当前位置： SCI文献检索 > Cell Host & Microbe期刊下所有文献 > A Knockout Screen of ApiAP2 Genes Reveals Networks of Interacting Transcriptional Regulators Controlling the Plasmodium Life Cycle.

A Knockout Screen of ApiAP2 Genes Reveals Networks of Interacting Transcriptional Regulators Controlling the Plasmodium Life Cycle.

Abstract：

:A family of apicomplexa-specific proteins containing AP2 DNA-binding domains (ApiAP2s) was identified in malaria parasites. This family includes sequence-specific transcription factors that are key regulators of development. However, functions for the majority of ApiAP2 genes remain unknown. Here, a systematic knockout screen in Plasmodium berghei identified ten ApiAP2 genes that were essential for mosquito transmission: four were critical for the formation of infectious ookinetes, and three were required for sporogony. We describe non-essential functions for AP2-O and AP2-SP proteins in blood stages, and identify AP2-G2 as a repressor active in both asexual and sexual stages. Comparative transcriptomics across mutants and developmental stages revealed clusters of co-regulated genes with shared cis promoter elements, whose expression can be controlled positively or negatively by different ApiAP2 factors. We propose that stage-specific interactions between ApiAP2 proteins on partly overlapping sets of target genes generate the complex transcriptional network that controls the Plasmodium life cycle.

journal_name

Cell Host Microbe

journal_title

Cell host & microbe

authors

Modrzynska K,Pfander C,Chappell L,Yu L,Suarez C,Dundas K,Gomes AR,Goulding D,Rayner JC,Choudhary J,Billker O

doi

10.1016/j.chom.2016.12.003

subject

Has Abstract

pub_date

2017-01-11 00:00:00

pages

11-22

issue

1

eissn

1931-3128

issn

1934-6069

pii

S1931-3128(16)30514-5

journal_volume

21

pub_type

杂志文章

相关文献

Cell Host & Microbe文献大全
  • Multi-Donor Longitudinal Antibody Repertoire Sequencing Reveals the Existence of Public Antibody Clonotypes in HIV-1 Infection.

    abstract：:Characterization of single antibody lineages within infected individuals has provided insights into the development of Env-specific antibodies. However, a systems-level understanding of the humoral response against HIV-1 is limited. Here, we interrogated the antibody repertoires of multiple HIV-infected donors from an...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2018.05.001

    authors： Setliff I,McDonnell WJ,Raju N,Bombardi RG,Murji AA,Scheepers C,Ziki R,Mynhardt C,Shepherd BE,Mamchak AA,Garrett N,Karim SA,Mallal SA,Crowe JE Jr,Morris L,Georgiev IS

    更新日期：2018-06-13 00:00:00

  • Anthrax toxin delivers a one-two punch.

    abstract：:Although anthrax toxin was identified as a major Bacillus anthracis virulence factor over 50 years ago, defining the physiologically relevant targets has been challenging. Liu et al. demonstrate that intoxication of myeloid-derived cells contributes to establishing infection but is not required for mortality resulting...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2010.10.011

    authors： Bradley KA,LeVine SM

    更新日期：2010-11-18 00:00:00

  • The Innate Sense of Bacteriophages.

    abstract：:Perturbation of the gut microbiota is associated with inflammatory bowel disease, obesity, and even cancer. In this issue of Cell Host & Microbe, Gogokhia et al. 2019 sought to kill cancer-causing bacteria with bacteriophages. However, the bacteriophages themselves directly stimulated an immune response, which worsene...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2019.01.020

    authors： Bollyky PL,Secor PR

    更新日期：2019-02-13 00:00:00

  • Impaired stimulation of p38α-MAPK/Vps41-HOPS by LPS from pathogenic Coxiella burnetii prevents trafficking to microbicidal phagolysosomes.

    abstract：:Variations in lipopolysaccharide (LPS), a bacterial outer membrane component, determine virulence of the obligate intracellular bacterium Coxiella burnetii, but the underlying mechanisms are unknown. We find that while avirulent C. burnetii LPS (avLPS) stimulates host p38α-MAPK signaling required for proper traffickin...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2012.10.015

    authors： Barry AO,Boucherit N,Mottola G,Vadovic P,Trouplin V,Soubeyran P,Capo C,Bonatti S,Nebreda A,Toman R,Lemichez E,Mege JL,Ghigo E

    更新日期：2012-12-13 00:00:00

  • Cooperating Commensals Restore Colonization Resistance to Vancomycin-Resistant Enterococcus faecium.

    abstract：:Antibiotic-mediated microbiota destruction and the consequent loss of colonization resistance can result in intestinal domination with vancomycin-resistant Enterococcus (VRE), leading to bloodstream infection in hospitalized patients. Clearance of VRE remains a challenging goal that, if achieved, would reduce systemic...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2017.04.002

    authors： Caballero S,Kim S,Carter RA,Leiner IM,Sušac B,Miller L,Kim GJ,Ling L,Pamer EG

    更新日期：2017-05-10 00:00:00

  • Restriction of Zika Virus by Host Innate Immunity.

    abstract：:Recent epidemics of Zika virus (ZIKV) have brought increasing concerns of heightened disease severity and neurotropism. In this issue of Cell Host & Microbe, Lazear et al. (2016) and Bayer et al. (2016) show that innate immunity can restrict ZIKV infection and disease development. ...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2016.04.019

    authors： Xie X,Shan C,Shi PY

    更新日期：2016-05-11 00:00:00

  • Induction of bone loss by pathobiont-mediated Nod1 signaling in the oral cavity.

    abstract：:Periodontitis is a common disease that is characterized by resorption of the alveolar bone and mediated by commensal bacteria that trigger host immune responses and bone destruction through unidentified mechanisms. We report that Nod1, an innate intracellular host receptor for bacterial peptidoglycan-related molecules...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2013.04.005

    authors： Jiao Y,Darzi Y,Tawaratsumida K,Marchesan JT,Hasegawa M,Moon H,Chen GY,Núñez G,Giannobile WV,Raes J,Inohara N

    更新日期：2013-05-15 00:00:00

  • Cofactors required for TLR7- and TLR9-dependent innate immune responses.

    abstract：:Pathogens commonly utilize endocytic pathways to gain cellular access. The endosomal pattern recognition receptors TLR7 and TLR9 detect pathogen-encoded nucleic acids to initiate MyD88-dependent proinflammatory responses to microbial infection. Using genome-wide RNAi screening and integrative systems-based analysis, w...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2012.02.002

    authors： Chiang CY,Engel A,Opaluch AM,Ramos I,Maestre AM,Secundino I,De Jesus PD,Nguyen QT,Welch G,Bonamy GM,Miraglia LJ,Orth AP,Nizet V,Fernandez-Sesma A,Zhou Y,Barton GM,Chanda SK

    更新日期：2012-03-15 00:00:00

  • Human formyl peptide receptor 2 senses highly pathogenic Staphylococcus aureus.

    abstract：:Virulence of emerging community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) and other highly pathogenic S. aureus strains depends on their production of phenol-soluble modulin (PSM) peptide toxins, which combine the capacities to attract and lyse neutrophils. The molecular basis of PSM-stimulated ...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2010.05.012

    authors： Kretschmer D,Gleske AK,Rautenberg M,Wang R,Köberle M,Bohn E,Schöneberg T,Rabiet MJ,Boulay F,Klebanoff SJ,van Kessel KA,van Strijp JA,Otto M,Peschel A

    更新日期：2010-06-25 00:00:00

  • A PfRH5-based vaccine is efficacious against heterologous strain blood-stage Plasmodium falciparum infection in aotus monkeys.

    abstract：:Antigenic diversity has posed a critical barrier to vaccine development against the pathogenic blood-stage infection of the human malaria parasite Plasmodium falciparum. To date, only strain-specific protection has been reported by trials of such vaccines in nonhuman primates. We recently showed that P. falciparum ret...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2014.11.017

    authors： Douglas AD,Baldeviano GC,Lucas CM,Lugo-Roman LA,Crosnier C,Bartholdson SJ,Diouf A,Miura K,Lambert LE,Ventocilla JA,Leiva KP,Milne KH,Illingworth JJ,Spencer AJ,Hjerrild KA,Alanine DG,Turner AV,Moorhead JT,Edgel KA,Wu

    更新日期：2015-01-14 00:00:00

  • Listeria Phages Induce Cas9 Degradation to Protect Lysogenic Genomes.

    abstract：:Bacterial CRISPR-Cas systems employ RNA-guided nucleases to destroy phage (viral) DNA. Phages, in turn, have evolved diverse "anti-CRISPR" proteins (Acrs) to counteract acquired immunity. In Listeria monocytogenes, prophages encode two to three distinct anti-Cas9 proteins, with acrIIA1 always present. However, the sig...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2020.04.001

    authors： Osuna BA,Karambelkar S,Mahendra C,Christie KA,Garcia B,Davidson AR,Kleinstiver BP,Kilcher S,Bondy-Denomy J

    更新日期：2020-07-08 00:00:00

  • In Vivo CRISPR Screen Identifies TgWIP as a Toxoplasma Modulator of Dendritic Cell Migration.

    abstract：:Toxoplasma can reach distant organs, especially the brain, leading to a lifelong chronic phase. However, genes involved in related in vivo processes are currently unknown. Here, we use focused CRISPR libraries to identify Toxoplasma genes that affect in vivo fitness. We focus on TgWIP, whose deletion affects Toxoplasm...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2019.09.008

    authors： Sangaré LO,Ólafsson EB,Wang Y,Yang N,Julien L,Camejo A,Pesavento P,Sidik SM,Lourido S,Barragan A,Saeij JPJ

    更新日期：2019-10-09 00:00:00

  • The toxoplasma apicoplast phosphate translocator links cytosolic and apicoplast metabolism and is essential for parasite survival.

    abstract：:Apicomplexa are unicellular eukaryotic pathogens that carry a vestigial algal endosymbiont, the apicoplast. The physiological function of the apicoplast and its integration into parasite metabolism remain poorly understood and at times controversial. We establish that the Toxoplasma apicoplast membrane-localized phosp...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2009.12.002

    authors： Brooks CF,Johnsen H,van Dooren GG,Muthalagi M,Lin SS,Bohne W,Fischer K,Striepen B

    更新日期：2010-01-21 00:00:00

  • Finding Leishmania: a deadly game of hide-and-seek.

    abstract：:Leishmaniasis is a chronic infection in which intracellular parasites avoid destruction by the immune system. Using intravital imaging, Filipe-Santos et al. (2009) demonstrate that some parasitized dendritic cells receive much less attention than others during their choreographed dance with T cells, suggesting that th...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章,评审

    doi：10.1016/j.chom.2009.07.002

    authors： Scott P

    更新日期：2009-07-23 00:00:00

  • A stable prefusion intermediate of the alphavirus fusion protein reveals critical features of class II membrane fusion.

    abstract：:Alphaviruses infect cells via a low-pH-triggered membrane fusion reaction mediated by the class II virus fusion protein E1, an elongated molecule with three extramembrane domains (DI-III). E1 drives fusion by inserting its fusion peptide loop into the target membrane and refolding to a hairpin-like trimer in which DII...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2008.10.012

    authors： Sánchez-San Martín C,Sosa H,Kielian M

    更新日期：2008-12-11 00:00:00

  • Plasmodium Merozoite TRAP Family Protein Is Essential for Vacuole Membrane Disruption and Gamete Egress from Erythrocytes.

    abstract：:Surface-associated TRAP (thrombospondin-related anonymous protein) family proteins are conserved across the phylum of apicomplexan parasites. TRAP proteins are thought to play an integral role in parasite motility and cell invasion by linking the extracellular environment with the parasite submembrane actomyosin motor...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2016.10.015

    authors： Bargieri DY,Thiberge S,Tay CL,Carey AF,Rantz A,Hischen F,Lorthiois A,Straschil U,Singh P,Singh S,Triglia T,Tsuboi T,Cowman A,Chitnis C,Alano P,Baum J,Pradel G,Lavazec C,Ménard R

    更新日期：2016-11-09 00:00:00

  • Calnexin bridges the gap toward a pan-fungal vaccine.

    abstract：:Vaccines are needed to combat the global rise in fungal diseases. In this issue of Cell Host & Microbe, Wüthrich et al. (2015) identify calnexin as a target of antigen-specific CD4 T cell responses against multiple fungal pathogens. This study illustrates that a conserved epitope triggers convergent cell-mediated immu...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2015.03.012

    authors： Rivera A,Hohl TM

    更新日期：2015-04-08 00:00:00

  • Modeling virus- and antibody-specific factors to predict human immunodeficiency virus neutralization efficiency.

    abstract：:Efforts to prevent human immunodeficiency virus type 1 (HIV-1) infection would benefit from understanding the factors that govern virus neutralization by antibodies. We present a mechanistic model for HIV-1 neutralization that includes both virus and antibody parameters. Variations in epitope integrity on the viral en...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2013.10.006

    authors： Haim H,Salas I,McGee K,Eichelberger N,Winter E,Pacheco B,Sodroski J

    更新日期：2013-11-13 00:00:00

  • HIV Latency: Stochastic across Multiple Scales.

    abstract：:Proviral latency is a major barrier to a cure for HIV. In this issue of Cell Host & Microbe, Hataye et al. (2019) show that reactivation of HIV latency is a non-deterministic, highly stochastic (i.e., noisy) process and propose that stochastic transitions to exponential viral expansion require a critical threshold of ...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2019.11.010

    authors： Hansen MMK,Martin B,Weinberger LS

    更新日期：2019-12-11 00:00:00

  • Bacteroides in the infant gut consume milk oligosaccharides via mucus-utilization pathways.

    abstract：:Newborns are colonized with an intestinal microbiota shortly after birth, but the factors governing the retention and abundance of specific microbial lineages are unknown. Nursing infants consume human milk oligosaccharides (HMOs) that pass undigested to the distal gut, where they may be digested by microbes. We deter...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2011.10.007

    authors： Marcobal A,Barboza M,Sonnenburg ED,Pudlo N,Martens EC,Desai P,Lebrilla CB,Weimer BC,Mills DA,German JB,Sonnenburg JL

    更新日期：2011-11-17 00:00:00

  • STEVOR is a Plasmodium falciparum erythrocyte binding protein that mediates merozoite invasion and rosetting.

    abstract：:Variant surface antigens play an important role in Plasmodium falciparum malaria pathogenesis and in immune evasion by the parasite. Although most work to date has focused on P. falciparum Erythrocyte Membrane Protein 1 (PfEMP1), two other multigene families encoding STEVOR and RIFIN are expressed in invasive merozoit...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2014.06.004

    authors： Niang M,Bei AK,Madnani KG,Pelly S,Dankwa S,Kanjee U,Gunalan K,Amaladoss A,Yeo KP,Bob NS,Malleret B,Duraisingh MT,Preiser PR

    更新日期：2014-07-09 00:00:00

  • Hijacking Host Angiogenesis to Drive Mycobacterial Growth.

    abstract：:In this issue of Cell Host & Microbe, Walton et al. (2018) uncover the mycobacterial factors that activate VEGF signaling and promote aberrant angiogenesis in the tuberculous granuloma. Preventing abnormal angiogenesis in the granuloma represents a potential therapeutic approach for tuberculosis. ...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2018.09.016

    authors： Uusi-Mäkelä M,Rämet M

    更新日期：2018-10-10 00:00:00

  • Surviving as a Community: Antibiotic Tolerance and Persistence in Bacterial Biofilms.

    abstract：:Biofilms are surface-associated bacterial communities that play both beneficial and harmful roles in nature, medicine, and industry. Tolerant and persister cells are thought to underlie biofilm-related bacterial recurrence in medical and industrial contexts. Here, we review recent progress aimed at understanding the m...

    journal_title：Cell host & microbe

    pub_type： 杂志文章,评审

    doi：10.1016/j.chom.2019.06.002

    authors： Yan J,Bassler BL

    更新日期：2019-07-10 00:00:00

  • The enteropathogenic E. coli effector EspB facilitates microvillus effacing and antiphagocytosis by inhibiting myosin function.

    abstract：:Enteropathogenic Escherichia coli (EPEC) destroys intestinal microvilli and suppresses phagocytosis by injecting effectors into infected cells through a type III secretion system (TTSS). EspB, a component of the TTSS, is also injected into the cytoplasm of host cells. However, the physiological functions of EspB withi...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2007.09.012

    authors： Iizumi Y,Sagara H,Kabe Y,Azuma M,Kume K,Ogawa M,Nagai T,Gillespie PG,Sasakawa C,Handa H

    更新日期：2007-12-13 00:00:00

  • Beating Cancer with a Gut Feeling.

    abstract：:Blockade of immune checkpoint molecules, a group of molecules normally involved in maintaining self-tolerance and limiting T cell responses, has emerged as a breakthrough in cancer therapy. Two recent studies published in Science show that, in mice, gut commensal microbes promote antitumor immunity and may determine t...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2015.11.014

    authors： Gorjifard S,Goldszmid RS

    更新日期：2015-12-09 00:00:00

  • All for one and one for all: herpesviral microRNAs close in on their prey.

    abstract：:Herpesviruses subvert immune cell activation by inhibiting NK cell receptor (NKG2D)-activating ligands such as MICB. A human cytomegalovirus microRNA was recently shown to repress MICB expression. Nachmani et al. (2009) extend this finding to two other human herpesviruses, providing evidence for a conserved functional...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2009.03.009

    authors： Dölken L,Jonjic S

    更新日期：2009-04-23 00:00:00

  • Bacterial Adaptation to the Host's Diet Is a Key Evolutionary Force Shaping Drosophila-Lactobacillus Symbiosis.

    abstract：:Animal-microbe facultative symbioses play a fundamental role in ecosystem and organismal health. Yet, due to the flexible nature of their association, the selection pressures that act on animals and their facultative symbionts remain elusive. Here we apply experimental evolution to Drosophila melanogaster associated w...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2018.06.001

    authors： Martino ME,Joncour P,Leenay R,Gervais H,Shah M,Hughes S,Gillet B,Beisel C,Leulier F

    更新日期：2018-07-11 00:00:00

  • Nutritional Support from the Intestinal Microbiota Improves Hematopoietic Reconstitution after Bone Marrow Transplantation in Mice.

    abstract：:Bone marrow transplantation (BMT) offers curative potential for patients with high-risk hematologic malignancies, but the post-transplantation period is characterized by profound immunodeficiency. Recent studies indicate that the intestinal microbiota not only regulates mucosal immunity, but can also contribute to sys...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2018.03.002

    authors： Staffas A,Burgos da Silva M,Slingerland AE,Lazrak A,Bare CJ,Holman CD,Docampo MD,Shono Y,Durham B,Pickard AJ,Cross JR,Stein-Thoeringer C,Velardi E,Tsai JJ,Jahn L,Jay H,Lieberman S,Smith OM,Pamer EG,Peled JU,Cohen

    更新日期：2018-04-11 00:00:00

  • Fungal Mimicry of a Mammalian Aminopeptidase Disables Innate Immunity and Promotes Pathogenicity.

    abstract：:Systemic fungal infections trigger marked immune-regulatory disturbances, but the mechanisms are poorly understood. We report that the pathogenic yeast of Blastomyces dermatitidis elaborates dipeptidyl-peptidase IVA (DppIVA), a close mimic of the mammalian ectopeptidase CD26, which modulates critical aspects of hemato...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2016.02.001

    authors： Sterkel AK,Lorenzini JL,Fites JS,Subramanian Vignesh K,Sullivan TD,Wuthrich M,Brandhorst T,Hernandez-Santos N,Deepe GS Jr,Klein BS

    更新日期：2016-03-09 00:00:00

  • Protectors of the Neonatal Gut: Clostridia Send Pathogens Packing.

    abstract：:Commensal bacteria are known to provide colonization resistance in the gut. But exactly which ones provide this function? In a recent paper in Science, Kim et al. (2017) revealed that Clostridia added to mouse infant gut microbiota are sufficient to limit colonization of pathogenic Enterobacteriaceae. ...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2017.06.002

    authors： Behnsen J

    更新日期：2017-06-14 00:00:00