Abstract：
:Vancomycin-resistant Enterococcus (VRE) are highly antibiotic-resistant and readily transmissible pathogens that cause severe infections in hospitalized patients. We discovered that lithocholic acid (LCA), a secondary bile acid prevalent in the cecum and colon of mice and humans, impairs separation of growing VRE diplococci, causing the formation of long chains and increased biofilm formation. Divalent cations reversed this LCA-induced switch to chaining and biofilm formation. Experimental evolution in the presence of LCA yielded mutations in the essential two-component kinase yycG/walK and three-component response regulator liaR that locked VRE in diplococcal mode, impaired biofilm formation, and increased susceptibility to the antibiotic daptomycin. These mutant VRE strains were deficient in host colonization because of their inability to compete with intestinal microbiota. This morphotype switch presents a potential non-bactericidal therapeutic target that may help clear VRE from the intestines of dominated patients, as occurs frequently during hematopoietic stem cell transplantation.
journal_name
Cell Host Microbejournal_title
Cell host & microbeauthors
McKenney PT,Yan J,Vaubourgeix J,Becattini S,Lampen N,Motzer A,Larson PJ,Dannaoui D,Fujisawa S,Xavier JB,Pamer EGdoi
10.1016/j.chom.2019.03.008subject
Has Abstractpub_date
2019-05-08 00:00:00pages
695-705.e5issue
5eissn
1931-3128issn
1934-6069pii
S1931-3128(19)30160-Xjournal_volume
25pub_type
杂志文章abstract：:Apicomplexa are unicellular eukaryotic pathogens that carry a vestigial algal endosymbiont, the apicoplast. The physiological function of the apicoplast and its integration into parasite metabolism remain poorly understood and at times controversial. We establish that the Toxoplasma apicoplast membrane-localized phosp...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2009.12.002
更新日期：2010-01-21 00:00:00
abstract：:Lujo virus (LUJV) is an arenavirus that emerged in 2008 associated with a cluster of human cases of severe hemorrhagic fever. In this issue of Cell Host & Microbe, Raaben et al. (2017) identify neuropilin (NRP)-2 as cell surface receptor and the tetraspannin protein CD63 as intracellular entry factor for LUJV. ...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2017.10.014
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abstract：:Intestinal reovirus infection can trigger T helper 1 (TH1) immunity to dietary antigen, raising the question of whether other viruses can have a similar impact. Here we show that the acute CW3 strain of murine norovirus, but not the persistent CR6 strain, induces TH1 immunity to dietary antigen. This property of CW3 i...
journal_title：Cell host & microbe
pub_type： 杂志文章
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abstract：:Intracellular pathogens like Shigella flexneri enter host cells by phagocytosis. Once inside, the pathogen breaks the vacuolar membrane for cytosolic access. The fate and function of the vacuolar membrane remnants are not clear. Examining Shigella-infected nonmyeloid cells, we observed that proteins associated with va...
journal_title：Cell host & microbe
pub_type： 杂志文章
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abstract：:Dengue hemorrhagic fever is shown to correlate with secondary infection with a virus serotype different from the previous infection. However, only a small fraction of secondary infections leads to hemorrhagic fever. A recent Science paper suggests that the fucosylation state and isotype of IgGs elicited in patients ma...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
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journal_title：Cell host & microbe
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journal_title：Cell host & microbe
pub_type： 杂志文章,评审
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journal_title：Cell host & microbe
pub_type： 评论,杂志文章
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journal_title：Cell host & microbe
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journal_title：Cell host & microbe
pub_type： 评论,杂志文章
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journal_title：Cell host & microbe
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journal_title：Cell host & microbe
pub_type： 杂志文章
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journal_title：Cell host & microbe
pub_type： 评论,杂志文章
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journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2014.02.001
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journal_title：Cell host & microbe
pub_type： 杂志文章
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更新日期：2013-05-15 00:00:00
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journal_title：Cell host & microbe
pub_type： 杂志文章
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journal_title：Cell host & microbe
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doi：10.1016/j.chom.2009.08.009
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journal_title：Cell host & microbe
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journal_title：Cell host & microbe
pub_type： 杂志文章,评审
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journal_title：Cell host & microbe
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journal_title：Cell host & microbe
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journal_title：Cell host & microbe
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journal_title：Cell host & microbe
pub_type： 评论,杂志文章
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journal_title：Cell host & microbe
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journal_title：Cell host & microbe
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journal_title：Cell host & microbe
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journal_title：Cell host & microbe
pub_type： 评论,杂志文章
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journal_title：Cell host & microbe
pub_type： 杂志文章
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更新日期：2013-01-16 00:00:00
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journal_title：Cell host & microbe
pub_type： 评论,杂志文章
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abstract：:Despite numerous attempts over many years to develop an HIV vaccine based on classical strategies, none has convincingly succeeded to date. A number of approaches are being pursued in the field, including building upon possible efficacy indicated by the recent RV144 clinical trial, which combined two HIV vaccines. Her...
journal_title：Cell host & microbe
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更新日期：2012-10-18 00:00:00
