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A tick mannose-binding lectin inhibitor interferes with the vertebrate complement cascade to enhance transmission of the lyme disease agent.

Abstract：

:The Lyme disease agent Borrelia burgdorferi is primarily transmitted to vertebrates by Ixodes ticks. The classical and alternative complement pathways are important in Borrelia eradication by the vertebrate host. We recently identified a tick salivary protein, designated P8, which reduced complement-mediated killing of Borrelia. We now discover that P8 interferes with the human lectin complement cascade, resulting in impaired neutrophil phagocytosis and chemotaxis and diminished Borrelia lysis. Therefore, P8 was renamed the tick salivary lectin pathway inhibitor (TSLPI). TSLPI-silenced ticks, or ticks exposed to TSLPI-immune mice, were hampered in Borrelia transmission. Moreover, Borrelia acquisition and persistence in tick midguts was impaired in ticks feeding on TSLPI-immunized, B. burgdorferi-infected mice. Together, our findings suggest an essential role for the lectin complement cascade in Borrelia eradication and demonstrate how a vector-borne pathogen co-opts a vector protein to facilitate early mammalian infection and vector colonization.

journal_name

Cell Host Microbe

journal_title

Cell host & microbe

authors

Schuijt TJ,Coumou J,Narasimhan S,Dai J,Deponte K,Wouters D,Brouwer M,Oei A,Roelofs JJ,van Dam AP,van der Poll T,Van't Veer C,Hovius JW,Fikrig E

doi

10.1016/j.chom.2011.06.010

subject

Has Abstract

pub_date

2011-08-18 00:00:00

pages

136-46

issue

2

eissn

1931-3128

issn

1934-6069

pii

S1931-3128(11)00219-8

journal_volume

10

pub_type

杂志文章

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