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Early-Life Formation of the Microbial and Immunological Environment of the Human Airways.

Abstract：

:Crosstalk between immune cells and the microbiota in mucosal tissues can set an individual on a trajectory toward health or disease. Little is known about these early-life events in the human respiratory tract. We examined bacterial colonization and immune system maturation in the lower airways over the first year of life. The lower respiratory tract microbiota forms within the first 2 postnatal months. Within the first weeks, three microbial profiles are evident, broadly distinguished as dysbiotic or diverse, and representing different microbial virulence potentials, including proteolysis of immunoglobulin A (IgA) that is critical for mucosal defense. Delivery mode determines microbiota constituents in preterm, but not term, births. Gestational age is a key determinant of immune maturation, with airway cells progressively increasing expression of proallergic cytokine interleukin-33 and genes linked with IgA. These data reveal microbial and immunological development in human airways, and may inform early-life interventions to prevent respiratory diseases.

journal_name

Cell Host Microbe

journal_title

Cell host & microbe

authors

Pattaroni C,Watzenboeck ML,Schneidegger S,Kieser S,Wong NC,Bernasconi E,Pernot J,Mercier L,Knapp S,Nicod LP,Marsland CP,Roth-Kleiner M,Marsland BJ

doi

10.1016/j.chom.2018.10.019

subject

Has Abstract

pub_date

2018-12-12 00:00:00

pages

857-865.e4

issue

6

eissn

1931-3128

issn

1934-6069

pii

S1931-3128(18)30557-2

journal_volume

24

pub_type

杂志文章

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