Abstract：
:Within the immune system multiple mechanisms balance the need for efficient pathogen recognition and destruction with the prevention of tissue damage by excessive, inappropriate or even self-targeting (auto)immune reactions. This immune homeostasis is a tightly regulated system which fails during tumor development, often due to the hijacking of its essential self-regulatory mechanisms by cancer cells. It is facilitated not only by tumor intrinsic properties, but also by the microbiome, host genetics and other factors. In certain ways many cancers can therefore be considered a rare failure of immune control rather than an uncommon or rare disease of the tissue of origin, as the acquisition of potentially oncogenic traits through mutation occurs constantly in most tissues during proliferation. Normally, aberrant cells are well-controlled by cell intrinsic (repair or apoptosis) and extrinsic (immune) mechanisms. However, occasionally oncogenic cells survive and escape control. Melanoma is one of the first cancer types where treatments aimed at restoring and enhancing an immune response to regain control over the tumor have been used with various success rates. With the advent of "modern" immunotherapeutics such as anti-CTLA-4 or anti-PD-1 antibodies that both target negative immune-regulatory pathways on immune cells resulting in durable responses in a proportion of patients, the importance of the interplay between the immune system and cancer has been established beyond doubt.
journal_name
Immunol Cell Bioljournal_title
Immunology and cell biologyauthors
da Gama Duarte J,Woods K,Andrews MC,Behren Adoi
10.1111/imcb.12001subject
Has Abstractpub_date
2018-05-01 00:00:00pages
497-506issue
5eissn
0818-9641issn
1440-1711journal_volume
96pub_type
杂志文章,评审abstract：:Mammalian target of rapamycin (mTOR) is a central regulator of cellular metabolic homeostasis that is highly conserved in evolution. Recent evidence has revealed the existence of a complex interplay between mTOR signalling and immunity. We review here the emerging role of mTOR signalling in the regulation of Toll-like...
journal_title：Immunology and cell biology
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journal_title：Immunology and cell biology
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journal_title：Immunology and cell biology
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Immunology and cell biology
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pub_type： 杂志文章
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journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
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更新日期：2007-02-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章
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更新日期：2003-02-01 00:00:00
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pub_type： 杂志文章
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journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
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更新日期：2016-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1111/j.1440-1711.2004.01216.x
更新日期：2004-02-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章
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更新日期：2013-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-10-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/sj.icb.7100023
更新日期：2007-04-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2012-02-01 00:00:00
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更新日期：2017-02-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章
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journal_title：Immunology and cell biology
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更新日期：2010-08-01 00:00:00
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journal_title：Immunology and cell biology
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journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
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更新日期：2000-08-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Immunology and cell biology
pub_type： 杂志文章
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更新日期：1992-06-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
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更新日期：1995-06-01 00:00:00
