Abstract:
:Sleeping sickness is characterized by waves of the extracellular parasite Trypanosoma brucei in host blood, with infections continuing for months or years until inevitable host death. These waves reflect the dynamic conflict between the outgrowth of a succession of parasite antigenic variants and their control by the host immune system. Although a contributor to these dynamics is the density-dependent differentiation from proliferative "slender forms" to transmissible "stumpy forms," an absence of markers discriminating stumpy forms has prevented accurate parameterization of this component. Here, we exploit the stumpy-specific PAD1 marker, which functionally defines transmission competence, to quantitatively monitor stumpy formation during chronic infections. This allows reconstruction of the temporal events early in infection. Mathematical modeling of these data describes the parameters controlling trypanosome within-host dynamics and provides strong support for a quorum-sensing-like mechanism. Our data reveal the dominance of transmission stages throughout infection, a consequence being austere use of the parasite's antigen repertoire.
journal_name
Cell Host Microbejournal_title
Cell host & microbeauthors
MacGregor P,Savill NJ,Hall D,Matthews KRdoi
10.1016/j.chom.2011.03.013subject
Has Abstractpub_date
2011-04-21 00:00:00pages
310-8issue
4eissn
1931-3128issn
1934-6069pii
S1931-3128(11)00100-4journal_volume
9pub_type
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