Abstract:
:The presence of bacteria within epithelial-lined compartments, such as the lung, elicits rapid recruitment of innate immune cells. In this issue of Cell Host & Microbe, Chun and Prince (2009) report that epithelial cells facilitate this process by reorganizing their intercellular junctions to enhance immune cell transmigration.
journal_name
Cell Host Microbejournal_title
Cell host & microbeauthors
Nalle SC,Turner JRdoi
10.1016/j.chom.2008.12.008subject
Has Abstractpub_date
2009-01-22 00:00:00pages
1-2issue
1eissn
1931-3128issn
1934-6069pii
S1931-3128(08)00408-3journal_volume
5pub_type
评论,杂志文章abstract::The complex microbial community residing within the intestine plays important roles in host defense. However, the impact of enteric infection and inflammation on this resident community has not been fully explored. In this issue of Cell Host & Microbe, Lupp and coworkers reveal that the composition of the intestinal m...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2007.07.006
更新日期:2007-08-16 00:00:00
abstract::Surface-associated TRAP (thrombospondin-related anonymous protein) family proteins are conserved across the phylum of apicomplexan parasites. TRAP proteins are thought to play an integral role in parasite motility and cell invasion by linking the extracellular environment with the parasite submembrane actomyosin motor...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2016.10.015
更新日期:2016-11-09 00:00:00
abstract::Eukaryotic small RNAs (sRNAs) are short non-coding regulatory molecules that induce RNA interference (RNAi). During microbial infection, host RNAi machinery is highly regulated and contributes to reprogramming gene expression and balancing plant immunity and growth. While most sRNAs function endogenously, some can tra...
journal_title:Cell host & microbe
pub_type: 杂志文章,评审
doi:10.1016/j.chom.2019.07.021
更新日期:2019-08-14 00:00:00
abstract::Hepatitis C virus (HCV) is a single-stranded RNA virus encoding a single polyprotein whose translation is driven by an internal ribosome entry site (IRES). HCV infection strongly induces antiviral interferon-stimulated gene (ISG) expression in the liver, yet it persists, suggesting that HCV can block ISG effector func...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2009.11.004
更新日期:2009-12-17 00:00:00
abstract::The emergence of circulating vaccine-derived polioviruses through evolution of the oral polio vaccine (OPV) poses a significant obstacle to polio eradication. Understanding the early genetic changes that occur as OPV evolves and transmits is important for preventing future outbreaks. Here, we use deep sequencing to de...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2020.10.011
更新日期:2021-01-13 00:00:00
abstract::The type 2 immune response evoked by intestinal nematode parasites contributes to worm expulsion and tolerance to associated tissue damage. We investigated whether this host response is affected by blocking signaling by the putative endogenous danger signal adenosine, which can be released during inflammation and host...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2014.02.001
更新日期:2014-03-12 00:00:00
abstract::Gut-dwelling Prevotella copri (P. copri), the most prevalent Prevotella species in the human gut, have been associated with diet and disease. However, our understanding of their diversity and function remains rudimentary because studies have been limited to 16S and metagenomic surveys and experiments using a single ty...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2019.10.013
更新日期:2019-11-13 00:00:00
abstract::Local infection in the Drosophila larval intestine elicits a systemic immune reaction in fat bodies. In this issue, Wu and colleagues (2012) show that this is a reactive oxygen species-dependent communication. ...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2012.04.003
更新日期:2012-04-19 00:00:00
abstract::The liver-specific microRNA, miR-122, stabilizes hepatitis C virus (HCV) RNA genomes by recruiting host argonaute 2 (AGO2) to the 5' end and preventing decay mediated by exonuclease Xrn1. However, HCV replication requires miR-122 in Xrn1-depleted cells, indicating additional functions. We show that miR-122 enhances HC...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2014.12.014
更新日期:2015-02-11 00:00:00
abstract::Horizontal gene transfer (HGT) facilitates spead of antibiotic resistance elements. In this issue of Cell Host & Microbe, Domenech et al. discover that compounds disrupting proton motive force block natural competence (COM) and interrupt intraspecies HGT and exchange of antibiotic resistance. Such strategies might min...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2020.03.013
更新日期:2020-04-08 00:00:00
abstract::Transition metals such as iron, zinc, copper, and manganese are essential for the growth and development of organisms ranging from bacteria to mammals. Numerous studies have focused on the impact of iron availability during bacterial and fungal infections, and increasing evidence suggests that copper is also involved ...
journal_title:Cell host & microbe
pub_type: 杂志文章,评审
doi:10.1016/j.chom.2012.01.009
更新日期:2012-02-16 00:00:00
abstract::The intestinal immune system has to strike a delicate balance between initiating inflammatory responses against invading bacterial pathogens and avoiding their induction against microbiota colonizing the lumen. Adequate inflammatory responses against bacterial invasion result in the lumenal secretion of antimicrobial ...
journal_title:Cell host & microbe
pub_type: 杂志文章,评审
doi:10.1016/j.chom.2010.06.003
更新日期:2010-07-22 00:00:00
abstract::Vaccines are needed to combat the global rise in fungal diseases. In this issue of Cell Host & Microbe, Wüthrich et al. (2015) identify calnexin as a target of antigen-specific CD4 T cell responses against multiple fungal pathogens. This study illustrates that a conserved epitope triggers convergent cell-mediated immu...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2015.03.012
更新日期:2015-04-08 00:00:00
abstract::The Nef protein of HIV-1 mediates immune evasion by relocating major histocompatibility complex (MHC) molecules and the immune costimulatory molecules CD80 and CD86 away from the monocytic cell surface. We describe a two-pronged mechanism by which Nef removes CD80 and CD86 from the cell surface. While MHCI, CD80, and ...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2007.01.001
更新日期:2007-03-15 00:00:00
abstract::The role of gut microbes in health and disease has often been surmised from stool, which is easily sampled and rich in microbial diversity, density, and abundance. Microbial analyses of stool have been accepted as measures to determine the relationship of gut microbiomes with host health and disease, based on the beli...
journal_title:Cell host & microbe
pub_type: 杂志文章,评审
doi:10.1016/j.chom.2019.08.011
更新日期:2019-09-11 00:00:00
abstract::Dietary supplementation with fermentable fiber suppresses adiposity and the associated parameters of metabolic syndrome. Microbiota-generated fiber-derived short-chain fatty acids (SCFAs) and free fatty acid receptors including GPR43 are thought to mediate these effects. We find that while fermentable (inulin), but no...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2017.11.003
更新日期:2018-01-10 00:00:00
abstract::Microtubules play an important role in the transport of viral pathogens during the establishment of their infection cycles. The microtubule cytoskeleton also facilitates efficient release of newly assembled progeny at later stages of infection. However, the precise effects of viral infection on microtubule dynamics ar...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2007.04.007
更新日期:2007-05-17 00:00:00
abstract::Biotrophic plant pathogens encounter a postinfection basal resistance layer controlled by the lipase-like protein enhanced disease susceptibility 1 (EDS1) and its sequence-related interaction partners, senescence-associated gene 101 (SAG101) and phytoalexin deficient 4 (PAD4). Maintainance of separate EDS1 family memb...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2013.11.006
更新日期:2013-12-11 00:00:00
abstract::Although anthrax toxin was identified as a major Bacillus anthracis virulence factor over 50 years ago, defining the physiologically relevant targets has been challenging. Liu et al. demonstrate that intoxication of myeloid-derived cells contributes to establishing infection but is not required for mortality resulting...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2010.10.011
更新日期:2010-11-18 00:00:00
abstract::Although Drosophila systemic immunity is extensively studied, little is known about the fly's intestine-specific responses to bacterial infection. Global gene expression analysis of Drosophila intestinal tissue to oral infection with the Gram-negative bacterium Erwinia carotovora revealed that immune responses in the ...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2009.01.003
更新日期:2009-02-19 00:00:00
abstract::The role of gut bacteria in complications of heart inflammation has previously not been fully understood. Gil-Cruz et al. (2019) demonstrate a commensal Bacteroides species that triggers a cross-immune response against a bacterial protein and heart epitope, causing cardiomyopathy. This study links commensal bacteria w...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2019.12.011
更新日期:2020-01-08 00:00:00
abstract::The clinically silent Plasmodium liver stage is an obligatory step in the establishment of malaria infection and disease. We report here that expression of heme oxygenase-1 (HO-1, encoded by Hmox1) is upregulated in the liver following infection by Plasmodium berghei and Plasmodium yoelii sporozoites. HO-1 overexpress...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2008.04.003
更新日期:2008-05-15 00:00:00
abstract::Microbial patterns are recognized by cell-surface receptors to initiate pattern-triggered immunity (PTI) in plants. Receptor-like cytoplasmic kinases (RLCKs), such as BIK1, and calcium-dependent protein kinases (CPKs) are engaged during PTI to activate the NADPH oxidase RBOHD for reactive oxygen species (ROS) producti...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2018.08.007
更新日期:2018-09-12 00:00:00
abstract::Persistent viral infections are the result of a series of connected events that culminate in diminished immunity and the inability to eliminate infection. By building our understanding of how distinct components of the immune system function both individually and collectively in productive versus abortive responses, n...
journal_title:Cell host & microbe
pub_type: 杂志文章,评审
doi:10.1016/j.chom.2013.05.014
更新日期:2013-06-12 00:00:00
abstract::Dietary factors, microbial composition, and metabolism are intimately intertwined into a complex network whose activities influence important intestinal functions. In a recent issue of Cell, Belcheva et al. (2014) show that microbial-derived butyrate promotes proliferation of cancer-initiated intestinal epithelial cel...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2014.07.011
更新日期:2014-08-13 00:00:00
abstract::Cell migration and invasion require the coordinated regulation of cytoskeletal architectural changes by signaling factors, including the actin-binding protein cortactin. Bacterial and viral pathogens subvert these signaling factors to promote their uptake, spread and dissemination. We show that the gastric pathogen He...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2011.05.007
更新日期:2011-06-16 00:00:00
abstract::Studying the microbial composition of internal organs and their associations with disease remains challenging due to the difficulty of acquiring clinical biopsies. We designed a statistical model to analyze the prevalence of species across sample types from The Cancer Genome Atlas (TCGA), revealing that species equipr...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2020.12.001
更新日期:2020-12-21 00:00:00
abstract::In 2014, an outbreak of avian A/H10N7 influenza virus occurred among seals along North-European coastal waters, significantly impacting seal populations. Here, we examine the cross-species transmission and mammalian adaptation of this influenza A virus, revealing changes in the hemagglutinin surface protein that incre...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2020.08.011
更新日期:2020-10-07 00:00:00
abstract::Recent studies have revealed remarkable species specificity of the Toll-like receptors (TLRs) TLR11 and TLR12 and the immunity-related GTPase (IRG) proteins that are essential elements for detection and immune control of Toxoplasma gondii in mice, but not in humans. The biological and evolutionary implications of thes...
journal_title:Cell host & microbe
pub_type: 杂志文章,评审
doi:10.1016/j.chom.2014.01.004
更新日期:2014-02-12 00:00:00
abstract::Human T cell leukemia virus type 1 (HTLV-1) is the causative agent of adult T cell leukemia and HTLV-1-associated myelopathies. In addition to T cells, HTLV-1 infects cells of the myeloid lineage, which play critical roles in the host innate response to viral infection. Investigating the monocyte depletion observed du...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2013.09.009
更新日期:2013-10-16 00:00:00