Abstract:
:Low pathogenic H7N9 influenza viruses have recently evolved to become highly pathogenic, raising concerns of a pandemic, particularly if these viruses acquire efficient human-to-human transmissibility. We compared a low pathogenic H7N9 virus with a highly pathogenic isolate, and two of its variants that represent neuraminidase inhibitor-sensitive and -resistant subpopulations detected within the isolate. The highly pathogenic H7N9 viruses replicated efficiently in mice, ferrets, and/or nonhuman primates, and were more pathogenic in mice and ferrets than the low pathogenic H7N9 virus, with the exception of the neuraminidase inhibitor-resistant virus, which showed mild-to-moderate attenuation. All viruses transmitted among ferrets via respiratory droplets, and the neuraminidase-sensitive variant killed several of the infected and exposed animals. Neuraminidase inhibitors showed limited effectiveness against these viruses in vivo, but the viruses were susceptible to a polymerase inhibitor. These results suggest that the highly pathogenic H7N9 virus has pandemic potential and should be closely monitored.
journal_name
Cell Host Microbejournal_title
Cell host & microbeauthors
Imai M,Watanabe T,Kiso M,Nakajima N,Yamayoshi S,Iwatsuki-Horimoto K,Hatta M,Yamada S,Ito M,Sakai-Tagawa Y,Shirakura M,Takashita E,Fujisaki S,McBride R,Thompson AJ,Takahashi K,Maemura T,Mitake H,Chiba S,Zhong G,Fandoi
10.1016/j.chom.2017.09.008subject
Has Abstractpub_date
2017-11-08 00:00:00pages
615-626.e8issue
5eissn
1931-3128issn
1934-6069pii
S1931-3128(17)30396-7journal_volume
22pub_type
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