Abstract：
:Vibrio parahaemolyticus, a Gram-negative halophilic bacterium that causes acute gastroenteritis in humans, is characterized by two type III secretion systems (T3SS), namely T3SS1 and T3SS2. T3SS2 is indispensable for enterotoxicity but the effector(s) involved are unknown. Here, we identify VopV as a critical effector that is required to mediate V. parahaemolyticus T3SS2-dependent enterotoxicity. VopV was found to possess multiple F-actin-binding domains and the enterotoxicity caused by VopV correlated with its F-actin-binding activity. Furthermore, a T3SS2-related secretion system and a vopV homologous gene were also involved in the enterotoxicity of a non-O1/non-O139 V. cholerae strain. These results indicate that the F-actin-targeting effector VopV is involved in enterotoxic activity of T3SS2-possessing bacterial pathogens.
journal_name
Cell Host Microbejournal_title
Cell host & microbeauthors
Hiyoshi H,Kodama T,Saito K,Gotoh K,Matsuda S,Akeda Y,Honda T,Iida Tdoi
10.1016/j.chom.2011.08.014subject
Has Abstractpub_date
2011-10-20 00:00:00pages
401-9issue
4eissn
1931-3128issn
1934-6069pii
S1931-3128(11)00286-1journal_volume
10pub_type
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