当前位置： SCI文献检索 > IMMUNOLOGY AND CELL BIOLOGY期刊下所有文献 > Listeria species escape from the phagosomes of interleukin-4-deactivated human macrophages independent of listeriolysin.

Listeria species escape from the phagosomes of interleukin-4-deactivated human macrophages independent of listeriolysin.

Abstract：

:Listeria monocytogenes is the causative agent of infections like sepsis and meningitis, especially in immunocompromised hosts. Human macrophages are able to phagocytose and digest L. monocytogenes but IL-4 prevents human macrophages from killing the bacteria, the mechanisms of which are unknown. In the present study, we examined various listeria species and strains including wild-type and deletion mutants in human macrophages pretreated with IL-4. To analyse the IL-4-mediated deactivation process, we combined quantitative infection assays with various morphologic methods. IL-4 facilitates survival and escape of the pathogenic L. monocytogenes wild-type strain 10403S from the macrophage phagosomes. In untreated macrophages, the isogenic listeriolysin deletion mutant strain DP-L2161 was killed and did not escape from the phagolysosomes. However, after macrophage deactivation with IL-4 DP-L2161 survived and escaped from the phagosomes. This was also the case, but to a lesser extent, even for the naturally avirulent L. innocua. As detected by confocal laser-scanning fluorescence microscopy and electron microscopy, IL-4 permitted the escape of all listeria species tested, including DP-L2161 and L. innocua from the phagosomal compartment of the macrophages. We conclude that escape from the phagosome and survival of the listeria species tested in IL-4-deactivated human macrophages is independent of the virulence factor listeriolysin.

journal_name

Immunol Cell Biol

journal_title

Immunology and cell biology

authors

Neumann K,Eppler E,Filgueira L,Groscurth P,Gasal E,Schaffner A,Schoedon G,Schneemann M

doi

10.1046/j.1440-1711.2003.01196.x

subject

Has Abstract

pub_date

2003-12-01 00:00:00

pages

431-9

issue

6

eissn

0818-9641

issn

1440-1711

pii

1196

journal_volume

81

pub_type

杂志文章,评审

相关文献

IMMUNOLOGY AND CELL BIOLOGY文献大全
  • Mycobacterium tuberculosis impairs dendritic cell response by altering CD1b, DC-SIGN and MR profile.

    abstract：:During a chronic infection such as tuberculosis, the pool of tissue dendritic cells (DC) must be renewed by recruitment of both circulating DC progenitors and monocytes (Mo). However, the microenvironment of the inflammatory site affects Mo differentiation. As DC are critical for initiating a Mycobacterium tuberculosi...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2010.22

    authors： Balboa L,Romero MM,Yokobori N,Schierloh P,Geffner L,Basile JI,Musella RM,Abbate E,de la Barrera S,Sasiain MC,Alemán M

    更新日期：2010-10-01 00:00:00

  • Immune regulation by histone deacetylases: a focus on the alteration of FOXP3 activity.

    abstract：:Several histone deacetylases (HDACs) are involved in the regulation of forkhead box protein P3 (FOXP3) expression and function by affecting features of FOXP3 protein stability. FOXP3, a forkhead family transcription factor specially expressed in regulatory T (Treg) cells, controls the expression of many key immune-reg...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.2011.101

    authors： Zhang H,Xiao Y,Zhu Z,Li B,Greene MI

    更新日期：2012-01-01 00:00:00

  • Human FoxP3(+)CD4(+) regulatory T cells: their knowns and unknowns.

    abstract：:Human regulatory T cells (Tregs) expressing the transcription factor FoxP3 play indispensable roles for the maintenance of immunological self-tolerance and immune homeostasis. In this review, we discuss immunological characteristics of human FoxP3(+) Tregs and to what extent they are similar to or different from the m...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.2010.137

    authors： Miyara M,Sakaguchi S

    更新日期：2011-03-01 00:00:00

  • Regulation of mucosal mast cell activation by short interfering RNAs targeting syntaxin4.

    abstract：:Mucosal mast cells (MMCs) have an important role in allergic inflammation, and effective antagonists are required for their regulation. To discover a possible mechanism of controlling the activation of MMCs, we investigated the expression and function of syntaxin4, one of the soluble membrane N-ethylmaleimide-sensitiv...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2011.41

    authors： Liu S,Nugroho AE,Shudou M,Maeyama K

    更新日期：2012-03-01 00:00:00

  • Targeted deletion of c-Met in thymic epithelial cells leads to an autoimmune phenotype.

    abstract：:Hepatocyte growth factor (HGF) and its receptor c-Met signaling have been implicated in regulating various types of cells including epithelial cells. We have previously reported that c-Met is expressed by thymic epithelial cells (TECs), and that in vivo administration of hybrid cytokines containing IL-7 and the beta- ...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1111/imcb.1026

    authors： Su M,Hu R,Song Y,Liu Y,Lai L

    更新日期：2018-02-01 00:00:00

  • The influence of hypoxia on the differentiation capacities and immunosuppressive properties of clonal mouse mesenchymal stromal cell lines.

    abstract：:Multipotent mesenchymal stromal cells are multipotent cells capable of differentiating into different mesodermal cell types. Enigmatically, mesenchymal stromal cells present in the bone marrow support early lymphopoiesis yet can inhibit mature lymphocyte growth. Critical features of the bone marrow microenvironment, s...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2014.30

    authors： Prado-Lòpez S,Duffy MM,Baustian C,Alagesan S,Hanley SA,Stocca A,Griffin MD,Ceredig R

    更新日期：2014-08-01 00:00:00

  • T-cell activation RhoGTPase-activating protein plays an important role in TH17-cell differentiation.

    abstract：:T-cell activation RhoGTPase-activating protein (TAGAP) is a GTPase-activating protein specific for RhoA that is exclusively expressed in activated T cells. Genome-wide association studies and metagenome SNPs analyses have indicated that TAGAP is associated with the pathogenesis of multiple autoimmune diseases, includi...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2017.27

    authors： Tamehiro N,Nishida K,Yanobu-Takanashi R,Goto M,Okamura T,Suzuki H

    更新日期：2017-09-01 00:00:00

  • A CD2 high-expressing stress-resistant human plasmacytoid dendritic-cell subset.

    abstract：:Human plasmacytoid dendritic cells (pDCs) were considered to be a phenotypically and functionally homogeneous cell population; however, recent analyses indicate potential heterogeneity. This is of major interest, given their importance in the induction of anti-viral responses and their role in creating immunologically...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2015.116

    authors： Bryant C,Fromm PD,Kupresanin F,Clark G,Lee K,Clarke C,Silveira PA,Suen H,Brown R,Newman E,Cunningham I,Ho PJ,Gibson J,Bradstock K,Joshua D,Hart DNj

    更新日期：2016-05-01 00:00:00

  • Monoclonal antibodies reactive with mucin expressed in breast cancer.

    abstract：:Three murine monoclonal antibodies (BC1, BC2 and BC3) were developed against human milk fat globule membrane (HMFGM). By immunoperoxidase staining, it was found that the antigenic determinants had a predominant distribution in breast cancer tissue. In addition, the antibodies reacted preferentially with mucin derived ...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1989.29

    authors： Xing PX,Tjandra JJ,Stacker SA,Teh JG,Thompson CH,McLaughlin PJ,McKenzie IF

    更新日期：1989-06-01 00:00:00

  • Use of CD107-based cell sorting ex vivo to enrich subdominant CD8+ T cells in culture.

    abstract：:CD8+ T lymphocytes are key effectors in the control of viral diseases and some tumours. In general, the majority of CD8+ T cells recognize a few immunodominant epitopes, but in some circumstances, subdominant specificities may be more relevant as targets for vaccines or immunotherapy. Epstein-Barr virus (EBV)-associat...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/sj.icb.7100083

    authors： Moor RJ,Morrison LE,Moss DJ,Tscharke DC

    更新日期：2007-10-01 00:00:00

  • Moving candidate vaccines into development from research: lessons from HIV.

    abstract：:There is a logarithmic increase in the cost and complexity of the research and development process when transitioning a promising candidate vaccine from the laboratory into the clinic. Managing complex development programs involving people from diverse technical, cultural and geographical backgrounds is a specialised ...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.2009.30

    authors： Sullivan M

    更新日期：2009-07-01 00:00:00

  • Human IgG2- and IgG4-expressing memory B cells display enhanced molecular and phenotypic signs of maturity and accumulate with age.

    abstract：:The mechanisms involved in sequential immunoglobulin G (IgG) class switching are still largely unknown. Sequential IG class switching is linked to higher levels of somatic hypermutation (SHM) in vivo, but it remains unclear if these are generated temporally during an immune response or upon activation in a secondary r...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2017.43

    authors： de Jong BG,IJspeert H,Marques L,van der Burg M,van Dongen JJ,Loos BG,van Zelm MC

    更新日期：2017-10-01 00:00:00

  • Gαs-coupled GPCRs GPR65 and GPR174. Downers for immune responses.

    abstract：:See also: Outstanding Observation by Wirasinha et al., Short Communication by Barnes & Cyster. ...

    journal_title：Immunology and cell biology

    pub_type： 评论,杂志文章

    doi：10.1111/imcb.12027

    authors： Robert R,Mackay CR

    更新日期：2018-04-01 00:00:00

  • Embryonic macrophages of early rat yolk sac: Immunohistochemistry and ultrastructure with reference to endodermal cell layer.

    abstract：:Macrophages are multifunctional cells that participate in numerous biological processes; they actively phagocytose foreign particles and cell debris. Embryonic tissue macrophages are present at early stages of mammalian development; their ontogeny and function is still under investigation. Our study used immunohistoch...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1046/j.1440-1711.2002.01109.x

    authors： El-Nefiawy N,Abdel-Hakim K,Yamashita A,Kanayama N

    更新日期：2002-10-01 00:00:00

  • Antibody blockade of Thy-1 (CD90) impairs mouse cytotoxic T lymphocyte induction by anti-CD3 monoclonal antibody.

    abstract：:Thy-1 (CD90) expressed by mouse T cells is known to have signal transducing properties, but the ability of Thy-1 to enhance cytotoxic T lymphocyte (CTL) development is not well understood. Here we show that stimulation of mouse T cells with monoclonal antibodies (mAb) to CD3, CD28 and Thy-1 (clone G7), which were coim...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1711.2005.01342.x

    authors： Haeryfar SM,Conrad DM,Musgrave B,Hoskin DW

    更新日期：2005-08-01 00:00:00

  • Seasoned adaptive antibody immunity for highly pathogenic pandemic influenza in humans.

    abstract：:Fundamentally new approaches are required for the development of vaccines to pre-empt and protect against emerging and pandemic influenzas. Current strategies involve post-emergent homotypic vaccines that are modelled upon select circulating 'seasonal' influenzas, but cannot induce cross-strain protection against newl...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.2011.38

    authors： Lynch GW,Selleck P,Church WB,Sullivan JS

    更新日期：2012-02-01 00:00:00

  • Purity of transferred CD8(+) T cells is crucial for safety and efficacy of combinatorial tumor immunotherapy in the absence of SHP-1.

    abstract：:Adoptive transfer of tumor-specific cytotoxic T cells is a promising advance in cancer therapy. Similarly, checkpoint inhibition has shown striking clinical results in some patients. Here we combine adoptive cell transfer with ablation of the checkpoint protein Src homology 2-domain-containing phosphatase 1 (SHP-1, Pt...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2016.45

    authors： Watson HA,Dolton G,Ohme J,Ladell K,Vigar M,Wehenkel S,Hindley J,Mohammed RN,Miners K,Luckwell RA,Price DA,Matthews RJ,Ager A

    更新日期：2016-09-01 00:00:00

  • Effect of a tapasin mutant on the assembly of the mouse MHC class I molecule H2-K(d).

    abstract：:Major histocompatibility complex (MHC) class I heavy chain/beta(2)m heterodimers assemble with antigenic peptides through interactions with peptide-loading complex proteins, including tapasin and ERp57. In human cells, a cysteine residue within tapasin (C95) has been shown to form a covalent bond with ERp57. In this s...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2009.59

    authors： Simone LC,Wang X,Tuli A,Solheim JC

    更新日期：2010-01-01 00:00:00

  • Lymphoid organ dendritic cells: beyond the Langerhans cells paradigm.

    abstract：:The immune system has developed mechanisms to detect and initiate responses to a continual barrage of immunological challenges. Dendritic cells (DC), a heterogeneous population of leucocytes, play a major role as immunosurveillance agents. To accomplish this function, DC are equipped with highly efficient mechanisms t...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1711.2004.01216.x

    authors： Wilson NS,Villadangos JA

    更新日期：2004-02-01 00:00:00

  • Antigen-driven CD4+ T-cell anergy: a pathway to peripheral T regulatory cells.

    abstract：:In their recent publication, Kuczma and colleagues have provided evidence that advances the relationship between naive T cells, T cell anergy and T regulatory cells. Their findings strengthen the understanding of how these T cell subsets function in relation to self and microbiota-derived epitopes to promote and maint...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1111/imcb.12424

    authors： Eggenhuizen PJ,Ng BH,Ooi JD

    更新日期：2020-12-04 00:00:00

  • The surface phenotype of activated T lymphocytes.

    abstract：:The surface phenotype of T cells reflects both their relative maturity and their activation state. To determine the pattern of surface markers characteristic of activated T cells, purified mature T cells were stimulated in vitro for periods of 0.5-5 days with Concanavalin-A (Con-A) or phorbol myristic acetate (PMA) an...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1988.39

    authors： Kelly K,Shortman K,Scollay R

    更新日期：1988-08-01 00:00:00

  • When versatility matters: activins/inhibins as key regulators of immunity.

    abstract：:Activins and inhibins are members of the transforming growth factor-β superfamily that have been considered crucial regulators of cell processes, such as differentiation, proliferation and apoptosis, in different cell types. Initial studies about the function of activin A in the immune system focused on the regulation...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.2011.32

    authors： Aleman-Muench GR,Soldevila G

    更新日期：2012-02-01 00:00:00

  • Redox balance of mouse medullary CD4 single-positive thymocytes.

    abstract：:After positive selection, the newly differentiated single-positive (SP) thymocytes undergo negative selection to eliminate autoreactive T cells, functional maturation to acquire immunocompetence and egress capability. To investigate whether the intracellular reduction/oxidation (redox) balance has an important role on...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2013.57

    authors： Jin R,Teng F,Xu X,Yao Y,Zhang S,Sun X,Zhang Y,Ge Q

    更新日期：2013-11-01 00:00:00

  • 'Reverse gear' cellular movement mediated by chemokines.

    abstract：:We sought to model the mechanism by which leucocytes may be actively repulsed by a beta-chemokine signal. This model is used to interpret an apparent paradox in chemokine biology, whereby high levels of a T-cell chemoattractant, stromal cell derived factor-1 (SDF-1), are present in bone marrow and thymic tissues despi...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1046/j.1440-1711.2001.01015.x

    authors： Zlatopolskiy A,Laurence J

    更新日期：2001-08-01 00:00:00

  • Recombinant vaccines against ovine footrot.

    abstract：:For the past 20 years footrot vaccines have evolved from simple bacterins to highly specific recombinant DNA (rDNA) fimbrial vaccines. The development of these vaccines has left a trail of discoveries, challenges and solutions; these processes continue as we move closer to understanding the requirements of a footrot v...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.1993.53

    authors： O'Meara TJ,Egerton JR,Raadsma HW

    更新日期：1993-10-01 00:00:00

  • Immunochemotherapy of human colon carcinoma xenografts in nude mice using combinations of idarubicin-monoclonal antibody conjugates.

    abstract：:Tumour cell heterogeneity is probably a principal cause of treatment failure and represents a formidable barrier for effective antibody-targeted chemotherapy. Idarubicin (Ida), a more potent and less cardiotoxic analogue of daunomycin, has been demonstrated to specifically target and eradicate homogeneous, cloned, mur...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1993.19

    authors： Smyth MJ,Foster HM,Andrew SM,Teh JG,Krauer K,McKenzie IF,Pietersz GA

    更新日期：1993-06-01 00:00:00

  • Effects of biological drug adalimumab on tumour necrosis factor-alpha-converting enzyme activation.

    abstract：:Tumour necrosis factor-alpha (TNF-alpha)-converting enzyme (TACE) is a membrane-bound metalloprotease and disintegrin. It is produced by a number of host cells and is known to shed and release cell-bound cytokines, particularly members of the TNF family. No investigations into the regulation of this enzyme by autoanti...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2009.97

    authors： Lisi S,Sisto M

    更新日期：2010-03-01 00:00:00

  • Production of interleukin-1 alpha and interleukin-2 by separate, phenotypically different leukaemia and human T cell lymphotropic virus-1-transformed T cell clones.

    abstract：:The relationship between interleukin-1 (IL-1) and interleukin-2 (IL-2) production and immunophenotype marker profiles was studied in a panel of 29 leukaemia and human T cell lymphotropic virus-1 (HTLV-1)-transformed T cell lines. Culture supernatants from six of the 29 T cell lines tested increased IL-2 production by ...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1993.56

    authors： Holán V,Minowada J

    更新日期：1993-12-01 00:00:00

  • Clustering T-cell GM1 lipid rafts increases cellular resistance to shear on fibronectin through changes in integrin affinity and cytoskeletal dynamics.

    abstract：:Lipid rafts are small laterally mobile microdomains that are highly enriched in lymphocyte signaling molecules. GM1 gangliosides are a common lipid raft component and have been shown to be important in many T-cell functions. The aggregation of specific GM1 lipid rafts can control many T-cell activation events, includi...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2008.103

    authors： Mitchell JS,Brown WS,Woodside DG,Vanderslice P,McIntyre BW

    更新日期：2009-05-01 00:00:00

  • Establishment of a natural suppressor cell line producing soluble suppressor factor other than transforming growth factor-beta.

    abstract：:Natural suppressor (NS) cell line (Clone 59) was established from the bone marrow of adult C3H/Hej mice in the presence of WEHI-3 conditioned media. Clone 59 cells suppressed the generation of cytotoxic T lymphocytes from normal mouse spleen. This suppression was seen at a responder-to-suppressor cell ratio of 1000:1 ...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1995.51

    authors： Yanagië H,Sugiyama H,Sekiguchi M

    更新日期：1995-08-01 00:00:00