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Cell-to-cell transfer of HIV-1 via virological synapses leads to endosomal virion maturation that activates viral membrane fusion.

Abstract：

:HIV-1 can infect T cells by cell-free virus or by direct virion transfer between cells through cell contact-induced structures called virological synapses (VS). During VS-mediated infection, virions accumulate within target cell endosomes. We show that after crossing the VS, the transferred virus undergoes both maturation and viral membrane fusion. Following VS transfer, viral membrane fusion occurs with delayed kinetics and transferred virions display reduced sensitivity to patient antisera compared to mature, cell-free virus. Furthermore, particle fusion requires that the transferred virions undergo proteolytic maturation within acceptor cell endosomes, which occurs over several hours. Rapid, live cell confocal microscopy demonstrated that viral fusion can occur in compartments that have moved away from the VS. Thus, HIV particle maturation activates viral fusion in target CD4+ T cell endosomes following transfer across the VS and may represent a pathway by which HIV evades antibody neutralization.

journal_name

Cell Host Microbe

journal_title

Cell host & microbe

authors

Dale BM,McNerney GP,Thompson DL,Hubner W,de Los Reyes K,Chuang FY,Huser T,Chen BK

doi

10.1016/j.chom.2011.10.015

subject

Has Abstract

pub_date

2011-12-15 00:00:00

pages

551-62

issue

6

eissn

1931-3128

issn

1934-6069

pii

S1931-3128(11)00370-2

journal_volume

10

pub_type

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