Abstract：
:During tuberculosis (TB) infection, the granuloma provides the microenvironment in which antigen-specific T cells colocate with and activate infected macrophages to inhibit the growth of Mycobacterium tuberculosis. Although the granuloma is the site for mycobacterial killing, virulent mycobacteria have developed a variety of mechanisms to resist this macrophage-mediated killing. These surviving mycobacteria become dormant, however, if host cellular immunity or the signals maintaining granuloma structure wane, or if mycobacteria resume replication, leading to reactivation of TB. This balance of life and death applies not only to the mycobacterium but also to the host macrophages that may undergo apoptosis or necrosis, leading to the characteristic caseous necrosis within the granuloma, and the potential spread of TB infection. The immunological factors controlling the development and maintenance of the granuloma will be reviewed.
journal_name
Immunol Cell Bioljournal_title
Immunology and cell biologyauthors
Saunders BM,Britton WJdoi
10.1038/sj.icb.7100027subject
Has Abstractpub_date
2007-02-01 00:00:00pages
103-11issue
2eissn
0818-9641issn
1440-1711pii
7100027journal_volume
85pub_type
杂志文章,评审abstract：:The CD8 co-receptor engages peptide-major histocompatibility complex class I (pMHCI) molecules at a largely invariant site distinct from the T-cell receptor (TCR)-binding platform and enhances the sensitivity of antigen-driven activation to promote effective CD8+ T-cell immunity. A small increase in the strength of th...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2016.85
更新日期：2017-01-01 00:00:00
abstract：:Mast cells (MC) can undergo significant changes in number and phenotype; these alterations result in the differential expression of growth factors and cytokines. Kit ligand (KL; stem cell factor) is produced by mesenchymal cells, and in the liver by biliary epithelial cells. Recent studies suggest that KL, and its rec...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1111/j.1440-1711.2005.01368.x
更新日期：2005-12-01 00:00:00
abstract：:The Australian populations of rainbow trout (Onchorhynchus mykiss) and Atlantic salmon (Salmo salar) were found to have similar immunological responses to local strains of Vibrio anguillarum as those reported for the more genetically diverse populations of these fish and strains of V. anguillarum found in the Northern...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.1992.51
更新日期：1992-12-01 00:00:00
abstract：:Acute rejection is the major determinant for the long-term survival of donor liver after liver transplantation (LT). The aim of this study was to examine the therapeutic potential of interleukin (IL)-10-FasL-overexpressing immature dendritic cells (imDCs) to induce local immunosuppression in liver grafts. imDCs derive...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1111/imcb.12252
更新日期：2019-09-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1046/j.1440-1711.1998.00749.x
更新日期：1998-06-01 00:00:00
abstract：:Immunotherapy of tumours using T cells expanded in vitro has met with mixed clinical success suggesting that a greater understanding of tumour/T-cell interaction is required. We used a HPV16E7 oncoprotein-based mouse tumour model to study this further. In this study, we demonstrate that a HPV16E7 tumour passes through...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1111/j.0818-9641.2004.01273.x
更新日期：2004-10-01 00:00:00
abstract：:The NK gene complex (NKC) on mouse chromosome 6 encodes receptors that are expressed on NK cells, such as Ly49H, and is involved in regulating NK cell control of virus infections, such as murine cytomegalovirus (MCMV). In the present study, we investigated the level of allelic heterogeneity in NKC loci in populations ...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1111/j.1440-1711.2005.01311.x
更新日期：2005-04-01 00:00:00
abstract：:CD8+ T lymphocytes are key effectors in the control of viral diseases and some tumours. In general, the majority of CD8+ T cells recognize a few immunodominant epitopes, but in some circumstances, subdominant specificities may be more relevant as targets for vaccines or immunotherapy. Epstein-Barr virus (EBV)-associat...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/sj.icb.7100083
更新日期：2007-10-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.1992.22
更新日期：1992-06-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1046/j.0818-9641.2002.01137.x
更新日期：2003-02-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.1994.13
更新日期：1994-02-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1046/j.1440-1711.1998.00756.x
更新日期：1998-08-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.1993.19
更新日期：1993-06-01 00:00:00
abstract：:Using 'knockin' mice to track and ablate dendritic cells (DCs) expressing notably the langerin (Cd207) gene, it has been possible to identify five DC subsets within the skin and to assess whether functional specialization exists among them. The present review summarizes recent information concerning the phenotype and ...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1038/icb.2010.34
更新日期：2010-05-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1046/j.1440-1711.2001.01015.x
更新日期：2001-08-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1038/icb.2015.45
更新日期：2015-10-01 00:00:00
abstract：:Alzheimer's disease (AD) is characterized by amyloid beta (Aβ) accumulation, tau pathology and neuroinflammation. Recently, there has been considerable interest in the role of neuroinflammation in directly contributing to the progression of AD. Studies in mice and humans have identified a role for microglial cells, th...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1111/imcb.12301
更新日期：2020-01-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章
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更新日期：2016-05-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
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更新日期：2012-01-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1046/j.1440-1711.1998.00753.x
更新日期：1998-08-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2008.98
更新日期：2009-03-01 00:00:00
abstract：:Interleukin (IL)-9-producing CD4(+) T cells are a novel subset of T helper (Th) cells that develops independently of the Th1, Th2, Th17 and regulatory T-cell lineages. Similar to the murine model, transforming growth factor (TGF)-beta and IL-4 directed human naive CD4(+) T cells to produce IL-9. Whereas IL-4 suppresse...
journal_title：Immunology and cell biology
pub_type： 杂志文章
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更新日期：2010-08-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1046/j.1440-1711.2000.00951.x
更新日期：2000-12-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.1997.33
更新日期：1997-04-01 00:00:00
abstract：:Genetic fusion of tandem repeats of the complement molecule C3d has been shown to considerably enhance immune responses to genetic vaccines. We have investigated the applicability of this approach to augment humoral immune responses toward vaccines delivered by recombinant adeno-associated virus (AAV) vectors. C3d(3)-...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2009.92
更新日期：2010-02-01 00:00:00
abstract：:Listeria monocytogenes is the causative agent of infections like sepsis and meningitis, especially in immunocompromised hosts. Human macrophages are able to phagocytose and digest L. monocytogenes but IL-4 prevents human macrophages from killing the bacteria, the mechanisms of which are unknown. In the present study, ...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1046/j.1440-1711.2003.01196.x
更新日期：2003-12-01 00:00:00
abstract：:The peroxisome proliferator-activated receptors (PPAR) are ligand-activated transcription factors. There are three genes that code for the PPAR isoforms: PPARalpha, PPARbeta and PPARgamma. In the present review, studies characterizing the various PPAR isoforms are discussed. Peroxisome proliferator-activated receptor ...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1046/j.1440-1711.2000.00921.x
更新日期：2000-08-01 00:00:00
abstract：:Longevity of plasma cells is dependent on their ability to access and reside in so-called survival niches that are predominantly located in the bone marrow. It is proposed that by some process a small fraction of the plasma cells generated in response to new antigen challenges can enter into the long-lived repertoire ...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1111/imcb.12346
更新日期：2020-07-01 00:00:00
abstract：:Regulating the strength and class of an immune response requires lymphocytes to act as complex signal integrating "machines", taking information from multiple sources while making decisions that affect the final outcome. Describing and understanding the decision-making behaviour of lymphocytes within the context of th...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/sj.icb.7100061
更新日期：2007-06-01 00:00:00
abstract：:The protein composition of Strongyloides ratti infective larvae and adult worms extracted sequentially in water, sodium deoxycholate and sodium dodecyl sulphate (SDS) and their excretory/secretory products were analysed by both one- and two-dimensional SDS-polyacrylamide gel electrophoresis. While many bands common to...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.1987.26
更新日期：1987-06-01 00:00:00
