Abstract:
:Antibiotic-mediated microbiota destruction and the consequent loss of colonization resistance can result in intestinal domination with vancomycin-resistant Enterococcus (VRE), leading to bloodstream infection in hospitalized patients. Clearance of VRE remains a challenging goal that, if achieved, would reduce systemic VRE infections and patient-to-patient transmission. Although obligate anaerobic commensal bacteria have been associated with colonization resistance to VRE, the specific bacterial species involved remain undefined. Herein, we demonstrate that a precisely defined consortium of commensal bacteria containing the Clostridium cluster XIVa species Blautia producta and Clostridium bolteae restores colonization resistance against VRE and clears VRE from the intestines of mice. While C. bolteae did not directly mediate VRE clearance, it enabled intestinal colonization with B. producta, which directly inhibited VRE growth. These findings suggest that therapeutic or prophylactic administration of defined bacterial consortia to individuals with compromised microbiota composition may reduce inter-patient transmission and intra-patient dissemination of highly antibiotic-resistant pathogens.
journal_name
Cell Host Microbejournal_title
Cell host & microbeauthors
Caballero S,Kim S,Carter RA,Leiner IM,Sušac B,Miller L,Kim GJ,Ling L,Pamer EGdoi
10.1016/j.chom.2017.04.002subject
Has Abstractpub_date
2017-05-10 00:00:00pages
592-602.e4issue
5eissn
1931-3128issn
1934-6069pii
S1931-3128(17)30148-8journal_volume
21pub_type
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