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A Large Polysaccharide Produced by Helicobacter hepaticus Induces an Anti-inflammatory Gene Signature in Macrophages.

Abstract：

:Interactions between the host and its microbiota are of mutual benefit and promote health. Complex molecular pathways underlie this dialog, but the identity of microbe-derived molecules that mediate the mutualistic state remains elusive. Helicobacter hepaticus is a member of the mouse intestinal microbiota that is tolerated by the host. In the absence of an intact IL-10 signaling, H. hepaticus induces an IL-23-driven inflammatory response in the intestine. Here we investigate the interactions between H. hepaticus and host immune cells that may promote mutualism, and the microbe-derived molecule(s) involved. Our results show that H. hepaticus triggers early IL-10 induction in intestinal macrophages and produces a large soluble polysaccharide that activates a specific MSK/CREB-dependent anti-inflammatory and repair gene signature via the receptor TLR2. These data identify a host-bacterial interaction that promotes mutualistic mechanisms at the intestinal interface. Further understanding of this pathway may provide novel prevention and treatment strategies for inflammatory bowel disease.

journal_name

Cell Host Microbe

journal_title

Cell host & microbe

authors

Danne C,Ryzhakov G,Martínez-López M,Ilott NE,Franchini F,Cuskin F,Lowe EC,Bullers SJ,Arthur JSC,Powrie F

doi

10.1016/j.chom.2017.11.002

subject

Has Abstract

pub_date

2017-12-13 00:00:00

pages

733-745.e5

issue

6

eissn

1931-3128

issn

1934-6069

pii

S1931-3128(17)30496-1

journal_volume

22

pub_type

杂志文章

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