Innate resistance against Toxoplasma gondii: an evolutionary tale of mice, cats, and men.

Abstract:

:Recent studies have revealed remarkable species specificity of the Toll-like receptors (TLRs) TLR11 and TLR12 and the immunity-related GTPase (IRG) proteins that are essential elements for detection and immune control of Toxoplasma gondii in mice, but not in humans. The biological and evolutionary implications of these findings for the T. gondii host-pathogen relationship and for human disease are discussed.

journal_name

Cell Host Microbe

journal_title

Cell host & microbe

authors

Gazzinelli RT,Mendonça-Neto R,Lilue J,Howard J,Sher A

doi

10.1016/j.chom.2014.01.004

subject

Has Abstract

pub_date

2014-02-12 00:00:00

pages

132-8

issue

2

eissn

1931-3128

issn

1934-6069

pii

S1931-3128(14)00027-4

journal_volume

15

pub_type

杂志文章,评审
  • This bud's for Vpu.

    abstract::Successful viruses must overcome the body's immune defenses. In this issue of Cell Host & Microbe, Goffinet et al. (2009) provide evidence that the host protein CD317, the target of the HIV Vpu protein, is part of an ancient innate immune response directed against budding viruses. ...

    journal_title:Cell host & microbe

    pub_type: 评论,杂志文章

    doi:10.1016/j.chom.2009.02.002

    authors: Collins KL

    更新日期:2009-03-19 00:00:00

  • Longitudinal Human Antibody Repertoire against Complete Viral Proteome from Ebola Virus Survivor Reveals Protective Sites for Vaccine Design.

    abstract::Evolution of antibody repertoire against the Ebola virus (EBOV) proteome was characterized in an acutely infected patient receiving supportive care alone to elucidate virus-host interactions over time. Differential kinetics are observed for IgM-IgG-IgA epitope diversity, antibody binding, and affinity maturation to EB...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2020.01.001

    authors: Khurana S,Ravichandran S,Hahn M,Coyle EM,Stonier SW,Zak SE,Kindrachuk J,Davey RT Jr,Dye JM,Chertow DS

    更新日期:2020-02-12 00:00:00

  • Virus budding and the ESCRT pathway.

    abstract::Enveloped viruses escape infected cells by budding through limiting membranes. In the decade since the discovery that HIV recruits cellular ESCRT (endosomal sorting complexes required for transport) machinery to facilitate viral budding, this pathway has emerged as the major escape route for enveloped viruses. In cell...

    journal_title:Cell host & microbe

    pub_type: 杂志文章,评审

    doi:10.1016/j.chom.2013.08.012

    authors: Votteler J,Sundquist WI

    更新日期:2013-09-11 00:00:00

  • Diversity of Functionally Permissive Sequences in the Receptor-Binding Site of Influenza Hemagglutinin.

    abstract::Influenza A virus hemagglutinin (HA) initiates viral entry by engaging host receptor sialylated glycans via its receptor-binding site (RBS). The amino acid sequence of the RBS naturally varies across avian and human influenza virus subtypes and is also evolvable. However, functional sequence diversity in the RBS has n...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2017.05.011

    authors: Wu NC,Xie J,Zheng T,Nycholat CM,Grande G,Paulson JC,Lerner RA,Wilson IA

    更新日期:2017-06-14 00:00:00

  • Surviving as a Community: Antibiotic Tolerance and Persistence in Bacterial Biofilms.

    abstract::Biofilms are surface-associated bacterial communities that play both beneficial and harmful roles in nature, medicine, and industry. Tolerant and persister cells are thought to underlie biofilm-related bacterial recurrence in medical and industrial contexts. Here, we review recent progress aimed at understanding the m...

    journal_title:Cell host & microbe

    pub_type: 杂志文章,评审

    doi:10.1016/j.chom.2019.06.002

    authors: Yan J,Bassler BL

    更新日期:2019-07-10 00:00:00

  • The toxoplasma apicoplast phosphate translocator links cytosolic and apicoplast metabolism and is essential for parasite survival.

    abstract::Apicomplexa are unicellular eukaryotic pathogens that carry a vestigial algal endosymbiont, the apicoplast. The physiological function of the apicoplast and its integration into parasite metabolism remain poorly understood and at times controversial. We establish that the Toxoplasma apicoplast membrane-localized phosp...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2009.12.002

    authors: Brooks CF,Johnsen H,van Dooren GG,Muthalagi M,Lin SS,Bohne W,Fischer K,Striepen B

    更新日期:2010-01-21 00:00:00

  • Establishing Causality: Opportunities of Synthetic Communities for Plant Microbiome Research.

    abstract::Plant microbiome research highlights the importance of indigenous microbial communities for host phenotypes such as growth and health. It aims to discover the molecular basis by which host-microbe and microbe-microbe interactions shape and maintain microbial communities and to understand the role of individual microor...

    journal_title:Cell host & microbe

    pub_type: 杂志文章,评审

    doi:10.1016/j.chom.2017.07.004

    authors: Vorholt JA,Vogel C,Carlström CI,Müller DB

    更新日期:2017-08-09 00:00:00

  • The oral commensal microbiota bites back through Nod1.

    abstract::The mechanisms through which commensal bacterial populations cause inflammatory disease when shifted to dysbiotic community structures are poorly understood. Jiao et al. (2013) demonstrate that, in the case of inflammatory disease in the mouth, stimulation of the intracellular pattern recognition receptor Nod1 is a cr...

    journal_title:Cell host & microbe

    pub_type: 评论,杂志文章

    doi:10.1016/j.chom.2013.05.001

    authors: Curtis M

    更新日期:2013-05-15 00:00:00

  • Colitis-Induced Th17 Cells Increase the Risk for Severe Subsequent Clostridium difficile Infection.

    abstract::Clostridium difficile infection (CDI) is the number one hospital-acquired infection in the United States. CDI is more common and severe in inflammatory bowel disease patients. Here, we studied the mechanism by which prior colitis exacerbates CDI. Mice were given dextran sulfate sodium (DSS) colitis, recovered for 2 we...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2019.03.003

    authors: Saleh MM,Frisbee AL,Leslie JL,Buonomo EL,Cowardin CA,Ma JZ,Simpson ME,Scully KW,Abhyankar MM,Petri WA Jr

    更新日期:2019-05-08 00:00:00

  • HIV-1 Neutralizing Antibody Signatures and Application to Epitope-Targeted Vaccine Design.

    abstract::Eliciting HIV-1-specific broadly neutralizing antibodies (bNAbs) remains a challenge for vaccine development, and the potential of passively delivered bNAbs for prophylaxis and therapeutics is being explored. We used neutralization data from four large virus panels to comprehensively map viral signatures associated wi...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2018.12.001

    authors: Bricault CA,Yusim K,Seaman MS,Yoon H,Theiler J,Giorgi EE,Wagh K,Theiler M,Hraber P,Macke JP,Kreider EF,Learn GH,Hahn BH,Scheid JF,Kovacs JM,Shields JL,Lavine CL,Ghantous F,Rist M,Bayne MG,Neubauer GH,McMahan K,

    更新日期:2019-01-09 00:00:00

  • A Bacterial Pathogen Targets a Host Rab-Family GTPase Defense Pathway with a GAP.

    abstract::Cell-autonomous defense mechanisms are potent strategies that protect individual cells against intracellular pathogens. The Rab-family GTPase Rab32 was previously shown to restrict the intracellular human pathogen Salmonella Typhi, but its potential broader role in antimicrobial defense remains unknown. We show that R...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2016.01.004

    authors: Spanò S,Gao X,Hannemann S,Lara-Tejero M,Galán JE

    更新日期:2016-02-10 00:00:00

  • Measles virus takes a two-pronged attack on PP1.

    abstract::During viral infection, RIG-I-like receptors (RLRs) are activated upon dephosphorylation by the phosphatase PP1, resulting in type I interferon production. In this issue, Davis et al. (2014) and Mesman et al. (2014) show that measles virus inhibits this antiviral response by targeting PP1 and thus preventing RLR depho...

    journal_title:Cell host & microbe

    pub_type: 评论,杂志文章

    doi:10.1016/j.chom.2014.06.013

    authors: Seya T

    更新日期:2014-07-09 00:00:00

  • Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection.

    abstract::Anti-helminth immunity involves CD4+ T cells, yet the precise effector mechanisms responsible for parasite killing or expulsion remain elusive. We now report an essential role for antibodies in mediating immunity against the enteric helminth Heligmosomoides polygyrus (Hp), a natural murine parasite that establishes ch...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2008.08.014

    authors: McCoy KD,Stoel M,Stettler R,Merky P,Fink K,Senn BM,Schaer C,Massacand J,Odermatt B,Oettgen HC,Zinkernagel RM,Bos NA,Hengartner H,Macpherson AJ,Harris NL

    更新日期:2008-10-16 00:00:00

  • Finding Leishmania: a deadly game of hide-and-seek.

    abstract::Leishmaniasis is a chronic infection in which intracellular parasites avoid destruction by the immune system. Using intravital imaging, Filipe-Santos et al. (2009) demonstrate that some parasitized dendritic cells receive much less attention than others during their choreographed dance with T cells, suggesting that th...

    journal_title:Cell host & microbe

    pub_type: 评论,杂志文章,评审

    doi:10.1016/j.chom.2009.07.002

    authors: Scott P

    更新日期:2009-07-23 00:00:00

  • Multiple targets of nitric oxide in the tricarboxylic acid cycle of Salmonella enterica serovar typhimurium.

    abstract::Host nitric oxide (NO⋅) production is important for controlling intracellular bacterial pathogens, including Salmonella enterica serovar Typhimurium, but the underlying mechanisms are incompletely understood. S. Typhmurium 14028s is prototrophic for all amino acids but cannot synthesize methionine (M) or lysine (K) du...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2011.06.004

    authors: Richardson AR,Payne EC,Younger N,Karlinsey JE,Thomas VC,Becker LA,Navarre WW,Castor ME,Libby SJ,Fang FC

    更新日期:2011-07-21 00:00:00

  • Automated Prediction and Annotation of Small Open Reading Frames in Microbial Genomes.

    abstract::Small open reading frames (smORFs) and their encoded microproteins play central roles in microbes. However, there is a vast unexplored space of smORFs within human-associated microbes. A recent bioinformatic analysis used evolutionary conservation signals to enhance prediction of small protein families. To facilitate ...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2020.11.002

    authors: Durrant MG,Bhatt AS

    更新日期:2021-01-13 00:00:00

  • Importance of glycans to the host-bacteroides mutualism in the mammalian intestine.

    abstract::Much of the mutualistic relationship between humans and their resident intestinal Bacteroides species is founded on glycans. The host provides plant polysaccharides and host-derived glycans and, in return, receives beneficial end products of bacterial fermentation. Glycans from the bacteria themselves are required for...

    journal_title:Cell host & microbe

    pub_type: 杂志文章,评审

    doi:10.1016/j.chom.2009.05.010

    authors: Comstock LE

    更新日期:2009-06-18 00:00:00

  • Arrhythmic Gut Microbiome Signatures Predict Risk of Type 2 Diabetes.

    abstract::Lifestyle, obesity, and the gut microbiome are important risk factors for metabolic disorders. We demonstrate in 1,976 subjects of a German population cohort (KORA) that specific microbiota members show 24-h oscillations in their relative abundance and identified 13 taxa with disrupted rhythmicity in type 2 diabetes (...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2020.06.004

    authors: Reitmeier S,Kiessling S,Clavel T,List M,Almeida EL,Ghosh TS,Neuhaus K,Grallert H,Linseisen J,Skurk T,Brandl B,Breuninger TA,Troll M,Rathmann W,Linkohr B,Hauner H,Laudes M,Franke A,Le Roy CI,Bell JT,Spector T,Bau

    更新日期:2020-08-12 00:00:00

  • Salmonella gut invasion involves TTSS-2-dependent epithelial traversal, basolateral exit, and uptake by epithelium-sampling lamina propria phagocytes.

    abstract::Salmonella Typhimurium causes diarrhea by infecting the epithelium and lamina propria of the intestinal mucosa and by secreting various effector proteins through type III secretion systems (TTSSs). However, the mechanisms by which Salmonella transverses the epithelium and is subsequently released into the lamina propr...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2011.11.013

    authors: Müller AJ,Kaiser P,Dittmar KE,Weber TC,Haueter S,Endt K,Songhet P,Zellweger C,Kremer M,Fehling HJ,Hardt WD

    更新日期:2012-01-19 00:00:00

  • A neuron-specific role for autophagy in antiviral defense against herpes simplex virus.

    abstract::Type I interferons (IFNs) are considered to be the universal mechanism by which viral infections are controlled. However, many IFN-stimulated genes (ISGs) rely on antiviral pathways that are toxic to host cells, which may be detrimental in nonrenewable cell types, such as neurons. We show that dorsal root ganglionic (...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2012.07.013

    authors: Yordy B,Iijima N,Huttner A,Leib D,Iwasaki A

    更新日期:2012-09-13 00:00:00

  • Cholesterol Metabolism by Uncultured Human Gut Bacteria Influences Host Cholesterol Level.

    abstract::The human microbiome encodes extensive metabolic capabilities, but our understanding of the mechanisms linking gut microbes to human metabolism remains limited. Here, we focus on the conversion of cholesterol to the poorly absorbed sterol coprostanol by the gut microbiota to develop a framework for the identification ...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2020.05.013

    authors: Kenny DJ,Plichta DR,Shungin D,Koppel N,Hall AB,Fu B,Vasan RS,Shaw SY,Vlamakis H,Balskus EP,Xavier RJ

    更新日期:2020-08-12 00:00:00

  • Serine phosphorylation of cortactin controls focal adhesion kinase activity and cell scattering induced by Helicobacter pylori.

    abstract::Cell migration and invasion require the coordinated regulation of cytoskeletal architectural changes by signaling factors, including the actin-binding protein cortactin. Bacterial and viral pathogens subvert these signaling factors to promote their uptake, spread and dissemination. We show that the gastric pathogen He...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2011.05.007

    authors: Tegtmeyer N,Wittelsberger R,Hartig R,Wessler S,Martinez-Quiles N,Backert S

    更新日期:2011-06-16 00:00:00

  • Duffy antigen receptor for chemokines mediates trans-infection of HIV-1 from red blood cells to target cells and affects HIV-AIDS susceptibility.

    abstract::Duffy antigen receptor for chemokines (DARC) expressed on red blood cells (RBCs) influences plasma levels of HIV-1-suppressive and proinflammatory chemokines such as CCL5/RANTES. DARC is also the RBC receptor for Plasmodium vivax. Africans with DARC -46C/C genotype, which confers a DARC-negative phenotype, are resista...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2008.06.002

    authors: He W,Neil S,Kulkarni H,Wright E,Agan BK,Marconi VC,Dolan MJ,Weiss RA,Ahuja SK

    更新日期:2008-07-17 00:00:00

  • A2B adenosine receptor induces protective antihelminth type 2 immune responses.

    abstract::The type 2 immune response evoked by intestinal nematode parasites contributes to worm expulsion and tolerance to associated tissue damage. We investigated whether this host response is affected by blocking signaling by the putative endogenous danger signal adenosine, which can be released during inflammation and host...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2014.02.001

    authors: Patel N,Wu W,Mishra PK,Chen F,Millman A,Csóka B,Koscsó B,Eltzschig HK,Haskó G,Gause WC

    更新日期:2014-03-12 00:00:00

  • HIV-1 envelope gp41 antibodies can originate from terminal ileum B cells that share cross-reactivity with commensal bacteria.

    abstract::Monoclonal antibodies derived from blood plasma cells of acute HIV-1-infected individuals are predominantly targeted to the HIV Env gp41 and cross-reactive with commensal bacteria. To understand this phenomenon, we examined anti-HIV responses in ileum B cells using recombinant antibody technology and probed their rela...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2014.07.003

    authors: Trama AM,Moody MA,Alam SM,Jaeger FH,Lockwood B,Parks R,Lloyd KE,Stolarchuk C,Scearce R,Foulger A,Marshall DJ,Whitesides JF,Jeffries TL Jr,Wiehe K,Morris L,Lambson B,Soderberg K,Hwang KK,Tomaras GD,Vandergrift N,Ja

    更新日期:2014-08-13 00:00:00

  • Durable protection from Herpes Simplex Virus-2 transmission following intravaginal application of siRNAs targeting both a viral and host gene.

    abstract::A vaginal microbicide should prevent pathogen transmission without disrupting tissue barriers to infection. Ideally, it would not need to be applied immediately before sexual intercourse, when compliance is a problem. Intravaginal administration of small interfering RNA (siRNA) lipoplexes targeting Herpes Simplex Viru...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2008.12.003

    authors: Wu Y,Navarro F,Lal A,Basar E,Pandey RK,Manoharan M,Feng Y,Lee SJ,Lieberman J,Palliser D

    更新日期:2009-01-22 00:00:00

  • The host nonsense-mediated mRNA decay pathway restricts Mammalian RNA virus replication.

    abstract::In addition to classically defined immune mechanisms, cell-intrinsic processes can restrict virus infection and have shaped virus evolution. The details of this virus-host interaction are still emerging. Following a genome-wide siRNA screen for host factors affecting replication of Semliki Forest virus (SFV), a positi...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2014.08.007

    authors: Balistreri G,Horvath P,Schweingruber C,Zünd D,McInerney G,Merits A,Mühlemann O,Azzalin C,Helenius A

    更新日期:2014-09-10 00:00:00

  • HIV-1 Nef assembles a Src family kinase-ZAP-70/Syk-PI3K cascade to downregulate cell-surface MHC-I.

    abstract::HIV-1 Nef, which is required for the efficient onset of AIDS, enhances viral replication and infectivity by exerting multiple effects on infected cells. Nef downregulates cell-surface MHC-I molecules by an uncharacterized PI3K pathway requiring the actions of two Nef motifs-EEEE(65) and PXXP(75). We report that the Ne...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2007.03.004

    authors: Hung CH,Thomas L,Ruby CE,Atkins KM,Morris NP,Knight ZA,Scholz I,Barklis E,Weinberg AD,Shokat KM,Thomas G

    更新日期:2007-04-19 00:00:00

  • Mycobacterium tuberculosis activates the DNA-dependent cytosolic surveillance pathway within macrophages.

    abstract::Cytosolic bacterial pathogens activate the cytosolic surveillance pathway (CSP) and induce innate immune responses, but how the host detects vacuolar pathogens like Mycobacterium tuberculosis is poorly understood. We show that M. tuberculosis also initiates the CSP upon macrophage infection via limited perforation of ...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2012.03.007

    authors: Manzanillo PS,Shiloh MU,Portnoy DA,Cox JS

    更新日期:2012-05-17 00:00:00

  • A stable prefusion intermediate of the alphavirus fusion protein reveals critical features of class II membrane fusion.

    abstract::Alphaviruses infect cells via a low-pH-triggered membrane fusion reaction mediated by the class II virus fusion protein E1, an elongated molecule with three extramembrane domains (DI-III). E1 drives fusion by inserting its fusion peptide loop into the target membrane and refolding to a hairpin-like trimer in which DII...

    journal_title:Cell host & microbe

    pub_type: 杂志文章

    doi:10.1016/j.chom.2008.10.012

    authors: Sánchez-San Martín C,Sosa H,Kielian M

    更新日期:2008-12-11 00:00:00