Abstract:
:Long before the cause was discovered, peptic ulcers were known to occur preferentially in individuals of certain blood groups. In this issue of Cell Host & Microbe, Moonens et al. (2016) perform structural analyses of the Helicobacter pylori adhesin BabA to determine how the bacteria discriminately bind different blood group glycans.
journal_name
Cell Host Microbejournal_title
Cell host & microbeauthors
Sweeney EG,Guillemin Kdoi
10.1016/j.chom.2015.12.013subject
Has Abstractpub_date
2016-01-13 00:00:00pages
5-7issue
1eissn
1931-3128issn
1934-6069pii
S1931-3128(15)00505-3journal_volume
19pub_type
评论,杂志文章abstract::In response to virus infection, cells can alter protein expression to modify cellular functions and limit viral replication. To examine host protein expression during infection with human cytomegalovirus (HCMV), an enveloped DNA virus, we performed a semiquantitative, temporal analysis of the cell surface proteome in ...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2012.05.012
更新日期:2012-07-19 00:00:00
abstract::Vaccines are needed to combat the global rise in fungal diseases. In this issue of Cell Host & Microbe, Wüthrich et al. (2015) identify calnexin as a target of antigen-specific CD4 T cell responses against multiple fungal pathogens. This study illustrates that a conserved epitope triggers convergent cell-mediated immu...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2015.03.012
更新日期:2015-04-08 00:00:00
abstract::In this issue of Cell Host & Microbe, Liang et al. (2019) show that α-defensins in the gastrointestinal tract sustain defenses to enteric pathogens during starvation. mTOR-dependent sensing of nutrient loss promotes production of an α-defensin regulator, which sustains α-defensin levels, loss of which increases lethal...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2019.04.009
更新日期:2019-05-08 00:00:00
abstract::Complement, a complex system of serum proteins, contributes to host defense through multiple mechanisms. In this issue of Cell Host & Microbe, Sorbara et al. (2018) discovered that cytosolic pathogens opsonized by complement are restricted by autophagy. This unexpected role for complement is important for cell-autonom...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2018.04.010
更新日期:2018-05-09 00:00:00
abstract::Invasion of epithelial cells by Shigella is a critical step in the pathogenesis of bacillary dysentery. In this issue of Cell Host & Microbe, Bergounioux et al. (2012) uncover a complex interplay of proinvasion, prosurvival, and prodeath signals centered on the activation of calpain protease by the Shigella VirA prote...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2012.02.004
更新日期:2012-03-15 00:00:00
abstract::Thiol-group oxidation of active and allosteric cysteines is a widespread regulatory posttranslational protein modification. Pathogenic bacteria, including Pseudomonas aeruginosa and Staphylococcus aureus, use regulatory cysteine oxidation to respond to and overcome reactive oxygen species (ROS) encountered in the host...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2013.02.004
更新日期:2013-03-13 00:00:00
abstract::Microbial CRISPR-Cas acts as a defense, but also as a gatekeeper controlling the flow of new genes into microbial genomes. In a recent Cell paper, Jiang et al. (2016) uncover the functional importance of transcription-dependent RNA targeting in type III-A CRISPR-Cas antiviral defense and provide insight into the co-ev...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2016.01.015
更新日期:2016-02-10 00:00:00
abstract::The inner colon mucus layer capacity to separate bacteria from the epithelium is dependent on bacterial colonizers signaling to the host epithelium. In this issue of Cell Host & Microbe, Wlodarska et al. (2017) demonstrate that the mucin-utilizing Peptostreptococcus russellii protects the host from inflammatory diseas...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2017.06.011
更新日期:2017-07-12 00:00:00
abstract::In this issue of Cell Host & Microbe, Walton et al. (2018) uncover the mycobacterial factors that activate VEGF signaling and promote aberrant angiogenesis in the tuberculous granuloma. Preventing abnormal angiogenesis in the granuloma represents a potential therapeutic approach for tuberculosis. ...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2018.09.016
更新日期:2018-10-10 00:00:00
abstract::Gut-dwelling Prevotella copri (P. copri), the most prevalent Prevotella species in the human gut, have been associated with diet and disease. However, our understanding of their diversity and function remains rudimentary because studies have been limited to 16S and metagenomic surveys and experiments using a single ty...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2019.10.013
更新日期:2019-11-13 00:00:00
abstract::Evolution of antibody repertoire against the Ebola virus (EBOV) proteome was characterized in an acutely infected patient receiving supportive care alone to elucidate virus-host interactions over time. Differential kinetics are observed for IgM-IgG-IgA epitope diversity, antibody binding, and affinity maturation to EB...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2020.01.001
更新日期:2020-02-12 00:00:00
abstract::Apicomplexa are unicellular eukaryotic pathogens that carry a vestigial algal endosymbiont, the apicoplast. The physiological function of the apicoplast and its integration into parasite metabolism remain poorly understood and at times controversial. We establish that the Toxoplasma apicoplast membrane-localized phosp...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2009.12.002
更新日期:2010-01-21 00:00:00
abstract::Type III secretion systems (T3SS) are used by bacteria to deliver proteins into the cytoplasm of eukaryotic cells. Most studies of T3SS have focused on the role of these secretion systems in specific host interactions. However, there is increasing evidence to suggest that T3SS are also used in interactions with multip...
journal_title:Cell host & microbe
pub_type: 杂志文章,评审
doi:10.1016/j.chom.2007.10.004
更新日期:2007-11-15 00:00:00
abstract::Although the replicative life cycle of HIV within CD4 T cells is understood in molecular detail, less is known about how this human retrovirus promotes the loss of CD4 T lymphocytes. It is this cell death process that drives clinical progression to acquired immune deficiency syndrome (AIDS). Recent studies have highli...
journal_title:Cell host & microbe
pub_type: 杂志文章,评审
doi:10.1016/j.chom.2016.02.012
更新日期:2016-03-09 00:00:00
abstract::Malaria starts with the infection of the liver by Plasmodium parasites. Although extensive analysis of Plasmodium has revealed the expression patterns of this parasite in every stage of its life cycle, the liver stage remained unexplored. Recently, Tarun et al. have published the first complete transcriptome and prote...
journal_title:Cell host & microbe
pub_type: 杂志文章,评审
doi:10.1016/j.chom.2008.01.004
更新日期:2008-02-14 00:00:00
abstract::Crosstalk between immune cells and the microbiota in mucosal tissues can set an individual on a trajectory toward health or disease. Little is known about these early-life events in the human respiratory tract. We examined bacterial colonization and immune system maturation in the lower airways over the first year of ...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2018.10.019
更新日期:2018-12-12 00:00:00
abstract::Vibrio parahaemolyticus, a Gram-negative halophilic bacterium that causes acute gastroenteritis in humans, is characterized by two type III secretion systems (T3SS), namely T3SS1 and T3SS2. T3SS2 is indispensable for enterotoxicity but the effector(s) involved are unknown. Here, we identify VopV as a critical effector...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2011.08.014
更新日期:2011-10-20 00:00:00
abstract::Salmonella Typhimurium causes diarrhea by infecting the epithelium and lamina propria of the intestinal mucosa and by secreting various effector proteins through type III secretion systems (TTSSs). However, the mechanisms by which Salmonella transverses the epithelium and is subsequently released into the lamina propr...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2011.11.013
更新日期:2012-01-19 00:00:00
abstract::The transitional epithelium of the bladder normally turns over slowly but upon injury undergoes rapid regeneration fueled by basal uroepithelial stem and/or early progenitor cells (USCs). Little is known about the mechanisms underlying the injury response. We investigate the mechanism of bladder epithelial regeneratio...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2009.04.005
更新日期:2009-05-08 00:00:00
abstract::The mechanisms through which commensal bacterial populations cause inflammatory disease when shifted to dysbiotic community structures are poorly understood. Jiao et al. (2013) demonstrate that, in the case of inflammatory disease in the mouth, stimulation of the intracellular pattern recognition receptor Nod1 is a cr...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2013.05.001
更新日期:2013-05-15 00:00:00
abstract::Low pathogenic H7N9 influenza viruses have recently evolved to become highly pathogenic, raising concerns of a pandemic, particularly if these viruses acquire efficient human-to-human transmissibility. We compared a low pathogenic H7N9 virus with a highly pathogenic isolate, and two of its variants that represent neur...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2017.09.008
更新日期:2017-11-08 00:00:00
abstract::Proviral latency is a major barrier to a cure for HIV. In this issue of Cell Host & Microbe, Hataye et al. (2019) show that reactivation of HIV latency is a non-deterministic, highly stochastic (i.e., noisy) process and propose that stochastic transitions to exponential viral expansion require a critical threshold of ...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2019.11.010
更新日期:2019-12-11 00:00:00
abstract::Anti-helminth immunity involves CD4+ T cells, yet the precise effector mechanisms responsible for parasite killing or expulsion remain elusive. We now report an essential role for antibodies in mediating immunity against the enteric helminth Heligmosomoides polygyrus (Hp), a natural murine parasite that establishes ch...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2008.08.014
更新日期:2008-10-16 00:00:00
abstract::Cytosolic bacterial pathogens activate the cytosolic surveillance pathway (CSP) and induce innate immune responses, but how the host detects vacuolar pathogens like Mycobacterium tuberculosis is poorly understood. We show that M. tuberculosis also initiates the CSP upon macrophage infection via limited perforation of ...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2012.03.007
更新日期:2012-05-17 00:00:00
abstract::Here I revisit our early experiments published in Cell Host & Microbe (Turnbaugh et al., 2008) showing that a diet rich in fat and simple sugars alters the gut microbiome in a manner that contributes to host adiposity, and reflect upon the remarkable advances and remaining challenges in this field. ...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2017.02.021
更新日期:2017-03-08 00:00:00
abstract::Viral proteins have evolved to target cellular organelles and usurp their functions for virus replication. Despite the knowledge of these critical functions for several organelles, little is known about peroxisomes during infection. Peroxisomes are primarily metabolic organelles with important functions in lipid metab...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2018.09.002
更新日期:2018-10-10 00:00:00
abstract::Herpesviruses subvert immune cell activation by inhibiting NK cell receptor (NKG2D)-activating ligands such as MICB. A human cytomegalovirus microRNA was recently shown to repress MICB expression. Nachmani et al. (2009) extend this finding to two other human herpesviruses, providing evidence for a conserved functional...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2009.03.009
更新日期:2009-04-23 00:00:00
abstract::The fusion peptide (FP) of HIV-1 envelope glycoprotein (Env) is essential for mediating viral entry. Detection of broadly neutralizing antibodies (bnAbs) that interact with the FP has revealed it as a site of vulnerability. We delineate X-ray and cryo-electron microscopy (cryo-EM) structures of bnAb ACS202, from an HI...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2019.04.011
更新日期:2019-06-12 00:00:00
abstract::Alphaviruses infect cells via a low-pH-triggered membrane fusion reaction mediated by the class II virus fusion protein E1, an elongated molecule with three extramembrane domains (DI-III). E1 drives fusion by inserting its fusion peptide loop into the target membrane and refolding to a hairpin-like trimer in which DII...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2008.10.012
更新日期:2008-12-11 00:00:00
abstract::The plant immune signaling network needs to be robust against attack from fast-evolving pathogens and tunable to optimize immune responses. We investigated the basis of robustness and tunability in the signaling network controlling pattern-triggered immunity (PTI) in Arabidopsis. A dynamic network model containing fou...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2013.12.002
更新日期:2014-01-15 00:00:00