Abstract：
:Intestinal reovirus infection can trigger T helper 1 (TH1) immunity to dietary antigen, raising the question of whether other viruses can have a similar impact. Here we show that the acute CW3 strain of murine norovirus, but not the persistent CR6 strain, induces TH1 immunity to dietary antigen. This property of CW3 is dependent on its major capsid protein, a virulence determinant. Transcriptional profiling of mesenteric lymph nodes following infection reveals an immunopathological signature that does not segregate with protective immunity but with loss of oral tolerance, in which interferon regulatory factor 1 is critical. These data show that viral capacity to trigger specific inflammatory pathways at sites where T cell responses to dietary antigens take place interferes with the development of tolerance to an oral antigen. Collectively, these data provide a foundation for the development of therapeutic strategies to prevent TH1-mediated complex immune disorders triggered by viral infections.
journal_name
Cell Host Microbejournal_title
Cell host & microbeauthors
Bouziat R,Biering SB,Kouame E,Sangani KA,Kang S,Ernest JD,Varma M,Brown JJ,Urbanek K,Dermody TS,Ng A,Hinterleitner R,Hwang S,Jabri Bdoi
10.1016/j.chom.2018.10.004subject
Has Abstractpub_date
2018-11-14 00:00:00pages
677-688.e5issue
5eissn
1931-3128issn
1934-6069pii
S1931-3128(18)30542-0journal_volume
24pub_type
杂志文章abstract：:In this issue of Cell Host & Microbe, Wilmore et al. (2018) co-housed isogenic mouse populations, uncovering commensal bacteria-induced serum IgA and IgA-producing bone marrow plasma cells as critical components of resistance against sepsis. They further identified gut microbial taxa that may account for the induction...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2018.02.007
更新日期：2018-03-14 00:00:00
abstract：:In an era of increasing antibiotic resistance, growing clinical need for new drugs, and few lead molecules, new research is helping to identify new targets and the mechanism of action of lead molecules. ...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2009.08.009
更新日期：2009-09-17 00:00:00
abstract：:Crosstalk between immune cells and the microbiota in mucosal tissues can set an individual on a trajectory toward health or disease. Little is known about these early-life events in the human respiratory tract. We examined bacterial colonization and immune system maturation in the lower airways over the first year of ...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2018.10.019
更新日期：2018-12-12 00:00:00
abstract：:Innate immune responses are characterized by precise gene expression whereby gene subsets are temporally induced to limit infection, although the mechanisms involved are incompletely understood. We show that antiviral immunity in Drosophila requires the transcriptional pausing pathway, including negative elongation fa...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2012.08.011
更新日期：2012-10-18 00:00:00
abstract：:The ability of the gut epithelium to defend against pathogens while tolerating harmless commensal organisms remains an important puzzle. In this issue of Cell Host & Microbe, Lee et al. (2015) reveal how pathogen-secreted uracil acts at two steps to induce ROS via the Hedgehog pathway. ...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2015.01.010
更新日期：2015-02-11 00:00:00
abstract：:Tir, a translocated effector protein from enteropathogenic E. coli (EPEC), contains two phosphotyrosines that initiate cellular signaling cascades, leading to localized actin polymerization into pedestals. A recent study now shows that two additional tyrosines within Tir recruit the inositol phosphatase SHIP2 to gener...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2009.12.006
更新日期：2010-01-21 00:00:00
abstract：:The life cycle of several viruses involves host or virally encoded small noncoding RNAs, which play important roles in posttranscriptional regulation. Small noncoding RNAs include microRNAs (miRNAs), which modulate the transcriptome, and small interfering RNAs (siRNAs), which are involved in pathogen defense in plants...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2012.05.019
更新日期：2012-08-16 00:00:00
abstract：:Complement, a complex system of serum proteins, contributes to host defense through multiple mechanisms. In this issue of Cell Host & Microbe, Sorbara et al. (2018) discovered that cytosolic pathogens opsonized by complement are restricted by autophagy. This unexpected role for complement is important for cell-autonom...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2018.04.010
更新日期：2018-05-09 00:00:00
abstract：:Evolution of antibody repertoire against the Ebola virus (EBOV) proteome was characterized in an acutely infected patient receiving supportive care alone to elucidate virus-host interactions over time. Differential kinetics are observed for IgM-IgG-IgA epitope diversity, antibody binding, and affinity maturation to EB...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2020.01.001
更新日期：2020-02-12 00:00:00
abstract：:Successful viruses must overcome the body's immune defenses. In this issue of Cell Host & Microbe, Goffinet et al. (2009) provide evidence that the host protein CD317, the target of the HIV Vpu protein, is part of an ancient innate immune response directed against budding viruses. ...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2009.02.002
更新日期：2009-03-19 00:00:00
abstract：:The difficulty in detecting rare infected cells immediately after mucosal HIV transmission has hindered our understanding of the initial cells targeted by the virus. Working with the macaque simian immunodeficiency virus (SIV) vaginal challenge model, we developed methodology to identify discrete foci of SIV (mac239) ...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2016.03.005
更新日期：2016-04-13 00:00:00
abstract：:Parasites undergo complex life cycles that comprise a wide variety of cellular differentiation events in different host compartments and transmission across multiple hosts. As parasites depend on host resources, it is not surprising they have developed efficient mechanisms to sense alterations and adapt to the availab...
journal_title：Cell host & microbe
pub_type： 杂志文章,评审
doi：10.1016/j.chom.2018.05.018
更新日期：2018-06-13 00:00:00
abstract：:Perturbation of the gut microbiota is associated with inflammatory bowel disease, obesity, and even cancer. In this issue of Cell Host & Microbe, Gogokhia et al. 2019 sought to kill cancer-causing bacteria with bacteriophages. However, the bacteriophages themselves directly stimulated an immune response, which worsene...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2019.01.020
更新日期：2019-02-13 00:00:00
abstract：:The Nef protein of HIV-1 mediates immune evasion by relocating major histocompatibility complex (MHC) molecules and the immune costimulatory molecules CD80 and CD86 away from the monocytic cell surface. We describe a two-pronged mechanism by which Nef removes CD80 and CD86 from the cell surface. While MHCI, CD80, and ...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2007.01.001
更新日期：2007-03-15 00:00:00
abstract：:Enteropathogenic Escherichia coli (EPEC) destroys intestinal microvilli and suppresses phagocytosis by injecting effectors into infected cells through a type III secretion system (TTSS). EspB, a component of the TTSS, is also injected into the cytoplasm of host cells. However, the physiological functions of EspB withi...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2007.09.012
更新日期：2007-12-13 00:00:00
abstract：:Many enveloped viruses hijack the cellular ESCRT machinery to catalyze their escape from host cells. One paper in a recent issue of Cell by Kostelansky et al. and another in this issue of Cell Host & Microbe by Morita et al. shed new light on the structure and function of ESCRT-I. Both papers focus on a fourth ESCRT-I...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2007.06.006
更新日期：2007-07-12 00:00:00
abstract：:Although Drosophila systemic immunity is extensively studied, little is known about the fly's intestine-specific responses to bacterial infection. Global gene expression analysis of Drosophila intestinal tissue to oral infection with the Gram-negative bacterium Erwinia carotovora revealed that immune responses in the ...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2009.01.003
更新日期：2009-02-19 00:00:00
abstract：:Defensins are naturally occurring antimicrobial peptides that disrupt bacterial membranes and prevent bacterial invasion of the host. Emerging studies indicate that certain defensins also block virus infection; however, the mechanism(s) involved are poorly understood. We demonstrate that human alpha-defensins inhibit ...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2007.12.001
更新日期：2008-01-17 00:00:00
abstract：:Typhoidal and non-typhoidal Salmonelleae (NTS) cause typhoid fever and gastroenteritis, respectively, in humans. Salmonella typhoid toxin contributes to typhoid disease progression and chronic infection, but little is known about the role of its NTS ortholog. We found that typhoid toxin and its NTS ortholog induce dif...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2020.04.005
更新日期：2020-06-10 00:00:00
abstract：:Recognition of peptidoglycan is integral to detection of gram-positive bacterial pathogens. In a recent issue of Cell, Wolf et al. (2016) report that detection of the N-acetylglucosamine component of peptidoglycan by the glycolytic enzyme hexokinase activates the NLRP3 inflammasome, revealing an intriguing interplay b...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2016.07.017
更新日期：2016-08-10 00:00:00
abstract：:Quorum-sensing molecules (QSMs) are secreted by bacteria to signal population density. Upon reaching a critical concentration, QSMs induce transcriptional alterations in bacteria, which enable virulence factor expression and biofilm formation. It is unclear whether mammalian hosts can recognize QSMs to trigger respons...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2019.06.003
更新日期：2019-07-10 00:00:00
abstract：:The presence of bacteria within epithelial-lined compartments, such as the lung, elicits rapid recruitment of innate immune cells. In this issue of Cell Host & Microbe, Chun and Prince (2009) report that epithelial cells facilitate this process by reorganizing their intercellular junctions to enhance immune cell trans...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2008.12.008
更新日期：2009-01-22 00:00:00
abstract：:Granulocyte-macrophage colony-stimulating factor (GM-CSF) promotes dendritic cell (DC) differentiation and survival in vitro. However, its role in host defense at the intestinal mucosa is unknown. We report that infection with the mouse enteric pathogen, Citrobacter rodentium, increased colonic GM-CSF production and C...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2010.01.006
更新日期：2010-02-18 00:00:00
abstract：:The RNAi pathway confers antiviral immunity in insects. Virus-specific siRNA responses are amplified via the reverse transcription of viral RNA to viral DNA (vDNA). The nature, biogenesis, and regulation of vDNA are unclear. We find that vDNA produced during RNA virus infection of Drosophila and mosquitoes is present ...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2018.02.001
更新日期：2018-03-14 00:00:00
abstract：:Human noroviruses are a major cause of epidemic and sporadic gastroenteritis worldwide and can chronically infect immunocompromised patients. Efforts to develop effective vaccines and antivirals have been hindered by the uncultivable nature and extreme genetic diversity of human noroviruses. Although they remain a par...
journal_title：Cell host & microbe
pub_type： 杂志文章,评审
doi：10.1016/j.chom.2014.05.015
更新日期：2014-06-11 00:00:00
abstract：:The intestinal microbiota is important for induction of inflammatory bowel disease (IBD). IBD is associated with complex shifts in microbiota composition, but it is unclear whether specific bacterial subsets induce IBD and, if so, whether their proportions in the microbiota are altered during disease. Here, we fulfill...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2011.04.009
更新日期：2011-05-19 00:00:00
abstract：:How gut cells distinguish between beneficial symbionts and deleterious pathobionts is a central question. In this issue of Cell Host & Microbe, Kim et al. (2020) demonstrate that the nucleoside catabolism pathway controlling bacterial uracil and ribose production is an essential trigger of the commensal to pathogen tr...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2020.02.008
更新日期：2020-03-11 00:00:00
abstract：:Autophagy provides a mechanism for cells to conserve nutrients, but was recently associated with immunity to intracellular pathogens. Here, Zhao et al. (2008) present direct in vivo evidence that autophagy is linked to macrophage control of Toxoplasma gondii and Listeria monocytogenes and highlights that this process ...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2008.10.008
更新日期：2008-11-13 00:00:00
abstract：:Dietary supplementation with fermentable fiber suppresses adiposity and the associated parameters of metabolic syndrome. Microbiota-generated fiber-derived short-chain fatty acids (SCFAs) and free fatty acid receptors including GPR43 are thought to mediate these effects. We find that while fermentable (inulin), but no...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2017.11.003
更新日期：2018-01-10 00:00:00
abstract：:The Salmonella enterica effector SteD depletes mature MHC class II (mMHCII) molecules from the surface of infected antigen-presenting cells through ubiquitination of the cytoplasmic tail of the mMHCII β chain. Here, through a genome-wide mutant screen of human antigen-presenting cells, we show that the NEDD4 family HE...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2020.04.024
更新日期：2020-07-08 00:00:00
