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Phosphoinositides influence pathogen surfing: EPEC rights the SHIP.

Abstract：

:Tir, a translocated effector protein from enteropathogenic E. coli (EPEC), contains two phosphotyrosines that initiate cellular signaling cascades, leading to localized actin polymerization into pedestals. A recent study now shows that two additional tyrosines within Tir recruit the inositol phosphatase SHIP2 to generate a PI(3,4)P2-enriched membrane platform that stabilizes pedestal assembly.

journal_name

Cell Host Microbe

journal_title

Cell host & microbe

authors

Campellone KG

doi

10.1016/j.chom.2009.12.006

subject

Has Abstract

pub_date

2010-01-21 00:00:00

pages

1-2

issue

1

eissn

1931-3128

issn

1934-6069

pii

S1931-3128(09)00416-8

journal_volume

7

pub_type

评论,杂志文章

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