Abstract:
:Innate immune responses are characterized by precise gene expression whereby gene subsets are temporally induced to limit infection, although the mechanisms involved are incompletely understood. We show that antiviral immunity in Drosophila requires the transcriptional pausing pathway, including negative elongation factor (NELF) that pauses RNA polymerase II (Pol II) and positive elongation factor b (P-TEFb), which releases paused Pol II to produce full-length transcripts. We identify a set of genes that is rapidly transcribed upon arbovirus infection, including components of antiviral pathways (RNA silencing, autophagy, JAK/STAT, Toll, and Imd) and various Toll receptors. Many of these genes require P-TEFb for expression and exhibit pausing-associated chromatin features. Furthermore, transcriptional pausing is critical for antiviral immunity in insects because NELF and P-TEFb are required to restrict viral replication in adult flies and vector mosquito cells. Thus, transcriptional pausing primes virally induced genes to facilitate rapid gene induction and robust antiviral responses.
journal_name
Cell Host Microbejournal_title
Cell host & microbeauthors
Xu J,Grant G,Sabin LR,Gordesky-Gold B,Yasunaga A,Tudor M,Cherry Sdoi
10.1016/j.chom.2012.08.011subject
Has Abstractpub_date
2012-10-18 00:00:00pages
531-43issue
4eissn
1931-3128issn
1934-6069pii
S1931-3128(12)00306-Xjournal_volume
12pub_type
杂志文章abstract::Vibrio parahaemolyticus, a Gram-negative halophilic bacterium that causes acute gastroenteritis in humans, is characterized by two type III secretion systems (T3SS), namely T3SS1 and T3SS2. T3SS2 is indispensable for enterotoxicity but the effector(s) involved are unknown. Here, we identify VopV as a critical effector...
journal_title:Cell host & microbe
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journal_title:Cell host & microbe
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journal_title:Cell host & microbe
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journal_title:Cell host & microbe
pub_type: 评论,杂志文章
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journal_title:Cell host & microbe
pub_type: 评论,杂志文章
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journal_title:Cell host & microbe
pub_type: 评论,杂志文章
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journal_title:Cell host & microbe
pub_type: 杂志文章
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journal_title:Cell host & microbe
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journal_title:Cell host & microbe
pub_type: 杂志文章
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journal_title:Cell host & microbe
pub_type: 杂志文章,评审
doi:10.1016/j.chom.2008.01.004
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journal_title:Cell host & microbe
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journal_title:Cell host & microbe
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journal_title:Cell host & microbe
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journal_title:Cell host & microbe
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journal_title:Cell host & microbe
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journal_title:Cell host & microbe
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