Abstract:
:Plant microbiome research highlights the importance of indigenous microbial communities for host phenotypes such as growth and health. It aims to discover the molecular basis by which host-microbe and microbe-microbe interactions shape and maintain microbial communities and to understand the role of individual microorganisms, as well as their collective ecosystem function. Here, we discuss reductionist approaches to disentangle the inherent complexity of interactions in situ. Experimentally tractable, synthetic communities enable testing of hypotheses by targeted manipulation in gnotobiotic systems. Modifications of microbial, host, and environmental parameters allow for the quantitative assessment of host and microbe characteristics with dynamic and spatial resolution. We summarize first insights from this emerging field and discuss current challenges and limitations. Using multifaceted approaches to detect interactions and functions will provide new insights into the fundamental biology of plant-microbe interactions and help to harness the power of the microbiome.
journal_name
Cell Host Microbejournal_title
Cell host & microbeauthors
Vorholt JA,Vogel C,Carlström CI,Müller DBdoi
10.1016/j.chom.2017.07.004subject
Has Abstractpub_date
2017-08-09 00:00:00pages
142-155issue
2eissn
1931-3128issn
1934-6069pii
S1931-3128(17)30287-1journal_volume
22pub_type
杂志文章,评审abstract::Botulinum neurotoxins (BoNTs), produced by various Clostridium strains, are a family of potent bacterial toxins and potential bioterrorism agents. Here we report that an Enterococcus faecium strain isolated from cow feces carries a BoNT-like toxin, designated BoNT/En. It cleaves both VAMP2 and SNAP-25, proteins that m...
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journal_title:Cell host & microbe
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journal_title:Cell host & microbe
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journal_title:Cell host & microbe
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journal_title:Cell host & microbe
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journal_title:Cell host & microbe
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journal_title:Cell host & microbe
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journal_title:Cell host & microbe
pub_type: 评论,杂志文章
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journal_title:Cell host & microbe
pub_type: 评论,杂志文章
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journal_title:Cell host & microbe
pub_type: 评论,杂志文章
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journal_title:Cell host & microbe
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journal_title:Cell host & microbe
pub_type: 杂志文章
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journal_title:Cell host & microbe
pub_type: 杂志文章
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journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2007.07.006
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journal_title:Cell host & microbe
pub_type: 评论,杂志文章
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journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2013.10.006
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journal_title:Cell host & microbe
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journal_title:Cell host & microbe
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journal_title:Cell host & microbe
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journal_title:Cell host & microbe
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journal_title:Cell host & microbe
pub_type: 杂志文章,评审
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journal_title:Cell host & microbe
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journal_title:Cell host & microbe
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journal_title:Cell host & microbe
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