Abstract:
:Recent studies have revealed remarkable species specificity of the Toll-like receptors (TLRs) TLR11 and TLR12 and the immunity-related GTPase (IRG) proteins that are essential elements for detection and immune control of Toxoplasma gondii in mice, but not in humans. The biological and evolutionary implications of these findings for the T. gondii host-pathogen relationship and for human disease are discussed.
journal_name
Cell Host Microbejournal_title
Cell host & microbeauthors
Gazzinelli RT,Mendonça-Neto R,Lilue J,Howard J,Sher Adoi
10.1016/j.chom.2014.01.004subject
Has Abstractpub_date
2014-02-12 00:00:00pages
132-8issue
2eissn
1931-3128issn
1934-6069pii
S1931-3128(14)00027-4journal_volume
15pub_type
杂志文章,评审abstract::Successful viruses must overcome the body's immune defenses. In this issue of Cell Host & Microbe, Goffinet et al. (2009) provide evidence that the host protein CD317, the target of the HIV Vpu protein, is part of an ancient innate immune response directed against budding viruses. ...
journal_title:Cell host & microbe
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abstract::Evolution of antibody repertoire against the Ebola virus (EBOV) proteome was characterized in an acutely infected patient receiving supportive care alone to elucidate virus-host interactions over time. Differential kinetics are observed for IgM-IgG-IgA epitope diversity, antibody binding, and affinity maturation to EB...
journal_title:Cell host & microbe
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journal_title:Cell host & microbe
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abstract::Biofilms are surface-associated bacterial communities that play both beneficial and harmful roles in nature, medicine, and industry. Tolerant and persister cells are thought to underlie biofilm-related bacterial recurrence in medical and industrial contexts. Here, we review recent progress aimed at understanding the m...
journal_title:Cell host & microbe
pub_type: 杂志文章,评审
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abstract::Apicomplexa are unicellular eukaryotic pathogens that carry a vestigial algal endosymbiont, the apicoplast. The physiological function of the apicoplast and its integration into parasite metabolism remain poorly understood and at times controversial. We establish that the Toxoplasma apicoplast membrane-localized phosp...
journal_title:Cell host & microbe
pub_type: 杂志文章
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journal_title:Cell host & microbe
pub_type: 评论,杂志文章
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journal_title:Cell host & microbe
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journal_title:Cell host & microbe
pub_type: 杂志文章
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journal_title:Cell host & microbe
pub_type: 杂志文章
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journal_title:Cell host & microbe
pub_type: 评论,杂志文章
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journal_title:Cell host & microbe
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journal_title:Cell host & microbe
pub_type: 评论,杂志文章,评审
doi:10.1016/j.chom.2009.07.002
更新日期:2009-07-23 00:00:00
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journal_title:Cell host & microbe
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journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2020.11.002
更新日期:2021-01-13 00:00:00
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journal_title:Cell host & microbe
pub_type: 杂志文章,评审
doi:10.1016/j.chom.2009.05.010
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journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2020.06.004
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journal_title:Cell host & microbe
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journal_title:Cell host & microbe
pub_type: 杂志文章
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journal_title:Cell host & microbe
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journal_title:Cell host & microbe
pub_type: 杂志文章
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journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2014.02.001
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journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2014.07.003
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abstract::A vaginal microbicide should prevent pathogen transmission without disrupting tissue barriers to infection. Ideally, it would not need to be applied immediately before sexual intercourse, when compliance is a problem. Intravaginal administration of small interfering RNA (siRNA) lipoplexes targeting Herpes Simplex Viru...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2008.12.003
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journal_title:Cell host & microbe
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journal_title:Cell host & microbe
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journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2012.03.007
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journal_title:Cell host & microbe
pub_type: 杂志文章
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