Abstract:
:Poxviruses are large DNA viruses that include the causal agent of human smallpox and vaccinia virus. Poxviruses replicate in cytoplasmic foci known as DNA factories. Here we show that a virus-encoded transcription factor, viral mRNA, cellular RNA-binding protein heterodimer G3BP/Caprin-1 (p137), translation initiation factors eIF4E and eIF4G, and ribosomal proteins are concentrated in the same subdomains of cytoplasmic DNA factories. Furthermore, a cell coinfected with two recombinant vaccinia viruses expressing a virus core protein fused to cyan or yellow fluorescent protein displayed separate cyan and yellow factories, indicating that each factory formed from a single genome and was the site of transcription and translation as well as DNA replication. Hijacking of the host translation apparatus within the factory likely enhances the efficiency of virus replication and contributes to the suppression of host protein synthesis, thereby facilitating poxvirus subjugation of the cell.
journal_name
Cell Host Microbejournal_title
Cell host & microbeauthors
Katsafanas GC,Moss Bdoi
10.1016/j.chom.2007.08.005subject
Has Abstractpub_date
2007-10-11 00:00:00pages
221-8issue
4eissn
1931-3128issn
1934-6069pii
S1931-3128(07)00215-6journal_volume
2pub_type
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