当前位置： SCI文献检索 > Cell Host & Microbe期刊下所有文献 > Identification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium.

Identification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium.

Abstract：

:Botulinum neurotoxins (BoNTs), produced by various Clostridium strains, are a family of potent bacterial toxins and potential bioterrorism agents. Here we report that an Enterococcus faecium strain isolated from cow feces carries a BoNT-like toxin, designated BoNT/En. It cleaves both VAMP2 and SNAP-25, proteins that mediate synaptic vesicle exocytosis in neurons, at sites distinct from known BoNT cleavage sites on these two proteins. Comparative genomic analysis determines that the E. faecium strain carrying BoNT/En is a commensal type and that the BoNT/En gene is located within a typical BoNT gene cluster on a 206 kb putatively conjugative plasmid. Although the host species targeted by BoNT/En remains to be determined, these findings establish an extended member of BoNTs and demonstrate the capability of E. faecium, a commensal organism ubiquitous in humans and animals and a leading cause of hospital-acquired multi-drug-resistant (MDR) infections, to horizontally acquire, and possibly disseminate, a unique BoNT gene cluster.

journal_name

Cell Host Microbe

journal_title

Cell host & microbe

authors

Zhang S,Lebreton F,Mansfield MJ,Miyashita SI,Zhang J,Schwartzman JA,Tao L,Masuyer G,Martínez-Carranza M,Stenmark P,Gilmore MS,Doxey AC,Dong M

doi

10.1016/j.chom.2017.12.018

subject

Has Abstract

pub_date

2018-02-14 00:00:00

pages

169-176.e6

issue

2

eissn

1931-3128

issn

1934-6069

pii

S1931-3128(17)30554-1

journal_volume

23

pub_type

杂志文章

相关文献

Cell Host & Microbe文献大全
  • A Large Polysaccharide Produced by Helicobacter hepaticus Induces an Anti-inflammatory Gene Signature in Macrophages.

    abstract：:Interactions between the host and its microbiota are of mutual benefit and promote health. Complex molecular pathways underlie this dialog, but the identity of microbe-derived molecules that mediate the mutualistic state remains elusive. Helicobacter hepaticus is a member of the mouse intestinal microbiota that is tol...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2017.11.002

    authors： Danne C,Ryzhakov G,Martínez-López M,Ilott NE,Franchini F,Cuskin F,Lowe EC,Bullers SJ,Arthur JSC,Powrie F

    更新日期：2017-12-13 00:00:00

  • Innate recognition of cell wall β-glucans drives invariant natural killer T cell responses against fungi.

    abstract：:iNKT cells are innate T lymphocytes recognizing endogenous and foreign lipid antigens presented in the MHC-like molecule CD1d. The semi-invariant iNKT cell TCR can detect certain bacterial and parasitic lipids and drive iNKT cell responses. How iNKT cells respond to fungi, however, is unknown. We found that CD1d-defic...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2011.09.011

    authors： Cohen NR,Tatituri RV,Rivera A,Watts GF,Kim EY,Chiba A,Fuchs BB,Mylonakis E,Besra GS,Levitz SM,Brigl M,Brenner MB

    更新日期：2011-11-17 00:00:00

  • The Impact of the Microbiome on Immunity to Vaccination in Humans.

    abstract：:Vaccines are the most effective means available for preventing infectious diseases. However, vaccine-induced immune responses are highly variable between individuals and between populations in different regions of the world. Understanding the basis of this variation is, thus, of fundamental importance to human health....

    journal_title：Cell host & microbe

    pub_type： 杂志文章,评审

    doi：10.1016/j.chom.2020.06.014

    authors： de Jong SE,Olin A,Pulendran B

    更新日期：2020-08-12 00:00:00

  • Transmission stages dominate trypanosome within-host dynamics during chronic infections.

    abstract：:Sleeping sickness is characterized by waves of the extracellular parasite Trypanosoma brucei in host blood, with infections continuing for months or years until inevitable host death. These waves reflect the dynamic conflict between the outgrowth of a succession of parasite antigenic variants and their control by the ...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2011.03.013

    authors： MacGregor P,Savill NJ,Hall D,Matthews KR

    更新日期：2011-04-21 00:00:00

  • Arrhythmic Gut Microbiome Signatures Predict Risk of Type 2 Diabetes.

    abstract：:Lifestyle, obesity, and the gut microbiome are important risk factors for metabolic disorders. We demonstrate in 1,976 subjects of a German population cohort (KORA) that specific microbiota members show 24-h oscillations in their relative abundance and identified 13 taxa with disrupted rhythmicity in type 2 diabetes (...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2020.06.004

    authors： Reitmeier S,Kiessling S,Clavel T,List M,Almeida EL,Ghosh TS,Neuhaus K,Grallert H,Linseisen J,Skurk T,Brandl B,Breuninger TA,Troll M,Rathmann W,Linkohr B,Hauner H,Laudes M,Franke A,Le Roy CI,Bell JT,Spector T,Bau

    更新日期：2020-08-12 00:00:00

  • The toxoplasma apicoplast phosphate translocator links cytosolic and apicoplast metabolism and is essential for parasite survival.

    abstract：:Apicomplexa are unicellular eukaryotic pathogens that carry a vestigial algal endosymbiont, the apicoplast. The physiological function of the apicoplast and its integration into parasite metabolism remain poorly understood and at times controversial. We establish that the Toxoplasma apicoplast membrane-localized phosp...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2009.12.002

    authors： Brooks CF,Johnsen H,van Dooren GG,Muthalagi M,Lin SS,Bohne W,Fischer K,Striepen B

    更新日期：2010-01-21 00:00:00

  • RIG-I goes beyond naked recognition.

    abstract：:It is currently unclear at which point during viral replication that RNA genomes are first recognized as nonself by the immune system. In this issue of Cell Host & Microbe, Weber et al. show that incoming nucleocapsid-bound genomes are sufficient to bind and activate innate immune sensors. ...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2013.02.012

    authors： Bowzard JB,Ranjan P,Sambhara S

    更新日期：2013-03-13 00:00:00

  • STEVOR is a Plasmodium falciparum erythrocyte binding protein that mediates merozoite invasion and rosetting.

    abstract：:Variant surface antigens play an important role in Plasmodium falciparum malaria pathogenesis and in immune evasion by the parasite. Although most work to date has focused on P. falciparum Erythrocyte Membrane Protein 1 (PfEMP1), two other multigene families encoding STEVOR and RIFIN are expressed in invasive merozoit...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2014.06.004

    authors： Niang M,Bei AK,Madnani KG,Pelly S,Dankwa S,Kanjee U,Gunalan K,Amaladoss A,Yeo KP,Bob NS,Malleret B,Duraisingh MT,Preiser PR

    更新日期：2014-07-09 00:00:00

  • Infection-Induced Peroxisome Biogenesis Is a Metabolic Strategy for Herpesvirus Replication.

    abstract：:Viral proteins have evolved to target cellular organelles and usurp their functions for virus replication. Despite the knowledge of these critical functions for several organelles, little is known about peroxisomes during infection. Peroxisomes are primarily metabolic organelles with important functions in lipid metab...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2018.09.002

    authors： Jean Beltran PM,Cook KC,Hashimoto Y,Galitzine C,Murray LA,Vitek O,Cristea IM

    更新日期：2018-10-10 00:00:00

  • Oral Administration of miR-30d from Feces of MS Patients Suppresses MS-like Symptoms in Mice by Expanding Akkermansia muciniphila.

    abstract：:Fecal transfer from healthy donors is being explored as a microbiome modality. MicroRNAs (miRNAs) have been found to affect the microbiome. Multiple sclerosis (MS) patients have been shown to have an altered gut microbiome. Here, we unexpectedly found that transfer of feces harvested at peak disease from the experimen...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2019.10.008

    authors： Liu S,Rezende RM,Moreira TG,Tankou SK,Cox LM,Wu M,Song A,Dhang FH,Wei Z,Costamagna G,Weiner HL

    更新日期：2019-12-11 00:00:00

  • Multi-Donor Longitudinal Antibody Repertoire Sequencing Reveals the Existence of Public Antibody Clonotypes in HIV-1 Infection.

    abstract：:Characterization of single antibody lineages within infected individuals has provided insights into the development of Env-specific antibodies. However, a systems-level understanding of the humoral response against HIV-1 is limited. Here, we interrogated the antibody repertoires of multiple HIV-infected donors from an...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2018.05.001

    authors： Setliff I,McDonnell WJ,Raju N,Bombardi RG,Murji AA,Scheepers C,Ziki R,Mynhardt C,Shepherd BE,Mamchak AA,Garrett N,Karim SA,Mallal SA,Crowe JE Jr,Morris L,Georgiev IS

    更新日期：2018-06-13 00:00:00

  • Autophagy: Suicide Prevention Hotline for the Gut Epithelium.

    abstract：:Autophagy is genetically associated with inflammatory bowel disease (IBD); however, its role remains unclear in disease pathogenesis. Three recent studies reveal a novel cytoprotective role of autophagy during viral, bacterial, and protozoan-triggered IBD (Burger et al., 2018; Matsuzawa-Ishimoto et al., 2017; Pott et ...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2018.01.015

    authors： Grizotte-Lake M,Vaishnava S

    更新日期：2018-02-14 00:00:00

  • Multiple targets of nitric oxide in the tricarboxylic acid cycle of Salmonella enterica serovar typhimurium.

    abstract：:Host nitric oxide (NO⋅) production is important for controlling intracellular bacterial pathogens, including Salmonella enterica serovar Typhimurium, but the underlying mechanisms are incompletely understood. S. Typhmurium 14028s is prototrophic for all amino acids but cannot synthesize methionine (M) or lysine (K) du...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2011.06.004

    authors： Richardson AR,Payne EC,Younger N,Karlinsey JE,Thomas VC,Becker LA,Navarre WW,Castor ME,Libby SJ,Fang FC

    更新日期：2011-07-21 00:00:00

  • Cell-to-cell transfer of HIV-1 via virological synapses leads to endosomal virion maturation that activates viral membrane fusion.

    abstract：:HIV-1 can infect T cells by cell-free virus or by direct virion transfer between cells through cell contact-induced structures called virological synapses (VS). During VS-mediated infection, virions accumulate within target cell endosomes. We show that after crossing the VS, the transferred virus undergoes both matura...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2011.10.015

    authors： Dale BM,McNerney GP,Thompson DL,Hubner W,de Los Reyes K,Chuang FY,Huser T,Chen BK

    更新日期：2011-12-15 00:00:00

  • Networking at the level of host immunity: immune cell interactions during persistent viral infections.

    abstract：:Persistent viral infections are the result of a series of connected events that culminate in diminished immunity and the inability to eliminate infection. By building our understanding of how distinct components of the immune system function both individually and collectively in productive versus abortive responses, n...

    journal_title：Cell host & microbe

    pub_type： 杂志文章,评审

    doi：10.1016/j.chom.2013.05.014

    authors： Ng CT,Snell LM,Brooks DG,Oldstone MB

    更新日期：2013-06-12 00:00:00

  • Importance of glycans to the host-bacteroides mutualism in the mammalian intestine.

    abstract：:Much of the mutualistic relationship between humans and their resident intestinal Bacteroides species is founded on glycans. The host provides plant polysaccharides and host-derived glycans and, in return, receives beneficial end products of bacterial fermentation. Glycans from the bacteria themselves are required for...

    journal_title：Cell host & microbe

    pub_type： 杂志文章,评审

    doi：10.1016/j.chom.2009.05.010

    authors： Comstock LE

    更新日期：2009-06-18 00:00:00

  • Host restriction factor SAMHD1 limits human T cell leukemia virus type 1 infection of monocytes via STING-mediated apoptosis.

    abstract：:Human T cell leukemia virus type 1 (HTLV-1) is the causative agent of adult T cell leukemia and HTLV-1-associated myelopathies. In addition to T cells, HTLV-1 infects cells of the myeloid lineage, which play critical roles in the host innate response to viral infection. Investigating the monocyte depletion observed du...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2013.09.009

    authors： Sze A,Belgnaoui SM,Olagnier D,Lin R,Hiscott J,van Grevenynghe J

    更新日期：2013-10-16 00:00:00

  • HIV-1 Nef assembles a Src family kinase-ZAP-70/Syk-PI3K cascade to downregulate cell-surface MHC-I.

    abstract：:HIV-1 Nef, which is required for the efficient onset of AIDS, enhances viral replication and infectivity by exerting multiple effects on infected cells. Nef downregulates cell-surface MHC-I molecules by an uncharacterized PI3K pathway requiring the actions of two Nef motifs-EEEE(65) and PXXP(75). We report that the Ne...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2007.03.004

    authors： Hung CH,Thomas L,Ruby CE,Atkins KM,Morris NP,Knight ZA,Scholz I,Barklis E,Weinberg AD,Shokat KM,Thomas G

    更新日期：2007-04-19 00:00:00

  • Hepatitis C virus RNA replication and assembly: living on the fat of the land.

    abstract：:Hepatitis C virus (HCV) is a major global health burden accounting for around 170 million chronic infections worldwide. Although highly potent direct-acting antiviral drugs to treat chronic hepatitis C have been approved recently, owing to their high costs and limited availability and a large number of undiagnosed inf...

    journal_title：Cell host & microbe

    pub_type： 杂志文章,评审

    doi：10.1016/j.chom.2014.10.008

    authors： Paul D,Madan V,Bartenschlager R

    更新日期：2014-11-12 00:00:00

  • Not Your Typical Anti-CRISPR.

    abstract：:In this issue of Cell Host & Microbe, two papers by Osuna et al. describe the characterization of AcrIIA1, an anti-CRISPR protein distributed widely among Listeria phages. AcrIIA1 functions as an anti-CRISPR and as a dynamic repressor of acr loci, suggesting it may play an important role in lysogeny. ...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2020.06.016

    authors： Johnson WE

    更新日期：2020-07-08 00:00:00

  • Digest this! A role for autophagy in controlling pathogens.

    abstract：:Autophagy provides a mechanism for cells to conserve nutrients, but was recently associated with immunity to intracellular pathogens. Here, Zhao et al. (2008) present direct in vivo evidence that autophagy is linked to macrophage control of Toxoplasma gondii and Listeria monocytogenes and highlights that this process ...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2008.10.008

    authors： Whitmarsh RJ,Hunter CA

    更新日期：2008-11-13 00:00:00

  • Caging and COM-Bating Antibiotic Resistance.

    abstract：:Horizontal gene transfer (HGT) facilitates spead of antibiotic resistance elements. In this issue of Cell Host & Microbe, Domenech et al. discover that compounds disrupting proton motive force block natural competence (COM) and interrupt intraspecies HGT and exchange of antibiotic resistance. Such strategies might min...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2020.03.013

    authors： Rosch JW,Tuomanen EI

    更新日期：2020-04-08 00:00:00

  • Shigella targets the mitochondrial checkpoint of programmed necrosis.

    abstract：:In nonmyeloid cells, Shigella hijacks the mitochondrial checkpoint of cell death, thereby inducing a regulated form of necrosis depending on Bnip3 and cyclophilin D. Carneiro et al. (2009) describe the interplay between this program and a prosurvival response transmitted via the Nod1/Rip2/NF-kappaB/Bcl-2 axis, which d...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章,评审

    doi：10.1016/j.chom.2009.01.002

    authors： Galluzzi L,Kroemer G

    更新日期：2009-02-19 00:00:00

  • Structural basis for signaling by exclusive EDS1 heteromeric complexes with SAG101 or PAD4 in plant innate immunity.

    abstract：:Biotrophic plant pathogens encounter a postinfection basal resistance layer controlled by the lipase-like protein enhanced disease susceptibility 1 (EDS1) and its sequence-related interaction partners, senescence-associated gene 101 (SAG101) and phytoalexin deficient 4 (PAD4). Maintainance of separate EDS1 family memb...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2013.11.006

    authors： Wagner S,Stuttmann J,Rietz S,Guerois R,Brunstein E,Bautor J,Niefind K,Parker JE

    更新日期：2013-12-11 00:00:00

  • Phosphorylation-Regulated Activation of the Arabidopsis RRS1-R/RPS4 Immune Receptor Complex Reveals Two Distinct Effector Recognition Mechanisms.

    abstract：:The Arabidopsis immune receptors RPS4 and RRS1 interact to co-confer responsiveness to bacterial effectors. The RRS1-R allele, with RPS4, responds to AvrRps4 and PopP2, whereas RRS1-S responds only to AvrRps4. Here, we show that the C terminus of RRS1-R but not RRS1-S is phosphorylated. Phosphorylation at Thr1214 in t...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2020.03.008

    authors： Guo H,Ahn HK,Sklenar J,Huang J,Ma Y,Ding P,Menke FLH,Jones JDG

    更新日期：2020-05-13 00:00:00

  • Epithelial IL-22RA1-mediated fucosylation promotes intestinal colonization resistance to an opportunistic pathogen.

    abstract：:Our intestinal microbiota harbors a diverse microbial community, often containing opportunistic bacteria with virulence potential. However, mutualistic host-microbial interactions prevent disease by opportunistic pathogens through poorly understood mechanisms. We show that the epithelial interleukin-22 receptor IL-22R...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2014.08.017

    authors： Pham TA,Clare S,Goulding D,Arasteh JM,Stares MD,Browne HP,Keane JA,Page AJ,Kumasaka N,Kane L,Mottram L,Harcourt K,Hale C,Arends MJ,Gaffney DJ,Sanger Mouse Genetics Project.,Dougan G,Lawley TD

    更新日期：2014-10-08 00:00:00

  • Neutrophils Cause an Intravascular Traffic Jam.

    abstract：:Neutrophil swarming is defined by large numbers of cells simultaneously and rapidly migrating to a site of injury or infection. In this issue of Cell Host & Microbe, Lee et al. (2018) demonstrate that intravascular swarming of neutrophils occurs in response to Candida albicans infection and causes vascular occlusion a...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2017.12.011

    authors： Minns MS,Pearlman E

    更新日期：2018-01-10 00:00:00

  • Plasmacytoid dendritic cells mediate anti-inflammatory responses to a gut commensal molecule via both innate and adaptive mechanisms.

    abstract：:Polysaccharide A (PSA), the archetypical immunomodulatory molecule of the gut commensal Bacteroides fragilis, induces regulatory T cells to secrete the anti-inflammatory cytokine interleukin-10 (IL-10). The cellular mediators of PSA's immunomodulatory properties are incompletely understood. In a mouse model of colitis...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2014.03.006

    authors： Dasgupta S,Erturk-Hasdemir D,Ochoa-Reparaz J,Reinecker HC,Kasper DL

    更新日期：2014-04-09 00:00:00

  • IgA Summons IgG to Take a Hit at HIV-1.

    abstract：:In this issue of Cell Host & Microbe, Jia et al. used a vesicular stomatitis virus-based probe to isolate B cells expressing broadly neutralizing HIV-1 antibodies. Besides identifying neutralizing epitopes, this study highlights potential protection afforded by IgA arising from either direct IgM-to-IgA or sequential I...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2020.05.017

    authors： Magri G,Cerutti A

    更新日期：2020-06-10 00:00:00

  • Induction of bone loss by pathobiont-mediated Nod1 signaling in the oral cavity.

    abstract：:Periodontitis is a common disease that is characterized by resorption of the alveolar bone and mediated by commensal bacteria that trigger host immune responses and bone destruction through unidentified mechanisms. We report that Nod1, an innate intracellular host receptor for bacterial peptidoglycan-related molecules...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2013.04.005

    authors： Jiao Y,Darzi Y,Tawaratsumida K,Marchesan JT,Hasegawa M,Moon H,Chen GY,Núñez G,Giannobile WV,Raes J,Inohara N

    更新日期：2013-05-15 00:00:00