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Arrhythmic Gut Microbiome Signatures Predict Risk of Type 2 Diabetes.

Abstract：

:Lifestyle, obesity, and the gut microbiome are important risk factors for metabolic disorders. We demonstrate in 1,976 subjects of a German population cohort (KORA) that specific microbiota members show 24-h oscillations in their relative abundance and identified 13 taxa with disrupted rhythmicity in type 2 diabetes (T2D). Cross-validated prediction models based on this signature similarly classified T2D. In an independent cohort (FoCus), disruption of microbial oscillation and the model for T2D classification was confirmed in 1,363 subjects. This arrhythmic risk signature was able to predict T2D in 699 KORA subjects 5 years after initial sampling, being most effective in combination with BMI. Shotgun metagenomic analysis functionally linked 26 metabolic pathways to the diurnal oscillation of gut bacteria. Thus, a cohort-specific risk pattern of arrhythmic taxa enables classification and prediction of T2D, suggesting a functional link between circadian rhythms and the microbiome in metabolic diseases.

journal_name

Cell Host Microbe

journal_title

Cell host & microbe

authors

Reitmeier S,Kiessling S,Clavel T,List M,Almeida EL,Ghosh TS,Neuhaus K,Grallert H,Linseisen J,Skurk T,Brandl B,Breuninger TA,Troll M,Rathmann W,Linkohr B,Hauner H,Laudes M,Franke A,Le Roy CI,Bell JT,Spector T,Bau

doi

10.1016/j.chom.2020.06.004

subject

Has Abstract

pub_date

2020-08-12 00:00:00

pages

258-272.e6

issue

2

eissn

1931-3128

issn

1934-6069

pii

S1931-3128(20)30343-7

journal_volume

28

pub_type

杂志文章

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