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Bone morphogenetic protein 4 signaling regulates epithelial renewal in the urinary tract in response to uropathogenic infection.

Abstract：

:The transitional epithelium of the bladder normally turns over slowly but upon injury undergoes rapid regeneration fueled by basal uroepithelial stem and/or early progenitor cells (USCs). Little is known about the mechanisms underlying the injury response. We investigate the mechanism of bladder epithelial regeneration in response to infection with uropathogenic E. coli (UPEC). Infection resulted in rapid sloughing of superficial cells, a marked inflammatory response, and a substantial spike in basal cell proliferation. In mice with induced urothelial ablation of a member of the TGF-beta receptor superfamily, bone morphogenetic protein (Bmp)-4 receptor, infection led to aberrant urothelial renewal resulting from a block in USC differentiation into superficial cells. Chemical injury also caused sloughing but no inflammation or USC activation. Together, our study indicates that UPEC infection but not chemical injury activates the USC niche, and Bmp signaling is required for regulation of the USC response to infection.

journal_name

Cell Host Microbe

journal_title

Cell host & microbe

authors

Mysorekar IU,Isaacson-Schmid M,Walker JN,Mills JC,Hultgren SJ

doi

10.1016/j.chom.2009.04.005

subject

Has Abstract

pub_date

2009-05-08 00:00:00

pages

463-75

issue

5

eissn

1931-3128

issn

1934-6069

pii

S1931-3128(09)00106-1

journal_volume

5

pub_type

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