Abstract：
:Although the replicative life cycle of HIV within CD4 T cells is understood in molecular detail, less is known about how this human retrovirus promotes the loss of CD4 T lymphocytes. It is this cell death process that drives clinical progression to acquired immune deficiency syndrome (AIDS). Recent studies have highlighted how abortive infection of resting and thus nonpermissive CD4 T cells in lymphoid tissues triggers a lethal innate immune response against the incomplete DNA products generated by inefficient viral reverse transcription in these cells. Sensing of these DNA fragments results in pyroptosis, a highly inflammatory form of programmed cell death, that potentially further perpetuates chronic inflammation and immune activation. As discussed here, these studies cast CD4 T cell death during HIV infection in a different light. Further, they identify drug targets that may be exploited to both block CD4 T cell demise and the chronic inflammatory response generated during pyroptosis.
journal_name
Cell Host Microbejournal_title
Cell host & microbeauthors
Doitsh G,Greene WCdoi
10.1016/j.chom.2016.02.012subject
Has Abstractpub_date
2016-03-09 00:00:00pages
280-91issue
3eissn
1931-3128issn
1934-6069pii
S1931-3128(16)30053-1journal_volume
19pub_type
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