Abstract:
:Recent reports indicate that both the inflammasome (Wlodarska et al., 2014) and autophagy (Patel et al., 2013) pathways in goblet cells control mucin secretion, defects in which are linked to difficulties in clearing pathogenic bacteria and maintaining intestinal homeostasis and control colitis.
journal_name
Cell Host Microbejournal_title
Cell host & microbeauthors
Johansson ME,Hansson GCdoi
10.1016/j.chom.2014.02.014subject
Has Abstractpub_date
2014-03-12 00:00:00pages
251-2issue
3eissn
1931-3128issn
1934-6069pii
S1931-3128(14)00072-9journal_volume
15pub_type
评论,杂志文章abstract::The oral microbial community represents the best-characterized consortium associated with the human host. There are strong correlations between the qualitative composition of the oral microbiota and clinically healthy or diseased states. However, additional studies are needed to elucidate the mechanisms that define th...
journal_title:Cell host & microbe
pub_type: 杂志文章,评审
doi:10.1016/j.chom.2011.09.008
更新日期:2011-10-20 00:00:00
abstract::In a recent Science paper, Teles et al. (2013) show that type I and II interferons (IFNs) are reciprocally expressed in the polar immune forms of leprosy, with type I IFNs inducing IL-10 that interferes with the antimycobacterial effects of type II IFNs (IFNγ) at the site of infection. ...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2013.04.001
更新日期:2013-04-17 00:00:00
abstract::The intracellular microbial nucleic acid sensors, TLR3 and STING, recognize pathogen molecules and signal to activate the interferon pathway. The TIR-domain containing protein TRIF is the sole adaptor of TLR3. Here, we report an essential role for TRIF in STING signaling: various activators of STING could not induce g...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2016.08.002
更新日期:2016-09-14 00:00:00
abstract::(+)strand RNA viruses have to overcome various points of restriction in the host to establish successful infection. In plants, this includes RNA silencing. To uncover additional bottlenecks to RNA virus infection, we genetically attenuated the impact of RNA silencing on transgenically expressed Potato virus X (PVX), a...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2014.08.001
更新日期:2014-09-10 00:00:00
abstract::Transition metals such as iron, zinc, copper, and manganese are essential for the growth and development of organisms ranging from bacteria to mammals. Numerous studies have focused on the impact of iron availability during bacterial and fungal infections, and increasing evidence suggests that copper is also involved ...
journal_title:Cell host & microbe
pub_type: 杂志文章,评审
doi:10.1016/j.chom.2012.01.009
更新日期:2012-02-16 00:00:00
abstract::An important report by Bryk et al. in this issue of Cell Host & Microbe describes the properties of a rhodanine prodrug active against nonmultiplying Mycobacterium tuberculosis (Mtb). Considering the tolerance of nonreplicating Mtb to most currently available agents, such a drug could be a major addition to our antitu...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2008.02.013
更新日期:2008-03-13 00:00:00
abstract::Botulinum neurotoxins (BoNTs), produced by various Clostridium strains, are a family of potent bacterial toxins and potential bioterrorism agents. Here we report that an Enterococcus faecium strain isolated from cow feces carries a BoNT-like toxin, designated BoNT/En. It cleaves both VAMP2 and SNAP-25, proteins that m...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2017.12.018
更新日期:2018-02-14 00:00:00
abstract::Human T cell leukemia virus type 1 (HTLV-1) is the causative agent of adult T cell leukemia and HTLV-1-associated myelopathies. In addition to T cells, HTLV-1 infects cells of the myeloid lineage, which play critical roles in the host innate response to viral infection. Investigating the monocyte depletion observed du...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2013.09.009
更新日期:2013-10-16 00:00:00
abstract::Hepatitis C virus (HCV) vaccine efforts are hampered by the extensive genetic diversity of HCV envelope glycoproteins E1 and E2. Structures of broadly neutralizing antibodies (bNAbs) (e.g., HEPC3, HEPC74) isolated from individuals who spontaneously cleared HCV infection facilitate immunogen design to elicit antibodies...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2018.10.009
更新日期:2018-11-14 00:00:00
abstract::Staphylococcus aureus epidemic strain USA300 is a highly successful pathogen. However, the underlying basis of this success is not clear. Now, Thurlow and colleagues (2013) provide evidence linking the bacterial arginine catabolic mobile element (ACME) to the dominance of USA300 as a pathogen of the skin. ...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2013.01.001
更新日期:2013-01-16 00:00:00
abstract::Many Rickettsia species are intracellular bacterial pathogens that use actin-based motility for spread during infection. However, while other bacteria assemble actin tails consisting of branched networks, Rickettsia assemble long parallel actin bundles, suggesting the use of a distinct mechanism for exploiting actin. ...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2010.04.008
更新日期:2010-05-20 00:00:00
abstract::Bone marrow transplantation (BMT) offers curative potential for patients with high-risk hematologic malignancies, but the post-transplantation period is characterized by profound immunodeficiency. Recent studies indicate that the intestinal microbiota not only regulates mucosal immunity, but can also contribute to sys...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2018.03.002
更新日期:2018-04-11 00:00:00
abstract::How gut cells distinguish between beneficial symbionts and deleterious pathobionts is a central question. In this issue of Cell Host & Microbe, Kim et al. (2020) demonstrate that the nucleoside catabolism pathway controlling bacterial uracil and ribose production is an essential trigger of the commensal to pathogen tr...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2020.02.008
更新日期:2020-03-11 00:00:00
abstract::Variations in lipopolysaccharide (LPS), a bacterial outer membrane component, determine virulence of the obligate intracellular bacterium Coxiella burnetii, but the underlying mechanisms are unknown. We find that while avirulent C. burnetii LPS (avLPS) stimulates host p38α-MAPK signaling required for proper traffickin...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2012.10.015
更新日期:2012-12-13 00:00:00
abstract::The deterministic force of natural selection and stochastic influence of drift shape RNA virus evolution. New deep-sequencing and microfluidics technologies allow us to quantify the effect of mutations and trace the evolution of viral populations with single-genome and single-nucleotide resolution. Such experiments ca...
journal_title:Cell host & microbe
pub_type: 杂志文章,评审
doi:10.1016/j.chom.2018.03.012
更新日期:2018-04-11 00:00:00
abstract::Eukaryotic small RNAs (sRNAs) are short non-coding regulatory molecules that induce RNA interference (RNAi). During microbial infection, host RNAi machinery is highly regulated and contributes to reprogramming gene expression and balancing plant immunity and growth. While most sRNAs function endogenously, some can tra...
journal_title:Cell host & microbe
pub_type: 杂志文章,评审
doi:10.1016/j.chom.2019.07.021
更新日期:2019-08-14 00:00:00
abstract::Viruses have evolved a remarkable array of strategies to escape the host's innate immune responses. In this issue of Cell Host & Microbe, Zhao et al. (2016b) reveal a viral strategy to inactivate RIG-I signaling that relies on deamidation of RIG-I. ...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2016.11.011
更新日期:2016-12-14 00:00:00
abstract::Thiol-group oxidation of active and allosteric cysteines is a widespread regulatory posttranslational protein modification. Pathogenic bacteria, including Pseudomonas aeruginosa and Staphylococcus aureus, use regulatory cysteine oxidation to respond to and overcome reactive oxygen species (ROS) encountered in the host...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2013.02.004
更新日期:2013-03-13 00:00:00
abstract::In this issue of Cell Host & Microbe, Wilmore et al. (2018) co-housed isogenic mouse populations, uncovering commensal bacteria-induced serum IgA and IgA-producing bone marrow plasma cells as critical components of resistance against sepsis. They further identified gut microbial taxa that may account for the induction...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2018.02.007
更新日期:2018-03-14 00:00:00
abstract::Dietary factors, microbial composition, and metabolism are intimately intertwined into a complex network whose activities influence important intestinal functions. In a recent issue of Cell, Belcheva et al. (2014) show that microbial-derived butyrate promotes proliferation of cancer-initiated intestinal epithelial cel...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2014.07.011
更新日期:2014-08-13 00:00:00
abstract::Hepatitis C virus genome replication occurs in endoplasmic reticulum-derived membrane compartments, but it is unknown how these structures arise. In this issue of Cell Host & Microbe, Reiss and colleagues (2011) show that the virus recruits a specific lipid kinase to replication sites, stimulates its kinase activity, ...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2011.01.002
更新日期:2011-01-20 00:00:00
abstract::Human type A Enteroviruses (EV-As) cause diseases ranging from hand-foot-and-mouth disease to poliomyelitis-like disease. Although cellular receptors are identified for some EV-As, they remain elusive for the majority of EV-As. We identify the cell surface molecule KREMEN1 as an entry receptor for coxsackievirus A10 (...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2018.03.019
更新日期:2018-05-09 00:00:00
abstract::Cell-autonomous defense mechanisms are potent strategies that protect individual cells against intracellular pathogens. The Rab-family GTPase Rab32 was previously shown to restrict the intracellular human pathogen Salmonella Typhi, but its potential broader role in antimicrobial defense remains unknown. We show that R...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2016.01.004
更新日期:2016-02-10 00:00:00
abstract::Characterization of single antibody lineages within infected individuals has provided insights into the development of Env-specific antibodies. However, a systems-level understanding of the humoral response against HIV-1 is limited. Here, we interrogated the antibody repertoires of multiple HIV-infected donors from an...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2018.05.001
更新日期:2018-06-13 00:00:00
abstract::Variant surface antigens play an important role in Plasmodium falciparum malaria pathogenesis and in immune evasion by the parasite. Although most work to date has focused on P. falciparum Erythrocyte Membrane Protein 1 (PfEMP1), two other multigene families encoding STEVOR and RIFIN are expressed in invasive merozoit...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2014.06.004
更新日期:2014-07-09 00:00:00
abstract::Toxoplasma can reach distant organs, especially the brain, leading to a lifelong chronic phase. However, genes involved in related in vivo processes are currently unknown. Here, we use focused CRISPR libraries to identify Toxoplasma genes that affect in vivo fitness. We focus on TgWIP, whose deletion affects Toxoplasm...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2019.09.008
更新日期:2019-10-09 00:00:00
abstract::Typhoidal and non-typhoidal Salmonelleae (NTS) cause typhoid fever and gastroenteritis, respectively, in humans. Salmonella typhoid toxin contributes to typhoid disease progression and chronic infection, but little is known about the role of its NTS ortholog. We found that typhoid toxin and its NTS ortholog induce dif...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2020.04.005
更新日期:2020-06-10 00:00:00
abstract::Studying the microbial composition of internal organs and their associations with disease remains challenging due to the difficulty of acquiring clinical biopsies. We designed a statistical model to analyze the prevalence of species across sample types from The Cancer Genome Atlas (TCGA), revealing that species equipr...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2020.12.001
更新日期:2020-12-21 00:00:00
abstract::Anti-helminth immunity involves CD4+ T cells, yet the precise effector mechanisms responsible for parasite killing or expulsion remain elusive. We now report an essential role for antibodies in mediating immunity against the enteric helminth Heligmosomoides polygyrus (Hp), a natural murine parasite that establishes ch...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2008.08.014
更新日期:2008-10-16 00:00:00
abstract::The HIV-1 accessory protein Vpr enhances infection of primary macrophages through unknown mechanisms. Recent studies demonstrated that Vpr interactions with the cellular DCAF1-DDB1-CUL4 E3 ubiquitin ligase complex limit activation of innate immunity and interferon (IFN) induction. We describe a restriction mechanism t...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2014.10.014
更新日期:2014-12-10 00:00:00