Abstract:
:In this issue of Cell Host & Microbe, Jia et al. used a vesicular stomatitis virus-based probe to isolate B cells expressing broadly neutralizing HIV-1 antibodies. Besides identifying neutralizing epitopes, this study highlights potential protection afforded by IgA arising from either direct IgM-to-IgA or sequential IgM-to-IgG-to-IgA class switching.
journal_name
Cell Host Microbejournal_title
Cell host & microbeauthors
Magri G,Cerutti Adoi
10.1016/j.chom.2020.05.017subject
Has Abstractpub_date
2020-06-10 00:00:00pages
854-856issue
6eissn
1931-3128issn
1934-6069pii
S1931-3128(20)30299-7journal_volume
27pub_type
评论,杂志文章abstract::Although Drosophila systemic immunity is extensively studied, little is known about the fly's intestine-specific responses to bacterial infection. Global gene expression analysis of Drosophila intestinal tissue to oral infection with the Gram-negative bacterium Erwinia carotovora revealed that immune responses in the ...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2009.01.003
更新日期:2009-02-19 00:00:00
abstract::Viral latency can be considered a metastable, nonproductive infection state that is capable of subsequent reactivation to repeat the infection cycle. Viral latent infections have numerous associated pathologies, including cancer, birth defects, neuropathy, cardiovascular disease, chronic inflammation, and immunologica...
journal_title:Cell host & microbe
pub_type: 杂志文章,评审
doi:10.1016/j.chom.2016.04.008
更新日期:2016-05-11 00:00:00
abstract::Viral proteins have evolved to target cellular organelles and usurp their functions for virus replication. Despite the knowledge of these critical functions for several organelles, little is known about peroxisomes during infection. Peroxisomes are primarily metabolic organelles with important functions in lipid metab...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2018.09.002
更新日期:2018-10-10 00:00:00
abstract::Variations in lipopolysaccharide (LPS), a bacterial outer membrane component, determine virulence of the obligate intracellular bacterium Coxiella burnetii, but the underlying mechanisms are unknown. We find that while avirulent C. burnetii LPS (avLPS) stimulates host p38α-MAPK signaling required for proper traffickin...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2012.10.015
更新日期:2012-12-13 00:00:00
abstract::Colitis results from breakdown of homeostasis between intestinal microbiota and the mucosal immune system, with both environmental and genetic influencing factors. Flagellin receptor TLR5-deficient mice (T5KO) display elevated intestinal proinflammatory gene expression and colitis with incomplete penetrance, providing...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2012.07.004
更新日期:2012-08-16 00:00:00
abstract::Cryopyrin (CIAS1, NLRP3) and ASC are components of the inflammasome, a multiprotein complex required for caspase-1 activation and cytokine IL-1beta production. CIAS1 mutations underlie autoinflammation characterized by excessive IL-1beta secretion. Disease-associated cryopyrin also causes a program of necrosis-like ce...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2007.07.009
更新日期:2007-09-13 00:00:00
abstract::Lifestyle, obesity, and the gut microbiome are important risk factors for metabolic disorders. We demonstrate in 1,976 subjects of a German population cohort (KORA) that specific microbiota members show 24-h oscillations in their relative abundance and identified 13 taxa with disrupted rhythmicity in type 2 diabetes (...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2020.06.004
更新日期:2020-08-12 00:00:00
abstract::Newborns are colonized with an intestinal microbiota shortly after birth, but the factors governing the retention and abundance of specific microbial lineages are unknown. Nursing infants consume human milk oligosaccharides (HMOs) that pass undigested to the distal gut, where they may be digested by microbes. We deter...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2011.10.007
更新日期:2011-11-17 00:00:00
abstract::During phagocytosis, microorganisms are taken up by immune cells into phagosomes. Through membrane-trafficking events mediated by SNARE proteins, phagosomes fuse with lysosomes, generating degradative phagolysosomes. Phagolysosomes contribute to host immunity by linking microbial killing within these organelles with a...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2013.06.003
更新日期:2013-07-17 00:00:00
abstract::Modification of the intestinal microbiome is an emerging target to improve health and prevent or treat a number of diseases. In this issue of Cell Host & Microbe, Maldonado-Gómez et al. (2016) uncover the basic principles that govern the successful establishment and persistence of an exogenously introduced gut bacteri...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2016.09.012
更新日期:2016-10-12 00:00:00
abstract::Efficient nutrient acquisition in the human gut is essential for microbial persistence. Although polysaccharides have been well-studied nutrients for the gut microbiome, other resources such as nucleic acids and nucleosides are less studied. We describe several ribose-utilization systems (RUSs) that are broadly repres...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2019.11.009
更新日期:2020-01-08 00:00:00
abstract::Local infection in the Drosophila larval intestine elicits a systemic immune reaction in fat bodies. In this issue, Wu and colleagues (2012) show that this is a reactive oxygen species-dependent communication. ...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2012.04.003
更新日期:2012-04-19 00:00:00
abstract::Neutralizing antibodies (NAbs) are traditionally thought to inhibit virus infection by preventing virion entry into target cells. In addition, antibodies can engage Fc receptors (FcRs) on immune cells to activate antiviral responses. We describe a mechanism by which NAbs inhibit chikungunya virus (CHIKV), the most com...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2018.07.018
更新日期:2018-09-12 00:00:00
abstract::HIV-1 can infect T cells by cell-free virus or by direct virion transfer between cells through cell contact-induced structures called virological synapses (VS). During VS-mediated infection, virions accumulate within target cell endosomes. We show that after crossing the VS, the transferred virus undergoes both matura...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2011.10.015
更新日期:2011-12-15 00:00:00
abstract::The intestinal immune system has to strike a delicate balance between initiating inflammatory responses against invading bacterial pathogens and avoiding their induction against microbiota colonizing the lumen. Adequate inflammatory responses against bacterial invasion result in the lumenal secretion of antimicrobial ...
journal_title:Cell host & microbe
pub_type: 杂志文章,评审
doi:10.1016/j.chom.2010.06.003
更新日期:2010-07-22 00:00:00
abstract::In this issue of Cell Host & Microbe, two papers by Osuna et al. describe the characterization of AcrIIA1, an anti-CRISPR protein distributed widely among Listeria phages. AcrIIA1 functions as an anti-CRISPR and as a dynamic repressor of acr loci, suggesting it may play an important role in lysogeny. ...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2020.06.016
更新日期:2020-07-08 00:00:00
abstract::The transitional epithelium of the bladder normally turns over slowly but upon injury undergoes rapid regeneration fueled by basal uroepithelial stem and/or early progenitor cells (USCs). Little is known about the mechanisms underlying the injury response. We investigate the mechanism of bladder epithelial regeneratio...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2009.04.005
更新日期:2009-05-08 00:00:00
abstract::Defensins are naturally occurring antimicrobial peptides that disrupt bacterial membranes and prevent bacterial invasion of the host. Emerging studies indicate that certain defensins also block virus infection; however, the mechanism(s) involved are poorly understood. We demonstrate that human alpha-defensins inhibit ...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2007.12.001
更新日期:2008-01-17 00:00:00
abstract::Eradication of pathogens from the bloodstream is critical to prevent disseminated infections and sepsis. Kupffer cells in the liver form an intravascular firewall that captures and clears pathogens from the blood. Here, we show that the catching and killing of circulating pathogens by Kupffer cells in vivo are promote...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2020.07.014
更新日期:2020-11-11 00:00:00
abstract::Human type A Enteroviruses (EV-As) cause diseases ranging from hand-foot-and-mouth disease to poliomyelitis-like disease. Although cellular receptors are identified for some EV-As, they remain elusive for the majority of EV-As. We identify the cell surface molecule KREMEN1 as an entry receptor for coxsackievirus A10 (...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2018.03.019
更新日期:2018-05-09 00:00:00
abstract::Monoclonal antibodies derived from blood plasma cells of acute HIV-1-infected individuals are predominantly targeted to the HIV Env gp41 and cross-reactive with commensal bacteria. To understand this phenomenon, we examined anti-HIV responses in ileum B cells using recombinant antibody technology and probed their rela...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2014.07.003
更新日期:2014-08-13 00:00:00
abstract::Polymorphisms in the essential autophagy gene Atg16L1 have been linked with susceptibility to Crohn's disease, a major type of inflammatory bowel disease (IBD). Although the inability to control intestinal bacteria is thought to underlie IBD, the role of Atg16L1 during extracellular intestinal bacterial infections has...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2013.07.013
更新日期:2013-08-14 00:00:00
abstract::Hepatitis C virus (HCV) is a single-stranded RNA virus encoding a single polyprotein whose translation is driven by an internal ribosome entry site (IRES). HCV infection strongly induces antiviral interferon-stimulated gene (ISG) expression in the liver, yet it persists, suggesting that HCV can block ISG effector func...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2009.11.004
更新日期:2009-12-17 00:00:00
abstract::Viruses have evolved a remarkable array of strategies to escape the host's innate immune responses. In this issue of Cell Host & Microbe, Zhao et al. (2016b) reveal a viral strategy to inactivate RIG-I signaling that relies on deamidation of RIG-I. ...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2016.11.011
更新日期:2016-12-14 00:00:00
abstract::In nonmyeloid cells, Shigella hijacks the mitochondrial checkpoint of cell death, thereby inducing a regulated form of necrosis depending on Bnip3 and cyclophilin D. Carneiro et al. (2009) describe the interplay between this program and a prosurvival response transmitted via the Nod1/Rip2/NF-kappaB/Bcl-2 axis, which d...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章,评审
doi:10.1016/j.chom.2009.01.002
更新日期:2009-02-19 00:00:00
abstract::Microbial CRISPR-Cas acts as a defense, but also as a gatekeeper controlling the flow of new genes into microbial genomes. In a recent Cell paper, Jiang et al. (2016) uncover the functional importance of transcription-dependent RNA targeting in type III-A CRISPR-Cas antiviral defense and provide insight into the co-ev...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2016.01.015
更新日期:2016-02-10 00:00:00
abstract::It is currently unclear at which point during viral replication that RNA genomes are first recognized as nonself by the immune system. In this issue of Cell Host & Microbe, Weber et al. show that incoming nucleocapsid-bound genomes are sufficient to bind and activate innate immune sensors. ...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2013.02.012
更新日期:2013-03-13 00:00:00
abstract::Swine influenza A viruses (swIAVs) can play a crucial role in the generation of new human pandemic viruses. In this study, in-depth passive surveillance comprising nearly 2,500 European swine holdings and more than 18,000 individual samples identified a year-round presence of up to four major swIAV lineages on more th...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2020.07.006
更新日期:2020-10-07 00:00:00
abstract::The antimicrobial peptide LL-37 is generated upon proteolytic cleavage of cathelicidin and limits invading pathogens by directly targeting microbial membranes as well as stimulating innate immune cell function. However, some microbes evade LL-37-mediated defense. Notably, group A Streptococcus (GAS) strains belonging ...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2015.09.004
更新日期:2015-10-14 00:00:00
abstract::Eliciting HIV-1-specific broadly neutralizing antibodies (bNAbs) remains a challenge for vaccine development, and the potential of passively delivered bNAbs for prophylaxis and therapeutics is being explored. We used neutralization data from four large virus panels to comprehensively map viral signatures associated wi...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2018.12.001
更新日期:2019-01-09 00:00:00