CD49b-dependent establishment of T helper cell memory.

abstract：:Ex vivo mammary explant systems are an excellent model to study interactions between epithelium and stromal cell types because they contain physiologically relevant heterotypic interactions in the background of genetically diverse patients. The intact human mammary tissue, termed patient-derived explant (PDE), can be ...

journal_title：Immunology and cell biology

authors： Gregory KJ,Morin SM,Kubosiak A,Ser-Dolansky J,Schalet BJ,Jerry DJ,Schneider SS

更新日期：2020-11-01 00:00:00

abstract：:Mycobacterium tuberculosis uses numerous mechanisms to avoid elimination by the infected host. In this study, we investigated the possibility whether, similar to other pathogens, M. tuberculosis exploits natural CD4+ CD25+ T-regulatory cells (Treg) to suppress the effector function of responding host lymphocytes, thus...

journal_title：Immunology and cell biology

authors： Quinn KM,McHugh RS,Rich FJ,Goldsack LM,de Lisle GW,Buddle BM,Delahunt B,Kirman JR

更新日期：2006-10-01 00:00:00

abstract：:Tumour cell heterogeneity is probably a principal cause of treatment failure and represents a formidable barrier for effective antibody-targeted chemotherapy. Idarubicin (Ida), a more potent and less cardiotoxic analogue of daunomycin, has been demonstrated to specifically target and eradicate homogeneous, cloned, mur...

journal_title：Immunology and cell biology

authors： Smyth MJ,Foster HM,Andrew SM,Teh JG,Krauer K,McKenzie IF,Pietersz GA

更新日期：1993-06-01 00:00:00

abstract：:Natural suppressor (NS) cell line (Clone 59) was established from the bone marrow of adult C3H/Hej mice in the presence of WEHI-3 conditioned media. Clone 59 cells suppressed the generation of cytotoxic T lymphocytes from normal mouse spleen. This suppression was seen at a responder-to-suppressor cell ratio of 1000:1 ...

journal_title：Immunology and cell biology

authors： Yanagië H,Sugiyama H,Sekiguchi M

更新日期：1995-08-01 00:00:00

abstract：:Cells with a low density of parasite-specific antigens on their surface are postulated to be susceptible to a cell-mediated attack but not to effector mechanisms normally activated following the binding of specific antibody to the infected cell. It is further postulated that such infected cells normally induce a cell-...

journal_title：Immunology and cell biology

authors： Bretscher PA

更新日期：1992-10-01 00:00:00

abstract：:Pseudomonas aeruginosa ocular infection causes extensive corneal neovascularization. The purpose of the present study was to investigate the role of the angiogenic factors macrophage inflammatory protein-2 (MIP-2) and vascular endothelial growth factor (VEGF) in the regulation of corneal neovascularization during P. a...

journal_title：Immunology and cell biology

authors： Xue ML,Thakur A,Willcox M

更新日期：2002-08-01 00:00:00

abstract：:Resistance to caspase-dependent apoptosis is often responsible for treatment failures in cancer. Finding novel therapeutic strategies that can activate alternative cell death programs appears to be appealing. Necroptosis is a form of programmed necrosis that occurs under caspase-deficient conditions. This alternative ...

journal_title：Immunology and cell biology

authors： Lalaoui N,Brumatti G

更新日期：2017-02-01 00:00:00

abstract：:Human plasmacytoid dendritic cells (pDCs) were considered to be a phenotypically and functionally homogeneous cell population; however, recent analyses indicate potential heterogeneity. This is of major interest, given their importance in the induction of anti-viral responses and their role in creating immunologically...

journal_title：Immunology and cell biology

authors： Bryant C,Fromm PD,Kupresanin F,Clark G,Lee K,Clarke C,Silveira PA,Suen H,Brown R,Newman E,Cunningham I,Ho PJ,Gibson J,Bradstock K,Joshua D,Hart DNj

更新日期：2016-05-01 00:00:00

abstract：:Tumour necrosis factor-alpha (TNF-alpha)-converting enzyme (TACE) is a membrane-bound metalloprotease and disintegrin. It is produced by a number of host cells and is known to shed and release cell-bound cytokines, particularly members of the TNF family. No investigations into the regulation of this enzyme by autoanti...

journal_title：Immunology and cell biology

authors： Lisi S,Sisto M

更新日期：2010-03-01 00:00:00

abstract：:The cellular effects of biodiesel emissions particulate matter (BDEP) and petroleum diesel emissions particulate matter (PDEP) were compared using a human airway cell line, A549. At concentrations of 25 microg/ml, diesel particulate matter induced the formation of multinucleate cells. In cells treated with a mixture o...

journal_title：Immunology and cell biology

authors： Ackland ML,Zou L,Freestone D,van de Waasenburg S,Michalczyk AA

更新日期：2007-11-01 00:00:00

abstract：:Mice infected with Sarcocystis muris showed a significant reduction in plaque-forming cells (PFC) and delayed-type hypersensitivity (DHS) responses to an unrelated protein antigen, bovine gamma-globulin, when compared with uninfected controls. This immunosuppression was observed only when infection preceded immunizati...

journal_title：Immunology and cell biology

authors： Gill HS,Charleston WA,Moriarty KM

更新日期：1988-01-01 00:00:00

abstract：:Tumour necrosis factor (TNF) is important in the development of inflammatory bowel disease. TNF-alpha-deficient mice show more severe colonic inflammation than wild-type (Wt) mice, but the underlying mechanism remains unclear. Using immunohistochemistry, enzyme-linked-immunosorbent assay and histopathology, we found t...

journal_title：Immunology and cell biology

authors： Xu Y,Hunt NH,Bao S

更新日期：2007-11-01 00:00:00

abstract：:The multimammate rat Mastomys natalensis, when infected with the filarial parasite Acanthocheilonema viteae, develops amicrofilaraemia. Worm recovery and the duration and intensity of microfilaraemia were analysed and related to the humoral and cellular immune responses of the host by using an antibody-dependent cell-...

journal_title：Immunology and cell biology

authors： Chandrashekar R,Rao UR,Subrahmanyam D

更新日期：1990-02-01 00:00:00

abstract：:A long-term culture (LTC) system has been established that supports the continuous production of dendritic cells (DC) from haemopoietic cells present in the culture. The production of cells depends on the presence of an intact stromal cell layer containing a mixture of fibroblasts and endothelial cells. Cells are shed...

journal_title：Immunology and cell biology

authors： O'Neill HC,Ni K,Wilson H

更新日期：1999-10-01 00:00:00

abstract：:Activin A, a member of the transforming growth factor-β superfamily, is a critical early mediator of acute inflammation. Activin A release coincides with the release of tumour necrosis factor-α (TNF-α) in models of lipopolysaccharide (LPS)-induced inflammation. The source of circulating activin A during acute inflamma...

journal_title：Immunology and cell biology

authors： Chen Y,Wu H,Winnall WR,Loveland KL,Makanji Y,Phillips DJ,Smith JA,Hedger MP

更新日期：2011-11-01 00:00:00

abstract：:Regulatory mechanisms in mucosal secretions and tissues recognize antigens and attenuate pro-inflammatory cytokine responses. Here, we asked whether human beta-defensin 3 (HBD3) serves as an upstream suppressor of cytokine signaling that binds and attenuates pro-inflammatory cytokine responses to recombinant hemagglut...

journal_title：Immunology and cell biology

authors： Pingel LC,Kohlgraf KG,Hansen CJ,Eastman CG,Dietrich DE,Burnell KK,Srikantha RN,Xiao X,Bélanger M,Progulske-Fox A,Cavanaugh JE,Guthmiller JM,Johnson GK,Joly S,Kurago ZB,Dawson DV,Brogden KA

更新日期：2008-11-01 00:00:00

abstract：:The Kunjin replicon was used to express a polytope that consisted of seven hepatitis C virus cytotoxic T lymphocyte epitopes and one influenza cytotoxic T lymphocyte epitope for vaccination studies. The self-replicating nature of, and expression from, the ribonucleic acid was confirmed in vitro. Initial vaccinations w...

journal_title：Immunology and cell biology

authors： Ward SM,Tindle RW,Khromykh AA,Gowans EJ

更新日期：2003-02-01 00:00:00

abstract：:Longevity of plasma cells is dependent on their ability to access and reside in so-called survival niches that are predominantly located in the bone marrow. It is proposed that by some process a small fraction of the plasma cells generated in response to new antigen challenges can enter into the long-lived repertoire ...

journal_title：Immunology and cell biology

authors： Tarlinton D

更新日期：2020-07-01 00:00:00

abstract：:Spleen cells from newborn mice are immunologically nonreactive and do not respond by proliferation upon stimulation with the T cell mitogen concanavalin-A (Con-A) or with recombinant interleukin-2 (IL-2). We have found that, in spite of the observed non-reactivity in the proliferative tests, cells from newborn mice we...

journal_title：Immunology and cell biology

authors： Lipoldová M,Holán V

更新日期：1991-12-01 00:00:00

abstract：:The mouse peritoneal cavity contains a unique population of B cells (Bla) with a high IgM/low IgD ratio, CD5+ (Ly1), MAC-1 + phenotype. These cells arise early in ontogeny, utilize a limited repertoire of immunoglobulin V genes, produce polyreactive IgM antibodies and have been implicated as the source of many auto-re...

journal_title：Immunology and cell biology

authors： Beagley KW,Murray AM,McGhee JR,Eldridge JH

更新日期：1995-10-01 00:00:00

abstract：:Multipotent mesenchymal stromal cells are multipotent cells capable of differentiating into different mesodermal cell types. Enigmatically, mesenchymal stromal cells present in the bone marrow support early lymphopoiesis yet can inhibit mature lymphocyte growth. Critical features of the bone marrow microenvironment, s...

journal_title：Immunology and cell biology

authors： Prado-Lòpez S,Duffy MM,Baustian C,Alagesan S,Hanley SA,Stocca A,Griffin MD,Ceredig R

更新日期：2014-08-01 00:00:00

abstract：:B and T lymphocyte attenuator (BTLA) is an important negative regulator of T-cell activation. T-cell activation involves partitioning of receptors into discrete membrane compartments known as lipid rafts and the formation of an immunological synapse (IS) between the T cell and antigen-presenting cell (APC). Here we sh...

journal_title：Immunology and cell biology

authors： Wu TH,Zhen Y,Zeng C,Yi HF,Zhao Y

更新日期：2007-11-01 00:00:00

abstract：:Dendritic cell (DC)-based immunotherapy has recently demonstrated a great potential for clinical applications; however, additional progress in the methods of tumor-specific antigen delivery to DCs is necessary for the further development of anti-tumor vaccines. To this end, a capsid-optimized adeno-associated virus se...

journal_title：Immunology and cell biology

authors： Pandya J,Ortiz L,Ling C,Rivers AE,Aslanidi G

更新日期：2014-02-01 00:00:00

abstract：:Previous studies established that the high density (resting) natural killer (NK) cell subset (R-NK) of peripheral blood NK cells is unresponsive to interleukin-2 (IL-2) but can be induced to proliferate when cultured with gamma-irradiated malignant melanoma (MM-170) cells or mitomycin-C-treated activated T cells in th...

journal_title：Immunology and cell biology

authors： Warren HS,Kinnear BF,Skipsey LJ

更新日期：1993-04-01 00:00:00

abstract：:A hypothesis if formulated for the mode of action of the 'atopy gene': the gene(s) causing an increased tendency to mount an IgE immune response to trivial environmental antigens. It is postulated that some antigens are not efficiently transported to the lymphoid organs, the location of the 'eutopic' immune system; mi...

journal_title：Immunology and cell biology

authors： Aalberse RC

更新日期：1996-04-01 00:00:00

abstract：:Endothelial cell (EC)-neutrophil (PMN) interactions are crucial in the resolution of bacterial infections. Prokaryotic RNA (pRNA) has been reported as a pathogen-associated molecular pattern that is released from bacteria upon death and is able to activate PMN. In this work, we studied the effects of pRNA on EC and in...

journal_title：Immunology and cell biology

authors： Castillo LA,Birnberg Weiss F,Rodriguez-Rodrigues N,Pittaluga JR,Martire-Greco D,Milillo MA,Grinstein SF,Camelli MR,Mena Aybar AJ,Landoni VI,Fernández GC

更新日期：2019-10-01 00:00:00

abstract：:The ability to accurately quantitate and experimentally examine epigenetic modifications across the human genome has exploded in the past decade. This has given rise to a wealth of new information concerning the contributions of epigenetic regulatory networks to the pathogenesis of human disease. In particular, immuno...

journal_title：Immunology and cell biology

authors： MacDonald IA,Hathaway NA

更新日期：2015-03-01 00:00:00

abstract：:A derivative of ammonia caramel colour (AC) is known to induce a selective lymphopenia in rats. Accordingly, the haematological effects were studied in mice of oral administration in drinking water of 2-acetyl-4(5)-tetrahydroxybutylimidazole (THI), the component of AC responsible for lymphopenia. Initially five groups...

journal_title：Immunology and cell biology

authors： Iscaro A,Mackay IR,O'Brien C

更新日期：1988-10-01 00:00:00

abstract：:The HECT-type E3 ligase Itch is increasingly being shown to have a vital role in immune regulation. Itch deficiency leads to deleterious inflammatory disorders both in mice and humans. By adding ubiquitin to the key signaling intermediates, Itch functions as a critical regulator of lymphocyte-cell activation, differen...

journal_title：Immunology and cell biology

authors： Venuprasad K,Zeng M,Baughan SL,Massoumi R

更新日期：2015-05-01 00:00:00

abstract：:Within the immune system multiple mechanisms balance the need for efficient pathogen recognition and destruction with the prevention of tissue damage by excessive, inappropriate or even self-targeting (auto)immune reactions. This immune homeostasis is a tightly regulated system which fails during tumor development, of...

journal_title：Immunology and cell biology

authors： da Gama Duarte J,Woods K,Andrews MC,Behren A

更新日期：2018-05-01 00:00:00