Abstract：
:The prototypic arenavirus lymphocytic choriomeningitis virus (LCMV), which naturally persists in rodents, represents a model for HIV, HBV, and HCV. Cleavage of the viral glycoprotein precursor by membrane-bound transcription factor peptidase, site 1 (Mbtps1 or site-1 protease), is crucial for the life cycle of arenaviruses and therefore represents a potential target for therapy. Recently, we reported a viable hypomorphic allele of Mbtps1 (woodrat) encoding a protease with diminished enzymatic activity. Using the woodrat allele, we examine the role of Mbtps1 during persistent LCMV infection. Surprisingly, Mbtps1 inhibition limits persistent but not acute viral infection and is associated with an organ/cell type-specific decrease in viral titers. Analysis of bone marrow-derived dendritic cells from woodrat mice supports their specific role in resolving persistent viral infection. These results support in vivo targeting of Mbtps1 in the treatment of arenavirus infections and demonstrate a critical role for dendritic cells in persistent viral infections.
journal_name
Cell Host Microbejournal_title
Cell host & microbeauthors
Popkin DL,Teijaro JR,Sullivan BM,Urata S,Rutschmann S,de la Torre JC,Kunz S,Beutler B,Oldstone Mdoi
10.1016/j.chom.2011.02.006subject
Has Abstractpub_date
2011-03-17 00:00:00pages
212-222issue
3eissn
1931-3128issn
1934-6069pii
S1931-3128(11)00062-Xjournal_volume
9pub_type
杂志文章abstract：:While there is growing appreciation that the microbiome regulates gut-brain signaling, the underlying mechanisms remain elusive. In this issue of Cell Host & Microbe, Bhattarai et al. (2018) identify bacteria-derived tryptamine as a ligand for the gut-epithelium-expressed GPCR 5-HT4 receptor, thereby functioning as a ...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2018.05.020
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abstract：:The innate and adaptive immune responses that confer resistance to the intracellular pathogen Toxoplasma gondii critically depend on IL-12 production, which drives interferon-γ (IFN-γ) expression. Certain cytokines can activate STAT3 and limit IL-12 production to prevent infection-associated immune pathology, but T. g...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2011.07.009
更新日期：2011-09-15 00:00:00
abstract：:Type I interferons (IFNs-I) fulfil multiple protective functions during pathogenic infections, but they can also cause detrimental effects and enhance immunopathology. Here, we report that IFNs-I promote the dysregulation of iron homeostasis in macrophages during systemic infections with the intracellular pathogen Can...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2020.01.023
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abstract：:Successful viruses must overcome the body's immune defenses. In this issue of Cell Host & Microbe, Goffinet et al. (2009) provide evidence that the host protein CD317, the target of the HIV Vpu protein, is part of an ancient innate immune response directed against budding viruses. ...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2009.02.002
更新日期：2009-03-19 00:00:00
abstract：:The link between bacteria and host chromatin remodeling is an emerging topic. The exciting recent discoveries on bacterial impact on host epigenetics, as discussed in this Review, highlight yet another strategy used by bacterial pathogens to interfere with key cellular processes. The study of how pathogens provoke hos...
journal_title：Cell host & microbe
pub_type： 杂志文章,评审
doi：10.1016/j.chom.2008.07.009
更新日期：2008-08-14 00:00:00
abstract：:The Cullin-RING E3 ligase (CRL) family is commonly hijacked by pathogens to redirect the host ubiquitin proteasome machinery to specific targets. During HIV infection, CRL5 is hijacked by HIV Vif to target viral restriction factors of the APOBEC3 family for ubiquitination and degradation. Here, using a quantitative pr...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2019.05.008
更新日期：2019-07-10 00:00:00
abstract：:RNA interference (RNAi) has been extensively used to identify host factors affecting virus infection but requires exogenous delivery of short interfering RNAs (siRNAs), thus limiting the technique to nonphysiological infection models and a single defined cell type. We report an alternative screening approach using siR...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2013.08.007
更新日期：2013-09-11 00:00:00
abstract：:Perturbation of the gut microbiota is associated with inflammatory bowel disease, obesity, and even cancer. In this issue of Cell Host & Microbe, Gogokhia et al. 2019 sought to kill cancer-causing bacteria with bacteriophages. However, the bacteriophages themselves directly stimulated an immune response, which worsene...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2019.01.020
更新日期：2019-02-13 00:00:00
abstract：:Studies described by Eisele et al. (2013) and Xavier et al. (2013) in this issue of Cell Host & Microbe show that the bacterial pathogens Salmonella and Brucella exploit the increased levels of glucose present in alternatively activated macrophages to sustain chronic infections in experimentally infected mice. ...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2013.07.016
更新日期：2013-08-14 00:00:00
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journal_title：Cell host & microbe
pub_type： 杂志文章,评审
doi：10.1016/j.chom.2020.06.014
更新日期：2020-08-12 00:00:00
abstract：:A vaginal microbicide should prevent pathogen transmission without disrupting tissue barriers to infection. Ideally, it would not need to be applied immediately before sexual intercourse, when compliance is a problem. Intravaginal administration of small interfering RNA (siRNA) lipoplexes targeting Herpes Simplex Viru...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2008.12.003
更新日期：2009-01-22 00:00:00
abstract：:Dengue hemorrhagic fever is shown to correlate with secondary infection with a virus serotype different from the previous infection. However, only a small fraction of secondary infections leads to hemorrhagic fever. A recent Science paper suggests that the fucosylation state and isotype of IgGs elicited in patients ma...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2017.02.011
更新日期：2017-03-08 00:00:00
abstract：:Herpes simplex virus 1 (HSV-1) establishes infections in humans and mice, but some non-human primates exhibit resistance via unknown mechanisms. Innate immune recognition pathways are highly conserved but are pivotal in determining susceptibility to DNA virus infections. We report that variation of a single amino acid...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2018.07.004
更新日期：2018-08-08 00:00:00
abstract：:Granulocyte-macrophage colony-stimulating factor (GM-CSF) promotes dendritic cell (DC) differentiation and survival in vitro. However, its role in host defense at the intestinal mucosa is unknown. We report that infection with the mouse enteric pathogen, Citrobacter rodentium, increased colonic GM-CSF production and C...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2010.01.006
更新日期：2010-02-18 00:00:00
abstract：:Live attenuated vaccines remain the safest, most cost-effective intervention against viral infections. Because live vaccine strains are generated empirically and the basis for attenuation is usually ill defined, many important viruses lack an efficient live vaccine. Here, we present a general strategy for the rational...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2008.08.003
更新日期：2008-09-11 00:00:00
abstract：:Enteric pathogens must overcome intestinal defenses to establish infection. In Drosophila, the ERK signaling pathway inhibits enteric virus infection. The intestinal microflora also impacts immunity but its role in enteric viral infection is unknown. Here we show that two signals are required to activate antiviral ERK...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2015.10.010
更新日期：2015-11-11 00:00:00
abstract：:The antimicrobial peptide LL-37 is generated upon proteolytic cleavage of cathelicidin and limits invading pathogens by directly targeting microbial membranes as well as stimulating innate immune cell function. However, some microbes evade LL-37-mediated defense. Notably, group A Streptococcus (GAS) strains belonging ...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2015.09.004
更新日期：2015-10-14 00:00:00
abstract：:Landscape ecology examines the relationships between the spatial arrangement of different landforms and the processes that give rise to spatial and temporal patterns in local community structure. The spatial ecology of the microbial communities that inhabit the human body-in particular, those of the nose, mouth, and t...
journal_title：Cell host & microbe
pub_type： 杂志文章,评审
doi：10.1016/j.chom.2017.03.011
更新日期：2017-04-12 00:00:00
abstract：:The difficulty in detecting rare infected cells immediately after mucosal HIV transmission has hindered our understanding of the initial cells targeted by the virus. Working with the macaque simian immunodeficiency virus (SIV) vaginal challenge model, we developed methodology to identify discrete foci of SIV (mac239) ...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2016.03.005
更新日期：2016-04-13 00:00:00
abstract：:Virulence of emerging community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) and other highly pathogenic S. aureus strains depends on their production of phenol-soluble modulin (PSM) peptide toxins, which combine the capacities to attract and lyse neutrophils. The molecular basis of PSM-stimulated ...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2010.05.012
更新日期：2010-06-25 00:00:00
abstract：:Trypanosomiasis is a devastating neglected tropical disease affecting livestock and humans. Humans are susceptible to two Trypanosoma brucei subspecies but protected from other trypanosomes by circulating high-density lipoprotein (HDL) complexes called trypanosome lytic factors (TLFs) 1 and 2. TLFs contain apolipoprot...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2020.04.012
更新日期：2020-07-08 00:00:00
abstract：:The presence of bacteria within epithelial-lined compartments, such as the lung, elicits rapid recruitment of innate immune cells. In this issue of Cell Host & Microbe, Chun and Prince (2009) report that epithelial cells facilitate this process by reorganizing their intercellular junctions to enhance immune cell trans...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2008.12.008
更新日期：2009-01-22 00:00:00
abstract：:Periodontitis is a common disease that is characterized by resorption of the alveolar bone and mediated by commensal bacteria that trigger host immune responses and bone destruction through unidentified mechanisms. We report that Nod1, an innate intracellular host receptor for bacterial peptidoglycan-related molecules...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2013.04.005
更新日期：2013-05-15 00:00:00
abstract：:The Nef protein of HIV-1 mediates immune evasion by relocating major histocompatibility complex (MHC) molecules and the immune costimulatory molecules CD80 and CD86 away from the monocytic cell surface. We describe a two-pronged mechanism by which Nef removes CD80 and CD86 from the cell surface. While MHCI, CD80, and ...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2007.01.001
更新日期：2007-03-15 00:00:00
abstract：:The role of gut bacteria in complications of heart inflammation has previously not been fully understood. Gil-Cruz et al. (2019) demonstrate a commensal Bacteroides species that triggers a cross-immune response against a bacterial protein and heart epitope, causing cardiomyopathy. This study links commensal bacteria w...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2019.12.011
更新日期：2020-01-08 00:00:00
abstract：:Influenza viruses are important pathogens which pose an ongoing threat to public health due to their ability to mutate and evade immunity elicited by prior infection or vaccination. Their evolutionary diversity is facilitated by the plasticity of the antigenically variable head domain of the major surface glycoprotein...
journal_title：Cell host & microbe
pub_type： 杂志文章,评审
doi：10.1016/j.chom.2018.06.016
更新日期：2018-07-11 00:00:00
abstract：:Recent reports indicate that both the inflammasome (Wlodarska et al., 2014) and autophagy (Patel et al., 2013) pathways in goblet cells control mucin secretion, defects in which are linked to difficulties in clearing pathogenic bacteria and maintaining intestinal homeostasis and control colitis. ...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2014.02.014
更新日期：2014-03-12 00:00:00
abstract：:Metabolic coupling of intracellular pathogens with host cells is essential for successful colonization of the host. Establishment of intracellular infection by the protozoan Trypanosoma cruzi leads to the development of human Chagas' disease, yet the functional contributions of the host cell toward the infection proce...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2012.11.011
更新日期：2013-01-16 00:00:00
abstract：:Studying the microbial composition of internal organs and their associations with disease remains challenging due to the difficulty of acquiring clinical biopsies. We designed a statistical model to analyze the prevalence of species across sample types from The Cancer Genome Atlas (TCGA), revealing that species equipr...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2020.12.001
更新日期：2020-12-21 00:00:00
abstract：:Despite numerous attempts over many years to develop an HIV vaccine based on classical strategies, none has convincingly succeeded to date. A number of approaches are being pursued in the field, including building upon possible efficacy indicated by the recent RV144 clinical trial, which combined two HIV vaccines. Her...
journal_title：Cell host & microbe
pub_type： 杂志文章,评审
doi：10.1016/j.chom.2012.09.008
更新日期：2012-10-18 00:00:00
