00:00

  • Nutritional Support from the Intestinal Microbiota Improves Hematopoietic Reconstitution after Bone Marrow Transplantation in Mice.

    abstract::Bone marrow transplantation (BMT) offers curative potential for patients with high-risk hematologic malignancies, but the post-transplantation period is characterized by profound immunodeficiency. Recent studies indicate that the intestinal microbiota not only regulates mucosal immunity, but can also contribute to sys...

    journal_title:Cell host & microbe

    pub_type: 杂志文章


    authors: Staffas A,Burgos da Silva M,Slingerland AE,Lazrak A,Bare CJ,Holman CD,Docampo MD,Shono Y,Durham B,Pickard AJ,Cross JR,Stein-Thoeringer C,Velardi E,Tsai JJ,Jahn L,Jay H,Lieberman S,Smith OM,Pamer EG,Peled JU,Cohen

    更新日期:2018-04-11 00:00:00

  • Understanding how hepatitis C virus builds its unctuous home.

    abstract::Hepatitis C virus genome replication occurs in endoplasmic reticulum-derived membrane compartments, but it is unknown how these structures arise. In this issue of Cell Host & Microbe, Reiss and colleagues (2011) show that the virus recruits a specific lipid kinase to replication sites, stimulates its kinase activity, ...

    journal_title:Cell host & microbe

    pub_type: 评论,杂志文章


    authors: Lindenbach BD

    更新日期:2011-01-20 00:00:00

  • Intestinal Bile Acids Induce a Morphotype Switch in Vancomycin-Resistant Enterococcus that Facilitates Intestinal Colonization.

    abstract::Vancomycin-resistant Enterococcus (VRE) are highly antibiotic-resistant and readily transmissible pathogens that cause severe infections in hospitalized patients. We discovered that lithocholic acid (LCA), a secondary bile acid prevalent in the cecum and colon of mice and humans, impairs separation of growing VRE dipl...

    journal_title:Cell host & microbe

    pub_type: 杂志文章


    authors: McKenney PT,Yan J,Vaubourgeix J,Becattini S,Lampen N,Motzer A,Larson PJ,Dannaoui D,Fujisawa S,Xavier JB,Pamer EG

    更新日期:2019-05-08 00:00:00

  • Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling.

    abstract::The ongoing epidemic of Zika virus (ZIKV) illustrates the importance of flaviviruses as emerging human pathogens. All vector-borne flaviviruses studied thus far have to overcome type I interferon (IFN) to replicate and cause disease in vertebrates. The mechanism(s) by which ZIKV antagonizes IFN signaling is unknown. H...

    journal_title:Cell host & microbe

    pub_type: 杂志文章


    authors: Grant A,Ponia SS,Tripathi S,Balasubramaniam V,Miorin L,Sourisseau M,Schwarz MC,Sánchez-Seco MP,Evans MJ,Best SM,García-Sastre A

    更新日期:2016-06-08 00:00:00