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Shigella targets the mitochondrial checkpoint of programmed necrosis.

Abstract：

:In nonmyeloid cells, Shigella hijacks the mitochondrial checkpoint of cell death, thereby inducing a regulated form of necrosis depending on Bnip3 and cyclophilin D. Carneiro et al. (2009) describe the interplay between this program and a prosurvival response transmitted via the Nod1/Rip2/NF-kappaB/Bcl-2 axis, which determines the fate of infected cells.

journal_name

Cell Host Microbe

journal_title

Cell host & microbe

authors

Galluzzi L,Kroemer G

doi

10.1016/j.chom.2009.01.002

subject

Has Abstract

pub_date

2009-02-19 00:00:00

pages

107-9

issue

2

eissn

1931-3128

issn

1934-6069

pii

S1931-3128(09)00027-4

journal_volume

5

pub_type

评论,杂志文章,评审

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