Abstract:
:Many enveloped viruses hijack the cellular ESCRT machinery to catalyze their escape from host cells. One paper in a recent issue of Cell by Kostelansky et al. and another in this issue of Cell Host & Microbe by Morita et al. shed new light on the structure and function of ESCRT-I. Both papers focus on a fourth ESCRT-I component that shapes ESCRT-I into an elongated structure and affects HIV-1 morphogenesis.
journal_name
Cell Host Microbejournal_title
Cell host & microbeauthors
Weissenhorn W,Göttlinger Hdoi
10.1016/j.chom.2007.06.006subject
Has Abstractpub_date
2007-07-12 00:00:00pages
1-2issue
1eissn
1931-3128issn
1934-6069pii
S1931-3128(07)00132-1journal_volume
2pub_type
评论,杂志文章abstract::The difficulty in detecting rare infected cells immediately after mucosal HIV transmission has hindered our understanding of the initial cells targeted by the virus. Working with the macaque simian immunodeficiency virus (SIV) vaginal challenge model, we developed methodology to identify discrete foci of SIV (mac239) ...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2016.03.005
更新日期:2016-04-13 00:00:00
abstract::Type I interferons (IFNs-I) fulfil multiple protective functions during pathogenic infections, but they can also cause detrimental effects and enhance immunopathology. Here, we report that IFNs-I promote the dysregulation of iron homeostasis in macrophages during systemic infections with the intracellular pathogen Can...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2020.01.023
更新日期:2020-03-11 00:00:00
abstract::Regulatory T cells (Tregs) are required to establish immune tolerance to commensal microbes. Tregs accumulate abruptly in the skin during a defined window of postnatal tissue development. However, the mechanisms mediating Treg migration to neonatal skin are unknown. Here we show that hair follicle (HF) development fac...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2017.03.001
更新日期:2017-04-12 00:00:00
abstract::Toxoplasma gondii, the causative agent of toxoplasmosis, is an intracellular parasite that demonstrates a remarkable ability to adapt to nutrient availability. In this issue of Cell Host & Microbe, Blume et al. (2015) describe the unique role of a gluconeogenic enzyme in regulation of glucose catabolism in T. gondii. ...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2015.07.012
更新日期:2015-08-12 00:00:00
abstract::Complement, a complex system of serum proteins, contributes to host defense through multiple mechanisms. In this issue of Cell Host & Microbe, Sorbara et al. (2018) discovered that cytosolic pathogens opsonized by complement are restricted by autophagy. This unexpected role for complement is important for cell-autonom...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2018.04.010
更新日期:2018-05-09 00:00:00
abstract::Defensins are naturally occurring antimicrobial peptides that disrupt bacterial membranes and prevent bacterial invasion of the host. Emerging studies indicate that certain defensins also block virus infection; however, the mechanism(s) involved are poorly understood. We demonstrate that human alpha-defensins inhibit ...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2007.12.001
更新日期:2008-01-17 00:00:00
abstract::Pioneering plant research has shown that many Nod-like receptors (NLRs) detect pathogens indirectly via recognizing modifications of other host proteins. In this issue, two groups show that the RPM1 NLR is activated by phosphorylation of the host protein RIN4, probably resulting from activation of a host kinase by pat...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2011.02.002
更新日期:2011-02-17 00:00:00
abstract::In this issue of Cell Host & Microbe, Jia et al. used a vesicular stomatitis virus-based probe to isolate B cells expressing broadly neutralizing HIV-1 antibodies. Besides identifying neutralizing epitopes, this study highlights potential protection afforded by IgA arising from either direct IgM-to-IgA or sequential I...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2020.05.017
更新日期:2020-06-10 00:00:00
abstract::The human microbiome encodes extensive metabolic capabilities, but our understanding of the mechanisms linking gut microbes to human metabolism remains limited. Here, we focus on the conversion of cholesterol to the poorly absorbed sterol coprostanol by the gut microbiota to develop a framework for the identification ...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2020.05.013
更新日期:2020-08-12 00:00:00
abstract::Genome degradation correlates with host adaptation and systemic disease in Salmonella. Most lineages of the S. enterica subspecies Typhimurium cause gastroenteritis in humans; however, the recently emerged ST313 lineage II pathovar commonly causes systemic bacteremia in sub-Saharan Africa. ST313 lineage II displays ge...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2017.01.009
更新日期:2017-02-08 00:00:00
abstract::Recent studies have revealed remarkable species specificity of the Toll-like receptors (TLRs) TLR11 and TLR12 and the immunity-related GTPase (IRG) proteins that are essential elements for detection and immune control of Toxoplasma gondii in mice, but not in humans. The biological and evolutionary implications of thes...
journal_title:Cell host & microbe
pub_type: 杂志文章,评审
doi:10.1016/j.chom.2014.01.004
更新日期:2014-02-12 00:00:00
abstract::iNKT cells are innate T lymphocytes recognizing endogenous and foreign lipid antigens presented in the MHC-like molecule CD1d. The semi-invariant iNKT cell TCR can detect certain bacterial and parasitic lipids and drive iNKT cell responses. How iNKT cells respond to fungi, however, is unknown. We found that CD1d-defic...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2011.09.011
更新日期:2011-11-17 00:00:00
abstract::Human noroviruses are a major cause of epidemic and sporadic gastroenteritis worldwide and can chronically infect immunocompromised patients. Efforts to develop effective vaccines and antivirals have been hindered by the uncultivable nature and extreme genetic diversity of human noroviruses. Although they remain a par...
journal_title:Cell host & microbe
pub_type: 杂志文章,评审
doi:10.1016/j.chom.2014.05.015
更新日期:2014-06-11 00:00:00
abstract::Typhoidal and non-typhoidal Salmonelleae (NTS) cause typhoid fever and gastroenteritis, respectively, in humans. Salmonella typhoid toxin contributes to typhoid disease progression and chronic infection, but little is known about the role of its NTS ortholog. We found that typhoid toxin and its NTS ortholog induce dif...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2020.04.005
更新日期:2020-06-10 00:00:00
abstract::Eradication of pathogens from the bloodstream is critical to prevent disseminated infections and sepsis. Kupffer cells in the liver form an intravascular firewall that captures and clears pathogens from the blood. Here, we show that the catching and killing of circulating pathogens by Kupffer cells in vivo are promote...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2020.07.014
更新日期:2020-11-11 00:00:00
abstract::The ecological dynamics underlying the coexistence between antagonistic populations of bacteria and their viruses, bacteriophages (phages), in the mammalian gut microbiota remain poorly understood. We challenged a murine synthetic bacterial community with phages to study the factors allowing phages-bacteria coexistenc...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2020.06.002
更新日期:2020-09-09 00:00:00
abstract::Intracellular pathogens manipulate host organelles to support replication within cells. For Legionella pneumophila, the bacterium translocates proteins that establish an endoplasmic reticulum (ER)-associated replication compartment. We show here that the bacterial Sde proteins target host reticulon 4 (Rtn4) to control...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2016.12.007
更新日期:2017-02-08 00:00:00
abstract::Eukaryotic small RNAs (sRNAs) are short non-coding regulatory molecules that induce RNA interference (RNAi). During microbial infection, host RNAi machinery is highly regulated and contributes to reprogramming gene expression and balancing plant immunity and growth. While most sRNAs function endogenously, some can tra...
journal_title:Cell host & microbe
pub_type: 杂志文章,评审
doi:10.1016/j.chom.2019.07.021
更新日期:2019-08-14 00:00:00
abstract::Influenza viruses of animals can cross species and infect humans. In this issue of Cell Host & Microbe, Zhang et al. (2015) and Tzarum et al. (2015) describe crystal structures and receptor-binding properties of hemagglutinins of avian-origin H10N8 and H6N1 influenza viruses. Human infections with these viruses are no...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2015.02.020
更新日期:2015-03-11 00:00:00
abstract::Newborns are colonized with an intestinal microbiota shortly after birth, but the factors governing the retention and abundance of specific microbial lineages are unknown. Nursing infants consume human milk oligosaccharides (HMOs) that pass undigested to the distal gut, where they may be digested by microbes. We deter...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2011.10.007
更新日期:2011-11-17 00:00:00
abstract::Probiotics are living microorganisms that are increasingly used as gastrointestinal therapeutics by virtue of their innate or engineered genetic function. Unlike abiotic therapeutics, probiotics can replicate in their intended site, subjecting their genomes and therapeutic properties to natural selection. We exposed t...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2019.02.005
更新日期:2019-04-10 00:00:00
abstract::The Salmonella enterica effector SteD depletes mature MHC class II (mMHCII) molecules from the surface of infected antigen-presenting cells through ubiquitination of the cytoplasmic tail of the mMHCII β chain. Here, through a genome-wide mutant screen of human antigen-presenting cells, we show that the NEDD4 family HE...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2020.04.024
更新日期:2020-07-08 00:00:00
abstract::In addition to classically defined immune mechanisms, cell-intrinsic processes can restrict virus infection and have shaped virus evolution. The details of this virus-host interaction are still emerging. Following a genome-wide siRNA screen for host factors affecting replication of Semliki Forest virus (SFV), a positi...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2014.08.007
更新日期:2014-09-10 00:00:00
abstract::Cytosolic bacterial pathogens activate the cytosolic surveillance pathway (CSP) and induce innate immune responses, but how the host detects vacuolar pathogens like Mycobacterium tuberculosis is poorly understood. We show that M. tuberculosis also initiates the CSP upon macrophage infection via limited perforation of ...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2012.03.007
更新日期:2012-05-17 00:00:00
abstract::Autophagy is genetically associated with inflammatory bowel disease (IBD); however, its role remains unclear in disease pathogenesis. Three recent studies reveal a novel cytoprotective role of autophagy during viral, bacterial, and protozoan-triggered IBD (Burger et al., 2018; Matsuzawa-Ishimoto et al., 2017; Pott et ...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2018.01.015
更新日期:2018-02-14 00:00:00
abstract::RIG-I detects double-stranded RNA (dsRNA) to trigger antiviral cytokine production. Protein deamidation is emerging as a post-translational modification that chiefly regulates protein function. We report here that UL37 of herpes simplex virus 1 (HSV-1) is a protein deamidase that targets RIG-I to block RNA-induced act...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2016.10.011
更新日期:2016-12-14 00:00:00
abstract::The antimicrobial peptide LL-37 is generated upon proteolytic cleavage of cathelicidin and limits invading pathogens by directly targeting microbial membranes as well as stimulating innate immune cell function. However, some microbes evade LL-37-mediated defense. Notably, group A Streptococcus (GAS) strains belonging ...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2015.09.004
更新日期:2015-10-14 00:00:00
abstract::Competition for nutrients is a key factor controlling pathogen colonization within the gastrointestinal tract. In this issue, Ferreyra et al. (2014) and Curtis et al. (2014) show that diverse enteric pathogens can exploit a metabolic byproduct from the commensal microbiota, succinate, to enhance their own virulence ex...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2014.11.012
更新日期:2014-12-10 00:00:00
abstract::Surface-associated TRAP (thrombospondin-related anonymous protein) family proteins are conserved across the phylum of apicomplexan parasites. TRAP proteins are thought to play an integral role in parasite motility and cell invasion by linking the extracellular environment with the parasite submembrane actomyosin motor...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2016.10.015
更新日期:2016-11-09 00:00:00
abstract::Recent epidemics of Zika virus (ZIKV) have brought increasing concerns of heightened disease severity and neurotropism. In this issue of Cell Host & Microbe, Lazear et al. (2016) and Bayer et al. (2016) show that innate immunity can restrict ZIKV infection and disease development. ...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2016.04.019
更新日期:2016-05-11 00:00:00